Click here to switch to the map view.

The map label for this gene is frdB [H]

Identifier: 108562610

GI number: 108562610

Start: 191344

End: 192081

Strand: Reverse

Name: frdB [H]

Synonym: HPAG1_0185

Alternate gene names: 108562610

Gene position: 192081-191344 (Counterclockwise)

Preceding gene: 108562611

Following gene: 108562609

Centisome position: 12.03

GC content: 44.04

Gene sequence:

>738_bases
ATGAGTGATAATGAACGAACGATTGTAATTAGAGTGCTAAAATTTGACCCTCAAAGCGCGGTGAGTAAGCCGCATTTTAA
AGAGTATCAATTGAAAGAAACTCCATCCATGACGCTCTTTATCGCTTTAAACCTCATCAGAGAGCATCAAGATCCGGATT
TGAGTTTTGATTTTGTGTGCCGCGCTGGGATTTGCGGATCTTGTGCGATGATGGTTAATGGGAGACCGAGATTGGCTTGT
AAAACCCTAACTTCTAGCTTTGAAAGCGGGGTGATTACGCTCATGCCCATGCCTAGTTTTACGCTCATTAAAGATTTGAG
CGTGAATACAGGCGATTGGTTTTTAGATATGACTAAAAGGGTGGAGAGCTGGGCGCATTCTAAAGAAGAAGTGGATATTA
CTAATCCGGAAAAAAGGATTGAGCCTGATGAAGCCCAAGAAGTCTTTGAATTAGACAGGTGTATTGAATGCGGGTGCTGT
ATCGCTTCTTGCGGGACCAAACTCATGCGCCCTAATTTCATTGGAGCTGCTGGCATGAACAGAGCCATGCGCTTTATGAT
TGACAGCCACGATGAAAGAAGCGATGATGATTTTTATGAGTTAGTCGGCGATGATGATGGTGTTTTTGGGTGCATGAGCC
TTATCGCTTGCCATGACACTTGCCCTAAAGAATTACCCTTGCAAAGCAGTATCGCCACTTTGCGCAACCGAATGTTGAAA
GTGGGTAAAAGCCGCTAA

Upstream 100 bases:

>100_bases
TTAGAAGATGAGGAAGTCAGGGCTAGGGGGGAACATTTGTATTCTTTCAATGTTCATGATTTATTAGACAAACACAACGC
TAATTTAAAAGGAGAACACC

Downstream 100 bases:

>100_bases
TTTCTTTTTAGTGGGTCGTTTTTGAAAATCTTTTTAGTCTTTCTAAGCGTCTTTTTTTTTAATGGGTGCTTTGGGTTAGT
CTATAAGACTCCCATTTCAA

Product: fumarate reductase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 245; Mature: 244

Protein sequence:

>245_residues
MSDNERTIVIRVLKFDPQSAVSKPHFKEYQLKETPSMTLFIALNLIREHQDPDLSFDFVCRAGICGSCAMMVNGRPRLAC
KTLTSSFESGVITLMPMPSFTLIKDLSVNTGDWFLDMTKRVESWAHSKEEVDITNPEKRIEPDEAQEVFELDRCIECGCC
IASCGTKLMRPNFIGAAGMNRAMRFMIDSHDERSDDDFYELVGDDDGVFGCMSLIACHDTCPKELPLQSSIATLRNRMLK
VGKSR

Sequences:

>Translated_245_residues
MSDNERTIVIRVLKFDPQSAVSKPHFKEYQLKETPSMTLFIALNLIREHQDPDLSFDFVCRAGICGSCAMMVNGRPRLAC
KTLTSSFESGVITLMPMPSFTLIKDLSVNTGDWFLDMTKRVESWAHSKEEVDITNPEKRIEPDEAQEVFELDRCIECGCC
IASCGTKLMRPNFIGAAGMNRAMRFMIDSHDERSDDDFYELVGDDDGVFGCMSLIACHDTCPKELPLQSSIATLRNRMLK
VGKSR
>Mature_244_residues
SDNERTIVIRVLKFDPQSAVSKPHFKEYQLKETPSMTLFIALNLIREHQDPDLSFDFVCRAGICGSCAMMVNGRPRLACK
TLTSSFESGVITLMPMPSFTLIKDLSVNTGDWFLDMTKRVESWAHSKEEVDITNPEKRIEPDEAQEVFELDRCIECGCCI
ASCGTKLMRPNFIGAAGMNRAMRFMIDSHDERSDDDFYELVGDDDGVFGCMSLIACHDTCPKELPLQSSIATLRNRMLKV
GKSR

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=229, Percent_Identity=30.5676855895196, Blast_Score=112, Evalue=3e-25,
Organism=Escherichia coli, GI1790596, Length=232, Percent_Identity=30.6034482758621, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1786943, Length=237, Percent_Identity=31.6455696202532, Blast_Score=108, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17533915, Length=236, Percent_Identity=27.5423728813559, Blast_Score=107, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6322987, Length=237, Percent_Identity=30.379746835443, Blast_Score=106, Evalue=3e-24,
Organism=Drosophila melanogaster, GI17137106, Length=233, Percent_Identity=31.3304721030043, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24643156, Length=225, Percent_Identity=30.2222222222222, Blast_Score=108, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006058
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 27611; Mature: 27480

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.9 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
10.2 %Cys+Met (Translated Protein)
4.9 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
9.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDNERTIVIRVLKFDPQSAVSKPHFKEYQLKETPSMTLFIALNLIREHQDPDLSFDFVC
CCCCCEEEEEEEEEECCHHHHCCCCCCCCCCCCCCCEEEHHHHHHHHHCCCCCCCHHHHH
RAGICGSCAMMVNGRPRLACKTLTSSFESGVITLMPMPSFTLIKDLSVNTGDWFLDMTKR
HCCCCCCEEEEECCCCCHHHHHHHHHHCCCEEEEECCCCCHHHEECCCCCCHHHHHHHHH
VESWAHSKEEVDITNPEKRIEPDEAQEVFELDRCIECGCCIASCGTKLMRPNFIGAAGMN
HHHHHCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCHHHHH
RAMRFMIDSHDERSDDDFYELVGDDDGVFGCMSLIACHDTCPKELPLQSSIATLRNRMLK
HHHHHHHCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
VGKSR
HCCCC
>Mature Secondary Structure 
SDNERTIVIRVLKFDPQSAVSKPHFKEYQLKETPSMTLFIALNLIREHQDPDLSFDFVC
CCCCEEEEEEEEEECCHHHHCCCCCCCCCCCCCCCEEEHHHHHHHHHCCCCCCCHHHHH
RAGICGSCAMMVNGRPRLACKTLTSSFESGVITLMPMPSFTLIKDLSVNTGDWFLDMTKR
HCCCCCCEEEEECCCCCHHHHHHHHHHCCCEEEEECCCCCHHHEECCCCCCHHHHHHHHH
VESWAHSKEEVDITNPEKRIEPDEAQEVFELDRCIECGCCIASCGTKLMRPNFIGAAGMN
HHHHHCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCHHHHH
RAMRFMIDSHDERSDDDFYELVGDDDGVFGCMSLIACHDTCPKELPLQSSIATLRNRMLK
HHHHHHHCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
VGKSR
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]