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The map label for this gene is frdA [H]

Identifier: 108562611

GI number: 108562611

Start: 192074

End: 194218

Strand: Reverse

Name: frdA [H]

Synonym: HPAG1_0186

Alternate gene names: 108562611

Gene position: 194218-192074 (Counterclockwise)

Preceding gene: 108562612

Following gene: 108562610

Centisome position: 12.17

GC content: 45.97

Gene sequence:

>2145_bases
ATGAAAATAACATATTGTGATGCGCTAATTATTGGAGGCGGGCTGGCCGGGTTAAGGGCTAGTATCGCATGCAAACAAAA
GGGTTTAAACACCATCGTTTTAAGCCTAGTGCCTGTCAGGCGTTCGCACTCTGCAGCCGCTCAAGGGGGCATGCAAGCGA
GCCTTGCGAACGCTAAAAAAAGCGAGGGCGATAATGAAGATTTACACTTTTTAGACACGGTTAAGGGGAGCGATTGGGGG
TGTGATCAGCAAGTGGCTAGAATGTTTGTAACCACTGCTCCTAAAGCCATTAGGGAATTGGCCAGTTGGGGGGTGCCTTG
GACTAGGATTAAAAAGGGCGATAGGCCTGCGGTCGTCAATGGTGAGCATGTAACTATCACTGAAAGAGATGACAGGCATG
GTTATATTTTAAGCCGTGATTTTGGTGGCACTAAAAAATGGCGCACATGTTTTACGGCTGATGCTACAGGGCATACCATG
CTTTATGCGGTCGCTAACGAAGCCTTACACCACAAAGTGGATATTCAAGACAGAAAGGACATGCTCGCTTTCATTCATCA
TAATAATAAATGCTATGGGGCGGTGGTAAGGGATTTGATCACAGGCGAAATTTCAGCGTATGTTTCTAAAGGCACGCTTT
TAGCTACTGGAGGTTATGGGCGCGTGTATAAACACACCACTAACGCCGTGATTTGCGATGGAGCCGGGGCGGCGAGCGCT
TTAGAAACCGGCGTGGCTAAATTAGGCAACATGGAGGCGGTGCAATTCCACCCTACCGCTTTAGTGCCAAGCGGGATTTT
AATGACTGAAGGTTGTAGGGGCGATGGCGGCGTTTTAAGAGACAAGTTTGGCAGACGCTTCATGCCCGCTTATGAGCCGG
AGAAAAAAGAGCTCGCAAGCAGAGATGTGGTCTCAAGGCGGATTTTAGAGCATATCCAAAAAGGCTATGGCGCCAAATCG
CCCTATGGGGATCATGTGTGGCTGGATATTGCTATTTTAGGGCGTAACCATGTGGAAAAAAATTTAAGGGATGTGCGCGA
TATTGCCATGACTTTTGCCGGCATTGATCCGGCCGATAGCGAAGAGCAAACCAAAGACAACATGCAAGGAGCACCCACCA
ATGAGCCTGAATACGGGCAAGCGATGGCCAAGCAAAAAGGCTGGATCCCCATAAAGCCCATGCAACACTATTCTATGGGT
GGGGTTAGGACAAACCCTAAAGGCGAAACCCATTTAAAAGGCTTGTTTTGCGCGGGTGAAGCGGCATGTTGGGATTTGCA
TGGGTTTAACCGCTTGGGGGGAAATTCTGTGAGTGAAGCGGTGGTCGCTGGCATGATCATAGGGGATTATTTTGCCTCGC
ATTGTTTGGAAGCGCAAATTGAAATCAACACGCAAAAGGTTGAAGCCTTCATTAAAGAAAGCCAAGATTATATGCACTTT
TTATTGCATAATGAAGGCAAAGAAGACGTGTATGAGATTAGAGAACGCATGAAAGAAGTCATGGATGAAAAAGTGGGCGT
TTTTAGGGAAGGCAAAAAATTAGAAGAAGCCCTTAAAGAATTGCAAGAGCTTTATGCGCGCTCCAAAAACATTTGCGTGA
AAAACAAGGTTTTGCACAATAACCCTGAATTAGAAGACGCTTACCGCACCAAAAAAATGCTCAAACTCGCGCTTTGCATC
ACTCAAGGAGCGTTACTGCGCACTGAAAGCAGAGGGGCTCACACAAGGATTGACTACCCTAAAAGAGACGATGAAAAATG
GCTTAATCGGACTCTAGCGAGTTGGCCTAGCGCTGAGCAAGACATGCCCACGATTGAATATGAAGAATTAGATGTGATGA
AAATGGAAATCAGCCCTGATTTTAGGGGCTATGGCAAAAAGGGCAATTTCATTCCTCACCCCAAAAAAGAAGAGCGCGAC
GCTGAGATTTTGAAAACGATTTTGGAATTAGAAAAACTTGGGAAAGACAGGGTAGAAGTCCAACACGCGCTCATGCCTTT
TGAATTGCAAGAAAAATACAAGGCTAGGAACATGCGTTTAGAAGATGAGGAAGTCAGGGCTAGGGGGGAACATTTGTATT
CTTTCAATGTTCATGATTTATTAGACAAACACAACGCTAATTTAAAAGGAGAACACCATGAGTGA

Upstream 100 bases:

>100_bases
TTACATTAAAAAAGGTTTAGAAAATAAGGACAATGGCATTAAAACCATGCAAGAAGCCATAGAAGCTGATGGGAAATTCC
ACAAAGAATAAGGGTAGAAA

Downstream 100 bases:

>100_bases
TAATGAACGAACGATTGTAATTAGAGTGCTAAAATTTGACCCTCAAAGCGCGGTGAGTAAGCCGCATTTTAAAGAGTATC
AATTGAAAGAAACTCCATCC

Product: fumarate reductase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 714; Mature: 714

Protein sequence:

>714_residues
MKITYCDALIIGGGLAGLRASIACKQKGLNTIVLSLVPVRRSHSAAAQGGMQASLANAKKSEGDNEDLHFLDTVKGSDWG
CDQQVARMFVTTAPKAIRELASWGVPWTRIKKGDRPAVVNGEHVTITERDDRHGYILSRDFGGTKKWRTCFTADATGHTM
LYAVANEALHHKVDIQDRKDMLAFIHHNNKCYGAVVRDLITGEISAYVSKGTLLATGGYGRVYKHTTNAVICDGAGAASA
LETGVAKLGNMEAVQFHPTALVPSGILMTEGCRGDGGVLRDKFGRRFMPAYEPEKKELASRDVVSRRILEHIQKGYGAKS
PYGDHVWLDIAILGRNHVEKNLRDVRDIAMTFAGIDPADSEEQTKDNMQGAPTNEPEYGQAMAKQKGWIPIKPMQHYSMG
GVRTNPKGETHLKGLFCAGEAACWDLHGFNRLGGNSVSEAVVAGMIIGDYFASHCLEAQIEINTQKVEAFIKESQDYMHF
LLHNEGKEDVYEIRERMKEVMDEKVGVFREGKKLEEALKELQELYARSKNICVKNKVLHNNPELEDAYRTKKMLKLALCI
TQGALLRTESRGAHTRIDYPKRDDEKWLNRTLASWPSAEQDMPTIEYEELDVMKMEISPDFRGYGKKGNFIPHPKKEERD
AEILKTILELEKLGKDRVEVQHALMPFELQEKYKARNMRLEDEEVRARGEHLYSFNVHDLLDKHNANLKGEHHE

Sequences:

>Translated_714_residues
MKITYCDALIIGGGLAGLRASIACKQKGLNTIVLSLVPVRRSHSAAAQGGMQASLANAKKSEGDNEDLHFLDTVKGSDWG
CDQQVARMFVTTAPKAIRELASWGVPWTRIKKGDRPAVVNGEHVTITERDDRHGYILSRDFGGTKKWRTCFTADATGHTM
LYAVANEALHHKVDIQDRKDMLAFIHHNNKCYGAVVRDLITGEISAYVSKGTLLATGGYGRVYKHTTNAVICDGAGAASA
LETGVAKLGNMEAVQFHPTALVPSGILMTEGCRGDGGVLRDKFGRRFMPAYEPEKKELASRDVVSRRILEHIQKGYGAKS
PYGDHVWLDIAILGRNHVEKNLRDVRDIAMTFAGIDPADSEEQTKDNMQGAPTNEPEYGQAMAKQKGWIPIKPMQHYSMG
GVRTNPKGETHLKGLFCAGEAACWDLHGFNRLGGNSVSEAVVAGMIIGDYFASHCLEAQIEINTQKVEAFIKESQDYMHF
LLHNEGKEDVYEIRERMKEVMDEKVGVFREGKKLEEALKELQELYARSKNICVKNKVLHNNPELEDAYRTKKMLKLALCI
TQGALLRTESRGAHTRIDYPKRDDEKWLNRTLASWPSAEQDMPTIEYEELDVMKMEISPDFRGYGKKGNFIPHPKKEERD
AEILKTILELEKLGKDRVEVQHALMPFELQEKYKARNMRLEDEEVRARGEHLYSFNVHDLLDKHNANLKGEHHE
>Mature_714_residues
MKITYCDALIIGGGLAGLRASIACKQKGLNTIVLSLVPVRRSHSAAAQGGMQASLANAKKSEGDNEDLHFLDTVKGSDWG
CDQQVARMFVTTAPKAIRELASWGVPWTRIKKGDRPAVVNGEHVTITERDDRHGYILSRDFGGTKKWRTCFTADATGHTM
LYAVANEALHHKVDIQDRKDMLAFIHHNNKCYGAVVRDLITGEISAYVSKGTLLATGGYGRVYKHTTNAVICDGAGAASA
LETGVAKLGNMEAVQFHPTALVPSGILMTEGCRGDGGVLRDKFGRRFMPAYEPEKKELASRDVVSRRILEHIQKGYGAKS
PYGDHVWLDIAILGRNHVEKNLRDVRDIAMTFAGIDPADSEEQTKDNMQGAPTNEPEYGQAMAKQKGWIPIKPMQHYSMG
GVRTNPKGETHLKGLFCAGEAACWDLHGFNRLGGNSVSEAVVAGMIIGDYFASHCLEAQIEINTQKVEAFIKESQDYMHF
LLHNEGKEDVYEIRERMKEVMDEKVGVFREGKKLEEALKELQELYARSKNICVKNKVLHNNPELEDAYRTKKMLKLALCI
TQGALLRTESRGAHTRIDYPKRDDEKWLNRTLASWPSAEQDMPTIEYEELDVMKMEISPDFRGYGKKGNFIPHPKKEERD
AEILKTILELEKLGKDRVEVQHALMPFELQEKYKARNMRLEDEEVRARGEHLYSFNVHDLLDKHNANLKGEHHE

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=578, Percent_Identity=33.9100346020761, Blast_Score=283, Evalue=5e-76,
Organism=Escherichia coli, GI1786942, Length=600, Percent_Identity=35.5, Blast_Score=304, Evalue=2e-83,
Organism=Escherichia coli, GI1790597, Length=613, Percent_Identity=34.094616639478, Blast_Score=294, Evalue=1e-80,
Organism=Escherichia coli, GI1788928, Length=588, Percent_Identity=29.421768707483, Blast_Score=186, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI17505833, Length=579, Percent_Identity=35.405872193437, Blast_Score=296, Evalue=2e-80,
Organism=Caenorhabditis elegans, GI17550100, Length=573, Percent_Identity=35.4275741710297, Blast_Score=295, Evalue=6e-80,
Organism=Caenorhabditis elegans, GI71986328, Length=483, Percent_Identity=24.0165631469979, Blast_Score=80, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6322701, Length=644, Percent_Identity=33.695652173913, Blast_Score=295, Evalue=1e-80,
Organism=Saccharomyces cerevisiae, GI6322416, Length=618, Percent_Identity=32.8478964401294, Blast_Score=285, Evalue=2e-77,
Organism=Drosophila melanogaster, GI17137288, Length=664, Percent_Identity=32.9819277108434, Blast_Score=293, Evalue=3e-79,
Organism=Drosophila melanogaster, GI24655642, Length=664, Percent_Identity=32.9819277108434, Blast_Score=293, Evalue=3e-79,
Organism=Drosophila melanogaster, GI24655647, Length=664, Percent_Identity=32.9819277108434, Blast_Score=293, Evalue=3e-79,
Organism=Drosophila melanogaster, GI24663005, Length=595, Percent_Identity=33.2773109243697, Blast_Score=259, Evalue=3e-69,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 80068; Mature: 80068

Theoretical pI: Translated: 7.32; Mature: 7.32

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKITYCDALIIGGGLAGLRASIACKQKGLNTIVLSLVPVRRSHSAAAQGGMQASLANAKK
CEEEEEEHEEECCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHCCCHHHHHHHHC
SEGDNEDLHFLDTVKGSDWGCDQQVARMFVTTAPKAIRELASWGVPWTRIKKGDRPAVVN
CCCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCHHHHCCCCCCCEEC
GEHVTITERDDRHGYILSRDFGGTKKWRTCFTADATGHTMLYAVANEALHHKVDIQDRKD
CCEEEEEECCCCCCEEEECCCCCCCHHCEEEEECCCCCEEEHHHHHHHHHCCCCCCCHHH
MLAFIHHNNKCYGAVVRDLITGEISAYVSKGTLLATGGYGRVYKHTTNAVICDGAGAASA
HEEEHHCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEECCCEEEECCCCHHHH
LETGVAKLGNMEAVQFHPTALVPSGILMTEGCRGDGGVLRDKFGRRFMPAYEPEKKELAS
HHHHHHHHCCCCEEEECCCEECCCCCEEECCCCCCCCCHHHHHCCCCCCCCCCHHHHHHH
RDVVSRRILEHIQKGYGAKSPYGDHVWLDIAILGRNHVEKNLRDVRDIAMTFAGIDPADS
HHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCC
EEQTKDNMQGAPTNEPEYGQAMAKQKGWIPIKPMQHYSMGGVRTNPKGETHLKGLFCAGE
HHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHCCCCCCCCCCCCCCHHCEEEECCC
AACWDLHGFNRLGGNSVSEAVVAGMIIGDYFASHCLEAQIEINTQKVEAFIKESQDYMHF
CCEEECCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEECHHHHHHHHHHHHHHHHH
LLHNEGKEDVYEIRERMKEVMDEKVGVFREGKKLEEALKELQELYARSKNICVKNKVLHN
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEECCEECC
NPELEDAYRTKKMLKLALCITQGALLRTESRGAHTRIDYPKRDDEKWLNRTLASWPSAEQ
CCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCC
DMPTIEYEELDVMKMEISPDFRGYGKKGNFIPHPKKEERDAEILKTILELEKLGKDRVEV
CCCCCEECCCEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHH
QHALMPFELQEKYKARNMRLEDEEVRARGEHLYSFNVHDLLDKHNANLKGEHHE
HHHHCCHHHHHHHHHHCCCCCHHHHHHCCCEEEECCHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MKITYCDALIIGGGLAGLRASIACKQKGLNTIVLSLVPVRRSHSAAAQGGMQASLANAKK
CEEEEEEHEEECCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHCCCHHHHHHHHC
SEGDNEDLHFLDTVKGSDWGCDQQVARMFVTTAPKAIRELASWGVPWTRIKKGDRPAVVN
CCCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCHHHHCCCCCCCEEC
GEHVTITERDDRHGYILSRDFGGTKKWRTCFTADATGHTMLYAVANEALHHKVDIQDRKD
CCEEEEEECCCCCCEEEECCCCCCCHHCEEEEECCCCCEEEHHHHHHHHHCCCCCCCHHH
MLAFIHHNNKCYGAVVRDLITGEISAYVSKGTLLATGGYGRVYKHTTNAVICDGAGAASA
HEEEHHCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEECCCEEEECCCCHHHH
LETGVAKLGNMEAVQFHPTALVPSGILMTEGCRGDGGVLRDKFGRRFMPAYEPEKKELAS
HHHHHHHHCCCCEEEECCCEECCCCCEEECCCCCCCCCHHHHHCCCCCCCCCCHHHHHHH
RDVVSRRILEHIQKGYGAKSPYGDHVWLDIAILGRNHVEKNLRDVRDIAMTFAGIDPADS
HHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCC
EEQTKDNMQGAPTNEPEYGQAMAKQKGWIPIKPMQHYSMGGVRTNPKGETHLKGLFCAGE
HHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHCCCCCCCCCCCCCCHHCEEEECCC
AACWDLHGFNRLGGNSVSEAVVAGMIIGDYFASHCLEAQIEINTQKVEAFIKESQDYMHF
CCEEECCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEECHHHHHHHHHHHHHHHHH
LLHNEGKEDVYEIRERMKEVMDEKVGVFREGKKLEEALKELQELYARSKNICVKNKVLHN
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEECCEECC
NPELEDAYRTKKMLKLALCITQGALLRTESRGAHTRIDYPKRDDEKWLNRTLASWPSAEQ
CCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCC
DMPTIEYEELDVMKMEISPDFRGYGKKGNFIPHPKKEERDAEILKTILELEKLGKDRVEV
CCCCCEECCCEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHH
QHALMPFELQEKYKARNMRLEDEEVRARGEHLYSFNVHDLLDKHNANLKGEHHE
HHHHCCHHHHHHHHHHCCCCCHHHHHHCCCEEEECCHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]