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The map label for this gene is hcpD [H]

Identifier: 108562583

GI number: 108562583

Start: 164535

End: 165455

Strand: Direct

Name: hcpD [H]

Synonym: HPAG1_0158

Alternate gene names: 108562583

Gene position: 164535-165455 (Clockwise)

Preceding gene: 108562581

Following gene: 108562596

Centisome position: 10.31

GC content: 41.69

Gene sequence:

>921_bases
ATGATAAAGAGTTGGACTAAAAAGTGGTTTTTGATTTTATTTTTAATGGCGAGTTGTTCCAGTTATTTGGTGGCTACAAC
CGGTGAGAAATATTTTAAAATGGCTACTCAAGCCTTTAAGAGAGGGGATTACCATAAGGCGGTGGCTTTTTATAAGAGGA
GCTGTAATTTGAGGGTGGGGGTTGGTTGCGCGAGTTTAGGCTCTATGTATGAGGATGGCGATGGCGTGGATCAGAATGTT
CCAAAAGCCGTTTTTTATTACAGAAGAGGGTGCAATTTAAGGAATCATTTGGCTTGCGCGAGTCTAGGCTCTATGTATGA
AGATGGCGATGGCGTTCAAAAAAACCTTCCAAAGGCTATCTATTATTATAGGAGAGGGTGCCACTTAAAGGGTGGGGTGA
GCTGCGGGAGTTTAGGTTTTATGTATTTTAATGGCACGGGCGTGAAGCAAAATTATGCCAAAGCCCTTTCTCTTTCTAAA
TACGCTTGCAGTTTGAATTACCGCATTAGTTGTAACTTTGTAGGGTATATGTATAGGAACGCCAAAGGCGTACAGAAGGA
TTTGAAAAAAGCCCTTGCGAATTTTAAAAGAGGGTGCCATTTGAAAGACGGAGCGAGCTGTGTGAGCTTGGGATACATGT
ATGAAGTCGGTATGGGTGTCAAGCAAAATGGAGAGCAAGCCTTGAATCTTTATAAAAATGGTTGTTATTTAAAAAGTGGG
AGCGGTTGTCATAATGTGGCGGTGATGTATTACACGGGTAAGGGCGCTCCAAAGGATTTAGATAAAGCCATTTCGTATTA
TAAGAAAGGTTGCACTCTAGGCTTTAGTGGTAGCTGTAAAGTGTTAGAAGAAGTGATTGGCAAGAAGTCTGATGATTTGC
AAGATGACGCGCAAAACGACACGCAAGATGATGCGCAATAA

Upstream 100 bases:

>100_bases
AATTTATTTTTTGACAATATTATACTATAATAACCAATTAGATTGGGGTTTTACTGATTTTTCTTTGTGTGAGCTTTGGC
TTAGTTTTGTAAGGAATGAG

Downstream 100 bases:

>100_bases
GCCAGAGTTTAGGGGCTAATGATTAAAACTCATCTTATAGGAATCTTTCTATATTCTCTCTTGCTATCAAATAGGGATTG
AAGCGTCTCTATTGATGGGG

Product: cysteine-rich protein D

Products: NA

Alternate protein names: Cysteine-rich protein D; Penicillin-binding protein 4; PBP 4 [H]

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MIKSWTKKWFLILFLMASCSSYLVATTGEKYFKMATQAFKRGDYHKAVAFYKRSCNLRVGVGCASLGSMYEDGDGVDQNV
PKAVFYYRRGCNLRNHLACASLGSMYEDGDGVQKNLPKAIYYYRRGCHLKGGVSCGSLGFMYFNGTGVKQNYAKALSLSK
YACSLNYRISCNFVGYMYRNAKGVQKDLKKALANFKRGCHLKDGASCVSLGYMYEVGMGVKQNGEQALNLYKNGCYLKSG
SGCHNVAVMYYTGKGAPKDLDKAISYYKKGCTLGFSGSCKVLEEVIGKKSDDLQDDAQNDTQDDAQ

Sequences:

>Translated_306_residues
MIKSWTKKWFLILFLMASCSSYLVATTGEKYFKMATQAFKRGDYHKAVAFYKRSCNLRVGVGCASLGSMYEDGDGVDQNV
PKAVFYYRRGCNLRNHLACASLGSMYEDGDGVQKNLPKAIYYYRRGCHLKGGVSCGSLGFMYFNGTGVKQNYAKALSLSK
YACSLNYRISCNFVGYMYRNAKGVQKDLKKALANFKRGCHLKDGASCVSLGYMYEVGMGVKQNGEQALNLYKNGCYLKSG
SGCHNVAVMYYTGKGAPKDLDKAISYYKKGCTLGFSGSCKVLEEVIGKKSDDLQDDAQNDTQDDAQ
>Mature_306_residues
MIKSWTKKWFLILFLMASCSSYLVATTGEKYFKMATQAFKRGDYHKAVAFYKRSCNLRVGVGCASLGSMYEDGDGVDQNV
PKAVFYYRRGCNLRNHLACASLGSMYEDGDGVQKNLPKAIYYYRRGCHLKGGVSCGSLGFMYFNGTGVKQNYAKALSLSK
YACSLNYRISCNFVGYMYRNAKGVQKDLKKALANFKRGCHLKDGASCVSLGYMYEVGMGVKQNGEQALNLYKNGCYLKSG
SGCHNVAVMYYTGKGAPKDLDKAISYYKKGCTLGFSGSCKVLEEVIGKKSDDLQDDAQNDTQDDAQ

Specific function: May hydrolyze 6-aminopenicillinic acid and 7- aminocephalosporanic acid (ACA) derivatives. Binds to penicillin [H]

COG id: COG0790

COG function: function code R; FOG: TPR repeat, SEL1 subfamily

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 4 TPR repeats [H]

Homologues:

Organism=Homo sapiens, GI151301150, Length=238, Percent_Identity=28.5714285714286, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI19923669, Length=185, Percent_Identity=31.3513513513514, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI87081769, Length=268, Percent_Identity=24.6268656716418, Blast_Score=89, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006597
- InterPro:   IPR011990 [H]

Pfam domain/function: PF08238 Sel1 [H]

EC number: =3.5.2.6 [H]

Molecular weight: Translated: 33859; Mature: 33859

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
8.2 %Cys+Met (Translated Protein)
4.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
8.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKSWTKKWFLILFLMASCSSYLVATTGEKYFKMATQAFKRGDYHKAVAFYKRSCNLRVG
CCCCHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEE
VGCASLGSMYEDGDGVDQNVPKAVFYYRRGCNLRNHLACASLGSMYEDGDGVQKNLPKAI
CCHHHHCCHHCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHCHHHH
YYYRRGCHLKGGVSCGSLGFMYFNGTGVKQNYAKALSLSKYACSLNYRISCNFVGYMYRN
HHHHCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHEEEEEEEEEEEEEEEEHHC
AKGVQKDLKKALANFKRGCHLKDGASCVSLGYMYEVGMGVKQNGEQALNLYKNGCYLKSG
CCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEECC
SGCHNVAVMYYTGKGAPKDLDKAISYYKKGCTLGFSGSCKVLEEVIGKKSDDLQDDAQND
CCCCEEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCHHCCCC
TQDDAQ
CCCCCC
>Mature Secondary Structure
MIKSWTKKWFLILFLMASCSSYLVATTGEKYFKMATQAFKRGDYHKAVAFYKRSCNLRVG
CCCCHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEE
VGCASLGSMYEDGDGVDQNVPKAVFYYRRGCNLRNHLACASLGSMYEDGDGVQKNLPKAI
CCHHHHCCHHCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHCHHHH
YYYRRGCHLKGGVSCGSLGFMYFNGTGVKQNYAKALSLSKYACSLNYRISCNFVGYMYRN
HHHHCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHEEEEEEEEEEEEEEEEHHC
AKGVQKDLKKALANFKRGCHLKDGASCVSLGYMYEVGMGVKQNGEQALNLYKNGCYLKSG
CCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEECC
SGCHNVAVMYYTGKGAPKDLDKAISYYKKGCTLGFSGSCKVLEEVIGKKSDDLQDDAQND
CCCCEEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCHHCCCC
TQDDAQ
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9252185; 10438788 [H]