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The map label for this gene is nadC [H]

Identifier: 108800032

GI number: 108800032

Start: 3241457

End: 3242323

Strand: Reverse

Name: nadC [H]

Synonym: Mmcs_3066

Alternate gene names: 108800032

Gene position: 3242323-3241457 (Counterclockwise)

Preceding gene: 108800033

Following gene: 108800029

Centisome position: 56.83

GC content: 71.05

Gene sequence:

>867_bases
GTGCTGCTGAGTCAGCTTTCGGAGACCGAGATCGCCGAAGCGCGCGCGGTCGTCGCGCGCGGACTCGAGGAGGACCTGCG
GTACGGGCCGGACGTCACCACGCAGGCGACCGTGCCGGCCGACGCGGCCACCACCGCGTCGATGCGCACCCGCGAACCCG
GGGTGGCCGCGGGGGTCGACGTGGCGCTGCTCGTGCTCGACGAGGTCATCGGTCCCGACGGCTATCGCGTGGTCGACCGC
GTCGAGGACGGCACCCGGCTCGAAGCGGGCGCGGCGCTGCTCACCCTGGACGCCCCGACCCGCGGCCTGCTCACTGCCGA
GCGCACGATGCTGAACCTGGTCTCGCACCTGTCGGGCATCGCGACCTCGACCGCCATGTGGGTGGACGCGGTGGCGGGTA
CGAACGCCAAGATCCGCGACACCCGCAAGACGCTGCCCGGTCTGCGGGCGCTGCAGAAGTACGCCGTGCGGGTCGGCGGC
GGGGTGAACCACCGGATGGGGTTGGGCGACGCGGCGCTGATCAAGGACAACCACGTGGCGGCCGCCGGATCGGTGGTGGC
GGCGCTGCGCGCGGTTCGGGCCGCAGCCCCTGGTCTGCCGTGCGAGGTCGAGGTGGATTCACTCGAACAACTCGACGAGG
TGCTCGCCGAGGACATCGAGTTGGTGCTGCTCGACAACTTCCCGGTCTGGCAGACCCAGATCGCCGTGCAGCGGCGCGAC
TCCCGTTCGCCGGCAACGAAACTGGAATCCTCGGGTGGACTGTCACTGGAGACGGCGGCCGAGTACGCGGGTACCGGCGT
CGACTACCTCGCCGTCGGGGCGCTCACCCATTCCGTGCGTGTGCTCGACATCGGCCTCGACGTCTGA

Upstream 100 bases:

>100_bases
ACCGCGCCGACCATCCGGACACCGACCCGGTGCAGGCGGTCAGCGGGGCGGTCGACCTGGACGAACACGGACACCTACGA
CTGAAGATGAGGGCGGACGC

Downstream 100 bases:

>100_bases
GACACCACCGCATCAGGCCGCGCGGCGCGTCAGTACCAGCGGGTCGCCGTCGGTGACGGCGATGGTGTGTTCGCTGTGGG
CGGTGCGCGAGCCGTCGGCC

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MLLSQLSETEIAEARAVVARGLEEDLRYGPDVTTQATVPADAATTASMRTREPGVAAGVDVALLVLDEVIGPDGYRVVDR
VEDGTRLEAGAALLTLDAPTRGLLTAERTMLNLVSHLSGIATSTAMWVDAVAGTNAKIRDTRKTLPGLRALQKYAVRVGG
GVNHRMGLGDAALIKDNHVAAAGSVVAALRAVRAAAPGLPCEVEVDSLEQLDEVLAEDIELVLLDNFPVWQTQIAVQRRD
SRSPATKLESSGGLSLETAAEYAGTGVDYLAVGALTHSVRVLDIGLDV

Sequences:

>Translated_288_residues
MLLSQLSETEIAEARAVVARGLEEDLRYGPDVTTQATVPADAATTASMRTREPGVAAGVDVALLVLDEVIGPDGYRVVDR
VEDGTRLEAGAALLTLDAPTRGLLTAERTMLNLVSHLSGIATSTAMWVDAVAGTNAKIRDTRKTLPGLRALQKYAVRVGG
GVNHRMGLGDAALIKDNHVAAAGSVVAALRAVRAAAPGLPCEVEVDSLEQLDEVLAEDIELVLLDNFPVWQTQIAVQRRD
SRSPATKLESSGGLSLETAAEYAGTGVDYLAVGALTHSVRVLDIGLDV
>Mature_288_residues
MLLSQLSETEIAEARAVVARGLEEDLRYGPDVTTQATVPADAATTASMRTREPGVAAGVDVALLVLDEVIGPDGYRVVDR
VEDGTRLEAGAALLTLDAPTRGLLTAERTMLNLVSHLSGIATSTAMWVDAVAGTNAKIRDTRKTLPGLRALQKYAVRVGG
GVNHRMGLGDAALIKDNHVAAAGSVVAALRAVRAAAPGLPCEVEVDSLEQLDEVLAEDIELVLLDNFPVWQTQIAVQRRD
SRSPATKLESSGGLSLETAAEYAGTGVDYLAVGALTHSVRVLDIGLDV

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=283, Percent_Identity=32.8621908127208, Blast_Score=127, Evalue=1e-29,
Organism=Escherichia coli, GI1786299, Length=272, Percent_Identity=43.0147058823529, Blast_Score=184, Evalue=7e-48,
Organism=Saccharomyces cerevisiae, GI6321162, Length=287, Percent_Identity=29.9651567944251, Blast_Score=116, Evalue=5e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 30181; Mature: 30181

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLSQLSETEIAEARAVVARGLEEDLRYGPDVTTQATVPADAATTASMRTREPGVAAGVD
CCCCHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCEECCCCCHHHHHHHHCCCCCCCCHHH
VALLVLDEVIGPDGYRVVDRVEDGTRLEAGAALLTLDAPTRGLLTAERTMLNLVSHLSGI
HHHHHHHHHHCCCCCEEHHHCCCCCEEECCEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
ATSTAMWVDAVAGTNAKIRDTRKTLPGLRALQKYAVRVGGGVNHRMGLGDAALIKDNHVA
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCHH
AAGSVVAALRAVRAAAPGLPCEVEVDSLEQLDEVLAEDIELVLLDNFPVWQTQIAVQRRD
HHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCC
SRSPATKLESSGGLSLETAAEYAGTGVDYLAVGALTHSVRVLDIGLDV
CCCCHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHCEEEEEECCCC
>Mature Secondary Structure
MLLSQLSETEIAEARAVVARGLEEDLRYGPDVTTQATVPADAATTASMRTREPGVAAGVD
CCCCHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCEECCCCCHHHHHHHHCCCCCCCCHHH
VALLVLDEVIGPDGYRVVDRVEDGTRLEAGAALLTLDAPTRGLLTAERTMLNLVSHLSGI
HHHHHHHHHHCCCCCEEHHHCCCCCEEECCEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
ATSTAMWVDAVAGTNAKIRDTRKTLPGLRALQKYAVRVGGGVNHRMGLGDAALIKDNHVA
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCHH
AAGSVVAALRAVRAAAPGLPCEVEVDSLEQLDEVLAEDIELVLLDNFPVWQTQIAVQRRD
HHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCC
SRSPATKLESSGGLSLETAAEYAGTGVDYLAVGALTHSVRVLDIGLDV
CCCCHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]