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The map label for this gene is exoA [H]

Identifier: 108798182

GI number: 108798182

Start: 1310771

End: 1311562

Strand: Direct

Name: exoA [H]

Synonym: Mmcs_1211

Alternate gene names: 108798182

Gene position: 1310771-1311562 (Clockwise)

Preceding gene: 108798180

Following gene: 108798183

Centisome position: 22.97

GC content: 69.44

Gene sequence:

>792_bases
GTGATAGTCAGCACCATCAACGTCAACGGCATCCGCGCCGCGGTCAAACAGCGGTCCACCGAGAACCTCGGGTTGCTGGC
GTGGCTGAAGGAGACCAGCGCCGACGTGGTGTGCCTGCAGGAGACCCGCGCCGACGACGACCAACTCGCCGACGCACTGG
CTCCCGCGCTGGCCGACGGCTGGCACCTCGCCTCGGCCAGCCCCCATCTGAAGGGCCGCAACGGGGTGGCGGTGCTGTCC
CGGCACGCCGTCACCGAACACCGCCGGATGGAGTCCGAGGAGTTCGGCGAACACGGCCGCTACCTCGAGGTGGACACCGG
CGGGTTGACCGTGGCGAGCGTTTACGTCCAGACCGGTGAGGCCGAGACAGACCGGCAGCTGGAGAAGGAACGGTTCATGG
CCGCGCTCGCGATGCGGATGGCGGAGATCCGCGGTACCGACGCCGTGGTGTGCGGCGACTGGAACATCGCCCACACCGAG
AACGACATCAAGAACTGGAAGGGCAACGTCAAGAAGTCCGGGTTCCTGCCGAGCGAACGCCAGTGGCTCACCGACCTCCT
CGGCACCGGGTGGGTGGACGTCGTGCGCGCGCTGCACCCCGACGTCGCCGGGCCCTACAGCTGGTGGTCGTGGCGGGGGC
GGGCGTTCGACAACGACGCCGGCTGGCGCATCGACTATCAGCTGGCCAGCCCGTCGCTCGCACCGCGGGCCCACATCGCC
CGGGTCGAGCGGGCCGACGCCTACGCGCTGCGCTGGTCGGACCACGCACCGGTCACCGTCGAATACTCGTGA

Upstream 100 bases:

>100_bases
CGTGGATCGGTGCGCGTTCGGTCATGCTGCCCGACATTAAAGGTGATACCGCCGGTACCGCAAGGCGGCCGGTCTGGCGC
CGTGACTAGGGTCTGGCGCC

Downstream 100 bases:

>100_bases
CCATCCCGCGTGGAAAGATCGAGGCATCATGAACTCCCCAGTCGAGACCCCGCCCGCCGTGCCTCGTGTCGTCTTCTCGG
GTGTGCAGCCCACCTCCGAT

Product: exodeoxyribonuclease III (xth)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MIVSTINVNGIRAAVKQRSTENLGLLAWLKETSADVVCLQETRADDDQLADALAPALADGWHLASASPHLKGRNGVAVLS
RHAVTEHRRMESEEFGEHGRYLEVDTGGLTVASVYVQTGEAETDRQLEKERFMAALAMRMAEIRGTDAVVCGDWNIAHTE
NDIKNWKGNVKKSGFLPSERQWLTDLLGTGWVDVVRALHPDVAGPYSWWSWRGRAFDNDAGWRIDYQLASPSLAPRAHIA
RVERADAYALRWSDHAPVTVEYS

Sequences:

>Translated_263_residues
MIVSTINVNGIRAAVKQRSTENLGLLAWLKETSADVVCLQETRADDDQLADALAPALADGWHLASASPHLKGRNGVAVLS
RHAVTEHRRMESEEFGEHGRYLEVDTGGLTVASVYVQTGEAETDRQLEKERFMAALAMRMAEIRGTDAVVCGDWNIAHTE
NDIKNWKGNVKKSGFLPSERQWLTDLLGTGWVDVVRALHPDVAGPYSWWSWRGRAFDNDAGWRIDYQLASPSLAPRAHIA
RVERADAYALRWSDHAPVTVEYS
>Mature_263_residues
MIVSTINVNGIRAAVKQRSTENLGLLAWLKETSADVVCLQETRADDDQLADALAPALADGWHLASASPHLKGRNGVAVLS
RHAVTEHRRMESEEFGEHGRYLEVDTGGLTVASVYVQTGEAETDRQLEKERFMAALAMRMAEIRGTDAVVCGDWNIAHTE
NDIKNWKGNVKKSGFLPSERQWLTDLLGTGWVDVVRALHPDVAGPYSWWSWRGRAFDNDAGWRIDYQLASPSLAPRAHIA
RVERADAYALRWSDHAPVTVEYS

Specific function: Major Apurinic-Apyrimidinic Endonuclease Of E.Coli. It Removes The Damaged DNA At Cytosines And Guanines By Cleaving On The 3' Side Of The Ap Site By A Beta-Elimination Reaction. It Exhibits 3'-5'-Exonuclease, 3'-Phosphomonoesterase, 3'-Repair Diesterase

COG id: COG0708

COG function: function code L; Exonuclease III

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA repair enzymes AP/ExoA family [H]

Homologues:

Organism=Homo sapiens, GI18375505, Length=269, Percent_Identity=31.2267657992565, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI18375503, Length=269, Percent_Identity=31.2267657992565, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI18375501, Length=269, Percent_Identity=31.2267657992565, Blast_Score=126, Evalue=3e-29,
Organism=Escherichia coli, GI1788046, Length=278, Percent_Identity=31.6546762589928, Blast_Score=98, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI71989536, Length=264, Percent_Identity=29.9242424242424, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI221330655, Length=260, Percent_Identity=30.7692307692308, Blast_Score=120, Evalue=9e-28,
Organism=Drosophila melanogaster, GI17136678, Length=264, Percent_Identity=31.4393939393939, Blast_Score=120, Evalue=1e-27,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000097
- InterPro:   IPR020847
- InterPro:   IPR020848
- InterPro:   IPR005135
- InterPro:   IPR004808 [H]

Pfam domain/function: PF03372 Exo_endo_phos [H]

EC number: =3.1.11.2 [H]

Molecular weight: Translated: 29246; Mature: 29246

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVSTINVNGIRAAVKQRSTENLGLLAWLKETSADVVCLQETRADDDQLADALAPALADG
CEEEEECCCHHHHHHHHCCCCCCEEEEEECCCCCCEEEEECCCCCHHHHHHHHHHHHHCC
WHLASASPHLKGRNGVAVLSRHAVTEHRRMESEEFGEHGRYLEVDTGGLTVASVYVQTGE
CEECCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHCCCCEEEEECCCEEEEEEEEECCC
AETDRQLEKERFMAALAMRMAEIRGTDAVVCGDWNIAHTENDIKNWKGNVKKSGFLPSER
CHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEECCCHHHHHHCCCCCCCCCCCCHH
QWLTDLLGTGWVDVVRALHPDVAGPYSWWSWRGRAFDNDAGWRIDYQLASPSLAPRAHIA
HHHHHHHCCCHHHHHHHHCCCCCCCCCHHCCCCCCCCCCCCCEEEEEECCCCCCCHHHHH
RVERADAYALRWSDHAPVTVEYS
HHHCCCEEEEEECCCCCEEEEEC
>Mature Secondary Structure
MIVSTINVNGIRAAVKQRSTENLGLLAWLKETSADVVCLQETRADDDQLADALAPALADG
CEEEEECCCHHHHHHHHCCCCCCEEEEEECCCCCCEEEEECCCCCHHHHHHHHHHHHHCC
WHLASASPHLKGRNGVAVLSRHAVTEHRRMESEEFGEHGRYLEVDTGGLTVASVYVQTGE
CEECCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHCCCCEEEEECCCEEEEEEEEECCC
AETDRQLEKERFMAALAMRMAEIRGTDAVVCGDWNIAHTENDIKNWKGNVKKSGFLPSER
CHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEECCCHHHHHHCCCCCCCCCCCCHH
QWLTDLLGTGWVDVVRALHPDVAGPYSWWSWRGRAFDNDAGWRIDYQLASPSLAPRAHIA
HHHHHHHCCCHHHHHHHHCCCCCCCCCHHCCCCCCCCCCCCCEEEEEECCCCCCCHHHHH
RVERADAYALRWSDHAPVTVEYS
HHHCCCEEEEEECCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377 [H]