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The map label for this gene is caiD [H]

Identifier: 108801043

GI number: 108801043

Start: 4347347

End: 4348096

Strand: Reverse

Name: caiD [H]

Synonym: Mmcs_4079

Alternate gene names: 108801043

Gene position: 4348096-4347347 (Counterclockwise)

Preceding gene: 108801044

Following gene: 108801042

Centisome position: 76.21

GC content: 67.2

Gene sequence:

>750_bases
GTGCTGATCATCACGATCAACCGCCCCGAGGCCCGCAACGCCGTCAACGCGTCGGTGTCCATCGGCGTGGGCGACGCCCT
GCAGGCCGCGCAGGAGGATCCGGAGATCCGGGCCGTCATCCTGACCGGCGCCGGAGACAAGTCCTTCTGTGCCGGAGCCG
ATCTCAAGGCGATCTCACGCGGTGAGAACCTGTTCCACCCCGAGCATTCGGAGTGGGGCTTCGCCGGGTACGTGCGGCAC
TTCATCGACAAGCCGACGATCGCCGCGGTCAACGGCACAGCACTGGGCGGCGGCACCGAACTCGCGCTGGCCAGCGATCT
GGTGGTGGCCGAGGAACGTGCGAAATTCGGTCTGCCCGAGGTGAAACGGGGCCTGATCGCCGGTGCCGGCGGCGTATTCC
GCATCGTCGAGCAGCTCCCTCGCAAGGTCGCGCTCGAGCTGATCTACACCGGTGAGCCGATCAGTGCGGCCGATGCGCTG
CGCTGGGGTCTGATCAACGATGTGGTGCCCGACGGCACCGTGGTGGACGCCGCGCTCAAACTCGCCGAGCGGATCACCTG
CAACGCGCCGCTGGCCGTGCAGGCCAGCAAGCGGGTGTCCTATGGCGCCGTCGACGGTGTGGTCGGCAGCGACGAGCCGT
TCTGGAAGCAGACGTTCAGCGAGTTCTCGACGCTGCTGAAGACCGAGGACGCCATGGAAGGGCCGCTGGCATTCGCGCAG
AAGCGCGAGCCGGTCTGGAAGGCGAAGTAA

Upstream 100 bases:

>100_bases
CGATGTGCGAGGGCGGCGGCCAGGCCAACGCGACCATCCTCGAACTGCTGTGACCGAAACGGCAACCGCCCCCGGCGCTC
TCACCGAGCGCCGGGGGAAC

Downstream 100 bases:

>100_bases
GCCAAGTACGACAAGACGTTAGGAACAGAAGATGAAGCGAACGATCTACGAAGCGGAGCACGAAGCCTTCCGCCAGACCG
TCAAGGATTACATCGAGCGT

Product: short chain enoyl-CoA hydratase

Products: L-Carnitine.; L-carnitinyl-CoA [C]

Alternate protein names: Crotonobetainyl-CoA hydratase [H]

Number of amino acids: Translated: 249; Mature: 249

Protein sequence:

>249_residues
MLIITINRPEARNAVNASVSIGVGDALQAAQEDPEIRAVILTGAGDKSFCAGADLKAISRGENLFHPEHSEWGFAGYVRH
FIDKPTIAAVNGTALGGGTELALASDLVVAEERAKFGLPEVKRGLIAGAGGVFRIVEQLPRKVALELIYTGEPISAADAL
RWGLINDVVPDGTVVDAALKLAERITCNAPLAVQASKRVSYGAVDGVVGSDEPFWKQTFSEFSTLLKTEDAMEGPLAFAQ
KREPVWKAK

Sequences:

>Translated_249_residues
MLIITINRPEARNAVNASVSIGVGDALQAAQEDPEIRAVILTGAGDKSFCAGADLKAISRGENLFHPEHSEWGFAGYVRH
FIDKPTIAAVNGTALGGGTELALASDLVVAEERAKFGLPEVKRGLIAGAGGVFRIVEQLPRKVALELIYTGEPISAADAL
RWGLINDVVPDGTVVDAALKLAERITCNAPLAVQASKRVSYGAVDGVVGSDEPFWKQTFSEFSTLLKTEDAMEGPLAFAQ
KREPVWKAK
>Mature_249_residues
MLIITINRPEARNAVNASVSIGVGDALQAAQEDPEIRAVILTGAGDKSFCAGADLKAISRGENLFHPEHSEWGFAGYVRH
FIDKPTIAAVNGTALGGGTELALASDLVVAEERAKFGLPEVKRGLIAGAGGVFRIVEQLPRKVALELIYTGEPISAADAL
RWGLINDVVPDGTVVDAALKLAERITCNAPLAVQASKRVSYGAVDGVVGSDEPFWKQTFSEFSTLLKTEDAMEGPLAFAQ
KREPVWKAK

Specific function: Catalyzes the reversible dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA [H]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=247, Percent_Identity=37.6518218623482, Blast_Score=155, Evalue=3e-38,
Organism=Homo sapiens, GI31542718, Length=246, Percent_Identity=29.6747967479675, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI68989263, Length=247, Percent_Identity=32.3886639676113, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI4502327, Length=262, Percent_Identity=34.3511450381679, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI70995211, Length=262, Percent_Identity=30.1526717557252, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI37594469, Length=175, Percent_Identity=30.8571428571429, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI37594471, Length=175, Percent_Identity=30.8571428571429, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI20127408, Length=172, Percent_Identity=27.906976744186, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI260274832, Length=175, Percent_Identity=32, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI45643119, Length=201, Percent_Identity=30.3482587064677, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI260275230, Length=201, Percent_Identity=30.3482587064677, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI221142681, Length=251, Percent_Identity=42.6294820717131, Blast_Score=194, Evalue=5e-51,
Organism=Escherichia coli, GI1787659, Length=249, Percent_Identity=37.3493975903614, Blast_Score=156, Evalue=1e-39,
Organism=Escherichia coli, GI1788597, Length=246, Percent_Identity=32.9268292682927, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1788682, Length=189, Percent_Identity=35.4497354497354, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI87082183, Length=237, Percent_Identity=30.8016877637131, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1787660, Length=255, Percent_Identity=31.7647058823529, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1790281, Length=202, Percent_Identity=33.1683168316832, Blast_Score=85, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17554946, Length=250, Percent_Identity=36.8, Blast_Score=151, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI25145438, Length=249, Percent_Identity=37.7510040160643, Blast_Score=147, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17540714, Length=201, Percent_Identity=38.3084577114428, Blast_Score=120, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI17560910, Length=253, Percent_Identity=32.4110671936759, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17534483, Length=263, Percent_Identity=29.277566539924, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17540306, Length=163, Percent_Identity=38.0368098159509, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17536985, Length=265, Percent_Identity=29.0566037735849, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI25144157, Length=242, Percent_Identity=27.6859504132231, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI25144160, Length=242, Percent_Identity=28.5123966942149, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17558304, Length=229, Percent_Identity=27.0742358078603, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17508951, Length=172, Percent_Identity=30.8139534883721, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17508953, Length=172, Percent_Identity=30.8139534883721, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI25144276, Length=172, Percent_Identity=30.8139534883721, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17549921, Length=201, Percent_Identity=27.363184079602, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17535521, Length=204, Percent_Identity=27.4509803921569, Blast_Score=67, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6320241, Length=183, Percent_Identity=30.6010928961749, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI20129971, Length=246, Percent_Identity=37.3983739837398, Blast_Score=141, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24653477, Length=246, Percent_Identity=37.3983739837398, Blast_Score=141, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24653139, Length=258, Percent_Identity=37.5968992248062, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI21357171, Length=202, Percent_Identity=35.1485148514851, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24650670, Length=186, Percent_Identity=33.8709677419355, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI19920382, Length=211, Percent_Identity=28.9099526066351, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28571730, Length=254, Percent_Identity=27.5590551181102, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28571729, Length=254, Percent_Identity=27.5590551181102, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24654903, Length=229, Percent_Identity=25.3275109170306, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19922422, Length=264, Percent_Identity=25.7575757575758, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19921000, Length=176, Percent_Identity=32.3863636363636, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022852
- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: 4.2.1.- [C]

Molecular weight: Translated: 26436; Mature: 26436

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIITINRPEARNAVNASVSIGVGDALQAAQEDPEIRAVILTGAGDKSFCAGADLKAISR
CEEEEECCCCCCCCCCCEEEECCCHHHHHHCCCCCEEEEEEECCCCCCCCCCCCHHHHHC
GENLFHPEHSEWGFAGYVRHFIDKPTIAAVNGTALGGGTELALASDLVVAEERAKFGLPE
CCCCCCCCCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCHH
VKRGLIAGAGGVFRIVEQLPRKVALELIYTGEPISAADALRWGLINDVVPDGTVVDAALK
HHHHHHCCCCHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHCCCCCHHHHHHHH
LAERITCNAPLAVQASKRVSYGAVDGVVGSDEPFWKQTFSEFSTLLKTEDAMEGPLAFAQ
HHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHH
KREPVWKAK
CCCCCCCCC
>Mature Secondary Structure
MLIITINRPEARNAVNASVSIGVGDALQAAQEDPEIRAVILTGAGDKSFCAGADLKAISR
CEEEEECCCCCCCCCCCEEEECCCHHHHHHCCCCCEEEEEEECCCCCCCCCCCCHHHHHC
GENLFHPEHSEWGFAGYVRHFIDKPTIAAVNGTALGGGTELALASDLVVAEERAKFGLPE
CCCCCCCCCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCHH
VKRGLIAGAGGVFRIVEQLPRKVALELIYTGEPISAADALRWGLINDVVPDGTVVDAALK
HHHHHHCCCCHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHCCCCCHHHHHHHH
LAERITCNAPLAVQASKRVSYGAVDGVVGSDEPFWKQTFSEFSTLLKTEDAMEGPLAFAQ
HHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHH
KREPVWKAK
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-Carnitine; D-carnitinyl-CoA [C]

Specific reaction: D-Carnitine = L-Carnitine. D-carnitinyl-CoA = L-carnitinyl-CoA [C]

General reaction: Isomerases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA