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The map label for this gene is zraS [H]

Identifier: 108759953

GI number: 108759953

Start: 5224523

End: 5226631

Strand: Reverse

Name: zraS [H]

Synonym: MXAN_4262

Alternate gene names: 108759953

Gene position: 5226631-5224523 (Counterclockwise)

Preceding gene: 108763297

Following gene: 108761933

Centisome position: 57.19

GC content: 70.74

Gene sequence:

>2109_bases
ATGCGGTACGCGCTCGTCCCCATCCTGTTGCTCTGTGTCGCCCTCACGACGGTGGGGGTGGGGGTGTTCACCCTGTTGGA
GCGCAACCGGGAGGCGCAGTGGCACCAGTTCGCGGTGGAGCGCCAGGCCCAGTTGGATGAGGCCACACGCGGGGTGGCGG
AGACGCTGGAGGACGTGGCGGAGGACCTGCGCTTCGCCGGGGAGCTGATGTCCCAGCCCGGCACGTTGGCGGAGCACCGG
CGGGAGATGCGGGCCCTGTTGGAGGCGGTGGGCCAGTACAAGGTCCTCATCGCCTACGACGCCAACGGCAAGGAATGGCT
GCGCATGTTGGACCGGCGCATGGGCAAGCAAGTAGCGCGAGCGCCCGTGTTGGCGCAGATGGCGGAGGCGGCCCGGCGGG
CCCTGCTGCGGCCGCCGGGGGACGTCACGCTGTCACCTCCCATGGAGGATGGCGGCTTGGACTCGCTGCGGGTCATGGCC
ACGGCGCTGCCCGTGGATGAGCAAGGCCGGCCCGAGGGCGCGGTGGCGGTGCTCGTCGACACGACATCCTTCTTCACGCC
GCTGCGCATCGTGACGTCGGACCCGGACGCGCGGCTGTTGCTCCTGGGCACCTATGGTCATCCGACCTCCGCCAGCGACG
CCACCCTGGCGGACTGGTTCCGGCGCCTGGAGACGGAGGGCGCATGGGTGCCGGGCTTCACGACGCTGGCGGCTCGCATG
CGCGAGGGGGAGCGCGGCGCGTTGCCGCTGCGCGCGGAGGAGGCCGAGCGATTGGGCCTGGGCCGCTCGGAGGCCATCGC
CGTGTTCACGCCCATCCGCGTCCGAGGTGGCAGCCATTGGGCCGCGGCCACGTTGGTGTCTACCGCGACGCTGCGATCGC
ATCAGCAGGCCCTCATCTGGCGGCTCCTGGCCGCGGCGCTGCTCGTGGCGCTCTTCCTGGTGACGTTCGCCGTGTACGTG
GTGCTGGCGCAGCGCCGCGCGGCCGCCTTGCGAGAGAGCCGTCAGCACGCGGACCAACTGGCGCACCTGCACGACAAGAC
GCAGAAGATTCTCGACCACATTCCTTCCGGGGTGCTGGCGCTCACCGTGGACGGGCGCATCAGCGCGGTGAACCAGGTGC
TCCGCGAGCGCATGCCTCCGGACGCCATTGGCGCGCCGTTGGAGACGGCGTTCCCCCAGGCACCGGCACCCGTGGTGTCC
CGGATTCGCGCCCTGGTGGAGGCCGCCGCGAGCGAGTCGCGCGCCCATGGCATCCTGGGTGAGACGCTGGTGCTCTTCGG
CGAGGAGGGCCGTTTCAATCTCCACGCGGTGCCGCTGGAGGCGCGCCACCCGGAGGTCCAGACCTTGTTGGTGGTGGAGG
ACCTGAGCAACGTGCGCGCGCTGGAGACGCAGTTGCTGCGCGCGGAGAAGCTGGCCACGGTGGGGGTGCTCGCCGCTGGT
ATCGCGCATGAGATTGGCACGCCGCTGGGCGTGGTGCGTGGGCGCGCGGAGTACGTGCTGGGCAAGCTGGGCAGGGAACA
CCCGCAGGGGCCTGGCATTGCCGTCATCATCGAGCAGATCGACCGGGTGAGCCGCACGCTGCGGCAGCTCCTGGACTTCT
CGCGCCTCCAGCCCACGGCGGTGCGGCCGGTGCCGCTCATCTCCCTGCTCCAGGACGTCCAGGAGTTGCTGCGCATGGAA
GTGGAGCGGCGCGGGGTTCGCTTCGAGGTGACCGTTCCGGAGACGCTGCCTCCACTGGCCGCGGACCCGGACCAGCTCCA
GCAGGTGCTGGTGAATCTGGCGCTCAACGCCTGCCACGCGTGTGGCGAGGGCGGGCAGGTGACGCTGGCCGCGGCGGTGC
CAGAGGCGGAGCCGTGGGGGCTGGTGGCGCTCACCCTCCGCGACGACGGCTGCGGCATTCCCCGGGAGCACCTCAATCAG
GTATTCGACCCCTTCTTCACCACCAAGAAGCGGGGACAGGGCACGGGACTGGGCCTGACGATGGTGGCTCACGTCGTGCG
CAACCATGGTGGCCGGCTGGAGCTGGAGAGCGAGGAGGGGCGGGGCACCTGCGTCACGGTGCTTTGGCCCATCGCGAAGC
CCAGCGCGGAGGAGCGGCATGTCGGTTGA

Upstream 100 bases:

>100_bases
AGTGTCAATCGCCAAAGTCGGCCCCCGGGCCGGCGAGCCTCCTGATTTCCCTGCTATTTCAAGGGGTTGGGGAGGGGCTG
GCGGTTAGACTCCGCGGGCC

Downstream 100 bases:

>100_bases
AGGACGCATCCTGGTCGTCGATGACCACGTGGACATGGGCCTCATGCTGCGGGAGCCCCTCACGGACGCGGGGTATGTCG
TGGACCTGGCTACGGGCGGC

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 702; Mature: 702

Protein sequence:

>702_residues
MRYALVPILLLCVALTTVGVGVFTLLERNREAQWHQFAVERQAQLDEATRGVAETLEDVAEDLRFAGELMSQPGTLAEHR
REMRALLEAVGQYKVLIAYDANGKEWLRMLDRRMGKQVARAPVLAQMAEAARRALLRPPGDVTLSPPMEDGGLDSLRVMA
TALPVDEQGRPEGAVAVLVDTTSFFTPLRIVTSDPDARLLLLGTYGHPTSASDATLADWFRRLETEGAWVPGFTTLAARM
REGERGALPLRAEEAERLGLGRSEAIAVFTPIRVRGGSHWAAATLVSTATLRSHQQALIWRLLAAALLVALFLVTFAVYV
VLAQRRAAALRESRQHADQLAHLHDKTQKILDHIPSGVLALTVDGRISAVNQVLRERMPPDAIGAPLETAFPQAPAPVVS
RIRALVEAAASESRAHGILGETLVLFGEEGRFNLHAVPLEARHPEVQTLLVVEDLSNVRALETQLLRAEKLATVGVLAAG
IAHEIGTPLGVVRGRAEYVLGKLGREHPQGPGIAVIIEQIDRVSRTLRQLLDFSRLQPTAVRPVPLISLLQDVQELLRME
VERRGVRFEVTVPETLPPLAADPDQLQQVLVNLALNACHACGEGGQVTLAAAVPEAEPWGLVALTLRDDGCGIPREHLNQ
VFDPFFTTKKRGQGTGLGLTMVAHVVRNHGGRLELESEEGRGTCVTVLWPIAKPSAEERHVG

Sequences:

>Translated_702_residues
MRYALVPILLLCVALTTVGVGVFTLLERNREAQWHQFAVERQAQLDEATRGVAETLEDVAEDLRFAGELMSQPGTLAEHR
REMRALLEAVGQYKVLIAYDANGKEWLRMLDRRMGKQVARAPVLAQMAEAARRALLRPPGDVTLSPPMEDGGLDSLRVMA
TALPVDEQGRPEGAVAVLVDTTSFFTPLRIVTSDPDARLLLLGTYGHPTSASDATLADWFRRLETEGAWVPGFTTLAARM
REGERGALPLRAEEAERLGLGRSEAIAVFTPIRVRGGSHWAAATLVSTATLRSHQQALIWRLLAAALLVALFLVTFAVYV
VLAQRRAAALRESRQHADQLAHLHDKTQKILDHIPSGVLALTVDGRISAVNQVLRERMPPDAIGAPLETAFPQAPAPVVS
RIRALVEAAASESRAHGILGETLVLFGEEGRFNLHAVPLEARHPEVQTLLVVEDLSNVRALETQLLRAEKLATVGVLAAG
IAHEIGTPLGVVRGRAEYVLGKLGREHPQGPGIAVIIEQIDRVSRTLRQLLDFSRLQPTAVRPVPLISLLQDVQELLRME
VERRGVRFEVTVPETLPPLAADPDQLQQVLVNLALNACHACGEGGQVTLAAAVPEAEPWGLVALTLRDDGCGIPREHLNQ
VFDPFFTTKKRGQGTGLGLTMVAHVVRNHGGRLELESEEGRGTCVTVLWPIAKPSAEERHVG
>Mature_702_residues
MRYALVPILLLCVALTTVGVGVFTLLERNREAQWHQFAVERQAQLDEATRGVAETLEDVAEDLRFAGELMSQPGTLAEHR
REMRALLEAVGQYKVLIAYDANGKEWLRMLDRRMGKQVARAPVLAQMAEAARRALLRPPGDVTLSPPMEDGGLDSLRVMA
TALPVDEQGRPEGAVAVLVDTTSFFTPLRIVTSDPDARLLLLGTYGHPTSASDATLADWFRRLETEGAWVPGFTTLAARM
REGERGALPLRAEEAERLGLGRSEAIAVFTPIRVRGGSHWAAATLVSTATLRSHQQALIWRLLAAALLVALFLVTFAVYV
VLAQRRAAALRESRQHADQLAHLHDKTQKILDHIPSGVLALTVDGRISAVNQVLRERMPPDAIGAPLETAFPQAPAPVVS
RIRALVEAAASESRAHGILGETLVLFGEEGRFNLHAVPLEARHPEVQTLLVVEDLSNVRALETQLLRAEKLATVGVLAAG
IAHEIGTPLGVVRGRAEYVLGKLGREHPQGPGIAVIIEQIDRVSRTLRQLLDFSRLQPTAVRPVPLISLLQDVQELLRME
VERRGVRFEVTVPETLPPLAADPDQLQQVLVNLALNACHACGEGGQVTLAAAVPEAEPWGLVALTLRDDGCGIPREHLNQ
VFDPFFTTKKRGQGTGLGLTMVAHVVRNHGGRLELESEEGRGTCVTVLWPIAKPSAEERHVG

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=234, Percent_Identity=35.8974358974359, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1788549, Length=375, Percent_Identity=28.5333333333333, Blast_Score=135, Evalue=7e-33,
Organism=Escherichia coli, GI1790300, Length=279, Percent_Identity=33.3333333333333, Blast_Score=93, Evalue=5e-20,
Organism=Escherichia coli, GI48994928, Length=284, Percent_Identity=26.4084507042254, Blast_Score=86, Evalue=8e-18,
Organism=Escherichia coli, GI1786600, Length=269, Percent_Identity=28.2527881040892, Blast_Score=80, Evalue=5e-16,
Organism=Escherichia coli, GI87081816, Length=278, Percent_Identity=26.6187050359712, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI1789149, Length=300, Percent_Identity=27.6666666666667, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1786912, Length=424, Percent_Identity=25.2358490566038, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1788393, Length=225, Percent_Identity=25.7777777777778, Blast_Score=76, Evalue=7e-15,
Organism=Escherichia coli, GI87082128, Length=267, Percent_Identity=26.5917602996255, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1790861, Length=238, Percent_Identity=28.9915966386555, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI145693157, Length=285, Percent_Identity=25.2631578947368, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1788713, Length=244, Percent_Identity=25.4098360655738, Blast_Score=66, Evalue=8e-12,
Organism=Escherichia coli, GI1790346, Length=226, Percent_Identity=26.9911504424779, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 76412; Mature: 76412

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYALVPILLLCVALTTVGVGVFTLLERNREAQWHQFAVERQAQLDEATRGVAETLEDVA
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EDLRFAGELMSQPGTLAEHRREMRALLEAVGQYKVLIAYDANGKEWLRMLDRRMGKQVAR
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHHH
APVLAQMAEAARRALLRPPGDVTLSPPMEDGGLDSLRVMATALPVDEQGRPEGAVAVLVD
HHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEE
TTSFFTPLRIVTSDPDARLLLLGTYGHPTSASDATLADWFRRLETEGAWVPGFTTLAARM
CCCCCCCEEEEECCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHH
REGERGALPLRAEEAERLGLGRSEAIAVFTPIRVRGGSHWAAATLVSTATLRSHQQALIW
HCCCCCCCCCCHHHHHHHCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
RLLAAALLVALFLVTFAVYVVLAQRRAAALRESRQHADQLAHLHDKTQKILDHIPSGVLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
LTVDGRISAVNQVLRERMPPDAIGAPLETAFPQAPAPVVSRIRALVEAAASESRAHGILG
EEECCHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHH
ETLVLFGEEGRFNLHAVPLEARHPEVQTLLVVEDLSNVRALETQLLRAEKLATVGVLAAG
CEEEEEECCCCEEEEEECCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAHEIGTPLGVVRGRAEYVLGKLGREHPQGPGIAVIIEQIDRVSRTLRQLLDFSRLQPTA
HHHHHCCCHHHHCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VRPVPLISLLQDVQELLRMEVERRGVRFEVTVPETLPPLAADPDQLQQVLVNLALNACHA
CCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHH
CGEGGQVTLAAAVPEAEPWGLVALTLRDDGCGIPREHLNQVFDPFFTTKKRGQGTGLGLT
CCCCCCEEEEEECCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHH
MVAHVVRNHGGRLELESEEGRGTCVTVLWPIAKPSAEERHVG
HHHHHHHCCCCEEEEECCCCCCEEEEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MRYALVPILLLCVALTTVGVGVFTLLERNREAQWHQFAVERQAQLDEATRGVAETLEDVA
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EDLRFAGELMSQPGTLAEHRREMRALLEAVGQYKVLIAYDANGKEWLRMLDRRMGKQVAR
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHHH
APVLAQMAEAARRALLRPPGDVTLSPPMEDGGLDSLRVMATALPVDEQGRPEGAVAVLVD
HHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEE
TTSFFTPLRIVTSDPDARLLLLGTYGHPTSASDATLADWFRRLETEGAWVPGFTTLAARM
CCCCCCCEEEEECCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHH
REGERGALPLRAEEAERLGLGRSEAIAVFTPIRVRGGSHWAAATLVSTATLRSHQQALIW
HCCCCCCCCCCHHHHHHHCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
RLLAAALLVALFLVTFAVYVVLAQRRAAALRESRQHADQLAHLHDKTQKILDHIPSGVLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
LTVDGRISAVNQVLRERMPPDAIGAPLETAFPQAPAPVVSRIRALVEAAASESRAHGILG
EEECCHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHH
ETLVLFGEEGRFNLHAVPLEARHPEVQTLLVVEDLSNVRALETQLLRAEKLATVGVLAAG
CEEEEEECCCCEEEEEECCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAHEIGTPLGVVRGRAEYVLGKLGREHPQGPGIAVIIEQIDRVSRTLRQLLDFSRLQPTA
HHHHHCCCHHHHCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VRPVPLISLLQDVQELLRMEVERRGVRFEVTVPETLPPLAADPDQLQQVLVNLALNACHA
CCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHH
CGEGGQVTLAAAVPEAEPWGLVALTLRDDGCGIPREHLNQVFDPFFTTKKRGQGTGLGLT
CCCCCCEEEEEECCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHH
MVAHVVRNHGGRLELESEEGRGTCVTVLWPIAKPSAEERHVG
HHHHHHHCCCCEEEEECCCCCCEEEEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503; 2666400; 11243806 [H]