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The map label for this gene is 108759621

Identifier: 108759621

GI number: 108759621

Start: 1049549

End: 1050073

Strand: Reverse

Name: 108759621

Synonym: MXAN_0919

Alternate gene names: NA

Gene position: 1050073-1049549 (Counterclockwise)

Preceding gene: 108759996

Following gene: 108763806

Centisome position: 11.49

GC content: 64.19

Gene sequence:

>525_bases
ATGGGCCGCCTGACCCCCATCAACTTCAAGAAGTGGATTGATGAGCACCGCCACCTGCTCAAGCCCCCCGTGGGCAACCA
GCAGGTGTGGGAGGACCGGGAGTTCATGGTCACCGTCGTCGGCGGGCCCAATGCGCGCACGGACTTCCACATCAACGAGG
GCGAGGAGTTCTTCTACCAGCTCGAGGGCACGATGAACCTGCGGGTCATCGACGAGGGCCAGGTGCAGGACATCCCCATC
CACGAAGGGGAGATATTCCTGCTGCCGCCCAACGTGCCCCACTCGCCCCAGCGTCCCGCGGGCACAGTGGGCCTGGTGCT
GGAGCGCCGCCGCCAGCCGAAGGAGCTGGATGGCTTCATGTGGCTGTGCCCGCAGTGCGGCGAGAAGCTCTACGAAGAGT
TCGTGCATGTCACCAACCTGGTGACGCAGCTTCCGCCCATCTTCGAGCACTTCTACGGCAACCCCGACAACTGCACCTGC
AAGAAGTGCGGGACGAAGGTGGTCAAGGGAGGTCCCGCCCGTTGA

Upstream 100 bases:

>100_bases
CAAGGACAACCCGCCGTGCCGCACCACGCTCGAAATCAACCGGCTGCCCACGCCGATTGCCATCGAGCTCAAGTGCATCG
CCACCATCGGAGGTGAATGA

Downstream 100 bases:

>100_bases
AAGTCGACATCCACACGCACCTCCTCCCCGCCCACCTGCCGCGCTTCGCCGAGCGCTACGGCTACGGCGGCTTCATCACC
CTGGACCACCATGCGCCCTG

Product: 3-hydroxyanthranilate 3,4-dioxygenase

Products: NA

Alternate protein names: 3-hydroxyanthranilate oxygenase; 3-HAO; 3-hydroxyanthranilic acid dioxygenase; HAD [H]

Number of amino acids: Translated: 174; Mature: 173

Protein sequence:

>174_residues
MGRLTPINFKKWIDEHRHLLKPPVGNQQVWEDREFMVTVVGGPNARTDFHINEGEEFFYQLEGTMNLRVIDEGQVQDIPI
HEGEIFLLPPNVPHSPQRPAGTVGLVLERRRQPKELDGFMWLCPQCGEKLYEEFVHVTNLVTQLPPIFEHFYGNPDNCTC
KKCGTKVVKGGPAR

Sequences:

>Translated_174_residues
MGRLTPINFKKWIDEHRHLLKPPVGNQQVWEDREFMVTVVGGPNARTDFHINEGEEFFYQLEGTMNLRVIDEGQVQDIPI
HEGEIFLLPPNVPHSPQRPAGTVGLVLERRRQPKELDGFMWLCPQCGEKLYEEFVHVTNLVTQLPPIFEHFYGNPDNCTC
KKCGTKVVKGGPAR
>Mature_173_residues
GRLTPINFKKWIDEHRHLLKPPVGNQQVWEDREFMVTVVGGPNARTDFHINEGEEFFYQLEGTMNLRVIDEGQVQDIPIH
EGEIFLLPPNVPHSPQRPAGTVGLVLERRRQPKELDGFMWLCPQCGEKLYEEFVHVTNLVTQLPPIFEHFYGNPDNCTCK
KCGTKVVKGGPAR

Specific function: Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-HAO family [H]

Homologues:

Organism=Homo sapiens, GI188497625, Length=166, Percent_Identity=44.578313253012, Blast_Score=146, Evalue=9e-36,
Organism=Caenorhabditis elegans, GI17562218, Length=161, Percent_Identity=42.8571428571429, Blast_Score=139, Evalue=6e-34,
Organism=Saccharomyces cerevisiae, GI6322485, Length=169, Percent_Identity=43.1952662721894, Blast_Score=129, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010329
- InterPro:   IPR011051
- InterPro:   IPR014710 [H]

Pfam domain/function: PF06052 3-HAO [H]

EC number: =1.13.11.6 [H]

Molecular weight: Translated: 19959; Mature: 19828

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRLTPINFKKWIDEHRHLLKPPVGNQQVWEDREFMVTVVGGPNARTDFHINEGEEFFYQ
CCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCCCEEECCCCEEEEE
LEGTMNLRVIDEGQVQDIPIHEGEIFLLPPNVPHSPQRPAGTVGLVLERRRQPKELDGFM
ECCCEEEEEECCCCEEECCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHCCCCCCCCCEE
WLCPQCGEKLYEEFVHVTNLVTQLPPIFEHFYGNPDNCTCKKCGTKVVKGGPAR
EECHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCHHHCCCEECCCCCCC
>Mature Secondary Structure 
GRLTPINFKKWIDEHRHLLKPPVGNQQVWEDREFMVTVVGGPNARTDFHINEGEEFFYQ
CCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCCCEEECCCCEEEEE
LEGTMNLRVIDEGQVQDIPIHEGEIFLLPPNVPHSPQRPAGTVGLVLERRRQPKELDGFM
ECCCEEEEEECCCCEEECCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHCCCCCCCCCEE
WLCPQCGEKLYEEFVHVTNLVTQLPPIFEHFYGNPDNCTCKKCGTKVVKGGPAR
EECHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCHHHCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]