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The map label for this gene is trpB [H]

Identifier: 108563659

GI number: 108563659

Start: 1296346

End: 1297527

Strand: Direct

Name: trpB [H]

Synonym: HPAG1_1234

Alternate gene names: 108563659

Gene position: 1296346-1297527 (Clockwise)

Preceding gene: 108563658

Following gene: 108563660

Centisome position: 81.21

GC content: 43.23

Gene sequence:

>1182_bases
ATGAATAAAAAAGCGTATTTTGGGGAGTTTGGAGGGAGTTTTGTTTCGGAGTTGTTAGTGCCTGCATTAAGAGAGTTAGA
ACAGGCGTTTGATGCGTGTTTGAAAGATGAAAAATTCCAAAAAGAATATTTTCGTCTTTTAAAAGATTTTGTGGGCCGTC
CTAGCCCTTTAACCTTGTGTCAAAACATCGTTTCTAACCCTAAAGTCAAGCTTTATTTAAAACGAGAGGATTTAATCCAT
GGCGGGGCGCACAAGACTAATCAAGCTCTAGGGCAAGCCCTTTTAGCGAAAAAAATGGGTAAAACAAGGATCATTGCTGA
AACAGGCGCTGGGCAGCATGGCGTGGCAACGGCTATCGCTTGCGCGTTATTGGGTTTAAAATGCGTGATTTTTATGGGAG
CTAAAGACATCAAGCGCCAGGAAATGAATGTTTTTAGAATGCGCTTATTAGGCGCTGAAGTGAGAGAAGTCAATTCAGGG
AGCGCGACGCTTAAAGACGCTGTGAATGAAGCCTTAAGAGATTGGGCGAGCAGTTACAAGGACACGCATTATTTGCTAGG
CACAGCCGCTGGGTCACACCCTTACCCCACAATGGTTAAAACCTTTCAAAAAATGATAGGCGATGAGGTTAAAAGCCAGA
TTTTAGAAAAAGAAAACCGCTTGCCTGATTATGTTATCGCATGCGTTGGAGGGGGGTCTAACGCTATAGGGATATTTAGC
GCGTTTTTAAACGATAAAGAGGTTAAACTCATAGGCGTAGAGCCGGCGGGTTTAGGGCTAGAAACCAATAAGCATGGAGC
GACTTTGAATAAGGGGCGTGTGGGGATTTTGCATGGGAATAAAACCTATCTTTTACAAGATGATGAAGGCCAGATTACAG
AAAGCCACAGCATTAGCGCTGGGCTTGATTATCCAGGAGTGGGGCCAGAACACAGCTATTTAAAAGAGAGTAAGCGTGCG
GTTTATGAAAGTGCAAGCGATCTTGAAGCGCTAGAAGCCTTTAGTTTGTTGTGCCAAAAAGAAGGCATTATCCCAGCGCT
AGAAAGCTCACACGCTTTAGCGTATGCTTTAAAATTCGCTCAAAAATGCGAAGAAGAAAGTATCATTGTGGTGAATTTGA
GCGGTCGGGGGGATAAGGATTTAAGCACCGTTTATAACGCTTTAAAAGGAGGTTTAAAATGA

Upstream 100 bases:

>100_bases
AGCGTTGGGGTTGGATTTCAATTCCGGTTTAGAAATAAGCCCTGGGATTAAAAATAAGGATAAAATCAAGCGATTAGCCC
GAATTTTAAGAGAGTATTAA

Downstream 100 bases:

>100_bases
GGTATCAAAACATGTTTGAAACCTTAAAAAAACAAGACAAAATGGCGTTTATCCCGTTTGTAACCTTGGGTGATCCCAAT
TATGAATGGAGTTTTGAAAT

Product: tryptophan synthase subunit beta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MNKKAYFGEFGGSFVSELLVPALRELEQAFDACLKDEKFQKEYFRLLKDFVGRPSPLTLCQNIVSNPKVKLYLKREDLIH
GGAHKTNQALGQALLAKKMGKTRIIAETGAGQHGVATAIACALLGLKCVIFMGAKDIKRQEMNVFRMRLLGAEVREVNSG
SATLKDAVNEALRDWASSYKDTHYLLGTAAGSHPYPTMVKTFQKMIGDEVKSQILEKENRLPDYVIACVGGGSNAIGIFS
AFLNDKEVKLIGVEPAGLGLETNKHGATLNKGRVGILHGNKTYLLQDDEGQITESHSISAGLDYPGVGPEHSYLKESKRA
VYESASDLEALEAFSLLCQKEGIIPALESSHALAYALKFAQKCEEESIIVVNLSGRGDKDLSTVYNALKGGLK

Sequences:

>Translated_393_residues
MNKKAYFGEFGGSFVSELLVPALRELEQAFDACLKDEKFQKEYFRLLKDFVGRPSPLTLCQNIVSNPKVKLYLKREDLIH
GGAHKTNQALGQALLAKKMGKTRIIAETGAGQHGVATAIACALLGLKCVIFMGAKDIKRQEMNVFRMRLLGAEVREVNSG
SATLKDAVNEALRDWASSYKDTHYLLGTAAGSHPYPTMVKTFQKMIGDEVKSQILEKENRLPDYVIACVGGGSNAIGIFS
AFLNDKEVKLIGVEPAGLGLETNKHGATLNKGRVGILHGNKTYLLQDDEGQITESHSISAGLDYPGVGPEHSYLKESKRA
VYESASDLEALEAFSLLCQKEGIIPALESSHALAYALKFAQKCEEESIIVVNLSGRGDKDLSTVYNALKGGLK
>Mature_393_residues
MNKKAYFGEFGGSFVSELLVPALRELEQAFDACLKDEKFQKEYFRLLKDFVGRPSPLTLCQNIVSNPKVKLYLKREDLIH
GGAHKTNQALGQALLAKKMGKTRIIAETGAGQHGVATAIACALLGLKCVIFMGAKDIKRQEMNVFRMRLLGAEVREVNSG
SATLKDAVNEALRDWASSYKDTHYLLGTAAGSHPYPTMVKTFQKMIGDEVKSQILEKENRLPDYVIACVGGGSNAIGIFS
AFLNDKEVKLIGVEPAGLGLETNKHGATLNKGRVGILHGNKTYLLQDDEGQITESHSISAGLDYPGVGPEHSYLKESKRA
VYESASDLEALEAFSLLCQKEGIIPALESSHALAYALKFAQKCEEESIIVVNLSGRGDKDLSTVYNALKGGLK

Specific function: The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine [H]

COG id: COG0133

COG function: function code E; Tryptophan synthase beta chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpB family [H]

Homologues:

Organism=Escherichia coli, GI1787515, Length=385, Percent_Identity=66.4935064935065, Blast_Score=534, Evalue=1e-153,
Organism=Saccharomyces cerevisiae, GI6321412, Length=384, Percent_Identity=53.6458333333333, Blast_Score=427, Evalue=1e-120,

Paralogues:

None

Copy number: 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 5,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR006653
- InterPro:   IPR006654
- InterPro:   IPR023026 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.1.20 [H]

Molecular weight: Translated: 42771; Mature: 42771

Theoretical pI: Translated: 8.06; Mature: 8.06

Prosite motif: PS00168 TRP_SYNTHASE_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKKAYFGEFGGSFVSELLVPALRELEQAFDACLKDEKFQKEYFRLLKDFVGRPSPLTLC
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHH
QNIVSNPKVKLYLKREDLIHGGAHKTNQALGQALLAKKMGKTRIIAETGAGQHGVATAIA
HHHHCCCCEEEEEEHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHH
CALLGLKCVIFMGAKDIKRQEMNVFRMRLLGAEVREVNSGSATLKDAVNEALRDWASSYK
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCC
DTHYLLGTAAGSHPYPTMVKTFQKMIGDEVKSQILEKENRLPDYVIACVGGGSNAIGIFS
CCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHH
AFLNDKEVKLIGVEPAGLGLETNKHGATLNKGRVGILHGNKTYLLQDDEGQITESHSISA
HHHCCCCEEEEEECCCCCCCCCCCCCCEECCCEEEEEECCEEEEEECCCCCCCCCCCCCC
GLDYPGVGPEHSYLKESKRAVYESASDLEALEAFSLLCQKEGIIPALESSHALAYALKFA
CCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
QKCEEESIIVVNLSGRGDKDLSTVYNALKGGLK
HHCCCCCEEEEEECCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNKKAYFGEFGGSFVSELLVPALRELEQAFDACLKDEKFQKEYFRLLKDFVGRPSPLTLC
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHH
QNIVSNPKVKLYLKREDLIHGGAHKTNQALGQALLAKKMGKTRIIAETGAGQHGVATAIA
HHHHCCCCEEEEEEHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHH
CALLGLKCVIFMGAKDIKRQEMNVFRMRLLGAEVREVNSGSATLKDAVNEALRDWASSYK
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCC
DTHYLLGTAAGSHPYPTMVKTFQKMIGDEVKSQILEKENRLPDYVIACVGGGSNAIGIFS
CCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHH
AFLNDKEVKLIGVEPAGLGLETNKHGATLNKGRVGILHGNKTYLLQDDEGQITESHSISA
HHHCCCCEEEEEECCCCCCCCCCCCCCEECCCEEEEEECCEEEEEECCCCCCCCCCCCCC
GLDYPGVGPEHSYLKESKRAVYESASDLEALEAFSLLCQKEGIIPALESSHALAYALKFA
CCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
QKCEEESIIVVNLSGRGDKDLSTVYNALKGGLK
HHCCCCCEEEEEECCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]