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The map label for this gene is hisD2 [H]

Identifier: 107023069

GI number: 107023069

Start: 1685603

End: 1686889

Strand: Reverse

Name: hisD2 [H]

Synonym: Bcen_1517

Alternate gene names: 107023069

Gene position: 1686889-1685603 (Counterclockwise)

Preceding gene: 107023073

Following gene: 107023068

Centisome position: 51.2

GC content: 63.71

Gene sequence:

>1287_bases
GTGATCCAGCATCTTAAGAAAAGCAAGCCGATGGAGGCGCAACTCGAGATCGCGAAGCAGGTGCGCGATACGGTCGAGCA
GATCATCGCGGACGTCGCCGCCAACGGGGACGCTGCCGTGCGCGAATACTCGATGCGGTTCGACAAATGGAACCCGGCAT
CCTTTCGGCTGACGGACGCGGAAATCAGCGCGTGCGTCGCGACCCTGTCGGAGCGCGAACTGGACGACATCAAGTTCGCG
CAGCAGCAGGTTCGCCGGTTTGCCCTGGCGCAGAAGGACGCATTGCGCGACGTCGAAGTCGAGACGCTGCCGGGCGTGGT
GCTCGGTCACCGCAACATTCCGGTGAATTCCGTCGGCTGCTATATCCCGGGCGGCAAGTATCCGTTGCTGGCTTCCGCTC
ATATGAGCGTGCTCACGGCCAAGGTTGCCGGCGTCAAGCGTGTGGTGGCCGTGGCGCCGCCGTTCGACGGCAAGCCGCAC
CCGGCGATCGTCACGGCGATGCATCTCGCGGGCGCGGACGAGATCTACTGCGTCGGCGGCGTGCAGGCGATTGCCGCATT
GGCGCTCGGTACGGATCAGTTCGAGCCGGTCGACATGATCGTCGGCCCGGGCAATGCCTACGTGGCCGAAGCGAAGCGCC
AGCTGTTCGGCAAGATCGGGATCGACCTGATCGCGGGCCCGACGGAGACGCTCGTCATCGCCGACGATTCGTCGGACGTC
GAGATCGTTGCGGCCGACCTGCTCGGCCAGGCCGAGCATGGCGTGAATTCGCCGGTCGTGTTCCTGACGAATTCCGCCAG
GCTCGCGGACGGCCTGCCGGCGGAGATCGAGCGCCAGCTAGCGGTGTTGCCGACAGCGGCCGTCGCGTCGGTCGCGTGGC
GCGACTATGGCGAGATCATTCTGTGCGACACCGTCGACGAAATGGTCGAAGAAGCCGACCGGATCGCGTCCGAGCACGTT
CAGGTCATGACGCGCGATCCGCTTTATTTCCTCGAGCACATGACGAACTACGGTGCGCTGTTTCTCGGCGACCGTACCAA
CGTGTCGTACGGCGACAAGGTGATCGGCACGAACCATACGTTGCCGACGACGAAGGCCGCGCGCTATACCGGTGGGCTGT
GGGTCGGCAAATTCATCAAGACCTGCACCTATCAGCGGGTGTTGACCGACGAAGCATCGGCCATGCTCGGCGAATACTGT
TCGCGACTGTGTGCAATGGAAGGCTTTGCAGGGCACAAGGAACAGGCCGATATCCGCGTTCGCCGCTTCGGAAAGCGAGC
GGACTGA

Upstream 100 bases:

>100_bases
CCCGCGAAAATTTGCTCGTGTGATCGAACTCGTTCGGATCGTGCACCGTCGCAACGCGGGTTTCGCGCTGCATGGTCGGG
AAACACTCTTGGAGATTTTT

Downstream 100 bases:

>100_bases
CATCGGGCCGAGAGATCGGGCAGCGATTCGGCACTCGAAAGAGTGCCGTTTTTTTTGCGTCGAATCGAGCGGGTTTGCGC
GGTTCCGCAGCGCGCGGAGG

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH 2 [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MIQHLKKSKPMEAQLEIAKQVRDTVEQIIADVAANGDAAVREYSMRFDKWNPASFRLTDAEISACVATLSERELDDIKFA
QQQVRRFALAQKDALRDVEVETLPGVVLGHRNIPVNSVGCYIPGGKYPLLASAHMSVLTAKVAGVKRVVAVAPPFDGKPH
PAIVTAMHLAGADEIYCVGGVQAIAALALGTDQFEPVDMIVGPGNAYVAEAKRQLFGKIGIDLIAGPTETLVIADDSSDV
EIVAADLLGQAEHGVNSPVVFLTNSARLADGLPAEIERQLAVLPTAAVASVAWRDYGEIILCDTVDEMVEEADRIASEHV
QVMTRDPLYFLEHMTNYGALFLGDRTNVSYGDKVIGTNHTLPTTKAARYTGGLWVGKFIKTCTYQRVLTDEASAMLGEYC
SRLCAMEGFAGHKEQADIRVRRFGKRAD

Sequences:

