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The map label for this gene is pyrC' [H]

Identifier: 108562693

GI number: 108562693

Start: 273485

End: 274621

Strand: Direct

Name: pyrC' [H]

Synonym: HPAG1_0268

Alternate gene names: 108562693

Gene position: 273485-274621 (Clockwise)

Preceding gene: 108562692

Following gene: 108562694

Centisome position: 17.13

GC content: 37.99

Gene sequence:

>1137_bases
ATGCTGTTAAAAAACGCTTCGTTTTATGATGATGAGGTTTTAAAAAGAGCGGATATCCGCTTAAAAGATTCCCTCATTAC
AGAGATTGAAGAAAACTTAAGCCCTACCAAAAATGAAGAAGTGATTGAGTGCAGGGATTTATTCGTGCTGCCAAGCTTCA
TTGATTTGAGCGTTACTGGTTTGGAGGGTTATGAAAATTTGAAACAAAAGGCTTTTAAAGGGGGGGTAGGGTTACTCAAT
GTTTTTAATTGCGATCAAAGCGGCATTAAAAATATTATGGCAATTAAAAACAACCAACTAGCCGACATCGCTACGCTTAA
AAATAAAGGGGGGGAAATTTTAATCGCGCCATCTGACGCCTTTTTAGAACTCATCAGCCACTATGCCAAATCCTACAACT
TGCCTCTTTTAATTTCTTTAGAAAATTCTTTTGAAGCCCTAAATAGTGGGGAATTAGCCTATGAATTGGGGCAAAATTTT
GTAGACAATGCGTTTGAAAACATGTGCTTGGTGCGTTTTATGGAAGTTTCTAGAGCGTTACAAATCCCCATGCTTTTAGA
TAAAGTGAATAGTATCACCACGCTCAAACTCATCAAAGCCTTTAACAATTTAGGAGCGCGTTTGCAAGCCCAAACGCCCT
TAAGCCATTTGATCTTAGATGAGAGCGTGTATGAAGATTATGAGCCACGATTTAAAATCGCCCCTCCTTTAAGGGATAAA
GAAGGTCAAAACGCCTTAAAAGAAGCTCTAAAAAATAACGAAATCGCCATGCTCACAAGCCTTCATGCTTCTAAAAATTC
TAACGCAGAGCTTTTTGAAGAAAGCGCTTTTGGGTGTGAGAGCATAGAGGACGCTTTTAGCGTGGCTTACACTTTTTTAG
TTCAAAAAAAGGTTATCAGCTTCCAACAGCTCATTAAAGTCATGGCGACTAATCAAGCGAGGTTTTTAAAACTCAATGCA
GGCGAGGTTAAAGAAAACCAATTAGCCAATCTCATGATTGTAGATTTAAACGCTCAAACGAGAGTTAATAATCAAAATTC
GCCCTTTTATGGTTTAGAATTATACGGCGAAGTTCAAAGAATGATTTTAAATGGGCAAACCACATTGATTAAGGAGAATG
CATGCAAGAAATCATAG

Upstream 100 bases:

>100_bases
TGAGATTGTTTCAGGGTTGGTGCTTATTTTAATGGGAATATTGATCATGACAAATTCTTTAGAAAGCCTGACTAACTTTT
TACAAAATTAGGAGGGTTTG

Downstream 100 bases:

>100_bases
GAGCGTCTTTAGTTTTTTTATGCAATGAAAAATGCGAAGTGTTAGAAGATTATGGCGTGGTCTTTGATGAAAAGATTGTT
GAAATAGGCGATTATCAAAG

Product: dihydroorotase

Products: N-carbamoyl-L-aspartate

Alternate protein names: Aspartate carbamoyltransferase 42 kDa non-catalytic chain [H]

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MLLKNASFYDDEVLKRADIRLKDSLITEIEENLSPTKNEEVIECRDLFVLPSFIDLSVTGLEGYENLKQKAFKGGVGLLN
VFNCDQSGIKNIMAIKNNQLADIATLKNKGGEILIAPSDAFLELISHYAKSYNLPLLISLENSFEALNSGELAYELGQNF
VDNAFENMCLVRFMEVSRALQIPMLLDKVNSITTLKLIKAFNNLGARLQAQTPLSHLILDESVYEDYEPRFKIAPPLRDK
EGQNALKEALKNNEIAMLTSLHASKNSNAELFEESAFGCESIEDAFSVAYTFLVQKKVISFQQLIKVMATNQARFLKLNA
GEVKENQLANLMIVDLNAQTRVNNQNSPFYGLELYGEVQRMILNGQTTLIKENACKKS

Sequences:

>Translated_378_residues
MLLKNASFYDDEVLKRADIRLKDSLITEIEENLSPTKNEEVIECRDLFVLPSFIDLSVTGLEGYENLKQKAFKGGVGLLN
VFNCDQSGIKNIMAIKNNQLADIATLKNKGGEILIAPSDAFLELISHYAKSYNLPLLISLENSFEALNSGELAYELGQNF
VDNAFENMCLVRFMEVSRALQIPMLLDKVNSITTLKLIKAFNNLGARLQAQTPLSHLILDESVYEDYEPRFKIAPPLRDK
EGQNALKEALKNNEIAMLTSLHASKNSNAELFEESAFGCESIEDAFSVAYTFLVQKKVISFQQLIKVMATNQARFLKLNA
GEVKENQLANLMIVDLNAQTRVNNQNSPFYGLELYGEVQRMILNGQTTLIKENACKKS
>Mature_378_residues
MLLKNASFYDDEVLKRADIRLKDSLITEIEENLSPTKNEEVIECRDLFVLPSFIDLSVTGLEGYENLKQKAFKGGVGLLN
VFNCDQSGIKNIMAIKNNQLADIATLKNKGGEILIAPSDAFLELISHYAKSYNLPLLISLENSFEALNSGELAYELGQNF
VDNAFENMCLVRFMEVSRALQIPMLLDKVNSITTLKLIKAFNNLGARLQAQTPLSHLILDESVYEDYEPRFKIAPPLRDK
EGQNALKEALKNNEIAMLTSLHASKNSNAELFEESAFGCESIEDAFSVAYTFLVQKKVISFQQLIKVMATNQARFLKLNA
GEVKENQLANLMIVDLNAQTRVNNQNSPFYGLELYGEVQRMILNGQTTLIKENACKKS

Specific function: Non-functional DHOase [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. PyrC' subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: 3.5.2.3

Molecular weight: Translated: 42367; Mature: 42367

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLKNASFYDDEVLKRADIRLKDSLITEIEENLSPTKNEEVIECRDLFVLPSFIDLSVTG
CCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHEEECCHHCEEEEC
LEGYENLKQKAFKGGVGLLNVFNCDQSGIKNIMAIKNNQLADIATLKNKGGEILIAPSDA
CHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHCCCCCCHHHHHHHCCCCEEEEECCHH
FLELISHYAKSYNLPLLISLENSFEALNSGELAYELGQNFVDNAFENMCLVRFMEVSRAL
HHHHHHHHHHHCCCCEEEEECCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QIPMLLDKVNSITTLKLIKAFNNLGARLQAQTPLSHLILDESVYEDYEPRFKIAPPLRDK
CCHHHHHHHCCHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHCCCCCEEECCCCCCC
EGQNALKEALKNNEIAMLTSLHASKNSNAELFEESAFGCESIEDAFSVAYTFLVQKKVIS
CCHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
FQQLIKVMATNQARFLKLNAGEVKENQLANLMIVDLNAQTRVNNQNSPFYGLELYGEVQR
HHHHHHHHHCCCEEEEEECCCCCCCCCCCEEEEEECCCCEECCCCCCCEEEHHHHHHHHH
MILNGQTTLIKENACKKS
HHHCCCCEEEECCCCCCC
>Mature Secondary Structure
MLLKNASFYDDEVLKRADIRLKDSLITEIEENLSPTKNEEVIECRDLFVLPSFIDLSVTG
CCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHEEECCHHCEEEEC
LEGYENLKQKAFKGGVGLLNVFNCDQSGIKNIMAIKNNQLADIATLKNKGGEILIAPSDA
CHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHCCCCCCHHHHHHHCCCCEEEEECCHH
FLELISHYAKSYNLPLLISLENSFEALNSGELAYELGQNFVDNAFENMCLVRFMEVSRAL
HHHHHHHHHHHCCCCEEEEECCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QIPMLLDKVNSITTLKLIKAFNNLGARLQAQTPLSHLILDESVYEDYEPRFKIAPPLRDK
CCHHHHHHHCCHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHCCCCCEEECCCCCCC
EGQNALKEALKNNEIAMLTSLHASKNSNAELFEESAFGCESIEDAFSVAYTFLVQKKVIS
CCHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
FQQLIKVMATNQARFLKLNAGEVKENQLANLMIVDLNAQTRVNNQNSPFYGLELYGEVQR
HHHHHHHHHCCCEEEEEECCCCCCCCCCCEEEEEECCCCEECCCCCCCEEEHHHHHHHHH
MILNGQTTLIKENACKKS
HHHCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-dihydroorotate; H2O

Specific reaction: (S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]