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The map label for this gene is priA [H]

Identifier: 108800025

GI number: 108800025

Start: 3235346

End: 3236116

Strand: Reverse

Name: priA [H]

Synonym: Mmcs_3059

Alternate gene names: 108800025

Gene position: 3236116-3235346 (Counterclockwise)

Preceding gene: 108800026

Following gene: 108800024

Centisome position: 56.72

GC content: 69.91

Gene sequence:

>771_bases
TTGTCCGTCGTGCCAGAGAAGTCGGTGTCCGAGAAAAGACCGTTGATCCTCCTCCCCGCCGTCGATGTCGTCGAAGGCCG
TGCCGTGCGCCTGGTACAGGGCAAGGCCGGCAGTGAAACCGAGTACGGGTCGGCGCTCGACGCCGCGCTCGGCTGGCAGC
GCGACGGGGCCGAGTGGATCCATCTGGTGGATCTCGACGCCGCGTTCGGGCGGGGGTCGAACCGCGAACTGCTCGCCGAC
GTCGTGGGCCGCCTCGATGTGGCGGTCGAACTGTCCGGCGGCATCCGTGACGACGAGTCGCTCGAGGCAGCGCTGGCCAC
CGGATGCGCCCGGGTCAACATCGGCACCGCCGCGCTGGAGAACCCGCAGTGGTGCGCGAAAGTCGTCGCCGAGTTCGGCG
ACAAGGTGGCAGTGGGCCTCGACGTCAAGATCGTCGACGATCAGCACCGCCTGCGCGGACGGGGTTGGGAGACCGACGGC
GGGGACCTGTGGGAGGTGCTCGACCGCCTCGACTCCGAAGGCTGCTCGCGCTACGTCGTCACCGACGTGACCAAGGACGG
CACCCTTCAGGGGCCGAACCTCGATCTGCTCGGCCGCGTCGCCGACCGCACCGATGCGCCGGTGATCGCCTCCGGCGGGG
TGTCCAGCCTCGACGATCTGCGCGCGATCGCCACGTTGACCGACCGGGGCGTCGAGGGTGCGATCGTCGGCAAAGCGCTG
TACGCCGGGCGCTTCACGCTGCCCGAGGCGCTGGCAGCGATGGGGCAGTAG

Upstream 100 bases:

>100_bases
GAGGATGGTCCGCTCTCGGCCACCCAGTTCCACCCGGAGAAGAGCGGTGACGCGGGCGCGGCACTGCTCCGCAACTGGGT
CGAGGAGCTCTGATCTAAGG

Downstream 100 bases:

>100_bases
GGCGTCGATGGCACTGGACGAGACCGACCTGCAGGGTCTGGTCGACGAGGCCGCGGCGATACTCGACGCCGCGTCCGAAC
CCTTCATCAGCGGGCACCGC

Product: phosphoribosyl isomerase A

Products: NA

Alternate protein names: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; N-(5'-phosphoribosyl)anthranilate isomerase; PRAI; Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [H]

Number of amino acids: Translated: 256; Mature: 255

Protein sequence:

>256_residues
MSVVPEKSVSEKRPLILLPAVDVVEGRAVRLVQGKAGSETEYGSALDAALGWQRDGAEWIHLVDLDAAFGRGSNRELLAD
VVGRLDVAVELSGGIRDDESLEAALATGCARVNIGTAALENPQWCAKVVAEFGDKVAVGLDVKIVDDQHRLRGRGWETDG
GDLWEVLDRLDSEGCSRYVVTDVTKDGTLQGPNLDLLGRVADRTDAPVIASGGVSSLDDLRAIATLTDRGVEGAIVGKAL
YAGRFTLPEALAAMGQ

Sequences:

>Translated_256_residues
MSVVPEKSVSEKRPLILLPAVDVVEGRAVRLVQGKAGSETEYGSALDAALGWQRDGAEWIHLVDLDAAFGRGSNRELLAD
VVGRLDVAVELSGGIRDDESLEAALATGCARVNIGTAALENPQWCAKVVAEFGDKVAVGLDVKIVDDQHRLRGRGWETDG
GDLWEVLDRLDSEGCSRYVVTDVTKDGTLQGPNLDLLGRVADRTDAPVIASGGVSSLDDLRAIATLTDRGVEGAIVGKAL
YAGRFTLPEALAAMGQ
>Mature_255_residues
SVVPEKSVSEKRPLILLPAVDVVEGRAVRLVQGKAGSETEYGSALDAALGWQRDGAEWIHLVDLDAAFGRGSNRELLADV
VGRLDVAVELSGGIRDDESLEAALATGCARVNIGTAALENPQWCAKVVAEFGDKVAVGLDVKIVDDQHRLRGRGWETDGG
DLWEVLDRLDSEGCSRYVVTDVTKDGTLQGPNLDLLGRVADRTDAPVIASGGVSSLDDLRAIATLTDRGVEGAIVGKALY
AGRFTLPEALAAMGQ

Specific function: Involved in both the histidine and tryptophan biosynthetic pathways [H]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family [H]

Homologues:

Organism=Escherichia coli, GI87082028, Length=247, Percent_Identity=34.8178137651822, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1788336, Length=252, Percent_Identity=23.015873015873, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR010188
- InterPro:   IPR023016
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00977 His_biosynth [H]

EC number: =5.3.1.16; =5.3.1.24 [H]

Molecular weight: Translated: 27031; Mature: 26899

Theoretical pI: Translated: 4.34; Mature: 4.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVVPEKSVSEKRPLILLPAVDVVEGRAVRLVQGKAGSETEYGSALDAALGWQRDGAEWI
CCCCCCCCCCCCCCEEEECCCHHHCCCEEEEEECCCCCCCCCCHHHHHHHCCCCCCCCEE
HLVDLDAAFGRGSNRELLADVVGRLDVAVELSGGIRDDESLEAALATGCARVNIGTAALE
EEEEEHHHHCCCCCHHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHCCCEEECCHHHCC
NPQWCAKVVAEFGDKVAVGLDVKIVDDQHRLRGRGWETDGGDLWEVLDRLDSEGCSRYVV
CHHHHHHHHHHCCCEEEEEEEEEEECCHHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEE
TDVTKDGTLQGPNLDLLGRVADRTDAPVIASGGVSSLDDLRAIATLTDRGVEGAIVGKAL
EECCCCCCCCCCCHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHCCCCCCEEEHHHH
YAGRFTLPEALAAMGQ
HCCCCCHHHHHHHHCC
>Mature Secondary Structure 
SVVPEKSVSEKRPLILLPAVDVVEGRAVRLVQGKAGSETEYGSALDAALGWQRDGAEWI
CCCCCCCCCCCCCEEEECCCHHHCCCEEEEEECCCCCCCCCCHHHHHHHCCCCCCCCEE
HLVDLDAAFGRGSNRELLADVVGRLDVAVELSGGIRDDESLEAALATGCARVNIGTAALE
EEEEEHHHHCCCCCHHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHCCCEEECCHHHCC
NPQWCAKVVAEFGDKVAVGLDVKIVDDQHRLRGRGWETDGGDLWEVLDRLDSEGCSRYVV
CHHHHHHHHHHCCCEEEEEEEEEEECCHHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEE
TDVTKDGTLQGPNLDLLGRVADRTDAPVIASGGVSSLDDLRAIATLTDRGVEGAIVGKAL
EECCCCCCCCCCCHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHCCCCCCEEEHHHH
YAGRFTLPEALAAMGQ
HCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA