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The map label for this gene is folE [H]

Identifier: 108763166

GI number: 108763166

Start: 3462992

End: 3463549

Strand: Direct

Name: folE [H]

Synonym: MXAN_2955

Alternate gene names: 108763166

Gene position: 3462992-3463549 (Clockwise)

Preceding gene: 108757451

Following gene: 108762255

Centisome position: 37.89

GC content: 73.3

Gene sequence:

>558_bases
ATGGCGCGTGCCGTGGCGGACTTCCTGCGCGCCGCCGGTCTGAACCTCCAGGACGTCCACCTGGCGGACACCCCCACGCG
CGTGGCCGAGGCCTGGGCGGCCGAGTTCCTCGACGGCTACAGCCGCACCCCGGAGCAGGCGCTGGGGGAGACGTTCCCCG
CGCCGCCGGGCTCCTCGGGCGAGCTGGTGGTGGTGACGGACCTGCGCTTCCACTCCATGTGTCCGCACCACCTGCTGCCG
CTCACCGGGCGGGCCCACGTGGCCTACGTGCCGGGCAAGCGGGTGGTGGGCTTTGGCCGGCTGTCATCGCTGGTGGACTG
CTTCGCGCACCGGCTCATCCTCCAGGAGGACATGGCGCGGGAAGTGGCGCGTTCCCTGGCGCAGGTGCTGGGCAGCCCCG
CCACTGCATGCATCATCGAAGCGGAGCAGGCGTGCCTGCGCCTGCGCGGGGACAAGCAGCGCGACGCCGTCACTCACGCG
GAGGCCTATGAAGGCACCCTGCGGCGCGACGGCCCCCTGCGCCGTGAGCTGTGGGCCCGGTTGGGGGCCCGGCGATGA

Upstream 100 bases:

>100_bases
GCCGGCCCCTTCCAGGAGCGATTCCACTGTGACTTCGTCCCGAGCCCGCCGCAAAGCCCCCGCCGCTGCCGCCCCCGCCG
CTGTCCCCGATACCTCGGCC

Downstream 100 bases:

>100_bases
GTGCGCCCCTGCCGCGCGTGGAGCCCGAGCGCGTGGCCCGCGTGCGCGAGGCGCTGGCCGCCGTTCTGGCTCCGGAGCAG
CTGCGCGTGGATGACGCCGC

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 185; Mature: 184

Protein sequence:

>185_residues
MARAVADFLRAAGLNLQDVHLADTPTRVAEAWAAEFLDGYSRTPEQALGETFPAPPGSSGELVVVTDLRFHSMCPHHLLP
LTGRAHVAYVPGKRVVGFGRLSSLVDCFAHRLILQEDMAREVARSLAQVLGSPATACIIEAEQACLRLRGDKQRDAVTHA
EAYEGTLRRDGPLRRELWARLGARR

Sequences:

>Translated_185_residues
MARAVADFLRAAGLNLQDVHLADTPTRVAEAWAAEFLDGYSRTPEQALGETFPAPPGSSGELVVVTDLRFHSMCPHHLLP
LTGRAHVAYVPGKRVVGFGRLSSLVDCFAHRLILQEDMAREVARSLAQVLGSPATACIIEAEQACLRLRGDKQRDAVTHA
EAYEGTLRRDGPLRRELWARLGARR
>Mature_184_residues
ARAVADFLRAAGLNLQDVHLADTPTRVAEAWAAEFLDGYSRTPEQALGETFPAPPGSSGELVVVTDLRFHSMCPHHLLPL
TGRAHVAYVPGKRVVGFGRLSSLVDCFAHRLILQEDMAREVARSLAQVLGSPATACIIEAEQACLRLRGDKQRDAVTHAE
AYEGTLRRDGPLRRELWARLGARR

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=177, Percent_Identity=30.5084745762712, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI4503949, Length=177, Percent_Identity=30.5084745762712, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI66932970, Length=150, Percent_Identity=30.6666666666667, Blast_Score=87, Evalue=9e-18,
Organism=Homo sapiens, GI66932972, Length=144, Percent_Identity=31.9444444444444, Blast_Score=86, Evalue=1e-17,
Organism=Escherichia coli, GI1788476, Length=152, Percent_Identity=30.2631578947368, Blast_Score=87, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17560486, Length=184, Percent_Identity=30.4347826086957, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6321706, Length=181, Percent_Identity=29.8342541436464, Blast_Score=94, Evalue=9e-21,
Organism=Drosophila melanogaster, GI24656796, Length=185, Percent_Identity=29.7297297297297, Blast_Score=90, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24656782, Length=185, Percent_Identity=29.7297297297297, Blast_Score=90, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24656791, Length=185, Percent_Identity=29.7297297297297, Blast_Score=90, Evalue=1e-18,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 20274; Mature: 20143

Theoretical pI: Translated: 8.01; Mature: 8.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARAVADFLRAAGLNLQDVHLADTPTRVAEAWAAEFLDGYSRTPEQALGETFPAPPGSSG
CHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCC
ELVVVTDLRFHSMCPHHLLPLTGRAHVAYVPGKRVVGFGRLSSLVDCFAHRLILQEDMAR
CEEEEECCHHHHCCCHHHCCCCCCCEEEECCCCCEECHHHHHHHHHHHHHHHHHHHHHHH
EVARSLAQVLGSPATACIIEAEQACLRLRGDKQRDAVTHAEAYEGTLRRDGPLRRELWAR
HHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHH
LGARR
HCCCC
>Mature Secondary Structure 
ARAVADFLRAAGLNLQDVHLADTPTRVAEAWAAEFLDGYSRTPEQALGETFPAPPGSSG
HHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCC
ELVVVTDLRFHSMCPHHLLPLTGRAHVAYVPGKRVVGFGRLSSLVDCFAHRLILQEDMAR
CEEEEECCHHHHCCCHHHCCCCCCCEEEECCCCCEECHHHHHHHHHHHHHHHHHHHHHHH
EVARSLAQVLGSPATACIIEAEQACLRLRGDKQRDAVTHAEAYEGTLRRDGPLRRELWAR
HHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHH
LGARR
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500782 [H]