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The map label for this gene is impA [H]

Identifier: 108800024

GI number: 108800024

Start: 3234523

End: 3235338

Strand: Reverse

Name: impA [H]

Synonym: Mmcs_3058

Alternate gene names: 108800024

Gene position: 3235338-3234523 (Counterclockwise)

Preceding gene: 108800025

Following gene: 108800023

Centisome position: 56.71

GC content: 68.5

Gene sequence:

>816_bases
ATGGCACTGGACGAGACCGACCTGCAGGGTCTGGTCGACGAGGCCGCGGCGATACTCGACGCCGCGTCCGAACCCTTCAT
CAGCGGGCACCGCGCCGATTCGGCGGTGCAGAAGAAGGGCAACGACTTCGCCACCGAGGTCGACCTGAAGATCGAACGGC
AGGTCGTCGATGCGCTCACCGCGGCCACCGGTATCGAGGTGCACGGTGAGGAGTACGGCGGCGCGGACATCGACTCACCG
CTGGTATGGGTGCTCGACCCCATCGACGGGACGTTCAACTACGCAGCCGGACTGCCCACCGCTGCGATCCTGCTCGGTCT
GCTGCGCGACGGGGAGCCCGTCGCCGGCCTGACGTGGCTGCCGTTCATGTCCCAGCGTTACACCGCCGTGGTCGGAAAGC
CGTTGTACGTCAACGGGCTTGAACAGCCTGCACTGCAGCCCGGTGCGTTGTCGGACTGTGTCGTGGGGACCGGGACGTTC
AACATCGACTCGCGTGGGCGCTTCCCAGGGCGCTGGCGGATGGCGCTGCTGGAGAACCTGAGCAGAAAGTGCAACCGGAT
CCGGATGCACGGCGCCACCGGACTCGACCTCGCCTACGCCGCCGGCGGTGCGCTCGGCGGGGCGATCAGCTTCGGCCACC
ACATCTGGGATCACGCCGCCGGTGTCGCGTTGGTGCGGGCCGCCGGTGGTGTGGTCACCGACCTGGCCGGGGCGGAGTGG
ACCCCGGATTCGAAGTCGGTGCTGGCCGGCTCCCCGCAGGTGCACGGTGAGATCCTCGAGATCGTGGCGTCGGTCGGCGC
CCCGGAGGAGTTCTGA

Upstream 100 bases:

>100_bases
ACCGACCGGGGCGTCGAGGGTGCGATCGTCGGCAAAGCGCTGTACGCCGGGCGCTTCACGCTGCCCGAGGCGCTGGCAGC
GATGGGGCAGTAGGGCGTCG

Downstream 100 bases:

>100_bases
TGGCCGCCGACAGAGGACTCGCGGTCCGCGTGATCCCGTGCCTCGACGTCGACGCCGGCCGCGTGGTCAAGGGCGTGAAC
TTCGAGAACCTGCGCGACGC

Product: inositol monophosphatase

Products: NA

Alternate protein names: I-1-Pase; IMPase; Inositol-1-phosphatase [H]

Number of amino acids: Translated: 271; Mature: 270

Protein sequence:

>271_residues
MALDETDLQGLVDEAAAILDAASEPFISGHRADSAVQKKGNDFATEVDLKIERQVVDALTAATGIEVHGEEYGGADIDSP
LVWVLDPIDGTFNYAAGLPTAAILLGLLRDGEPVAGLTWLPFMSQRYTAVVGKPLYVNGLEQPALQPGALSDCVVGTGTF
NIDSRGRFPGRWRMALLENLSRKCNRIRMHGATGLDLAYAAGGALGGAISFGHHIWDHAAGVALVRAAGGVVTDLAGAEW
TPDSKSVLAGSPQVHGEILEIVASVGAPEEF

Sequences:

>Translated_271_residues
MALDETDLQGLVDEAAAILDAASEPFISGHRADSAVQKKGNDFATEVDLKIERQVVDALTAATGIEVHGEEYGGADIDSP
LVWVLDPIDGTFNYAAGLPTAAILLGLLRDGEPVAGLTWLPFMSQRYTAVVGKPLYVNGLEQPALQPGALSDCVVGTGTF
NIDSRGRFPGRWRMALLENLSRKCNRIRMHGATGLDLAYAAGGALGGAISFGHHIWDHAAGVALVRAAGGVVTDLAGAEW
TPDSKSVLAGSPQVHGEILEIVASVGAPEEF
>Mature_270_residues
ALDETDLQGLVDEAAAILDAASEPFISGHRADSAVQKKGNDFATEVDLKIERQVVDALTAATGIEVHGEEYGGADIDSPL
VWVLDPIDGTFNYAAGLPTAAILLGLLRDGEPVAGLTWLPFMSQRYTAVVGKPLYVNGLEQPALQPGALSDCVVGTGTFN
IDSRGRFPGRWRMALLENLSRKCNRIRMHGATGLDLAYAAGGALGGAISFGHHIWDHAAGVALVRAAGGVVTDLAGAEWT
PDSKSVLAGSPQVHGEILEIVASVGAPEEF

Specific function: Catalyzes the dephosphorylation of inositol-1-phosphate (I-1-P) to yield free myo-inositol, a key metabolite in mycobacteria (Probable) [H]

COG id: COG0483

COG function: function code G; Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Homo sapiens, GI7657236, Length=176, Percent_Identity=30.6818181818182, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI5031789, Length=259, Percent_Identity=25.4826254826255, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI221625487, Length=259, Percent_Identity=25.4826254826255, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1788882, Length=235, Percent_Identity=30.6382978723404, Blast_Score=102, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI193202570, Length=223, Percent_Identity=31.8385650224215, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI193202572, Length=222, Percent_Identity=30.1801801801802, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6320493, Length=267, Percent_Identity=26.2172284644195, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI21357329, Length=269, Percent_Identity=29.7397769516729, Blast_Score=101, Evalue=5e-22,
Organism=Drosophila melanogaster, GI21357303, Length=233, Percent_Identity=29.1845493562232, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24664922, Length=282, Percent_Identity=23.758865248227, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24664926, Length=242, Percent_Identity=26.0330578512397, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24664918, Length=279, Percent_Identity=25.8064516129032, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000760
- InterPro:   IPR020550 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.25 [H]

Molecular weight: Translated: 28337; Mature: 28206

Theoretical pI: Translated: 4.40; Mature: 4.40

Prosite motif: PS00630 IMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALDETDLQGLVDEAAAILDAASEPFISGHRADSAVQKKGNDFATEVDLKIERQVVDALT
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCEEEECHHHHHHHHHHHH
AATGIEVHGEEYGGADIDSPLVWVLDPIDGTFNYAAGLPTAAILLGLLRDGEPVAGLTWL
HHCCCEEECCCCCCCCCCCCEEEEECCCCCCCCHHCCCHHHHHHHHHHCCCCCCCCEEHH
PFMSQRYTAVVGKPLYVNGLEQPALQPGALSDCVVGTGTFNIDSRGRFPGRWRMALLENL
HHHHCCHHHHHCCCEEECCCCCCCCCCCCCCCCEEECCEEECCCCCCCCHHHHHHHHHHH
SRKCNRIRMHGATGLDLAYAAGGALGGAISFGHHIWDHAAGVALVRAAGGVVTDLAGAEW
HHHHHHEEECCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCC
TPDSKSVLAGSPQVHGEILEIVASVGAPEEF
CCCCCCEECCCCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
ALDETDLQGLVDEAAAILDAASEPFISGHRADSAVQKKGNDFATEVDLKIERQVVDALT
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCEEEECHHHHHHHHHHHH
AATGIEVHGEEYGGADIDSPLVWVLDPIDGTFNYAAGLPTAAILLGLLRDGEPVAGLTWL
HHCCCEEECCCCCCCCCCCCEEEEECCCCCCCCHHCCCHHHHHHHHHHCCCCCCCCEEHH
PFMSQRYTAVVGKPLYVNGLEQPALQPGALSDCVVGTGTFNIDSRGRFPGRWRMALLENL
HHHHCCHHHHHCCCEEECCCCCCCCCCCCCCCCEEECCEEECCCCCCCCHHHHHHHHHHH
SRKCNRIRMHGATGLDLAYAAGGALGGAISFGHHIWDHAAGVALVRAAGGVVTDLAGAEW
HHHHHHEEECCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCC
TPDSKSVLAGSPQVHGEILEIVASVGAPEEF
CCCCCCEECCCCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9401044 [H]