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The map label for this gene is 108763806

Identifier: 108763806

GI number: 108763806

Start: 1048536

End: 1049552

Strand: Reverse

Name: 108763806

Synonym: MXAN_0918

Alternate gene names: NA

Gene position: 1049552-1048536 (Counterclockwise)

Preceding gene: 108759621

Following gene: 108758280

Centisome position: 11.48

GC content: 69.32

Gene sequence:

>1017_bases
TTGAAAGTCGACATCCACACGCACCTCCTCCCCGCCCACCTGCCGCGCTTCGCCGAGCGCTACGGCTACGGCGGCTTCAT
CACCCTGGACCACCATGCGCCCTGCCGCGCGCGCATGCTCCGGGATGACGGCAAGTTCTTCCGCGAAATCGAAAGCAACT
GCTGGGACCCGGTGAAGCGCATCGAGGAGTGCGACGCGGCCGGCGTCCACGTCCAGGTGCTGTCCACGATTCCCGTCATG
TTCGGCTACTGGACGAAGCCCGAGCACGGCGCGGACCTGGCGCGCTTCCTCAATGACCACCTCGCCTCCGTGGTGCACGC
GCACCCCAAGCGCTTCGTGGGCCTGGGCACGGTGCCGCTCCAGTCCCCGGAGCTGGCGGTGCGCGAGCTGGAGCGCTGCG
TGAAGGAGTTGGGGCTGGCGGGCGTGCAGATTGGCTCGCACGTCAACGACTGGAACCTGTCCGACCCGGCGCTGTTCCCC
TTCTTCGAGGCCGCCAGCGAGCTGGGCGCGTCCGTCTTCGTCCACCCGTGGGACATGATGGGCGAGGCGAAGATGCAGAA
GTACTGGCTGCCGTGGCTGGTGGGCATGCCGGCCGAGGTGTCGCTGGCCATCTGCTCCGTCATCTTCGGCGGCGTGCTGG
AGCGGCTGCCCAAGCTGCGCTTCGCCTTCGCGCACGGCGGCGGCGCGTTCCCACACACGCTCGGCCGGATTCAGCACGGC
TTCGAGGCCCGGCCTGACCTGGTGGCCGTGGACAACAAGGTGCCGCCCCGGGACTACCTGGGCCGCTTCTGGGTGGACTC
GCTGGTCCACGACCCGGAGGCGCTGCGCTACATCGTCCGGCTCTTCGGGCAGGACAAGGTGGCGCTCGGCAGTGACTACC
CCTTCCCCCTGGGCGAGGACCGCCCGGGCACGCTCATCGAGTCCCTGACCGAGCTGGAACCCGCCGCGCGGGAGCGGCTG
CTCTGGCGCAACGCCTTCGATTGGCTGGGACGCGCCCCCGAGGACTTCGCACCATGA

Upstream 100 bases:

>100_bases
TGACGCAGCTTCCGCCCATCTTCGAGCACTTCTACGGCAACCCCGACAACTGCACCTGCAAGAAGTGCGGGACGAAGGTG
GTCAAGGGAGGTCCCGCCCG

Downstream 100 bases:

>100_bases
CGACGCCGTACCTCTTCGAGGACTCCGAGTCCTTCGCGCGGAAGTTGGACGCGGAAGACGCGCTGCGCGGCTACCGCGAC
GCGTTCCACTTCCCGCCCGG

Product: 2-amino-3-carboxylmuconate-6-semialdehyde decarboxylase

Products: 2-aminomuconate semialdehyde; CO2

Alternate protein names: Amidohydrolase; Amidohydrolase/Decarboxylase; Metal-Dependent Hydrolase; Amidohydrolase Family Protein; 2-Amino-3-Carboxymuconate-6-Semialdehyde Decarboxylase; Hydrolase; 2-Amino-3-Carboxylmuconate-6-Semialdehyde Decarboxylase; O-Pyrocatechuate Decarboxylase; Amidohydrolase Family; 2-Amino-3-Carboxymuconate 6-Semialdehyde Decarboxylase; 4-Oxalomesaconate Hydratase; 2-Amino-3-Carboxymuconate-6- Semialdehyde Decarboxylase; Tryptophan 2 3-Dioxygenase; Decarboxylase; 2 3-Dihydroxybenzoic Acid Decarboxylase; Amidase; 5-Carboxyvanillate Decarboxylase; Metal-Dependent Hydrolase Of TIM-Barrel Fold; Barh Protein; Amidohydrolase 2 Family Protein; Metal Dependent Hydrolase; Minocarboxymuconate-Semialdehyde Decarboxylase.; 5-Carboxy-2-Hydroxymuconate-6-Semialdehyde Decarboxylase

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MKVDIHTHLLPAHLPRFAERYGYGGFITLDHHAPCRARMLRDDGKFFREIESNCWDPVKRIEECDAAGVHVQVLSTIPVM
FGYWTKPEHGADLARFLNDHLASVVHAHPKRFVGLGTVPLQSPELAVRELERCVKELGLAGVQIGSHVNDWNLSDPALFP
FFEAASELGASVFVHPWDMMGEAKMQKYWLPWLVGMPAEVSLAICSVIFGGVLERLPKLRFAFAHGGGAFPHTLGRIQHG
FEARPDLVAVDNKVPPRDYLGRFWVDSLVHDPEALRYIVRLFGQDKVALGSDYPFPLGEDRPGTLIESLTELEPAARERL
LWRNAFDWLGRAPEDFAP

Sequences:

>Translated_338_residues
MKVDIHTHLLPAHLPRFAERYGYGGFITLDHHAPCRARMLRDDGKFFREIESNCWDPVKRIEECDAAGVHVQVLSTIPVM
FGYWTKPEHGADLARFLNDHLASVVHAHPKRFVGLGTVPLQSPELAVRELERCVKELGLAGVQIGSHVNDWNLSDPALFP
FFEAASELGASVFVHPWDMMGEAKMQKYWLPWLVGMPAEVSLAICSVIFGGVLERLPKLRFAFAHGGGAFPHTLGRIQHG
FEARPDLVAVDNKVPPRDYLGRFWVDSLVHDPEALRYIVRLFGQDKVALGSDYPFPLGEDRPGTLIESLTELEPAARERL
LWRNAFDWLGRAPEDFAP
>Mature_338_residues
MKVDIHTHLLPAHLPRFAERYGYGGFITLDHHAPCRARMLRDDGKFFREIESNCWDPVKRIEECDAAGVHVQVLSTIPVM
FGYWTKPEHGADLARFLNDHLASVVHAHPKRFVGLGTVPLQSPELAVRELERCVKELGLAGVQIGSHVNDWNLSDPALFP
FFEAASELGASVFVHPWDMMGEAKMQKYWLPWLVGMPAEVSLAICSVIFGGVLERLPKLRFAFAHGGGAFPHTLGRIQHG
FEARPDLVAVDNKVPPRDYLGRFWVDSLVHDPEALRYIVRLFGQDKVALGSDYPFPLGEDRPGTLIESLTELEPAARERL
LWRNAFDWLGRAPEDFAP

Specific function: Unknown

COG id: COG2159

COG function: function code R; Predicted metal-dependent hydrolase of the TIM-barrel fold

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI109715856, Length=336, Percent_Identity=57.1428571428571, Blast_Score=418, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI71995651, Length=329, Percent_Identity=46.5045592705167, Blast_Score=323, Evalue=7e-89,
Organism=Caenorhabditis elegans, GI71995655, Length=378, Percent_Identity=41.2698412698413, Blast_Score=296, Evalue=1e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 4.1.1.45

Molecular weight: Translated: 38042; Mature: 38042

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVDIHTHLLPAHLPRFAERYGYGGFITLDHHAPCRARMLRDDGKFFREIESNCWDPVKR
CEECCHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCHHHHH
IEECDAAGVHVQVLSTIPVMFGYWTKPEHGADLARFLNDHLASVVHAHPKRFVGLGTVPL
HHHHCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHEECCCCCC
QSPELAVRELERCVKELGLAGVQIGSHVNDWNLSDPALFPFFEAASELGASVFVHPWDMM
CCHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCEEEECCHHHH
GEAKMQKYWLPWLVGMPAEVSLAICSVIFGGVLERLPKLRFAFAHGGGAFPHTLGRIQHG
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHEEHCCCCCCCHHHHHHHHHC
FEARPDLVAVDNKVPPRDYLGRFWVDSLVHDPEALRYIVRLFGQDKVALGSDYPFPLGED
CCCCCCEEEECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEECCCCCCCCCCCC
RPGTLIESLTELEPAARERLLWRNAFDWLGRAPEDFAP
CCCHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKVDIHTHLLPAHLPRFAERYGYGGFITLDHHAPCRARMLRDDGKFFREIESNCWDPVKR
CEECCHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCHHHHH
IEECDAAGVHVQVLSTIPVMFGYWTKPEHGADLARFLNDHLASVVHAHPKRFVGLGTVPL
HHHHCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHEECCCCCC
QSPELAVRELERCVKELGLAGVQIGSHVNDWNLSDPALFPFFEAASELGASVFVHPWDMM
CCHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCEEEECCHHHH
GEAKMQKYWLPWLVGMPAEVSLAICSVIFGGVLERLPKLRFAFAHGGGAFPHTLGRIQHG
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHEEHCCCCCCCHHHHHHHHHC
FEARPDLVAVDNKVPPRDYLGRFWVDSLVHDPEALRYIVRLFGQDKVALGSDYPFPLGED
CCCCCCEEEECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEECCCCCCCCCCCC
RPGTLIESLTELEPAARERLLWRNAFDWLGRAPEDFAP
CCCHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2-amino-3-(3-oxoprop-2-enyl)-but-2-enedioate

Specific reaction: 2-amino-3-(3-oxoprop-2-enyl)-but-2-enedioate = 2-aminomuconate semialdehyde + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA