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The map label for this gene is coaBC [H]

Identifier: 103488657

GI number: 103488657

Start: 3339222

End: 3340484

Strand: Reverse

Name: coaBC [H]

Synonym: Sala_3182

Alternate gene names: 103488657

Gene position: 3340484-3339222 (Counterclockwise)

Preceding gene: 103488658

Following gene: 103488656

Centisome position: 99.86

GC content: 68.33

Gene sequence:

>1263_bases
ATGACCAGGCCCCGCATCCTGCTGATCGTCGGCGGCGGCATTGCCGCCTATAAGAGCGTCGAGCTTGTCCGCCTGTTGCG
CAAGGCCGACATGACCGTGCGCTGCGTCCTAACGCGCGCGGGCGAGCAGTTCGTGACGCCATTGACCCTCGCGGCGCTCA
GCGAGAACAAGGTCTATACCAGCCTCTTCGACCTGACGGACGAGGTCGAGATGGGGCATATCCAGCTATCCCGCGAGGCC
GATCTGGTCGTGGTCGCGCCCGCCACCGCCGACCTGATGGCCAGGATGGCGGCAGGCATCGCCGACGATCTGGCGACAAC
CCTGCTGCTCGCGACCGACAAGCCGGTGCTCGCCGCGCCCGCGATGAATGTCCGCATGTGGCTGCACCCGGCGACGCAGC
GCAATATCGCGGCGCTGCGCGGCGACGGGGTGACGGTGATGGAGCCCGACGAGGGCGAGATGGCGTGCGGCGAATATGGC
CCCGGACGGCTGCCCGAACCCGACGCGATTTTTGCGGCGATCGAGGCGGCGCTCGCGAACGCGCCCGCGCCGTCGGTCCT
GTCGGGACAGCCCGACTTCGCCCCCGCGAACCACCGCCCGCTCCACGGGCGGCGCATCCTGATCACCGCGGGGCCGACGC
ACGAGCCGATCGACCCCGTGCGCTATATCGCCAACCGGTCGAGCGGCAAGCAGGGCTTTGCAATCGCCGCCGCCGCCGCC
GAGGCAGGCGCCGAGGTGCTGCTGATCGCCGGCCCCGTCCCGCTGCCGACGCCGCCGGGCGTGATCCGCGTCGATGTCGA
GACCGCGGTCGAAATGGCGACCGAGGTCGAAGCGGGGCTGCCCGTTGACGCCGCGATCATGGTCGCCGCGGTTGCCGACT
GGCGCGCCGCAGAAAGCCAGGCACAGAAGATCAAGAAGGATGGCAGCGGACGGGTTCCGCCGCTCGCGCTCGCGGAAAAT
CCCGACATATTGGCGAGCGTCGCCCAATCATCCCGACGCCCGCCGCTGCTGATCGGTTTTGCCGCCGAGACCAACGACGT
CATCGCGCACGCCGAGGCAAAGCTCGCGCGCAAGGGATGCGACTGGATCGTCGCCAACGATGTGTCCGCCGACCCCATGG
GCGGCGAGAGCAACCGGGTGCATATCGTTAGCAACGGCGGGGTAGACAGCTGGGACCGTTTGCCCAAAGCGGTCGTCGCC
CGCAAATTGATGGAAAAGATTGCCGATGAGCTTGACCAACGCGCCCCCCTCGAACGTGATTGA

Upstream 100 bases:

>100_bases
GATCCCGCTCGATCGCCTGCAGCGCCCGGTGGCCAATCTTGAAGCGGAGCATTATGCGATCATGAGCGCGCTCGACATGT
TGACCACGGGGTTCTGACAG

Downstream 100 bases:

>100_bases
AATCGCGATCCAGCGCCTGCCGAACGGCGGCGGCCTGCCCCTGCCCGCCTATGCGTCCGCTGGCGCCGCGGGGATGGATG
TCGTCGCGGCCGAGACGCTG

Product: phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MTRPRILLIVGGGIAAYKSVELVRLLRKADMTVRCVLTRAGEQFVTPLTLAALSENKVYTSLFDLTDEVEMGHIQLSREA
DLVVVAPATADLMARMAAGIADDLATTLLLATDKPVLAAPAMNVRMWLHPATQRNIAALRGDGVTVMEPDEGEMACGEYG
PGRLPEPDAIFAAIEAALANAPAPSVLSGQPDFAPANHRPLHGRRILITAGPTHEPIDPVRYIANRSSGKQGFAIAAAAA
EAGAEVLLIAGPVPLPTPPGVIRVDVETAVEMATEVEAGLPVDAAIMVAAVADWRAAESQAQKIKKDGSGRVPPLALAEN
PDILASVAQSSRRPPLLIGFAAETNDVIAHAEAKLARKGCDWIVANDVSADPMGGESNRVHIVSNGGVDSWDRLPKAVVA
RKLMEKIADELDQRAPLERD

Sequences:

>Translated_420_residues
MTRPRILLIVGGGIAAYKSVELVRLLRKADMTVRCVLTRAGEQFVTPLTLAALSENKVYTSLFDLTDEVEMGHIQLSREA
DLVVVAPATADLMARMAAGIADDLATTLLLATDKPVLAAPAMNVRMWLHPATQRNIAALRGDGVTVMEPDEGEMACGEYG
PGRLPEPDAIFAAIEAALANAPAPSVLSGQPDFAPANHRPLHGRRILITAGPTHEPIDPVRYIANRSSGKQGFAIAAAAA
EAGAEVLLIAGPVPLPTPPGVIRVDVETAVEMATEVEAGLPVDAAIMVAAVADWRAAESQAQKIKKDGSGRVPPLALAEN
PDILASVAQSSRRPPLLIGFAAETNDVIAHAEAKLARKGCDWIVANDVSADPMGGESNRVHIVSNGGVDSWDRLPKAVVA
RKLMEKIADELDQRAPLERD
>Mature_419_residues
TRPRILLIVGGGIAAYKSVELVRLLRKADMTVRCVLTRAGEQFVTPLTLAALSENKVYTSLFDLTDEVEMGHIQLSREAD
LVVVAPATADLMARMAAGIADDLATTLLLATDKPVLAAPAMNVRMWLHPATQRNIAALRGDGVTVMEPDEGEMACGEYGP
GRLPEPDAIFAAIEAALANAPAPSVLSGQPDFAPANHRPLHGRRILITAGPTHEPIDPVRYIANRSSGKQGFAIAAAAAE
AGAEVLLIAGPVPLPTPPGVIRVDVETAVEMATEVEAGLPVDAAIMVAAVADWRAAESQAQKIKKDGSGRVPPLALAENP
DILASVAQSSRRPPLLIGFAAETNDVIAHAEAKLARKGCDWIVANDVSADPMGGESNRVHIVSNGGVDSWDRLPKAVVAR
KLMEKIADELDQRAPLERD

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=185, Percent_Identity=31.8918918918919, Blast_Score=83, Evalue=6e-16,
Organism=Escherichia coli, GI87082301, Length=414, Percent_Identity=46.3768115942029, Blast_Score=300, Evalue=2e-82,
Organism=Caenorhabditis elegans, GI17560194, Length=198, Percent_Identity=27.2727272727273, Blast_Score=75, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6322762, Length=181, Percent_Identity=25.9668508287293, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24657262, Length=185, Percent_Identity=29.7297297297297, Blast_Score=79, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 44322; Mature: 44191

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRPRILLIVGGGIAAYKSVELVRLLRKADMTVRCVLTRAGEQFVTPLTLAALSENKVYT
CCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHCHHEEEECCCCCEEH
SLFDLTDEVEMGHIQLSREADLVVVAPATADLMARMAAGIADDLATTLLLATDKPVLAAP
HHHHCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHEEEEECCCCEEECC
AMNVRMWLHPATQRNIAALRGDGVTVMEPDEGEMACGEYGPGRLPEPDAIFAAIEAALAN
CCEEEEEEECCCCCCEEEEECCCEEEECCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHC
APAPSVLSGQPDFAPANHRPLHGRRILITAGPTHEPIDPVRYIANRSSGKQGFAIAAAAA
CCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHCCCCCCCCEEEEEEHH
EAGAEVLLIAGPVPLPTPPGVIRVDVETAVEMATEVEAGLPVDAAIMVAAVADWRAAESQ
HCCCEEEEEECCCCCCCCCCEEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
AQKIKKDGSGRVPPLALAENPDILASVAQSSRRPPLLIGFAAETNDVIAHAEAKLARKGC
HHHHHHCCCCCCCCEEECCCCHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHCCC
DWIVANDVSADPMGGESNRVHIVSNGGVDSWDRLPKAVVARKLMEKIADELDQRAPLERD
CEEEECCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TRPRILLIVGGGIAAYKSVELVRLLRKADMTVRCVLTRAGEQFVTPLTLAALSENKVYT
CCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHCHHEEEECCCCCEEH
SLFDLTDEVEMGHIQLSREADLVVVAPATADLMARMAAGIADDLATTLLLATDKPVLAAP
HHHHCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHEEEEECCCCEEECC
AMNVRMWLHPATQRNIAALRGDGVTVMEPDEGEMACGEYGPGRLPEPDAIFAAIEAALAN
CCEEEEEEECCCCCCEEEEECCCEEEECCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHC
APAPSVLSGQPDFAPANHRPLHGRRILITAGPTHEPIDPVRYIANRSSGKQGFAIAAAAA
CCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHCCCCCCCCEEEEEEHH
EAGAEVLLIAGPVPLPTPPGVIRVDVETAVEMATEVEAGLPVDAAIMVAAVADWRAAESQ
HCCCEEEEEECCCCCCCCCCEEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
AQKIKKDGSGRVPPLALAENPDILASVAQSSRRPPLLIGFAAETNDVIAHAEAKLARKGC
HHHHHHCCCCCCCCEEECCCCHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHCCC
DWIVANDVSADPMGGESNRVHIVSNGGVDSWDRLPKAVVARKLMEKIADELDQRAPLERD
CEEEECCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]