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The map label for this gene is hisD [H]

Identifier: 108800029

GI number: 108800029

Start: 3238491

End: 3239915

Strand: Reverse

Name: hisD [H]

Synonym: Mmcs_3063

Alternate gene names: 108800029

Gene position: 3239915-3238491 (Counterclockwise)

Preceding gene: 108800032

Following gene: 108800028

Centisome position: 56.79

GC content: 71.86

Gene sequence:

>1425_bases
GTGAATGTATCGCCGGTGACGATGGCCCGCATCGACTTGCGCGGGAGGACTCTGTCCACTGCGCAGTTGCGGTCGGCGCT
GCCGCGTGGCGGTGTCGACGTCGACGCCGTCGTGCCGAAGGTCCGCCCGATCGTCGAGGCCGTCGCCGAGCGCGGCGCCG
AGGCCGCACTCGAATACGGCGAGGCGTTCGACGGGGTCCGTCCCGCGTCGGTGCGCGTGCCTGCCGAGCGGTTGGCGTCG
GCGCTGGCCGAACTCGATCCCGACGTCCGCGCGGCGCTGCAGGTCGCGATCGACCGGGCCCGCGCTGTACACGCCGACCA
GCGACGCACCGACACCACGACCACCCTGGCCCCCGGAGCGACCGTCACCGAACGCTGGGTGCCGCTCGAGCGGGTCGGGC
TCTACGTACCGGGCGGCAACGCGGTCTACCCCTCGAGTGTGGTGATGAACGTGGTGCCCGCCCAGACCGCGGGCGTCGAC
TCGCTGGTCATCGCCAGCCCGCCGCAGGCCGACCACGGGGGACTGCCACACCCGACCATCCTGGCGGCCGCCGCGCTCCT
CGGCGTCGACGAGGTGTGGGCGGTCGGCGGCGCCCAGGCCGTCGCGCTGCTGGCCTACGGCGGCACCGATATCGATGGCA
CTGGGGCAAGCGGAGCGCCGGGAGATGGCACTGGGGCAAGCGGAGCGCCGGGAGATGGCACTGGGGCAAGCGGAGCGCCG
GGAGATGGCACCGAGCTCGCGCCGGTGGACATGATCACCGGCCCCGGCAACATCTACGTCACCGCCGCCAAGCGGATCTG
CCGCTCACAGGTCGGCATCGACGCCGAGGCCGGGCCGACCGAGATCGCGGTGCTGGCCGACCACACCGCCGATCCGGTGC
ATGTCGCGGCCGACCTGATCAGCCAGGCCGAACACGACGAGATGGCCGCCAGCGTGCTGGTGACCACGAGCCCCGACCTG
GCCGACGCCATCGACCGTGAACTGCGGCGCCAGCTCGAGACGACGGTGCACCGCGAACGCGTCAGCACGGCACTGACCGG
TGAGCAGTCCGCGATCGTGCTCGTCGACGACCTCGACGCCGGGGTGCGGGTCGTGAACGCCTACGCCGCAGAACATCTCG
AGATCCAGACGGTCGACGCCGCCGAGGTGGCCGGCCGGATCCGTTCTGCCGGTGCGATCTTCGTCGGTCCGTACGCGCCG
GTCAGCCTCGGGGACTACTGCGCCGGGTCGAACCACGTGCTGCCGACGGCGGGGTGCGCCCGCCACTCCAGCGGTCTGTC
GGTGCAGACGTTCCTGCGCGGCATCCACGTCGTCGACTACACCGAGGCGGCGCTCAAGGACGTGTCGGGATACGTGATCA
CCCTGGCGCAGGCCGAGAACCTGCCCGCCCACGGCGAAGCGGTGCGACGGAGGTTCGAGTCATGA

Upstream 100 bases:

>100_bases
TACTTGATCTGGAGGCGATCCATCCACTCCGGGAACATCTTCGGCAGCTCCGACACGACGGCTCCAATACGATTTGGCCT
GCTCTGGGACAATGGACAGC

Downstream 100 bases:

>100_bases
CCGTGGGGGAGCGGATCACCCTCGCCGACCTGCCCCTGCGGGATGACCTGCGCGGAAAGTCACCCTACGGTGCACCGCAA
CTGCAGGTGCCGGTGCGGCT

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MNVSPVTMARIDLRGRTLSTAQLRSALPRGGVDVDAVVPKVRPIVEAVAERGAEAALEYGEAFDGVRPASVRVPAERLAS
ALAELDPDVRAALQVAIDRARAVHADQRRTDTTTTLAPGATVTERWVPLERVGLYVPGGNAVYPSSVVMNVVPAQTAGVD
SLVIASPPQADHGGLPHPTILAAAALLGVDEVWAVGGAQAVALLAYGGTDIDGTGASGAPGDGTGASGAPGDGTGASGAP
GDGTELAPVDMITGPGNIYVTAAKRICRSQVGIDAEAGPTEIAVLADHTADPVHVAADLISQAEHDEMAASVLVTTSPDL
ADAIDRELRRQLETTVHRERVSTALTGEQSAIVLVDDLDAGVRVVNAYAAEHLEIQTVDAAEVAGRIRSAGAIFVGPYAP
VSLGDYCAGSNHVLPTAGCARHSSGLSVQTFLRGIHVVDYTEAALKDVSGYVITLAQAENLPAHGEAVRRRFES

Sequences:

>Translated_474_residues
MNVSPVTMARIDLRGRTLSTAQLRSALPRGGVDVDAVVPKVRPIVEAVAERGAEAALEYGEAFDGVRPASVRVPAERLAS
ALAELDPDVRAALQVAIDRARAVHADQRRTDTTTTLAPGATVTERWVPLERVGLYVPGGNAVYPSSVVMNVVPAQTAGVD
SLVIASPPQADHGGLPHPTILAAAALLGVDEVWAVGGAQAVALLAYGGTDIDGTGASGAPGDGTGASGAPGDGTGASGAP
GDGTELAPVDMITGPGNIYVTAAKRICRSQVGIDAEAGPTEIAVLADHTADPVHVAADLISQAEHDEMAASVLVTTSPDL
ADAIDRELRRQLETTVHRERVSTALTGEQSAIVLVDDLDAGVRVVNAYAAEHLEIQTVDAAEVAGRIRSAGAIFVGPYAP
VSLGDYCAGSNHVLPTAGCARHSSGLSVQTFLRGIHVVDYTEAALKDVSGYVITLAQAENLPAHGEAVRRRFES
>Mature_474_residues
MNVSPVTMARIDLRGRTLSTAQLRSALPRGGVDVDAVVPKVRPIVEAVAERGAEAALEYGEAFDGVRPASVRVPAERLAS
ALAELDPDVRAALQVAIDRARAVHADQRRTDTTTTLAPGATVTERWVPLERVGLYVPGGNAVYPSSVVMNVVPAQTAGVD
SLVIASPPQADHGGLPHPTILAAAALLGVDEVWAVGGAQAVALLAYGGTDIDGTGASGAPGDGTGASGAPGDGTGASGAP
GDGTELAPVDMITGPGNIYVTAAKRICRSQVGIDAEAGPTEIAVLADHTADPVHVAADLISQAEHDEMAASVLVTTSPDL
ADAIDRELRRQLETTVHRERVSTALTGEQSAIVLVDDLDAGVRVVNAYAAEHLEIQTVDAAEVAGRIRSAGAIFVGPYAP
VSLGDYCAGSNHVLPTAGCARHSSGLSVQTFLRGIHVVDYTEAALKDVSGYVITLAQAENLPAHGEAVRRRFES

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=456, Percent_Identity=35.3070175438597, Blast_Score=229, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6319819, Length=462, Percent_Identity=33.7662337662338, Blast_Score=229, Evalue=5e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 48628; Mature: 48628

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVSPVTMARIDLRGRTLSTAQLRSALPRGGVDVDAVVPKVRPIVEAVAERGAEAALEYG
CCCCCEEEEEEEECCCEECHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHH
EAFDGVRPASVRVPAERLASALAELDPDVRAALQVAIDRARAVHADQRRTDTTTTLAPGA
HHHCCCCCCEEECCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCC
TVTERWVPLERVGLYVPGGNAVYPSSVVMNVVPAQTAGVDSLVIASPPQADHGGLPHPTI
CHHHHCCCHHHCEEEECCCCCCCCCHHHHEECCCCCCCCCEEEEECCCCCCCCCCCCHHH
LAAAALLGVDEVWAVGGAQAVALLAYGGTDIDGTGASGAPGDGTGASGAPGDGTGASGAP
HHHHHHHCHHHHHHCCCHHEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GDGTELAPVDMITGPGNIYVTAAKRICRSQVGIDAEAGPTEIAVLADHTADPVHVAADLI
CCCCCCCCEEEEECCCCEEEHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHH
SQAEHDEMAASVLVTTSPDLADAIDRELRRQLETTVHRERVSTALTGEQSAIVLVDDLDA
HHHHHHHHHEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
GVRVVNAYAAEHLEIQTVDAAEVAGRIRSAGAIFVGPYAPVSLGDYCAGSNHVLPTAGCA
CHHHHHHHHHHCEEEEECCHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCH
RHSSGLSVQTFLRGIHVVDYTEAALKDVSGYVITLAQAENLPAHGEAVRRRFES
HCCCCCCHHHHHHHCEEEEHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHCC
>Mature Secondary Structure
MNVSPVTMARIDLRGRTLSTAQLRSALPRGGVDVDAVVPKVRPIVEAVAERGAEAALEYG
CCCCCEEEEEEEECCCEECHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHH
EAFDGVRPASVRVPAERLASALAELDPDVRAALQVAIDRARAVHADQRRTDTTTTLAPGA
HHHCCCCCCEEECCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCC
TVTERWVPLERVGLYVPGGNAVYPSSVVMNVVPAQTAGVDSLVIASPPQADHGGLPHPTI
CHHHHCCCHHHCEEEECCCCCCCCCHHHHEECCCCCCCCCEEEEECCCCCCCCCCCCHHH
LAAAALLGVDEVWAVGGAQAVALLAYGGTDIDGTGASGAPGDGTGASGAPGDGTGASGAP
HHHHHHHCHHHHHHCCCHHEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GDGTELAPVDMITGPGNIYVTAAKRICRSQVGIDAEAGPTEIAVLADHTADPVHVAADLI
CCCCCCCCEEEEECCCCEEEHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHH
SQAEHDEMAASVLVTTSPDLADAIDRELRRQLETTVHRERVSTALTGEQSAIVLVDDLDA
HHHHHHHHHEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
GVRVVNAYAAEHLEIQTVDAAEVAGRIRSAGAIFVGPYAPVSLGDYCAGSNHVLPTAGCA
CHHHHHHHHHHCEEEEECCHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCH
RHSSGLSVQTFLRGIHVVDYTEAALKDVSGYVITLAQAENLPAHGEAVRRRFES
HCCCCCCHHHHHHHCEEEEHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1435262 [H]