>Translated_428_residues
MIQHLKKSKPMEAQLEIAKQVRDTVEQIIADVAANGDAAVREYSMRFDKWNPASFRLTDAEISACVATLSERELDDIKFA
QQQVRRFALAQKDALRDVEVETLPGVVLGHRNIPVNSVGCYIPGGKYPLLASAHMSVLTAKVAGVKRVVAVAPPFDGKPH
PAIVTAMHLAGADEIYCVGGVQAIAALALGTDQFEPVDMIVGPGNAYVAEAKRQLFGKIGIDLIAGPTETLVIADDSSDV
EIVAADLLGQAEHGVNSPVVFLTNSARLADGLPAEIERQLAVLPTAAVASVAWRDYGEIILCDTVDEMVEEADRIASEHV
QVMTRDPLYFLEHMTNYGALFLGDRTNVSYGDKVIGTNHTLPTTKAARYTGGLWVGKFIKTCTYQRVLTDEASAMLGEYC
SRLCAMEGFAGHKEQADIRVRRFGKRAD
>Mature_428_residues
MIQHLKKSKPMEAQLEIAKQVRDTVEQIIADVAANGDAAVREYSMRFDKWNPASFRLTDAEISACVATLSERELDDIKFA
QQQVRRFALAQKDALRDVEVETLPGVVLGHRNIPVNSVGCYIPGGKYPLLASAHMSVLTAKVAGVKRVVAVAPPFDGKPH
PAIVTAMHLAGADEIYCVGGVQAIAALALGTDQFEPVDMIVGPGNAYVAEAKRQLFGKIGIDLIAGPTETLVIADDSSDV
EIVAADLLGQAEHGVNSPVVFLTNSARLADGLPAEIERQLAVLPTAAVASVAWRDYGEIILCDTVDEMVEEADRIASEHV
QVMTRDPLYFLEHMTNYGALFLGDRTNVSYGDKVIGTNHTLPTTKAARYTGGLWVGKFIKTCTYQRVLTDEASAMLGEYC
SRLCAMEGFAGHKEQADIRVRRFGKRAD

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=420, Percent_Identity=38.3333333333333, Blast_Score=257, Evalue=1e-69,
Organism=Saccharomyces cerevisiae, GI6319819, Length=426, Percent_Identity=33.8028169014084, Blast_Score=209, Evalue=8e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 46384; Mature: 46384

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQHLKKSKPMEAQLEIAKQVRDTVEQIIADVAANGDAAVREYSMRFDKWNPASFRLTDA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCEEEEHH
EISACVATLSERELDDIKFAQQQVRRFALAQKDALRDVEVETLPGVVLGHRNIPVNSVGC
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCEEEECCCCCCCCCEE
YIPGGKYPLLASAHMSVLTAKVAGVKRVVAVAPPFDGKPHPAIVTAMHLAGADEIYCVGG
EECCCCCCEEHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCHHEEEEHHCCCCCEEEECH
VQAIAALALGTDQFEPVDMIVGPGNAYVAEAKRQLFGKIGIDLIAGPTETLVIADDSSDV
HHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCEEEECCCCEEEEECCCCCC
EIVAADLLGQAEHGVNSPVVFLTNSARLADGLPAEIERQLAVLPTAAVASVAWRDYGEII
EEEEHHHHHHHHCCCCCCEEEEECCCHHCCCCCHHHHHHHHHCCHHHHHHHHHHCCCCEE
LCDTVDEMVEEADRIASEHVQVMTRDPLYFLEHMTNYGALFLGDRTNVSYGDKVIGTNHT
EECCHHHHHHHHHHHHHHHHHEEECCHHHHHHHHCCCCEEEEECCCCCCCCCEEECCCCC
LPTTKAARYTGGLWVGKFIKTCTYQRVLTDEASAMLGEYCSRLCAMEGFAGHKEQADIRV
CCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
RRFGKRAD
HHCCCCCC
>Mature Secondary Structure
MIQHLKKSKPMEAQLEIAKQVRDTVEQIIADVAANGDAAVREYSMRFDKWNPASFRLTDA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCEEEEHH
EISACVATLSERELDDIKFAQQQVRRFALAQKDALRDVEVETLPGVVLGHRNIPVNSVGC
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCEEEECCCCCCCCCEE
YIPGGKYPLLASAHMSVLTAKVAGVKRVVAVAPPFDGKPHPAIVTAMHLAGADEIYCVGG
EECCCCCCEEHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCHHEEEEHHCCCCCEEEECH
VQAIAALALGTDQFEPVDMIVGPGNAYVAEAKRQLFGKIGIDLIAGPTETLVIADDSSDV
HHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCEEEECCCCEEEEECCCCCC
EIVAADLLGQAEHGVNSPVVFLTNSARLADGLPAEIERQLAVLPTAAVASVAWRDYGEII
EEEEHHHHHHHHCCCCCCEEEEECCCHHCCCCCHHHHHHHHHCCHHHHHHHHHHCCCCEE
LCDTVDEMVEEADRIASEHVQVMTRDPLYFLEHMTNYGALFLGDRTNVSYGDKVIGTNHT
EECCHHHHHHHHHHHHHHHHHEEECCHHHHHHHHCCCCEEEEECCCCCCCCCEEECCCCC
LPTTKAARYTGGLWVGKFIKTCTYQRVLTDEASAMLGEYCSRLCAMEGFAGHKEQADIRV
CCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
RRFGKRAD
HHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]