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The map label for this gene is fadA [H]

Identifier: 108801044

GI number: 108801044

Start: 4348144

End: 4349301

Strand: Reverse

Name: fadA [H]

Synonym: Mmcs_4080

Alternate gene names: 108801044

Gene position: 4349301-4348144 (Counterclockwise)

Preceding gene: 108801046

Following gene: 108801043

Centisome position: 76.23

GC content: 68.65

Gene sequence:

>1158_bases
ATGGCTGAAGCCGTCATCGTCGAGGCTGTACGGTCGCCCGTCGGCAAGCGCAACGGCGGTCTGTCGGGGGTGCACCCGGC
CGAACTGTCCGCTCAGGTGCTCAACGGCCTGGTGGAGCGCGCCGGGGTGGACCCCGCGCTGGTCGACGATGTCATCTGGG
GCTGCGTCATGCAGGCCGGTGAGCAGGCGCTCGACATCGCCCGCACCGCGGTGCTGTCCGCAGGCTGGCCCGAGACCGTC
CCCGGGGTGACCGTGGACCGCCAGTGCGGTTCCAGCCAGCAGTCGCTGCACTTCGCCGTCGCCGGCGTGGTGGCGGGTCA
CTACGACGTGGTCGTCGCCGGCGGCGTCGAGTCGATGTCGCGGACCCCGATGGGTTCCTCGCTGGCCAACGGCGGAAACC
CGTACGGCGAGTCGTTCAAGGCCCGCTACAGCCAGACCCCGAACCAGGGCGTCGGCGCCGAGATGATCGCCGAGCAGTGG
GGCTTCAGCCGCACCGAGCTCGACGAGTTCTCCCTGCGTTCGCATGAGAAGGCCGCCGCCGCACAGGATTCCGGTGCCTT
CAAGGACCAGATCGTCGGCATCGAGACCAAGGACGCGGACGGCAACGACACCGTCGTGCTCGAGGACGGCGGTATCCGCC
GCGGCGGCACCGTCGAGTCGATGGCCAAGATCAAGCCCGCGTTCCGTGAGGACGGCGTGATCCACGCCGGCAACTCCAGC
CAGATCTCCGACGGTTCGGCCGCGCTGCTGATCATGTCGGCGGATAAGGCCAAGGACCTCGGCCTCAAGCCATTGGCCAA
GGTGCACACCGCGGTGCTCGCCGGCGCCGACCCGGTCATCATGCTGACCGCGCCGATCCCGGCCACCCAGAAGGCGCTGA
AGAAGTCGGGTCTGAGCCTCGACCAGATCGGCGCGTTCGAGGTCAACGAGGCCTTCGCGCCGGTGCCGATGGCCTGGCTG
AAGGACATCGGGGCCGACGAGTCCAAGCTCAACCCCAACGGAGGCGCGATCGCGCTCGGCCACCCGCTCGGTGGCTCCGG
TGCGCGAATCCTGACGACGCTGCTGTACCACATGCGCGACAACAACATTCAGTACGGCCTGCAGACGATGTGCGAGGGCG
GCGGCCAGGCCAACGCGACCATCCTCGAACTGCTGTGA

Upstream 100 bases:

>100_bases
AGGCTGACCCCACCAACCAGTAGGTTGACCTAGTAAACCTTGTCCTCTACCGTCGTGTCCAAGTGTGTGGAGCGGTATCC
GACTTCGAAGGAGAAGTGTC

Downstream 100 bases:

>100_bases
CCGAAACGGCAACCGCCCCCGGCGCTCTCACCGAGCGCCGGGGGAACGTGCTGATCATCACGATCAACCGCCCCGAGGCC
CGCAACGCCGTCAACGCGTC

Product: acetyl-CoA C-acyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta [H]

Number of amino acids: Translated: 385; Mature: 384

Protein sequence:

>385_residues
MAEAVIVEAVRSPVGKRNGGLSGVHPAELSAQVLNGLVERAGVDPALVDDVIWGCVMQAGEQALDIARTAVLSAGWPETV
PGVTVDRQCGSSQQSLHFAVAGVVAGHYDVVVAGGVESMSRTPMGSSLANGGNPYGESFKARYSQTPNQGVGAEMIAEQW
GFSRTELDEFSLRSHEKAAAAQDSGAFKDQIVGIETKDADGNDTVVLEDGGIRRGGTVESMAKIKPAFREDGVIHAGNSS
QISDGSAALLIMSADKAKDLGLKPLAKVHTAVLAGADPVIMLTAPIPATQKALKKSGLSLDQIGAFEVNEAFAPVPMAWL
KDIGADESKLNPNGGAIALGHPLGGSGARILTTLLYHMRDNNIQYGLQTMCEGGGQANATILELL

Sequences:

>Translated_385_residues
MAEAVIVEAVRSPVGKRNGGLSGVHPAELSAQVLNGLVERAGVDPALVDDVIWGCVMQAGEQALDIARTAVLSAGWPETV
PGVTVDRQCGSSQQSLHFAVAGVVAGHYDVVVAGGVESMSRTPMGSSLANGGNPYGESFKARYSQTPNQGVGAEMIAEQW
GFSRTELDEFSLRSHEKAAAAQDSGAFKDQIVGIETKDADGNDTVVLEDGGIRRGGTVESMAKIKPAFREDGVIHAGNSS
QISDGSAALLIMSADKAKDLGLKPLAKVHTAVLAGADPVIMLTAPIPATQKALKKSGLSLDQIGAFEVNEAFAPVPMAWL
KDIGADESKLNPNGGAIALGHPLGGSGARILTTLLYHMRDNNIQYGLQTMCEGGGQANATILELL
>Mature_384_residues
AEAVIVEAVRSPVGKRNGGLSGVHPAELSAQVLNGLVERAGVDPALVDDVIWGCVMQAGEQALDIARTAVLSAGWPETVP
GVTVDRQCGSSQQSLHFAVAGVVAGHYDVVVAGGVESMSRTPMGSSLANGGNPYGESFKARYSQTPNQGVGAEMIAEQWG
FSRTELDEFSLRSHEKAAAAQDSGAFKDQIVGIETKDADGNDTVVLEDGGIRRGGTVESMAKIKPAFREDGVIHAGNSSQ
ISDGSAALLIMSADKAKDLGLKPLAKVHTAVLAGADPVIMLTAPIPATQKALKKSGLSLDQIGAFEVNEAFAPVPMAWLK
DIGADESKLNPNGGAIALGHPLGGSGARILTTLLYHMRDNNIQYGLQTMCEGGGQANATILELL

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=388, Percent_Identity=37.1134020618557, Blast_Score=243, Evalue=2e-64,
Organism=Homo sapiens, GI4501853, Length=394, Percent_Identity=39.3401015228426, Blast_Score=243, Evalue=2e-64,
Organism=Homo sapiens, GI4557237, Length=397, Percent_Identity=35.5163727959698, Blast_Score=228, Evalue=7e-60,
Organism=Homo sapiens, GI148539872, Length=389, Percent_Identity=36.5038560411311, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI4504327, Length=423, Percent_Identity=33.806146572104, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI194353979, Length=384, Percent_Identity=28.6458333333333, Blast_Score=135, Evalue=5e-32,
Organism=Escherichia coli, GI48994986, Length=394, Percent_Identity=45.1776649746193, Blast_Score=306, Evalue=2e-84,
Organism=Escherichia coli, GI1787663, Length=399, Percent_Identity=39.8496240601504, Blast_Score=269, Evalue=2e-73,
Organism=Escherichia coli, GI87082165, Length=392, Percent_Identity=39.030612244898, Blast_Score=256, Evalue=1e-69,
Organism=Escherichia coli, GI1788554, Length=396, Percent_Identity=41.1616161616162, Blast_Score=256, Evalue=2e-69,
Organism=Escherichia coli, GI1788683, Length=422, Percent_Identity=29.6208530805687, Blast_Score=164, Evalue=9e-42,
Organism=Caenorhabditis elegans, GI133906874, Length=388, Percent_Identity=38.659793814433, Blast_Score=257, Evalue=9e-69,
Organism=Caenorhabditis elegans, GI17535921, Length=393, Percent_Identity=33.0788804071247, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI25147385, Length=394, Percent_Identity=31.9796954314721, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17551802, Length=428, Percent_Identity=29.2056074766355, Blast_Score=166, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17535917, Length=391, Percent_Identity=28.6445012787724, Blast_Score=145, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6322031, Length=394, Percent_Identity=34.5177664974619, Blast_Score=194, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6325229, Length=396, Percent_Identity=34.0909090909091, Blast_Score=189, Evalue=5e-49,
Organism=Drosophila melanogaster, GI24655093, Length=393, Percent_Identity=36.6412213740458, Blast_Score=237, Evalue=1e-62,
Organism=Drosophila melanogaster, GI17648125, Length=389, Percent_Identity=34.9614395886889, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24640423, Length=397, Percent_Identity=33.7531486146096, Blast_Score=214, Evalue=9e-56,
Organism=Drosophila melanogaster, GI17137578, Length=423, Percent_Identity=32.6241134751773, Blast_Score=197, Evalue=1e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012805
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 39889; Mature: 39757

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEAVIVEAVRSPVGKRNGGLSGVHPAELSAQVLNGLVERAGVDPALVDDVIWGCVMQAG
CCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHC
EQALDIARTAVLSAGWPETVPGVTVDRQCGSSQQSLHFAVAGVVAGHYDVVVAGGVESMS
HHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHCCEEEEEECCHHHHH
RTPMGSSLANGGNPYGESFKARYSQTPNQGVGAEMIAEQWGFSRTELDEFSLRSHEKAAA
CCCCCCHHCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHH
AQDSGAFKDQIVGIETKDADGNDTVVLEDGGIRRGGTVESMAKIKPAFREDGVIHAGNSS
HCCCCCCHHHEEEEEECCCCCCCEEEECCCCCCCCCCHHHHHHHCHHHHCCCEEECCCCC
QISDGSAALLIMSADKAKDLGLKPLAKVHTAVLAGADPVIMLTAPIPATQKALKKSGLSL
CCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHCCCCH
DQIGAFEVNEAFAPVPMAWLKDIGADESKLNPNGGAIALGHPLGGSGARILTTLLYHMRD
HHCCCEECCCCCCCCCHHHHHHCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHCC
NNIQYGLQTMCEGGGQANATILELL
CCHHHHHHHHHCCCCCCCCEEEEEC
>Mature Secondary Structure 
AEAVIVEAVRSPVGKRNGGLSGVHPAELSAQVLNGLVERAGVDPALVDDVIWGCVMQAG
CCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHC
EQALDIARTAVLSAGWPETVPGVTVDRQCGSSQQSLHFAVAGVVAGHYDVVVAGGVESMS
HHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHCCEEEEEECCHHHHH
RTPMGSSLANGGNPYGESFKARYSQTPNQGVGAEMIAEQWGFSRTELDEFSLRSHEKAAA
CCCCCCHHCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHH
AQDSGAFKDQIVGIETKDADGNDTVVLEDGGIRRGGTVESMAKIKPAFREDGVIHAGNSS
HCCCCCCHHHEEEEEECCCCCCCEEEECCCCCCCCCCHHHHHHHCHHHHCCCEEECCCCC
QISDGSAALLIMSADKAKDLGLKPLAKVHTAVLAGADPVIMLTAPIPATQKALKKSGLSL
CCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHCCCCH
DQIGAFEVNEAFAPVPMAWLKDIGADESKLNPNGGAIALGHPLGGSGARILTTLLYHMRD
HHCCCEECCCCCCCCCHHHHHHCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHCC
NNIQYGLQTMCEGGGQANATILELL
CCHHHHHHHHHCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA