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The map label for this gene is kmo

Identifier: 108761061

GI number: 108761061

Start: 1045872

End: 1047266

Strand: Reverse

Name: kmo

Synonym: MXAN_0916

Alternate gene names: 108761061

Gene position: 1047266-1045872 (Counterclockwise)

Preceding gene: 108758280

Following gene: 108763856

Centisome position: 11.46

GC content: 68.32

Gene sequence:

>1395_bases
GTGAGTGAGGCGCGCAAGGACACCGTCACCGTGGTGGGCGCGGGGCTGGTGGGCTCGCTGCTCTCCATCTACCTGGCGCG
CCGGGGCCACACCGTGGAGCTGCTGGAGCGACGCCCGGACATGCGGCGCGAAACAGTCGACGGGGGCCGCTCCATCAACC
TGGCCATCTCCACGCGCGGGCTGCATGCGCTCCGGCAGGTGGGCCTGGAAAACGAGGCGCTGAAGCACGCCATCCCCATG
CGCGGGCGGATGATTCACCCGCCGCAAGGCGAGCTCGTCTACCAGCCCTACGGCAAGGACGACTCGCAGCACATCAACGC
GATGTCGCGCGGGTGGCTGAACGCCTTCCTCATGACGGCGGCGGAGGCCACCGGGAAGGTGCGCATCCGCTTCAAGCAGC
GGGTGACGGATGTGGACTTCGGCTCGGGCGCGCTCACGGTGCACGACGACGCCACCGGAGAGGCGCGCCAGGAGCCCGGC
CGCGTGGTGTTCGGCACGGACGGCTCCGCCTCCGCCATCCGCCAGGCCTTGGAGAAGCGGCCGGACTTCAAGGGGACGCA
GGAGCAGCTCGGCCACGGGTACAAGGAATTGACGATTCCGGCGGGCCCCGGCGGCGCGTTCCAGATGGAGAAGCACGCGC
TCCACATCTGGCCTCGCGGCACGTTCATGTTGATCGCGCTGCCCGACGAGGAAGGCAGCTTCACCTGCACGCTGTTCCTG
CCCTGGCAGGGGCCGGTGAGCTTCGCGTCCCTGGACACGCCCGCGAAGCTGGAGGCGTTCTTCGGCGCGCAGTTCCCAGA
TGCGAAGGCGCTCATCCCGGACCTGGTGGAGGCGTTCTTCTCGCGTCCCACGGGCAGCATGGTGACGGTGAAGGGCGCGC
CCTGGCACGCGGGTGGGCAGACGCTGCTGCTGGGCGACGCCGCGCACGCCATCGTCCCCTTCTTCGGCCAGGGGATGAAC
TGCGGCTTCGAGGACTGCGTCGTCCTGGACCAACTGCTGGGACAGGGCGCCGGCTGGGAGCAGGTCTTCACGGACTTCGA
ACGCCTGCGCAAGACGAACGCGGACGCCATCGCCGACATGGCGGTGGAGAACTTCGTCGAGATGCGCGACAGCACTGGCG
ACCCGCGCTTCCTGTTTCGGAAGGCCGTGGAGAAGGTGCTGCTCAACGCCTTCCCGGGCGAGTTCGTCAGCCGCTACTCC
CTGGTGAGCTTCAGCCACGTGCCTTACCGGCTGGCCTATCAGATGGGTGCGCTGACGGACGGCATCGTCTCCGAGCTGAG
CGAGGGCCTGCCTCGGGCGGAAGACGTGGACCTGAAGCGCGCGGCGGAGCTCATCCGGAGCCGGCTGACACCATTCATGA
AGGAGCACGCTGATGGATTTCGGACTGAAGGGTAG

Upstream 100 bases:

>100_bases
GACTTCCGCAAGCCGGACATCATCCGCGCCGCGCCCGCGCCGCTCTACAACTCCTTCACGGACGTGTACCGCTTCGTGAA
GACGCTGGAGGGCCACGCCC

Downstream 100 bases:

>100_bases
ACGCGCGCTGGTGATGGGCGCGTCCGCGGGGCTGGGTTACGCCATCGCGGAGGCGTTGGTGAAGGAAGGCGCCACGGTGG
CCATCTGCTCGCGCGGTGGC

Product: putative kynurenine 3-monooxygenase

Products: NA

Alternate protein names: Kynurenine 3-hydroxylase

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MSEARKDTVTVVGAGLVGSLLSIYLARRGHTVELLERRPDMRRETVDGGRSINLAISTRGLHALRQVGLENEALKHAIPM
RGRMIHPPQGELVYQPYGKDDSQHINAMSRGWLNAFLMTAAEATGKVRIRFKQRVTDVDFGSGALTVHDDATGEARQEPG
RVVFGTDGSASAIRQALEKRPDFKGTQEQLGHGYKELTIPAGPGGAFQMEKHALHIWPRGTFMLIALPDEEGSFTCTLFL
PWQGPVSFASLDTPAKLEAFFGAQFPDAKALIPDLVEAFFSRPTGSMVTVKGAPWHAGGQTLLLGDAAHAIVPFFGQGMN
CGFEDCVVLDQLLGQGAGWEQVFTDFERLRKTNADAIADMAVENFVEMRDSTGDPRFLFRKAVEKVLLNAFPGEFVSRYS
LVSFSHVPYRLAYQMGALTDGIVSELSEGLPRAEDVDLKRAAELIRSRLTPFMKEHADGFRTEG

Sequences:

>Translated_464_residues
MSEARKDTVTVVGAGLVGSLLSIYLARRGHTVELLERRPDMRRETVDGGRSINLAISTRGLHALRQVGLENEALKHAIPM
RGRMIHPPQGELVYQPYGKDDSQHINAMSRGWLNAFLMTAAEATGKVRIRFKQRVTDVDFGSGALTVHDDATGEARQEPG
RVVFGTDGSASAIRQALEKRPDFKGTQEQLGHGYKELTIPAGPGGAFQMEKHALHIWPRGTFMLIALPDEEGSFTCTLFL
PWQGPVSFASLDTPAKLEAFFGAQFPDAKALIPDLVEAFFSRPTGSMVTVKGAPWHAGGQTLLLGDAAHAIVPFFGQGMN
CGFEDCVVLDQLLGQGAGWEQVFTDFERLRKTNADAIADMAVENFVEMRDSTGDPRFLFRKAVEKVLLNAFPGEFVSRYS
LVSFSHVPYRLAYQMGALTDGIVSELSEGLPRAEDVDLKRAAELIRSRLTPFMKEHADGFRTEG
>Mature_463_residues
SEARKDTVTVVGAGLVGSLLSIYLARRGHTVELLERRPDMRRETVDGGRSINLAISTRGLHALRQVGLENEALKHAIPMR
GRMIHPPQGELVYQPYGKDDSQHINAMSRGWLNAFLMTAAEATGKVRIRFKQRVTDVDFGSGALTVHDDATGEARQEPGR
VVFGTDGSASAIRQALEKRPDFKGTQEQLGHGYKELTIPAGPGGAFQMEKHALHIWPRGTFMLIALPDEEGSFTCTLFLP
WQGPVSFASLDTPAKLEAFFGAQFPDAKALIPDLVEAFFSRPTGSMVTVKGAPWHAGGQTLLLGDAAHAIVPFFGQGMNC
GFEDCVVLDQLLGQGAGWEQVFTDFERLRKTNADAIADMAVENFVEMRDSTGDPRFLFRKAVEKVLLNAFPGEFVSRYSL
VSFSHVPYRLAYQMGALTDGIVSELSEGLPRAEDVDLKRAAELIRSRLTPFMKEHADGFRTEG

Specific function: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid

COG id: COG0654

COG function: function code HC; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aromatic-ring hydroxylase family. KMO subfamily

Homologues:

Organism=Homo sapiens, GI187960045, Length=418, Percent_Identity=42.5837320574163, Blast_Score=324, Evalue=1e-88,
Organism=Caenorhabditis elegans, GI17562934, Length=441, Percent_Identity=34.0136054421769, Blast_Score=259, Evalue=2e-69,
Organism=Caenorhabditis elegans, GI212646493, Length=411, Percent_Identity=27.9805352798054, Blast_Score=166, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI193208447, Length=373, Percent_Identity=27.3458445040214, Blast_Score=144, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6319372, Length=429, Percent_Identity=34.2657342657343, Blast_Score=232, Evalue=9e-62,
Organism=Drosophila melanogaster, GI28573964, Length=404, Percent_Identity=41.3366336633663, Blast_Score=297, Evalue=8e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KMO_MYXXD (Q1DDU6)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_629177.1
- ProteinModelPortal:   Q1DDU6
- STRING:   Q1DDU6
- GeneID:   4103649
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_0916
- TIGR:   MXAN_0916
- eggNOG:   COG0654
- HOGENOM:   HBG430104
- OMA:   HWQKKVI
- PhylomeDB:   Q1DDU6
- ProtClustDB:   CLSK903475
- BioCyc:   MXAN246197:MXAN_0916-MONOMER
- InterPro:   IPR002938
- InterPro:   IPR003042
- PRINTS:   PR00420

Pfam domain/function: PF01494 FAD_binding_3

EC number: =1.14.13.9

Molecular weight: Translated: 50921; Mature: 50789

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEARKDTVTVVGAGLVGSLLSIYLARRGHTVELLERRPDMRRETVDGGRSINLAISTRG
CCCCCCCEEEEEEHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHCCCCCEEEEEEECHH
LHALRQVGLENEALKHAIPMRGRMIHPPQGELVYQPYGKDDSQHINAMSRGWLNAFLMTA
HHHHHHCCCCHHHHHHHCCCCCCEECCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHH
AEATGKVRIRFKQRVTDVDFGSGALTVHDDATGEARQEPGRVVFGTDGSASAIRQALEKR
HCCCCEEEEEEEHHCCCCCCCCCEEEEECCCCCCHHCCCCCEEEECCCCHHHHHHHHHHC
PDFKGTQEQLGHGYKELTIPAGPGGAFQMEKHALHIWPRGTFMLIALPDEEGSFTCTLFL
CCCCCCHHHHCCCCEEEEEECCCCCCEEEECCEEEEECCCEEEEEEEECCCCCEEEEEEE
PWQGPVSFASLDTPAKLEAFFGAQFPDAKALIPDLVEAFFSRPTGSMVTVKGAPWHAGGQ
ECCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCC
TLLLGDAAHAIVPFFGQGMNCGFEDCVVLDQLLGQGAGWEQVFTDFERLRKTNADAIADM
EEEECCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHH
AVENFVEMRDSTGDPRFLFRKAVEKVLLNAFPGEFVSRYSLVSFSHVPYRLAYQMGALTD
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHEECCCCHHHHHHHHCCHH
GIVSELSEGLPRAEDVDLKRAAELIRSRLTPFMKEHADGFRTEG
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SEARKDTVTVVGAGLVGSLLSIYLARRGHTVELLERRPDMRRETVDGGRSINLAISTRG
CCCCCCEEEEEEHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHCCCCCEEEEEEECHH
LHALRQVGLENEALKHAIPMRGRMIHPPQGELVYQPYGKDDSQHINAMSRGWLNAFLMTA
HHHHHHCCCCHHHHHHHCCCCCCEECCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHH
AEATGKVRIRFKQRVTDVDFGSGALTVHDDATGEARQEPGRVVFGTDGSASAIRQALEKR
HCCCCEEEEEEEHHCCCCCCCCCEEEEECCCCCCHHCCCCCEEEECCCCHHHHHHHHHHC
PDFKGTQEQLGHGYKELTIPAGPGGAFQMEKHALHIWPRGTFMLIALPDEEGSFTCTLFL
CCCCCCHHHHCCCCEEEEEECCCCCCEEEECCEEEEECCCEEEEEEEECCCCCEEEEEEE
PWQGPVSFASLDTPAKLEAFFGAQFPDAKALIPDLVEAFFSRPTGSMVTVKGAPWHAGGQ
ECCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCC
TLLLGDAAHAIVPFFGQGMNCGFEDCVVLDQLLGQGAGWEQVFTDFERLRKTNADAIADM
EEEECCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHH
AVENFVEMRDSTGDPRFLFRKAVEKVLLNAFPGEFVSRYSLVSFSHVPYRLAYQMGALTD
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHEECCCCHHHHHHHHCCHH
GIVSELSEGLPRAEDVDLKRAAELIRSRLTPFMKEHADGFRTEG
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA