Click here to switch to the map view.

The map label for this gene is sufS [H]

Identifier: 108764069

GI number: 108764069

Start: 1347322

End: 1348545

Strand: Direct

Name: sufS [H]

Synonym: MXAN_1156

Alternate gene names: 108764069

Gene position: 1347322-1348545 (Clockwise)

Preceding gene: 108760528

Following gene: 108760309

Centisome position: 14.74

GC content: 69.04

Gene sequence:

>1224_bases
ATGAGCGGCTTCGACGTGAATCAGGTCCGTAAGGACTTCCCCATCCTCGACCAGGAGGTGCGGGGCCGGCCGCTGGTGTA
CCTGGACAGCGCCGCCACGGCGCAGAAGCCGCAGGCCGTCATCGACGCGCTGGTGCGCTTCTATCAGCACGACAACGCCA
ACGTGCACCGCGGCGTCCACGTGTTGTCCGAGCGCGCCACGGAGGCCTACGAGGGCGCGCGTGAGACGGTGCGCCGCTTC
ATCAACGCCCGGGACGTGAAGGAAGTCGTCTTCGTGCGTGGCACCACCGAGGCCATCAACCTGGTGGCGCAGACGTACGG
GCGCAAGCACATTGGCGCCGGGGACGAGGTGCTCATCACCCAGATGGAGCACCACGCCAACATCGTCCCCTGGCGGATGC
TGTGCGAGCAGACGGGCGCCGTGCTCAAGGTCATCCCCGTGGATGACCGGGGCGAGCTGGTGCTGGACGCCGTGGACGCG
CTGCTGACGGAGCGCACCCGCATCCTCGCGGTGACGCACGTGTCCAACGCGCTGGGCACCGTGGCGCCGGTGAAGGAGCT
CACGCGGCGGGCCCACGCGAAGGGCATCCCCGTGCTGGTGGACGGCGCACAGGCGGTGACGCACTTCCCCGTGGACGTGC
AGGACCTGGGCTGCGACTTCTACGCCTTCAGCGGGCACAAGATGTTCGGCCCCACCGGCATCGGCGTGCTGTACGGGCGC
AAGGAGCGTCTGGATGCGATGCCGCCCTACCAGGGCGGCGGCGACATGATCCTCTCCGTGACGATGGAGAAGGTGACGTA
CAACCGGGTGCCGTACCGCTTCGAGGCGGGCACGCCCAACCTGGAGGGCGCGGTGGGGTTGGCGGCGGCCATCCGCTATC
TGGAGGCGCTGGGGATGGAGAACGTCGCCGCGCACGACCGGGAGCTGCTGGCCTACGCCACGCAGGCGCTGGAGTCGGTG
CCGGGGCTGCGCATGGTGGGCACGGCGCGCGAGAAGTCCGGCGTGTTGTCCTTCATGCTGGCGGATATCCACCCGCACGA
CGTGGGCACCATCCTGGACCGCGAGGGCATCTGCATCCGCACCGGCCACCACTGCGCGCAGCCGGTGATGCAGCACTTCA
AGGTGCCGGCCACGTCCCGGGCGTCGCTGGCGCTCTACAACACGCGCGAGGATGTGGACGCGCTCGTCCGTGGCCTGCAC
AAGGTCCTGGAGGTGTTCCAGTGA

Upstream 100 bases:

>100_bases
GCGAGGTGGTGGAGGCGGTGCCCGCCGGCCCTGTGCGCGCGAACATCGAAGCGCTCCTGGCCTTGAAGCTGCCAGGCGCG
GCGCAGCGCGAGGTGACGGC

Downstream 100 bases:

>100_bases
GTGCGTCGGATGACTTGAAGGACCTCTATCAAGAGGTCGTGCTGGAGCACTCCAAGCGGCCGCGCAACTACCGCGTGGTG
GAGGGCGCCACCGCGGAGGC

Product: cysteine desulfurase SufS

Products: NA

Alternate protein names: Selenocysteine beta-lyase; SCL; Selenocysteine lyase; Selenocysteine reductase [H]

Number of amino acids: Translated: 407; Mature: 406

Protein sequence:

>407_residues
MSGFDVNQVRKDFPILDQEVRGRPLVYLDSAATAQKPQAVIDALVRFYQHDNANVHRGVHVLSERATEAYEGARETVRRF
INARDVKEVVFVRGTTEAINLVAQTYGRKHIGAGDEVLITQMEHHANIVPWRMLCEQTGAVLKVIPVDDRGELVLDAVDA
LLTERTRILAVTHVSNALGTVAPVKELTRRAHAKGIPVLVDGAQAVTHFPVDVQDLGCDFYAFSGHKMFGPTGIGVLYGR
KERLDAMPPYQGGGDMILSVTMEKVTYNRVPYRFEAGTPNLEGAVGLAAAIRYLEALGMENVAAHDRELLAYATQALESV
PGLRMVGTAREKSGVLSFMLADIHPHDVGTILDREGICIRTGHHCAQPVMQHFKVPATSRASLALYNTREDVDALVRGLH
KVLEVFQ

Sequences:

>Translated_407_residues
MSGFDVNQVRKDFPILDQEVRGRPLVYLDSAATAQKPQAVIDALVRFYQHDNANVHRGVHVLSERATEAYEGARETVRRF
INARDVKEVVFVRGTTEAINLVAQTYGRKHIGAGDEVLITQMEHHANIVPWRMLCEQTGAVLKVIPVDDRGELVLDAVDA
LLTERTRILAVTHVSNALGTVAPVKELTRRAHAKGIPVLVDGAQAVTHFPVDVQDLGCDFYAFSGHKMFGPTGIGVLYGR
KERLDAMPPYQGGGDMILSVTMEKVTYNRVPYRFEAGTPNLEGAVGLAAAIRYLEALGMENVAAHDRELLAYATQALESV
PGLRMVGTAREKSGVLSFMLADIHPHDVGTILDREGICIRTGHHCAQPVMQHFKVPATSRASLALYNTREDVDALVRGLH
KVLEVFQ
>Mature_406_residues
SGFDVNQVRKDFPILDQEVRGRPLVYLDSAATAQKPQAVIDALVRFYQHDNANVHRGVHVLSERATEAYEGARETVRRFI
NARDVKEVVFVRGTTEAINLVAQTYGRKHIGAGDEVLITQMEHHANIVPWRMLCEQTGAVLKVIPVDDRGELVLDAVDAL
LTERTRILAVTHVSNALGTVAPVKELTRRAHAKGIPVLVDGAQAVTHFPVDVQDLGCDFYAFSGHKMFGPTGIGVLYGRK
ERLDAMPPYQGGGDMILSVTMEKVTYNRVPYRFEAGTPNLEGAVGLAAAIRYLEALGMENVAAHDRELLAYATQALESVP
GLRMVGTAREKSGVLSFMLADIHPHDVGTILDREGICIRTGHHCAQPVMQHFKVPATSRASLALYNTREDVDALVRGLHK
VLEVFQ

Specific function: Cysteine desulfurases mobilize the sulfur from L- cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under speci

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=235, Percent_Identity=31.4893617021277, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI156713448, Length=331, Percent_Identity=27.4924471299094, Blast_Score=89, Evalue=6e-18,
Organism=Escherichia coli, GI1787970, Length=400, Percent_Identity=55.75, Blast_Score=474, Evalue=1e-135,
Organism=Escherichia coli, GI1789175, Length=406, Percent_Identity=44.5812807881773, Blast_Score=356, Evalue=2e-99,
Organism=Escherichia coli, GI48994898, Length=232, Percent_Identity=30.6034482758621, Blast_Score=107, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI25143064, Length=231, Percent_Identity=32.034632034632, Blast_Score=121, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI193211090, Length=386, Percent_Identity=25.1295336787565, Blast_Score=96, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6319831, Length=233, Percent_Identity=31.3304721030043, Blast_Score=117, Evalue=2e-27,
Organism=Drosophila melanogaster, GI20129463, Length=251, Percent_Identity=33.0677290836653, Blast_Score=131, Evalue=9e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7; =4.4.1.16 [H]

Molecular weight: Translated: 44754; Mature: 44623

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGFDVNQVRKDFPILDQEVRGRPLVYLDSAATAQKPQAVIDALVRFYQHDNANVHRGVH
CCCCCHHHHHHCCCCCCHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHH
VLSERATEAYEGARETVRRFINARDVKEVVFVRGTTEAINLVAQTYGRKHIGAGDEVLIT
HHHHHHHHHHHHHHHHHHHHHCCCCHHHEEEECCCHHHHHHHHHHHCCCCCCCCCCEEEE
QMEHHANIVPWRMLCEQTGAVLKVIPVDDRGELVLDAVDALLTERTRILAVTHVSNALGT
EHHHCCCCCHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHCCCEEEEEEEHHHHHHH
VAPVKELTRRAHAKGIPVLVDGAQAVTHFPVDVQDLGCDFYAFSGHKMFGPTGIGVLYGR
HHHHHHHHHHHHHCCCCEEEECCHHHEECCCCHHHCCCCEEEECCCEEECCCCCEEEECC
KERLDAMPPYQGGGDMILSVTMEKVTYNRVPYRFEAGTPNLEGAVGLAAAIRYLEALGME
HHHCCCCCCCCCCCCEEEEEEEHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCC
NVAAHDRELLAYATQALESVPGLRMVGTAREKSGVLSFMLADIHPHDVGTILDREGICIR
HHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHCCHHHHHHHCCCCCCHHHHCCCCCCEEE
TGHHCAQPVMQHFKVPATSRASLALYNTREDVDALVRGLHKVLEVFQ
CCCHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
SGFDVNQVRKDFPILDQEVRGRPLVYLDSAATAQKPQAVIDALVRFYQHDNANVHRGVH
CCCCHHHHHHCCCCCCHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHH
VLSERATEAYEGARETVRRFINARDVKEVVFVRGTTEAINLVAQTYGRKHIGAGDEVLIT
HHHHHHHHHHHHHHHHHHHHHCCCCHHHEEEECCCHHHHHHHHHHHCCCCCCCCCCEEEE
QMEHHANIVPWRMLCEQTGAVLKVIPVDDRGELVLDAVDALLTERTRILAVTHVSNALGT
EHHHCCCCCHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHCCCEEEEEEEHHHHHHH
VAPVKELTRRAHAKGIPVLVDGAQAVTHFPVDVQDLGCDFYAFSGHKMFGPTGIGVLYGR
HHHHHHHHHHHHHCCCCEEEECCHHHEECCCCHHHCCCCEEEECCCEEECCCCCEEEECC
KERLDAMPPYQGGGDMILSVTMEKVTYNRVPYRFEAGTPNLEGAVGLAAAIRYLEALGME
HHHCCCCCCCCCCCCEEEEEEEHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCC
NVAAHDRELLAYATQALESVPGLRMVGTAREKSGVLSFMLADIHPHDVGTILDREGICIR
HHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHCCHHHHHHHCCCCCCHHHHCCCCCCEEE
TGHHCAQPVMQHFKVPATSRASLALYNTREDVDALVRGLHKVLEVFQ
CCCHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA