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The map label for this gene is trpC [H]

Identifier: 108563658

GI number: 108563658

Start: 1294987

End: 1296345

Strand: Direct

Name: trpC [H]

Synonym: HPAG1_1233

Alternate gene names: 108563658

Gene position: 1294987-1296345 (Clockwise)

Preceding gene: 108563657

Following gene: 108563659

Centisome position: 81.12

GC content: 36.87

Gene sequence:

>1359_bases
ATGCCTAGCGTGTTAGAAAACATCCTTAAAGACAAGCTCTTAGAAGTTTCTATGCTTAAAAAAAATCACGCTTTAGCGGC
AAACATAAACCCAAGCGACAGGGATTTTAAAAAAGCGTTACTAGAAAAAAAGACCAGCTTTATTTTAGAATGCAAAAAAG
CATCGCCCTCTAAAGGTTTAATCAGAAAAGATTTTGATCTGTTGGAAATAGCCAAGACTTATGAAAAATTCGCCTCTTGT
ATTTCAGTTTTAGCCGATTCTAAATATTTTTTAGGCTCTTATGAAAACATTAAGATTGTTTCGCAGCATTCCACCAAGCC
CATTTTATGCAAAGATTTTATCATTGATGCTTTTCAAATCAAACTCGCTAGAATGATGGGGGCTAATGCGGTGCTTTTAA
TGTTAAGCGTGTTAGATGATAAAAATTATTTAGAGCTTTTCAACCTCGCTAAATCCTTAAACATGAGCGTGCTGACTGAA
GTTTCTAACCAGCAAGAAATCAAGCGCTTGCTCAAACTCCAATACGACATTATAGGCATCAATAACAGGGATTTGCACAC
CCTGACAACCGACATTAACAACACGCTCAAATTGCGCTCTCTCTTGCCTAAAGACGCGCTCGTGGTGAGTGAGTCCGGTA
TTTATTCGCACACACAAATCAAAGCCCTAGCTCCTCATGTGAATGGCTTTTTAGTGGGCAGCTCTTTAATGAAAGAAAAG
GATTTGAAAAAAGCGTGTATTAAATTGATTTTAGGCGAAAATAAAGTGTGCGGGCTTACAAAAATTAAAGACGCTAAAGC
CGTTTATAAAAACCATTTTATTTATGGGGGTTTGATTTTTGAAAAATCTTCGCCCCGATACATCAAGCCTAAAAAAGCCC
TAAAAATCACAAAAGCGGTTAAAAAATTGGATTTTGTGGGCGTGTTTGTGAAAGATAAGATTAAAAAAATTCAAAAAATC
GCTAAAAAGCTTGATTTAAAAGCGGTGCAGCTTTATGGCTATTCGCAAAAAGAAATCGCTCAATTAAAAAAATCGCTCCC
TAAAACTTGCGCGATTTGGCAAGTAGTGAGTGTGATGGACGCTAACGATTTAGCGCCTAAAATTAAAGAAGCCTCTCTCA
TCTTATACGACACTAAGGGGGATAAAATGGGAGGCAATGGCGTGAGTTTTGATTGGGGTATTTTAGAAAATGTCAAAACG
CCTTTCATGTTAGCTGGTGGGCTTAATTTGGATAATATTCAAAAAGCCTTGAAAGTTAAAGCGTTGGGGTTGGATTTCAA
TTCCGGTTTAGAAATAAGCCCTGGGATTAAAAATAAGGATAAAATCAAGCGATTAGCCCGAATTTTAAGAGAGTATTAA

Upstream 100 bases:

>100_bases
CATAAGGCTAAAGATTTAAAAGAGGGCGTGAGCATGACTTTAGAGCATTTAAAAACCAAAGCGCCTTATACGCATTTGCA
AAAAATCATAAGGCTAAGCC

Downstream 100 bases:

>100_bases
ATGAATAAAAAAGCGTATTTTGGGGAGTTTGGAGGGAGTTTTGTTTCGGAGTTGTTAGTGCCTGCATTAAGAGAGTTAGA
ACAGGCGTTTGATGCGTGTT

Product: bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase

Products: NA

Alternate protein names: Indole-3-glycerol phosphate synthase; IGPS; N-(5'-phospho-ribosyl)anthranilate isomerase; PRAI [H]

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MPSVLENILKDKLLEVSMLKKNHALAANINPSDRDFKKALLEKKTSFILECKKASPSKGLIRKDFDLLEIAKTYEKFASC
ISVLADSKYFLGSYENIKIVSQHSTKPILCKDFIIDAFQIKLARMMGANAVLLMLSVLDDKNYLELFNLAKSLNMSVLTE
VSNQQEIKRLLKLQYDIIGINNRDLHTLTTDINNTLKLRSLLPKDALVVSESGIYSHTQIKALAPHVNGFLVGSSLMKEK
DLKKACIKLILGENKVCGLTKIKDAKAVYKNHFIYGGLIFEKSSPRYIKPKKALKITKAVKKLDFVGVFVKDKIKKIQKI
AKKLDLKAVQLYGYSQKEIAQLKKSLPKTCAIWQVVSVMDANDLAPKIKEASLILYDTKGDKMGGNGVSFDWGILENVKT
PFMLAGGLNLDNIQKALKVKALGLDFNSGLEISPGIKNKDKIKRLARILREY

Sequences:

>Translated_452_residues
MPSVLENILKDKLLEVSMLKKNHALAANINPSDRDFKKALLEKKTSFILECKKASPSKGLIRKDFDLLEIAKTYEKFASC
ISVLADSKYFLGSYENIKIVSQHSTKPILCKDFIIDAFQIKLARMMGANAVLLMLSVLDDKNYLELFNLAKSLNMSVLTE
VSNQQEIKRLLKLQYDIIGINNRDLHTLTTDINNTLKLRSLLPKDALVVSESGIYSHTQIKALAPHVNGFLVGSSLMKEK
DLKKACIKLILGENKVCGLTKIKDAKAVYKNHFIYGGLIFEKSSPRYIKPKKALKITKAVKKLDFVGVFVKDKIKKIQKI
AKKLDLKAVQLYGYSQKEIAQLKKSLPKTCAIWQVVSVMDANDLAPKIKEASLILYDTKGDKMGGNGVSFDWGILENVKT
PFMLAGGLNLDNIQKALKVKALGLDFNSGLEISPGIKNKDKIKRLARILREY
>Mature_451_residues
PSVLENILKDKLLEVSMLKKNHALAANINPSDRDFKKALLEKKTSFILECKKASPSKGLIRKDFDLLEIAKTYEKFASCI
SVLADSKYFLGSYENIKIVSQHSTKPILCKDFIIDAFQIKLARMMGANAVLLMLSVLDDKNYLELFNLAKSLNMSVLTEV
SNQQEIKRLLKLQYDIIGINNRDLHTLTTDINNTLKLRSLLPKDALVVSESGIYSHTQIKALAPHVNGFLVGSSLMKEKD
LKKACIKLILGENKVCGLTKIKDAKAVYKNHFIYGGLIFEKSSPRYIKPKKALKITKAVKKLDFVGVFVKDKIKKIQKIA
KKLDLKAVQLYGYSQKEIAQLKKSLPKTCAIWQVVSVMDANDLAPKIKEASLILYDTKGDKMGGNGVSFDWGILENVKTP
FMLAGGLNLDNIQKALKVKALGLDFNSGLEISPGIKNKDKIKRLARILREY

Specific function: Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the trpF domain; the second reaction is catalyzed by the synthase, coded by the trpC domain [H]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the trpF family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=457, Percent_Identity=45.9518599562363, Blast_Score=378, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6322638, Length=238, Percent_Identity=36.9747899159664, Blast_Score=129, Evalue=7e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR001240
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS; PF00697 PRAI [H]

EC number: =4.1.1.48; =5.3.1.24 [H]

Molecular weight: Translated: 50623; Mature: 50492

Theoretical pI: Translated: 10.32; Mature: 10.32

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSVLENILKDKLLEVSMLKKNHALAANINPSDRDFKKALLEKKTSFILECKKASPSKGL
CCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHEEEECCCCCCCCC
IRKDFDLLEIAKTYEKFASCISVLADSKYFLGSYENIKIVSQHSTKPILCKDFIIDAFQI
HHCCHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCEEEEECCCCCCEEHHHHHHHHHHH
KLARMMGANAVLLMLSVLDDKNYLELFNLAKSLNMSVLTEVSNQQEIKRLLKLQYDIIGI
HHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHEEEC
NNRDLHTLTTDINNTLKLRSLLPKDALVVSESGIYSHTQIKALAPHVNGFLVGSSLMKEK
CCCCCEEEECCCCCHHHHHHHCCCCCEEEECCCCCCCHHHHHHCCCCCCEEECHHHHHHH
DLKKACIKLILGENKVCGLTKIKDAKAVYKNHFIYGGLIFEKSSPRYIKPKKALKITKAV
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCEEEEEEEEECCCCCCCCCHHHHHHHHHH
KKLDFVGVFVKDKIKKIQKIAKKLDLKAVQLYGYSQKEIAQLKKSLPKTCAIWQVVSVMD
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCHHHHHHHHHHHHC
ANDLAPKIKEASLILYDTKGDKMGGNGVSFDWGILENVKTPFMLAGGLNLDNIQKALKVK
CCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHCCCCCEEEECCCCHHHHHHHHHHH
ALGLDFNSGLEISPGIKNKDKIKRLARILREY
EEECCCCCCCEECCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
PSVLENILKDKLLEVSMLKKNHALAANINPSDRDFKKALLEKKTSFILECKKASPSKGL
CHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHEEEECCCCCCCCC
IRKDFDLLEIAKTYEKFASCISVLADSKYFLGSYENIKIVSQHSTKPILCKDFIIDAFQI
HHCCHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCEEEEECCCCCCEEHHHHHHHHHHH
KLARMMGANAVLLMLSVLDDKNYLELFNLAKSLNMSVLTEVSNQQEIKRLLKLQYDIIGI
HHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHEEEC
NNRDLHTLTTDINNTLKLRSLLPKDALVVSESGIYSHTQIKALAPHVNGFLVGSSLMKEK
CCCCCEEEECCCCCHHHHHHHCCCCCEEEECCCCCCCHHHHHHCCCCCCEEECHHHHHHH
DLKKACIKLILGENKVCGLTKIKDAKAVYKNHFIYGGLIFEKSSPRYIKPKKALKITKAV
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCEEEEEEEEECCCCCCCCCHHHHHHHHHH
KKLDFVGVFVKDKIKKIQKIAKKLDLKAVQLYGYSQKEIAQLKKSLPKTCAIWQVVSVMD
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCHHHHHHHHHHHHC
ANDLAPKIKEASLILYDTKGDKMGGNGVSFDWGILENVKTPFMLAGGLNLDNIQKALKVK
CCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHCCCCCEEEECCCCHHHHHHHHHHH
ALGLDFNSGLEISPGIKNKDKIKRLARILREY
EEECCCCCCCEECCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]