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The map label for this gene is kynU

Identifier: 108758280

GI number: 108758280

Start: 1047259

End: 1048539

Strand: Reverse

Name: kynU

Synonym: MXAN_0917

Alternate gene names: 108758280

Gene position: 1048539-1047259 (Counterclockwise)

Preceding gene: 108763806

Following gene: 108761061

Centisome position: 11.47

GC content: 69.71

Gene sequence:

>1281_bases
ATGACGACGCCGTACCTCTTCGAGGACTCCGAGTCCTTCGCGCGGAAGTTGGACGCGGAAGACGCGCTGCGCGGCTACCG
CGACGCGTTCCACTTCCCGCCCGGCCCGGACGGCAAGCCGGTGGTGTACCTGGCGGGCAACTCGCTGGGCCTCCAGCCGC
GCAACGCCGCGCGCTACATCCAGGAGGAGCTGGAGGACTGGGCGCGGCTGGGCGTGGAGGGACACCACCACGGCCGCCAC
CCGTGGCTGCACTACCACGAGCTCGTCACCGAGCATGCCGCGCGGCTGGTGGGCGCCAAGCCGTTGGAAGTGGTGGTGAT
GAACACCCTGTCGGTGAACCTGCACCTGATGATGGTGTCGTTCTACCGGCCCACGAAGCAGCGCTTCAAAATCCTGGTGG
AGGCCGGCGCCTTCCCGTCGGACCAGTACGCCGTCGCCTCCCAGGTGCGCTTCCACGGCTACGACGCGCGCGAGGCCGTG
CTGGAGCTGAAGCCGCGCGAGGGCGAGGAGACGCTGCGCACCGAGGACATCCTCGAAACCATTGAGCGTCACGGCCACGA
GGTGGCGCTGGTGATGCTGGGCAGCGTGAACTACCTCACCGGGCAGGCGTTCGACCTGGCCGCGATTACGAAGGCCGCGC
ACGCCAAGGGCTGCTTCGTCGGCTTCGACCTGGCGCACGGCGCGGGCAACCTGAGGTTGTCGCTGCACGACGACGGACCG
GACTTCGCGGTGTGGTGCTCGTACAAGTACCTCAACGCCGGCCCGGGCGCGCTGGGCGGCGTGTTCGTCCATGAGCGGCA
CGCGCACACGAAGGACCTCCCCCGCTTCGAGGGCTGGTGGGGCCACGACAAGCAGACGCGCTTCCAGATGGGGCCCACCT
TCAGCGCGCTGCCGGGCGCGGAGGGGTGGCAGCTGTCCAACCCGCCCATCTTCCAGCTCGCGGCGCTGCGCGCGTCCCTG
GAGCTGTTCGACCAGGCTGGCATGGCGGCGCTGCGCGCCAAGAGCGAGCGGCTCACCGGCTACCTGGAGTTCCTGCTGGA
CCGGCTGCCCGAGGGATTCGTGCGCATCACCACGCCCCGGGACGTGAAGCAGCGCGGGGCCCAGCTCTCCCTGCGCTTCC
GCGGCGAGCCCCAGGGCCTGCTGAAGCGCCTGGGAGACGCGGGCATCATCTGCGACTTCCGCAAGCCGGACATCATCCGC
GCCGCGCCCGCGCCGCTCTACAACTCCTTCACGGACGTGTACCGCTTCGTGAAGACGCTGGAGGGCCACGCCCGTGAGTG
A

Upstream 100 bases:

>100_bases
TCATCGAGTCCCTGACCGAGCTGGAACCCGCCGCGCGGGAGCGGCTGCTCTGGCGCAACGCCTTCGATTGGCTGGGACGC
GCCCCCGAGGACTTCGCACC

Downstream 100 bases:

>100_bases
GGCGCGCAAGGACACCGTCACCGTGGTGGGCGCGGGGCTGGTGGGCTCGCTGCTCTCCATCTACCTGGCGCGCCGGGGCC
ACACCGTGGAGCTGCTGGAG

Product: kynureninase

Products: NA

Alternate protein names: L-kynurenine hydrolase

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MTTPYLFEDSESFARKLDAEDALRGYRDAFHFPPGPDGKPVVYLAGNSLGLQPRNAARYIQEELEDWARLGVEGHHHGRH
PWLHYHELVTEHAARLVGAKPLEVVVMNTLSVNLHLMMVSFYRPTKQRFKILVEAGAFPSDQYAVASQVRFHGYDAREAV
LELKPREGEETLRTEDILETIERHGHEVALVMLGSVNYLTGQAFDLAAITKAAHAKGCFVGFDLAHGAGNLRLSLHDDGP
DFAVWCSYKYLNAGPGALGGVFVHERHAHTKDLPRFEGWWGHDKQTRFQMGPTFSALPGAEGWQLSNPPIFQLAALRASL
ELFDQAGMAALRAKSERLTGYLEFLLDRLPEGFVRITTPRDVKQRGAQLSLRFRGEPQGLLKRLGDAGIICDFRKPDIIR
AAPAPLYNSFTDVYRFVKTLEGHARE

Sequences:

>Translated_426_residues
MTTPYLFEDSESFARKLDAEDALRGYRDAFHFPPGPDGKPVVYLAGNSLGLQPRNAARYIQEELEDWARLGVEGHHHGRH
PWLHYHELVTEHAARLVGAKPLEVVVMNTLSVNLHLMMVSFYRPTKQRFKILVEAGAFPSDQYAVASQVRFHGYDAREAV
LELKPREGEETLRTEDILETIERHGHEVALVMLGSVNYLTGQAFDLAAITKAAHAKGCFVGFDLAHGAGNLRLSLHDDGP
DFAVWCSYKYLNAGPGALGGVFVHERHAHTKDLPRFEGWWGHDKQTRFQMGPTFSALPGAEGWQLSNPPIFQLAALRASL
ELFDQAGMAALRAKSERLTGYLEFLLDRLPEGFVRITTPRDVKQRGAQLSLRFRGEPQGLLKRLGDAGIICDFRKPDIIR
AAPAPLYNSFTDVYRFVKTLEGHARE
>Mature_425_residues
TTPYLFEDSESFARKLDAEDALRGYRDAFHFPPGPDGKPVVYLAGNSLGLQPRNAARYIQEELEDWARLGVEGHHHGRHP
WLHYHELVTEHAARLVGAKPLEVVVMNTLSVNLHLMMVSFYRPTKQRFKILVEAGAFPSDQYAVASQVRFHGYDAREAVL
ELKPREGEETLRTEDILETIERHGHEVALVMLGSVNYLTGQAFDLAAITKAAHAKGCFVGFDLAHGAGNLRLSLHDDGPD
FAVWCSYKYLNAGPGALGGVFVHERHAHTKDLPRFEGWWGHDKQTRFQMGPTFSALPGAEGWQLSNPPIFQLAALRASLE
LFDQAGMAALRAKSERLTGYLEFLLDRLPEGFVRITTPRDVKQRGAQLSLRFRGEPQGLLKRLGDAGIICDFRKPDIIRA
APAPLYNSFTDVYRFVKTLEGHARE

Specific function: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively

COG id: COG3844

COG function: function code E; Kynureninase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kynureninase family

Homologues:

Organism=Homo sapiens, GI4504937, Length=429, Percent_Identity=48.4848484848485, Blast_Score=419, Evalue=1e-117,
Organism=Homo sapiens, GI74101437, Length=278, Percent_Identity=50.7194244604317, Blast_Score=286, Evalue=3e-77,
Organism=Caenorhabditis elegans, GI17550466, Length=430, Percent_Identity=45.5813953488372, Blast_Score=389, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6323261, Length=445, Percent_Identity=44.2696629213483, Blast_Score=352, Evalue=5e-98,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KYNU_MYXXD (Q1DDU5)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_629178.1
- ProteinModelPortal:   Q1DDU5
- SMR:   Q1DDU5
- STRING:   Q1DDU5
- GeneID:   4104929
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_0917
- TIGR:   MXAN_0917
- eggNOG:   COG3844
- HOGENOM:   HBG523016
- OMA:   MTDDIAL
- PhylomeDB:   Q1DDU5
- ProtClustDB:   CLSK2486953
- BioCyc:   MXAN246197:MXAN_0917-MONOMER
- GO:   GO:0005737
- InterPro:   IPR000192
- InterPro:   IPR010111
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR14084
- TIGRFAMs:   TIGR01814

Pfam domain/function: PF00266 Aminotran_5; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =3.7.1.3

Molecular weight: Translated: 47761; Mature: 47630

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: NA

Important sites: BINDING 110-110 BINDING 111-111 BINDING 223-223 BINDING 226-226 BINDING 248-248 BINDING 279-279 BINDING 307-307

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPYLFEDSESFARKLDAEDALRGYRDAFHFPPGPDGKPVVYLAGNSLGLQPRNAARYI
CCCCCEECCCHHHHHHCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCHHHHHH
QEELEDWARLGVEGHHHGRHPWLHYHELVTEHAARLVGAKPLEVVVMNTLSVNLHLMMVS
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEEEEEEEEE
FYRPTKQRFKILVEAGAFPSDQYAVASQVRFHGYDAREAVLELKPREGEETLRTEDILET
HHCCCHHHEEEEEECCCCCCCCHHHHHHHEECCCCHHHHHHCCCCCCCHHHHHHHHHHHH
IERHGHEVALVMLGSVNYLTGQAFDLAAITKAAHAKGCFVGFDLAHGAGNLRLSLHDDGP
HHHCCCEEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCEEEEEEECCCC
DFAVWCSYKYLNAGPGALGGVFVHERHAHTKDLPRFEGWWGHDKQTRFQMGPTFSALPGA
CEEEEEEEEEECCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCC
EGWQLSNPPIFQLAALRASLELFDQAGMAALRAKSERLTGYLEFLLDRLPEGFVRITTPR
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCH
DVKQRGAQLSLRFRGEPQGLLKRLGDAGIICDFRKPDIIRAAPAPLYNSFTDVYRFVKTL
HHHHCCCEEEEEECCCHHHHHHHCCCCCEEEECCCCCEEECCCCHHHHHHHHHHHHHHHH
EGHARE
HCCCCC
>Mature Secondary Structure 
TTPYLFEDSESFARKLDAEDALRGYRDAFHFPPGPDGKPVVYLAGNSLGLQPRNAARYI
CCCCEECCCHHHHHHCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCHHHHHH
QEELEDWARLGVEGHHHGRHPWLHYHELVTEHAARLVGAKPLEVVVMNTLSVNLHLMMVS
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEEEEEEEEE
FYRPTKQRFKILVEAGAFPSDQYAVASQVRFHGYDAREAVLELKPREGEETLRTEDILET
HHCCCHHHEEEEEECCCCCCCCHHHHHHHEECCCCHHHHHHCCCCCCCHHHHHHHHHHHH
IERHGHEVALVMLGSVNYLTGQAFDLAAITKAAHAKGCFVGFDLAHGAGNLRLSLHDDGP
HHHCCCEEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCEEEEEEECCCC
DFAVWCSYKYLNAGPGALGGVFVHERHAHTKDLPRFEGWWGHDKQTRFQMGPTFSALPGA
CEEEEEEEEEECCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCC
EGWQLSNPPIFQLAALRASLELFDQAGMAALRAKSERLTGYLEFLLDRLPEGFVRITTPR
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCH
DVKQRGAQLSLRFRGEPQGLLKRLGDAGIICDFRKPDIIRAAPAPLYNSFTDVYRFVKTL
HHHHCCCEEEEEECCCHHHHHHHCCCCCEEEECCCCCEEECCCCHHHHHHHHHHHHHHHH
EGHARE
HCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA