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The map label for this gene is nhaA [H]

Identifier: 108563926

GI number: 108563926

Start: 1562318

End: 1563634

Strand: Reverse

Name: nhaA [H]

Synonym: HPAG1_1501

Alternate gene names: 108563926

Gene position: 1563634-1562318 (Counterclockwise)

Preceding gene: 108563927

Following gene: 108563925

Centisome position: 97.95

GC content: 42.07

Gene sequence:

>1317_bases
ATGAATGTCAAAAAAACAGAAAACGCGCTCAGTTTGACGCTTAAAAACTTTATTAAAAGCGAGTCTTTTGGAGGGATTTT
CCTCTTTTTAAACGCTGTTTTAGCGATGGTGGTGGCTAATTCGTTTTTAAAAGAAAGTTATTTTGCACTATGGCACACCC
CTTTTGGGTTTCAAATAGGGGATTTTTTTATTGGCTTTAGTTTGCACAACTGGATTGATGATGTCTTAATGGCGTTATTC
TTTTTAATGATAGGCTTAGAGATCAAGCGAGAATTGTTATTTGGGGAATTATCCAGTTTCAAAAAAGCTTCTTTCCCTGT
GATTGCAGCCATAGGGGGCATGATAGCTCCAGGATTGATTTATTTTTTTCTTAACGCTGACACGCCCTCTCAGCATGGTT
TTGGGATCCCCATGGCGACGGATATTGCGTTCGCTTTAGGCGTGATCATGCTTTTAGGCAAGAGGGTGCCAACCGCCTTA
AAGGTTTTTTTAATCACTCTAGCGGTGGCTGATGACTTGGGGGCTATTGTGGTGATCGCGCTCTTTTATACCACGAATTT
AAAATTCGCATGGCTTTTAGGGGCTTTAGGGGTGGTTCTTATTTTAGCGGTATTGAACCGCTTGAATGTCCGCTCGCTTG
TCCCTTACTTGCTTTTAGGGGTGTTGCTTTGGTTTTGCGTGCATCAAAGCGGTATCCATGCGACAATCGCTGCAGTGATT
CTAGCTTTTATGATACCGGTGAAAATCCCTAAAGATTCTAAAAATGTAGAGCTTTTGGAATTAGGCAAACGATACGCAGA
GACGAGTTCAGGAGCGCTTTTGACCAAAGAGCAGCAAGAAATCTTGCATTCTATTGAAGAAAAAGCGAGCGCTTTACAAA
GCCCCTTAGAAAGATTGGAGCATTTTTTAGCCCCCATTAGCGGGTATTTCATCATGCCCTTATTCGCGTTTGCAAACGCT
GGGGTGAGCGTTGATTCTAGCATCAATTTAGAAGTGGATAAGGTGCTTTTAGGGGTTATTTTAGGGCTTTGCTTGGGCAA
GCCTTTAGGGATTTTCTTAATCACTTTTATAAGCGAAAAGCTTAAAATCACCGCGCGCCCTAAAGGCATCAGCTGGTGGC
ATATTTTAGGGGCTGGGCTTTTAGCAGGGATTGGCTTTACCATGTCTATGTTTATTTCTAATCTGGCTTTCACGAGCGAG
CATAAAGACGCTATGGAAGTGGCAAAGATTGCGATTTTGCTCGGATCTTTGATTTCTGGAATCATAGGGGCTTTGTATTT
ATTTGCGCTAGACAAAAGAGCGGCTTTAAAGAAATAG

Upstream 100 bases:

>100_bases
CTCAAGCCCCCCATTTTAAGATACAAGCGGGCATCATTTACGCTCATAAAAGACTGCTTGAAAAATTATGGGTTTGAAAT
TAAAAATTTTAAGGTTGTCT

Downstream 100 bases:

>100_bases
TTAAAAATGCTATAATTTGAGCTTGAAACATCTTTTAAGGAAATTAAATGGGACAAATTAGAGACATTCTAACGACGCTT
TTACCCCTTGTGGTGTTGTT

Product: pH-dependent sodium/proton antiporter

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MNVKKTENALSLTLKNFIKSESFGGIFLFLNAVLAMVVANSFLKESYFALWHTPFGFQIGDFFIGFSLHNWIDDVLMALF
FLMIGLEIKRELLFGELSSFKKASFPVIAAIGGMIAPGLIYFFLNADTPSQHGFGIPMATDIAFALGVIMLLGKRVPTAL
KVFLITLAVADDLGAIVVIALFYTTNLKFAWLLGALGVVLILAVLNRLNVRSLVPYLLLGVLLWFCVHQSGIHATIAAVI
LAFMIPVKIPKDSKNVELLELGKRYAETSSGALLTKEQQEILHSIEEKASALQSPLERLEHFLAPISGYFIMPLFAFANA
GVSVDSSINLEVDKVLLGVILGLCLGKPLGIFLITFISEKLKITARPKGISWWHILGAGLLAGIGFTMSMFISNLAFTSE
HKDAMEVAKIAILLGSLISGIIGALYLFALDKRAALKK

Sequences:

>Translated_438_residues
MNVKKTENALSLTLKNFIKSESFGGIFLFLNAVLAMVVANSFLKESYFALWHTPFGFQIGDFFIGFSLHNWIDDVLMALF
FLMIGLEIKRELLFGELSSFKKASFPVIAAIGGMIAPGLIYFFLNADTPSQHGFGIPMATDIAFALGVIMLLGKRVPTAL
KVFLITLAVADDLGAIVVIALFYTTNLKFAWLLGALGVVLILAVLNRLNVRSLVPYLLLGVLLWFCVHQSGIHATIAAVI
LAFMIPVKIPKDSKNVELLELGKRYAETSSGALLTKEQQEILHSIEEKASALQSPLERLEHFLAPISGYFIMPLFAFANA
GVSVDSSINLEVDKVLLGVILGLCLGKPLGIFLITFISEKLKITARPKGISWWHILGAGLLAGIGFTMSMFISNLAFTSE
HKDAMEVAKIAILLGSLISGIIGALYLFALDKRAALKK
>Mature_438_residues
MNVKKTENALSLTLKNFIKSESFGGIFLFLNAVLAMVVANSFLKESYFALWHTPFGFQIGDFFIGFSLHNWIDDVLMALF
FLMIGLEIKRELLFGELSSFKKASFPVIAAIGGMIAPGLIYFFLNADTPSQHGFGIPMATDIAFALGVIMLLGKRVPTAL
KVFLITLAVADDLGAIVVIALFYTTNLKFAWLLGALGVVLILAVLNRLNVRSLVPYLLLGVLLWFCVHQSGIHATIAAVI
LAFMIPVKIPKDSKNVELLELGKRYAETSSGALLTKEQQEILHSIEEKASALQSPLERLEHFLAPISGYFIMPLFAFANA
GVSVDSSINLEVDKVLLGVILGLCLGKPLGIFLITFISEKLKITARPKGISWWHILGAGLLAGIGFTMSMFISNLAFTSE
HKDAMEVAKIAILLGSLISGIIGALYLFALDKRAALKK

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family [H]

Homologues:

Organism=Escherichia coli, GI1786201, Length=417, Percent_Identity=45.3237410071942, Blast_Score=290, Evalue=1e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670 [H]

Pfam domain/function: PF06965 Na_H_antiport_1 [H]

EC number: NA

Molecular weight: Translated: 47729; Mature: 47729

Theoretical pI: Translated: 9.22; Mature: 9.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA