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The map label for this gene is ppiC [C]

Identifier: 108562596

GI number: 108562596

Start: 177121

End: 178020

Strand: Direct

Name: ppiC [C]

Synonym: HPAG1_0171

Alternate gene names: 108562596

Gene position: 177121-178020 (Clockwise)

Preceding gene: 108562583

Following gene: 108562597

Centisome position: 11.1

GC content: 39.44

Gene sequence:

>900_bases
ATGAAAAAAAATATCTTGAATTTAGCGTTAGTGGGCGCGTTGAGTGCGTCGTTTTTGATGGCTAAGCCGGCTCATAACGC
AAATAACGCTACGCACAACACGAAAAAAGCGACTGATTCTTCAGCAGGCGTGTTAGCGACAGTGGATGGCAGACCCATCA
CTAAAAGCGATTTTGACATGATCAAACAGCGCAACCCTAATTTTGATTTTGACAAGCTTAAAGAGAAAGAAAAAGAAGCC
TTGATTGAGCAAGCTATTCGCACCGCGCTTGTAGAAAATGAAGCTAAAACCGAGAAATTGGACAGCACTCCAGAATTTAA
AGCGATGATGGAAGCGGTTAAAAAACAGGCTTTAGTGGAATTTTGGGCTAAAAAACAGGCTGAAGAAGTGAAAAAAGTCC
AAATCCCAGAAAAAGAAATGCAAGATTTTTACAACGCTAATAAAGATCAGCTTTTTGTCAAGCAAGAAGCTCATGCTAGG
CATATTTTAGTGAAAACCGAAGATGAGGCTAAACGGATTATTTCTGAGATTGACAAACAGCCAAAGGCTAAAAAAGAAGC
CAAATTCATTGAGTTAGCCAATCGGGATACGATTGATCCTAACAGCAAGAACGCGCAAAATGGCGGTGATTTGGGGAAAT
TCCAAAAGAACCAAATGGCTCCGGATTTTTCTAAAGCCGCTTTCGCTTTAACTCCTGGGGATTACACTAAAACCCCCGTT
AAAACAGAGTTTGGTTATCATATTATCTATTTGATTTCTAAAGATAGCCCTGTAACTTATACTTATGAACAGGCTAAACC
TACCATTAAGGGGATGTTACAAGAAAAGCTTTTCCAAGAACGCATGAATCAACGCATTGAGGAACTAAGAAAGCACGCTA
AAATTGTTATCAACAAGTAA

Upstream 100 bases:

>100_bases
TTAATGTGAGTTTTCTGTAATCATGATAGCTGATTTTGTTTTAAATTTGCTATAATGTGAATTTAATGATGAAAATTAGT
TTAGAGTGGAGAACAACACA

Downstream 100 bases:

>100_bases
TTGATGAGGTGTTGTTATGCTAGTTAAAGGTAATGAAATCTTATTGAAAGCCCATGAAGAAGGTTATGGGGTGGGGGCGT
TTAATTTCGTGAATTTTGAA

Product: peptidyl-prolyl cis-trans isomerase C

Products: peptidylproline (omega=0) [C]

Alternate protein names: NA

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MKKNILNLALVGALSASFLMAKPAHNANNATHNTKKATDSSAGVLATVDGRPITKSDFDMIKQRNPNFDFDKLKEKEKEA
LIEQAIRTALVENEAKTEKLDSTPEFKAMMEAVKKQALVEFWAKKQAEEVKKVQIPEKEMQDFYNANKDQLFVKQEAHAR
HILVKTEDEAKRIISEIDKQPKAKKEAKFIELANRDTIDPNSKNAQNGGDLGKFQKNQMAPDFSKAAFALTPGDYTKTPV
KTEFGYHIIYLISKDSPVTYTYEQAKPTIKGMLQEKLFQERMNQRIEELRKHAKIVINK

Sequences:

>Translated_299_residues
MKKNILNLALVGALSASFLMAKPAHNANNATHNTKKATDSSAGVLATVDGRPITKSDFDMIKQRNPNFDFDKLKEKEKEA
LIEQAIRTALVENEAKTEKLDSTPEFKAMMEAVKKQALVEFWAKKQAEEVKKVQIPEKEMQDFYNANKDQLFVKQEAHAR
HILVKTEDEAKRIISEIDKQPKAKKEAKFIELANRDTIDPNSKNAQNGGDLGKFQKNQMAPDFSKAAFALTPGDYTKTPV
KTEFGYHIIYLISKDSPVTYTYEQAKPTIKGMLQEKLFQERMNQRIEELRKHAKIVINK
>Mature_299_residues
MKKNILNLALVGALSASFLMAKPAHNANNATHNTKKATDSSAGVLATVDGRPITKSDFDMIKQRNPNFDFDKLKEKEKEA
LIEQAIRTALVENEAKTEKLDSTPEFKAMMEAVKKQALVEFWAKKQAEEVKKVQIPEKEMQDFYNANKDQLFVKQEAHAR
HILVKTEDEAKRIISEIDKQPKAKKEAKFIELANRDTIDPNSKNAQNGGDLGKFQKNQMAPDFSKAAFALTPGDYTKTPV
KTEFGYHIIYLISKDSPVTYTYEQAKPTIKGMLQEKLFQERMNQRIEELRKHAKIVINK

Specific function: Ppiases Accelerate The Folding Of Proteins. It Prefers Amino Acid Residues With Hydrophobic Side Chains Like Leucine And Phenylalanine In The P1 Position Of The Peptides Substrates. [C]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000297
- InterPro:   IPR023058 [H]

Pfam domain/function: PF00639 Rotamase [H]

EC number: 5.2.1.8 [C]

Molecular weight: Translated: 33985; Mature: 33985

Theoretical pI: Translated: 9.96; Mature: 9.96

Prosite motif: PS01096 PPIC_PPIASE_1 ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKNILNLALVGALSASFLMAKPAHNANNATHNTKKATDSSAGVLATVDGRPITKSDFDM
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHH
IKQRNPNFDFDKLKEKEKEALIEQAIRTALVENEAKTEKLDSTPEFKAMMEAVKKQALVE
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHHHH
FWAKKQAEEVKKVQIPEKEMQDFYNANKDQLFVKQEAHARHILVKTEDEAKRIISEIDKQ
HHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEECCCCCEEEEECCHHHHHHHHHHHCC
PKAKKEAKFIELANRDTIDPNSKNAQNGGDLGKFQKNQMAPDFSKAAFALTPGDYTKTPV
CCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCCCHHCCEEEECCCCCCCCCC
KTEFGYHIIYLISKDSPVTYTYEQAKPTIKGMLQEKLFQERMNQRIEELRKHAKIVINK
CCCCCEEEEEEEECCCCCEEEHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCC
>Mature Secondary Structure
MKKNILNLALVGALSASFLMAKPAHNANNATHNTKKATDSSAGVLATVDGRPITKSDFDM
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHH
IKQRNPNFDFDKLKEKEKEALIEQAIRTALVENEAKTEKLDSTPEFKAMMEAVKKQALVE
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHHHH
FWAKKQAEEVKKVQIPEKEMQDFYNANKDQLFVKQEAHARHILVKTEDEAKRIISEIDKQ
HHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEECCCCCEEEEECCHHHHHHHHHHHCC
PKAKKEAKFIELANRDTIDPNSKNAQNGGDLGKFQKNQMAPDFSKAAFALTPGDYTKTPV
CCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCCCHHCCEEEECCCCCCCCCC
KTEFGYHIIYLISKDSPVTYTYEQAKPTIKGMLQEKLFQERMNQRIEELRKHAKIVINK
CCCCCEEEEEEEECCCCCEEEHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Peptidoproline (omega=180) [C]

Specific reaction: Peptidoproline (omega=180) = peptidylproline (omega=0) [C]

General reaction: Rotation (Single bond) [C]

Inhibitor: cyclosporins [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]