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The map label for this gene is hisI [H]

Identifier: 108800022

GI number: 108800022

Start: 3233391

End: 3233738

Strand: Reverse

Name: hisI [H]

Synonym: Mmcs_3056

Alternate gene names: 108800022

Gene position: 3233738-3233391 (Counterclockwise)

Preceding gene: 108800023

Following gene: 108800021

Centisome position: 56.68

GC content: 68.68

Gene sequence:

>348_bases
GTGGCTCTCGATCCGGAGATCGCCTCGCGGCTCAAACGCAACGCCGACGGTCTGTTCACCGCCGTCGCGCAGGAACGCGG
CACCGGTCAGGTGCTGATGGTGGCGTGGATGGACGACATCGCGCTGGACCGCACGATGCGCACCCGTAACGCCACCTACT
GGTCGCGCTCGCGCGGTGAGCACTGGGTCAAGGGCGAGACGTCGGGCCACACGCAGCACGTGCACTCGGTGCGCCTGGAC
TGCGACGGCGACACCGTCCTGCTCGAGGTGGAGCAGTCCGGTCCGGCCTGCCACACCGGCACACACACCTGCTTCGACGC
CGACGTGCTGTTGGCCCCGGAGGCTTAA

Upstream 100 bases:

>100_bases
GCGCCGACGCCGTGTTGGCGGCCAGCGTCTTCCACTTCAAGGAACTCACGATCGGTCAGGTCAAGGCGGCGATGGCGGCA
GAAGGGATCACGGTGCGGTA

Downstream 100 bases:

>100_bases
GCTTCCCGGTGTGAAGAGGTCGGCGGCGGCCGTCATCGGCGGGGCCACGGCTGCGGTCGCGGCCGGGCGGTATCTTTTGG
CACGAGAAGCGCTGAGTGCC

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH [H]

Number of amino acids: Translated: 115; Mature: 114

Protein sequence:

>115_residues
MALDPEIASRLKRNADGLFTAVAQERGTGQVLMVAWMDDIALDRTMRTRNATYWSRSRGEHWVKGETSGHTQHVHSVRLD
CDGDTVLLEVEQSGPACHTGTHTCFDADVLLAPEA

Sequences:

>Translated_115_residues
MALDPEIASRLKRNADGLFTAVAQERGTGQVLMVAWMDDIALDRTMRTRNATYWSRSRGEHWVKGETSGHTQHVHSVRLD
CDGDTVLLEVEQSGPACHTGTHTCFDADVLLAPEA
>Mature_114_residues
ALDPEIASRLKRNADGLFTAVAQERGTGQVLMVAWMDDIALDRTMRTRNATYWSRSRGEHWVKGETSGHTQHVHSVRLDC
DGDTVLLEVEQSGPACHTGTHTCFDADVLLAPEA

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=90, Percent_Identity=43.3333333333333, Blast_Score=89, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH [H]

EC number: =3.5.4.19 [H]

Molecular weight: Translated: 12691; Mature: 12560

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALDPEIASRLKRNADGLFTAVAQERGTGQVLMVAWMDDIALDRTMRTRNATYWSRSRGE
CCCCHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEECCCHHHHHHHHCCCCCEECCCCCC
HWVKGETSGHTQHVHSVRLDCDGDTVLLEVEQSGPACHTGTHTCFDADVLLAPEA
EEECCCCCCCCEEEEEEEEECCCCEEEEEECCCCCCCCCCCCCEECCCEEEECCC
>Mature Secondary Structure 
ALDPEIASRLKRNADGLFTAVAQERGTGQVLMVAWMDDIALDRTMRTRNATYWSRSRGE
CCCHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEECCCHHHHHHHHCCCCCEECCCCCC
HWVKGETSGHTQHVHSVRLDCDGDTVLLEVEQSGPACHTGTHTCFDADVLLAPEA
EEECCCCCCCCEEEEEEEEECCCCEEEEEECCCCCCCCCCCCCEECCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA