Click here to switch to the map view.

The map label for this gene is mltD [H]

Identifier: 108563946

GI number: 108563946

Start: 1583950

End: 1585062

Strand: Reverse

Name: mltD [H]

Synonym: HPAG1_1521

Alternate gene names: 108563946

Gene position: 1585062-1583950 (Counterclockwise)

Preceding gene: 108563947

Following gene: 108563945

Centisome position: 99.29

GC content: 39.26

Gene sequence:

>1113_bases
ATGTCAAAAAGAATGAAGTGTTTTAGTCAAAAATGGTTGGTTTTTTTTGTTACCCTTTTATTGGCCTCTTTAGCCCATGC
GAAAATGGCTTTTGAATCTAATATTGACACCAAAGCGCTAGAGGCCTTTGGGGTTAATGCGAGCTTTTTATCCCAAATGC
CAAACGCTTTAAAAAAAATGAATAAAGAAGAAGAATGGAAAAAGTTAGTCAAAAGATTTGATGCGAATTACCAGTTCATC
CCCATCATTAAAAACATGCTCATAGAAGCGAGCGTGCCGCAAGAATTTTTATTTTTAGCCATGGCCGAGTCCAAATTTTC
ATCAAGGGCTTATAGCAGGAAAAAAGCGGTAGGGATTTGGCAATTCATGCCAAGCACGGCTAAAGAATTAGGGCTTAAGG
TCAATCATTACATTGACGAAAGAAGAGACCCCATTAAAAGCACTCAAGCAGCAATCGCTTATTTGAAACGGCTCTACAAA
CAAACCGGGGAATGGTATTTGGTCGCTATGGCGTATAATTACGGCTTACGCAAGGTTCAAAACGCTATTAAAGCCGCCGG
CACTTCGGACATTAAGATTTTGTTAGATGAAGATAAAAAATACCTCCCTAAAGAAACACGAGAGTATATCCGCTCCATTC
TAAGCCTGGCGTTAAAATTCAACAGACTAGACAACCTCAAAGATAAAGAATACTTGCTCAATCGCGGGGCGAGGGTGAGT
TTAGTGGGCGTTCCGTTTAAAAGGCGCACTTCTTTAGTCCAAGTAGCCAAAAATTTAAACTTGAGTTTAGAAACCTTAAA
ATCCTACAACCACCAATTCCGTTATAACATTCTGCCCTCTAAAGACCCCACTTACACCATTTATATCCCTTATGAAAAAC
TCGCTCTTTTCAAACAACGCCAGTTCAAGCAGCATAAAAGTGCTCCAACCAAAAGCCCTTTTATCACCCATGTGGTCTTG
CCTAAAGAAACCCTATCTTCTATCGCTAAACGCTATCAAGTCAGTATTTCCAGTATCCAATTAGCCAATAACCTCAAAGA
TTCTAATATTTTTATCCACCAGCGCTTAATCATCCCTACCAACAAAAAATTACTCGCTACAAGGGAATTTTAA

Upstream 100 bases:

>100_bases
AGTTTCCCCTGAAAATAAGGCTGTGTTAGAAAGCGTTATTCAAGTTTAGTTATAATCAAAGCTATTTTAAAAGCTGGATA
GCTGTAGTTATTAGGATGCG

Downstream 100 bases:

>100_bases
TGGGTTTGGCGTTGAAACAAGTTTGTTTTTTAGGCGTTATTTTTTTGATTAGCGCTTGTGCGGTTAAAAAAGAGGGGGTA
AAGAATTTGTCTTACAAGCA

Product: regulatory protein DniR

Products: 1,6-Anhydrobond In The Muramic Acid Residue [C]

Alternate protein names: Murein hydrolase D; Regulatory protein dniR [H]

Number of amino acids: Translated: 370; Mature: 369

Protein sequence:

>370_residues
MSKRMKCFSQKWLVFFVTLLLASLAHAKMAFESNIDTKALEAFGVNASFLSQMPNALKKMNKEEEWKKLVKRFDANYQFI
PIIKNMLIEASVPQEFLFLAMAESKFSSRAYSRKKAVGIWQFMPSTAKELGLKVNHYIDERRDPIKSTQAAIAYLKRLYK
QTGEWYLVAMAYNYGLRKVQNAIKAAGTSDIKILLDEDKKYLPKETREYIRSILSLALKFNRLDNLKDKEYLLNRGARVS
LVGVPFKRRTSLVQVAKNLNLSLETLKSYNHQFRYNILPSKDPTYTIYIPYEKLALFKQRQFKQHKSAPTKSPFITHVVL
PKETLSSIAKRYQVSISSIQLANNLKDSNIFIHQRLIIPTNKKLLATREF

Sequences:

>Translated_370_residues
MSKRMKCFSQKWLVFFVTLLLASLAHAKMAFESNIDTKALEAFGVNASFLSQMPNALKKMNKEEEWKKLVKRFDANYQFI
PIIKNMLIEASVPQEFLFLAMAESKFSSRAYSRKKAVGIWQFMPSTAKELGLKVNHYIDERRDPIKSTQAAIAYLKRLYK
QTGEWYLVAMAYNYGLRKVQNAIKAAGTSDIKILLDEDKKYLPKETREYIRSILSLALKFNRLDNLKDKEYLLNRGARVS
LVGVPFKRRTSLVQVAKNLNLSLETLKSYNHQFRYNILPSKDPTYTIYIPYEKLALFKQRQFKQHKSAPTKSPFITHVVL
PKETLSSIAKRYQVSISSIQLANNLKDSNIFIHQRLIIPTNKKLLATREF
>Mature_369_residues
SKRMKCFSQKWLVFFVTLLLASLAHAKMAFESNIDTKALEAFGVNASFLSQMPNALKKMNKEEEWKKLVKRFDANYQFIP
IIKNMLIEASVPQEFLFLAMAESKFSSRAYSRKKAVGIWQFMPSTAKELGLKVNHYIDERRDPIKSTQAAIAYLKRLYKQ
TGEWYLVAMAYNYGLRKVQNAIKAAGTSDIKILLDEDKKYLPKETREYIRSILSLALKFNRLDNLKDKEYLLNRGARVSL
VGVPFKRRTSLVQVAKNLNLSLETLKSYNHQFRYNILPSKDPTYTIYIPYEKLALFKQRQFKQHKSAPTKSPFITHVVLP
KETLSSIAKRYQVSISSIQLANNLKDSNIFIHQRLIIPTNKKLLATREF

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division [H]

COG id: COG0741

COG function: function code M; Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains)

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 LysM repeats [H]

Homologues:

Organism=Escherichia coli, GI1786405, Length=289, Percent_Identity=31.8339100346021, Blast_Score=108, Evalue=7e-25,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008258
- InterPro:   IPR010511
- InterPro:   IPR018392
- InterPro:   IPR002482
- InterPro:   IPR000189 [H]

Pfam domain/function: PF01476 LysM; PF06474 MLTD_N; PF01464 SLT [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 42930; Mature: 42799

Theoretical pI: Translated: 10.64; Mature: 10.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKRMKCFSQKWLVFFVTLLLASLAHAKMAFESNIDTKALEAFGVNASFLSQMPNALKKM
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHC
NKEEEWKKLVKRFDANYQFIPIIKNMLIEASVPQEFLFLAMAESKFSSRAYSRKKAVGIW
CCHHHHHHHHHHHCCCCEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
QFMPSTAKELGLKVNHYIDERRDPIKSTQAAIAYLKRLYKQTGEWYLVAMAYNYGLRKVQ
HHCCHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHH
NAIKAAGTSDIKILLDEDKKYLPKETREYIRSILSLALKFNRLDNLKDKEYLLNRGARVS
HHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCEEE
LVGVPFKRRTSLVQVAKNLNLSLETLKSYNHQFRYNILPSKDPTYTIYIPYEKLALFKQR
EEECCHHHHHHHHHHHHCCCCHHHHHHHCCCEEEEEECCCCCCCEEEEECHHHHHHHHHH
QFKQHKSAPTKSPFITHVVLPKETLSSIAKRYQVSISSIQLANNLKDSNIFIHQRLIIPT
HHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECC
NKKLLATREF
CCCEEEECCC
>Mature Secondary Structure 
SKRMKCFSQKWLVFFVTLLLASLAHAKMAFESNIDTKALEAFGVNASFLSQMPNALKKM
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHC
NKEEEWKKLVKRFDANYQFIPIIKNMLIEASVPQEFLFLAMAESKFSSRAYSRKKAVGIW
CCHHHHHHHHHHHCCCCEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
QFMPSTAKELGLKVNHYIDERRDPIKSTQAAIAYLKRLYKQTGEWYLVAMAYNYGLRKVQ
HHCCHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHH
NAIKAAGTSDIKILLDEDKKYLPKETREYIRSILSLALKFNRLDNLKDKEYLLNRGARVS
HHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCEEE
LVGVPFKRRTSLVQVAKNLNLSLETLKSYNHQFRYNILPSKDPTYTIYIPYEKLALFKQR
EEECCHHHHHHHHHHHHCCCCHHHHHHHCCCEEEEEECCCCCCCEEEEECHHHHHHHHHH
QFKQHKSAPTKSPFITHVVLPKETLSSIAKRYQVSISSIQLANNLKDSNIFIHQRLIIPT
HHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECC
NKKLLATREF
CCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic Bond Between N-Acetylmuramic Acid And N-Acetylglucosamine Residues, Thereby Conserving The Energy In A Newly Synthesized 1,6-Anhydrobond In The Muramic Acid Residue. [C]

General reaction: Cleavage Of The Beta-1,4-Glycosidic Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]