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The map label for this gene is dut [H]

Identifier: 103488656

GI number: 103488656

Start: 3338711

End: 3339229

Strand: Reverse

Name: dut [H]

Synonym: Sala_3181

Alternate gene names: 103488656

Gene position: 3339229-3338711 (Counterclockwise)

Preceding gene: 103488657

Following gene: 103488655

Centisome position: 99.82

GC content: 69.36

Gene sequence:

>519_bases
GTGATTGAAATCGCGATCCAGCGCCTGCCGAACGGCGGCGGCCTGCCCCTGCCCGCCTATGCGTCCGCTGGCGCCGCGGG
GATGGATGTCGTCGCGGCCGAGACGCTGACGATCCGCCCCGGCACGCGCCACGCGGTCGCGACGGGGTTCGCGATGGCGA
TCCCGCTGGGCTATGAAGTGCAGGTGCGGCCGCGGTCGGGGCTGGCGCTCAAACATGGCATCACCTGTCTCAACACGCCG
GGGACGATCGACAGCGACTATCGCGGCGAAGTAAAGGTGATCCTCGCCAATCTGGGCGACGAAAATTTCGAGGTGAAGCG
CGGCGACCGCATCGCGCAGCTGGTCCCTGCCCCGGTGCAGCGCGCGACCTTTGCCGAGGTCGACAGGCTGGACGACACCG
CGCGCGGTGCGGGCGGCTTCGGATCGACCGGGATCGAAAGCGACGCCGCCGACGAAACCGCGAACGCCGCCGGCCTCGCC
TCGCTGTCGGGCATCAAATTGCGCCGACCCGCCGAATAG

Upstream 100 bases:

>100_bases
GGCGGGGTAGACAGCTGGGACCGTTTGCCCAAAGCGGTCGTCGCCCGCAAATTGATGGAAAAGATTGCCGATGAGCTTGA
CCAACGCGCCCCCCTCGAAC

Downstream 100 bases:

>100_bases
TGCTGAACGACGCCGAACTCGACCGCTATGCCCGCCAGATCATTCTGCCGGCCTTTGGCGGCACGGGTCAGGCGAAGCTG
AAAGGGAGCCATGTCGCGAT

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase (dut)

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase [H]

Number of amino acids: Translated: 172; Mature: 172

Protein sequence:

>172_residues
MIEIAIQRLPNGGGLPLPAYASAGAAGMDVVAAETLTIRPGTRHAVATGFAMAIPLGYEVQVRPRSGLALKHGITCLNTP
GTIDSDYRGEVKVILANLGDENFEVKRGDRIAQLVPAPVQRATFAEVDRLDDTARGAGGFGSTGIESDAADETANAAGLA
SLSGIKLRRPAE

Sequences:

>Translated_172_residues
MIEIAIQRLPNGGGLPLPAYASAGAAGMDVVAAETLTIRPGTRHAVATGFAMAIPLGYEVQVRPRSGLALKHGITCLNTP
GTIDSDYRGEVKVILANLGDENFEVKRGDRIAQLVPAPVQRATFAEVDRLDDTARGAGGFGSTGIESDAADETANAAGLA
SLSGIKLRRPAE
>Mature_172_residues
MIEIAIQRLPNGGGLPLPAYASAGAAGMDVVAAETLTIRPGTRHAVATGFAMAIPLGYEVQVRPRSGLALKHGITCLNTP
GTIDSDYRGEVKVILANLGDENFEVKRGDRIAQLVPAPVQRATFAEVDRLDDTARGAGGFGSTGIESDAADETANAAGLA
SLSGIKLRRPAE

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA [H]

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family [H]

Homologues:

Organism=Homo sapiens, GI70906444, Length=127, Percent_Identity=51.1811023622047, Blast_Score=112, Evalue=1e-25,
Organism=Homo sapiens, GI4503423, Length=127, Percent_Identity=51.1811023622047, Blast_Score=112, Evalue=1e-25,
Organism=Homo sapiens, GI70906441, Length=127, Percent_Identity=51.1811023622047, Blast_Score=111, Evalue=3e-25,
Organism=Escherichia coli, GI1790071, Length=146, Percent_Identity=40.4109589041096, Blast_Score=102, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI71988561, Length=141, Percent_Identity=51.063829787234, Blast_Score=136, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6319729, Length=129, Percent_Identity=44.9612403100775, Blast_Score=105, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24583610, Length=141, Percent_Identity=40.4255319148936, Blast_Score=97, Evalue=6e-21,
Organism=Drosophila melanogaster, GI19921126, Length=141, Percent_Identity=40.4255319148936, Blast_Score=97, Evalue=7e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008180
- InterPro:   IPR008181 [H]

Pfam domain/function: PF00692 dUTPase [H]

EC number: =3.6.1.23 [H]

Molecular weight: Translated: 17778; Mature: 17778

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEIAIQRLPNGGGLPLPAYASAGAAGMDVVAAETLTIRPGTRHAVATGFAMAIPLGYEV
CEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCCHHHHCEEEEECCCCEE
QVRPRSGLALKHGITCLNTPGTIDSDYRGEVKVILANLGDENFEVKRGDRIAQLVPAPVQ
EECCCCCCCHHHCCEEECCCCCCCCCCCCEEEEEEEECCCCCEEEECCCEEEHHCCCCCC
RATFAEVDRLDDTARGAGGFGSTGIESDAADETANAAGLASLSGIKLRRPAE
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCC
>Mature Secondary Structure
MIEIAIQRLPNGGGLPLPAYASAGAAGMDVVAAETLTIRPGTRHAVATGFAMAIPLGYEV
CEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCCHHHHCEEEEECCCCEE
QVRPRSGLALKHGITCLNTPGTIDSDYRGEVKVILANLGDENFEVKRGDRIAQLVPAPVQ
EECCCCCCCHHHCCEEECCCCCCCCCCCCEEEEEEEECCCCCEEEECCCEEEHHCCCCCC
RATFAEVDRLDDTARGAGGFGSTGIESDAADETANAAGLASLSGIKLRRPAE
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA