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The map label for this gene is atoC [H]

Identifier: 108761933

GI number: 108761933

Start: 5223175

End: 5224533

Strand: Reverse

Name: atoC [H]

Synonym: MXAN_4261

Alternate gene names: 108761933

Gene position: 5224533-5223175 (Counterclockwise)

Preceding gene: 108759953

Following gene: 108763779

Centisome position: 57.16

GC content: 70.79

Gene sequence:

>1359_bases
ATGTCGGTTGAAGGACGCATCCTGGTCGTCGATGACCACGTGGACATGGGCCTCATGCTGCGGGAGCCCCTCACGGACGC
GGGGTATGTCGTGGACCTGGCTACGGGCGGCGAAGCGGCCATCCGGATGGCGCGCGCACAGGCCTACGACGCGGTGCTGT
GTGACTTGCGCATGGAAGGGGTGGACGGCCTGGACGTGCTGGAGGCCGTGCGGGCGCTCGACTCGGACATCCCCGTGTTG
ATGATGACGGCCTTCGGCGGCGTGGAGAGCGCGGTGGAGGCGATGAAGCGCGGCGCGTACCACTACTTCACCAAGCCCTT
CCGCTTGGATGAGGTGCTGCTCTTCCTCGAGCGCGCCTTGAAGGAGCGCAGGCTCCAGGTGGAGAACCGGGCCCTGCGGC
GCGCCGCCGCCGAGCGCAGCGGGCTGGGGGCGCTGGTGGGCCGAAGCGCGGCGATGCGGAACCTCTACGAGCTCATCGAC
CGCGTGGCCTACGCCCAGGCGGCGGTGCTGCTGCGAGGCCCGAGCGGCACGGGCAAGGAGTTGGTGGCGCGCGCGCTGCA
CTTCCAGGGGCCTCGCGCCTCCGGGCCCTTCGTGGCGGTCAACTGCACGGCGCTGCCACATGACTTGCTGGAGAGTGAGC
TGTTCGGTCACCTCAAGGGGGCCTTCACCGGCGCGACCCACGCCCGCCGCGGCCTCTTCGTGGAGGCGGATGGGGGCACG
CTGTTCCTGGACGAGATTGGCGACATGCCGCTGGAGCTCCAGGCCCGCCTGCTGCGCGTCCTGGAGGACGGCGAGGTGCG
CGCGGTGGGCGCCGACGGCAGCCGCACCGTGGACGTGCGCATCGTCGCCGCCACGCACCAGGACCTGGACGCCCGCGTGC
GCGAGGGCCGCTTCCGCGCGGACCTGTTCTACCGGCTCAATGTCGTGACACTGCTGTTGCCTCCGCTGGCGGAGCGGCGC
GAGGACATCCCCTTGTTGGTGGAGCACTTCACGGCTCGCGCCCGCGCGCGCAACCCTCGCTCCCGCATGCAGTCCCTGTC
TCCGGAGGCGGTGGCCGCGCTCGCGACCTTGCCTTGGCCGGGAAACGTGCGTGAGCTGGAGAACCTGATAGAGCGGCTGG
CGGTGATGGTGGCGAGCGAAGTCGTGGGGCTGGAGGAGTTGCGCCCACACCTGCCACCCGAGGCGCCGGAGGTGCAGCCC
TTGGTGATGGCGCAGCACGCGCTGTGGCCCCTGCGGCGGCTGGAGGCGGAGTACATCGCGTGGATGGTGACACGCTGCGG
CGGGAACAAGACGCGCGCCGCGGAGGTGCTCGGCATCGATGTGTCCACCATCCACCGGCGCGAACGGGAGCGCGGGTAG

Upstream 100 bases:

>100_bases
CGCAACCATGGTGGCCGGCTGGAGCTGGAGAGCGAGGAGGGGCGGGGCACCTGCGTCACGGTGCTTTGGCCCATCGCGAA
GCCCAGCGCGGAGGAGCGGC

Downstream 100 bases:

>100_bases
GGGCGCGCGAGACACCGTGGTAATCCGCCAGGGACGTCTGGCGTGATGCAACGGTTCATCCGCACGTTGCCCGGGCTCTC
GGGGCGGGGACAGCGGGCAT

Product: sigma-54 dependent DNA-binding response regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MSVEGRILVVDDHVDMGLMLREPLTDAGYVVDLATGGEAAIRMARAQAYDAVLCDLRMEGVDGLDVLEAVRALDSDIPVL
MMTAFGGVESAVEAMKRGAYHYFTKPFRLDEVLLFLERALKERRLQVENRALRRAAAERSGLGALVGRSAAMRNLYELID
RVAYAQAAVLLRGPSGTGKELVARALHFQGPRASGPFVAVNCTALPHDLLESELFGHLKGAFTGATHARRGLFVEADGGT
LFLDEIGDMPLELQARLLRVLEDGEVRAVGADGSRTVDVRIVAATHQDLDARVREGRFRADLFYRLNVVTLLLPPLAERR
EDIPLLVEHFTARARARNPRSRMQSLSPEAVAALATLPWPGNVRELENLIERLAVMVASEVVGLEELRPHLPPEAPEVQP
LVMAQHALWPLRRLEAEYIAWMVTRCGGNKTRAAEVLGIDVSTIHRRERERG

Sequences:

>Translated_452_residues
MSVEGRILVVDDHVDMGLMLREPLTDAGYVVDLATGGEAAIRMARAQAYDAVLCDLRMEGVDGLDVLEAVRALDSDIPVL
MMTAFGGVESAVEAMKRGAYHYFTKPFRLDEVLLFLERALKERRLQVENRALRRAAAERSGLGALVGRSAAMRNLYELID
RVAYAQAAVLLRGPSGTGKELVARALHFQGPRASGPFVAVNCTALPHDLLESELFGHLKGAFTGATHARRGLFVEADGGT
LFLDEIGDMPLELQARLLRVLEDGEVRAVGADGSRTVDVRIVAATHQDLDARVREGRFRADLFYRLNVVTLLLPPLAERR
EDIPLLVEHFTARARARNPRSRMQSLSPEAVAALATLPWPGNVRELENLIERLAVMVASEVVGLEELRPHLPPEAPEVQP
LVMAQHALWPLRRLEAEYIAWMVTRCGGNKTRAAEVLGIDVSTIHRRERERG
>Mature_451_residues
SVEGRILVVDDHVDMGLMLREPLTDAGYVVDLATGGEAAIRMARAQAYDAVLCDLRMEGVDGLDVLEAVRALDSDIPVLM
MTAFGGVESAVEAMKRGAYHYFTKPFRLDEVLLFLERALKERRLQVENRALRRAAAERSGLGALVGRSAAMRNLYELIDR
VAYAQAAVLLRGPSGTGKELVARALHFQGPRASGPFVAVNCTALPHDLLESELFGHLKGAFTGATHARRGLFVEADGGTL
FLDEIGDMPLELQARLLRVLEDGEVRAVGADGSRTVDVRIVAATHQDLDARVREGRFRADLFYRLNVVTLLLPPLAERRE
DIPLLVEHFTARARARNPRSRMQSLSPEAVAALATLPWPGNVRELENLIERLAVMVASEVVGLEELRPHLPPEAPEVQPL
VMAQHALWPLRRLEAEYIAWMVTRCGGNKTRAAEVLGIDVSTIHRRERERG

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1790437, Length=440, Percent_Identity=47.7272727272727, Blast_Score=367, Evalue=1e-102,
Organism=Escherichia coli, GI1788550, Length=456, Percent_Identity=43.640350877193, Blast_Score=366, Evalue=1e-102,
Organism=Escherichia coli, GI1790299, Length=469, Percent_Identity=42.4307036247335, Blast_Score=340, Evalue=1e-94,
Organism=Escherichia coli, GI1788905, Length=440, Percent_Identity=39.5454545454545, Blast_Score=301, Evalue=6e-83,
Organism=Escherichia coli, GI87082117, Length=265, Percent_Identity=50.9433962264151, Blast_Score=254, Evalue=1e-68,
Organism=Escherichia coli, GI1789233, Length=314, Percent_Identity=45.5414012738853, Blast_Score=245, Evalue=4e-66,
Organism=Escherichia coli, GI1789087, Length=290, Percent_Identity=45.8620689655172, Blast_Score=232, Evalue=4e-62,
Organism=Escherichia coli, GI87082152, Length=316, Percent_Identity=43.9873417721519, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI1786524, Length=333, Percent_Identity=44.7447447447448, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI87081872, Length=313, Percent_Identity=38.9776357827476, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI1787583, Length=240, Percent_Identity=43.3333333333333, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI1789828, Length=270, Percent_Identity=39.2592592592593, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI87081858, Length=300, Percent_Identity=31.3333333333333, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1786784, Length=108, Percent_Identity=35.1851851851852, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1789402, Length=124, Percent_Identity=34.6774193548387, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI87082012, Length=108, Percent_Identity=29.6296296296296, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 49855; Mature: 49724

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVEGRILVVDDHVDMGLMLREPLTDAGYVVDLATGGEAAIRMARAQAYDAVLCDLRMEG
CCCCCEEEEEECCCCCCHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCC
VDGLDVLEAVRALDSDIPVLMMTAFGGVESAVEAMKRGAYHYFTKPFRLDEVLLFLERAL
CCCHHHHHHHHHHCCCCCEEEEHHCCCHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHH
KERRLQVENRALRRAAAERSGLGALVGRSAAMRNLYELIDRVAYAQAAVLLRGPSGTGKE
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHH
LVARALHFQGPRASGPFVAVNCTALPHDLLESELFGHLKGAFTGATHARRGLFVEADGGT
HHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHCCEEEECCCCE
LFLDEIGDMPLELQARLLRVLEDGEVRAVGADGSRTVDVRIVAATHQDLDARVREGRFRA
EEHHHHCCCCHHHHHHHHHHHCCCCEEEECCCCCEEEEEEEEEECCCCHHHHHHCCCHHH
DLFYRLNVVTLLLPPLAERREDIPLLVEHFTARARARNPRSRMQSLSPEAVAALATLPWP
HHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHCCCCC
GNVRELENLIERLAVMVASEVVGLEELRPHLPPEAPEVQPLVMAQHALWPLRRLEAEYIA
CCHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
WMVTRCGGNKTRAAEVLGIDVSTIHRRERERG
HHHHHCCCCCCCCHHEEECCHHHHHHHHHCCC
>Mature Secondary Structure 
SVEGRILVVDDHVDMGLMLREPLTDAGYVVDLATGGEAAIRMARAQAYDAVLCDLRMEG
CCCCEEEEEECCCCCCHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCC
VDGLDVLEAVRALDSDIPVLMMTAFGGVESAVEAMKRGAYHYFTKPFRLDEVLLFLERAL
CCCHHHHHHHHHHCCCCCEEEEHHCCCHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHH
KERRLQVENRALRRAAAERSGLGALVGRSAAMRNLYELIDRVAYAQAAVLLRGPSGTGKE
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHH
LVARALHFQGPRASGPFVAVNCTALPHDLLESELFGHLKGAFTGATHARRGLFVEADGGT
HHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHCCEEEECCCCE
LFLDEIGDMPLELQARLLRVLEDGEVRAVGADGSRTVDVRIVAATHQDLDARVREGRFRA
EEHHHHCCCCHHHHHHHHHHHCCCCEEEECCCCCEEEEEEEEEECCCCHHHHHHCCCHHH
DLFYRLNVVTLLLPPLAERREDIPLLVEHFTARARARNPRSRMQSLSPEAVAALATLPWP
HHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHCCCCC
GNVRELENLIERLAVMVASEVVGLEELRPHLPPEAPEVQPLVMAQHALWPLRRLEAEYIA
CCHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
WMVTRCGGNKTRAAEVLGIDVSTIHRRERERG
HHHHHCCCCCCCCHHEEECCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]