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The map label for this gene is moeB [H]

Identifier: 103488655

GI number: 103488655

Start: 3337962

End: 3338711

Strand: Reverse

Name: moeB [H]

Synonym: Sala_3180

Alternate gene names: 103488655

Gene position: 3338711-3337962 (Counterclockwise)

Preceding gene: 103488656

Following gene: 103488654

Centisome position: 99.81

GC content: 69.2

Gene sequence:

>750_bases
GTGCTGAACGACGCCGAACTCGACCGCTATGCCCGCCAGATCATTCTGCCGGCCTTTGGCGGCACGGGTCAGGCGAAGCT
GAAAGGGAGCCATGTCGCGATCATCGGCGCGGGCGGCATCGGCTGTCCGGCGATCACCTATCTCGCCGCGGCGGGCGTCG
GCAAGCTGACGATCATCGACGATGACCATGTCGAGCTTTCGAACCTGCAACGCCAGCCGCTGTTCACCGACGCCGACGTC
GGCGCGCCGAAGGCGATGGTCGCGGCCGATGCGGCGTGGCGGATCAATCCGCATGTGGAAGCGATCGCGGTGGCCGAACG
GCTGGACGAGGCCAATGCGGCGGCGCTGCTGGCGGGCGCGAGCCTGATCCTCGACGGCTGTGACAATTTCGCCACGCGGC
TGGCGGTCAACCGCGCGGCGGTGACGCTGCAAATCCCTTTGCTCTCGGCCGCGATCGGCGCGTTCGAGGGGCAGGTCGCG
CTGTACGAGGGCTGGCGCGGCGAGAGCCCCTGTTACGCCTGCCTGGTCGGCAACGATCCCGACCGGCCGGGGATCAACTG
CGCCGAACAGGGCGTGATGGGCGCGCTGGCGGGGATGGTCGGGACGATGGCGGCGCTGGAAACAGTACGCGCGCTGTCGG
GCTGGGGCACGCCACTGGTCGGGCGCCTCGCGATCATCGACATGCTCGACCGGCGCTGGCGCGAAGTGGCGGTCGCGAAG
GAACCGGAGTGTCCGATATGCCGGGGCTGA

Upstream 100 bases:

>100_bases
TCGGATCGACCGGGATCGAAAGCGACGCCGCCGACGAAACCGCGAACGCCGCCGGCCTCGCCTCGCTGTCGGGCATCAAA
TTGCGCCGACCCGCCGAATA

Downstream 100 bases:

>100_bases
ACATCATCGTCGCGGCGGCCGAGGGGCGGCGCTTTTGCGCCGCGCTCGAAACCGCGATCGCCGCCGTCGCGCTGGGCCAG
CGGGCGCGCCTGTTCTTGCA

Product: UBA/THIF-type NAD/FAD binding fold

Products: NA

Alternate protein names: MoaD protein adenylase; Molybdopterin-converting factor subunit 1 adenylase [H]

Number of amino acids: Translated: 249; Mature: 249

Protein sequence:

>249_residues
MLNDAELDRYARQIILPAFGGTGQAKLKGSHVAIIGAGGIGCPAITYLAAAGVGKLTIIDDDHVELSNLQRQPLFTDADV
GAPKAMVAADAAWRINPHVEAIAVAERLDEANAAALLAGASLILDGCDNFATRLAVNRAAVTLQIPLLSAAIGAFEGQVA
LYEGWRGESPCYACLVGNDPDRPGINCAEQGVMGALAGMVGTMAALETVRALSGWGTPLVGRLAIIDMLDRRWREVAVAK
EPECPICRG

Sequences:

>Translated_249_residues
MLNDAELDRYARQIILPAFGGTGQAKLKGSHVAIIGAGGIGCPAITYLAAAGVGKLTIIDDDHVELSNLQRQPLFTDADV
GAPKAMVAADAAWRINPHVEAIAVAERLDEANAAALLAGASLILDGCDNFATRLAVNRAAVTLQIPLLSAAIGAFEGQVA
LYEGWRGESPCYACLVGNDPDRPGINCAEQGVMGALAGMVGTMAALETVRALSGWGTPLVGRLAIIDMLDRRWREVAVAK
EPECPICRG
>Mature_249_residues
MLNDAELDRYARQIILPAFGGTGQAKLKGSHVAIIGAGGIGCPAITYLAAAGVGKLTIIDDDHVELSNLQRQPLFTDADV
GAPKAMVAADAAWRINPHVEAIAVAERLDEANAAALLAGASLILDGCDNFATRLAVNRAAVTLQIPLLSAAIGAFEGQVA
LYEGWRGESPCYACLVGNDPDRPGINCAEQGVMGALAGMVGTMAALETVRALSGWGTPLVGRLAIIDMLDRRWREVAVAK
EPECPICRG

Specific function: Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein moaD [H]

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hesA/moeB/thiF family [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=229, Percent_Identity=41.0480349344978, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI4885649, Length=147, Percent_Identity=31.2925170068027, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI38045948, Length=166, Percent_Identity=36.7469879518072, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI38045942, Length=218, Percent_Identity=27.9816513761468, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI38045944, Length=218, Percent_Identity=27.9816513761468, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1787048, Length=249, Percent_Identity=44.1767068273092, Blast_Score=205, Evalue=2e-54,
Organism=Escherichia coli, GI87082356, Length=249, Percent_Identity=42.9718875502008, Blast_Score=171, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI17540406, Length=241, Percent_Identity=38.1742738589212, Blast_Score=177, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI193203301, Length=153, Percent_Identity=32.6797385620915, Blast_Score=88, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6321903, Length=214, Percent_Identity=41.1214953271028, Blast_Score=157, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6320598, Length=180, Percent_Identity=27.2222222222222, Blast_Score=75, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6322639, Length=160, Percent_Identity=31.25, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6325323, Length=160, Percent_Identity=29.375, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24582879, Length=248, Percent_Identity=40.7258064516129, Blast_Score=179, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24660640, Length=157, Percent_Identity=36.3057324840764, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI28573937, Length=169, Percent_Identity=34.3195266272189, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI20129973, Length=113, Percent_Identity=38.9380530973451, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR012730
- InterPro:   IPR016040
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 25940; Mature: 25940

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNDAELDRYARQIILPAFGGTGQAKLKGSHVAIIGAGGIGCPAITYLAAAGVGKLTIID
CCCHHHHHHHHHHEEEECCCCCCCEEECCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEE
DDHVELSNLQRQPLFTDADVGAPKAMVAADAAWRINPHVEAIAVAERLDEANAAALLAGA
CCCCCHHHCCCCCCCCCCCCCCCCCEEECCCEEEECCCHHHHHHHHHHCCCCHHHHHHHH
SLILDGCDNFATRLAVNRAAVTLQIPLLSAAIGAFEGQVALYEGWRGESPCYACLVGNDP
HHEEHHHHHHHHHHHHCCEEEEEEEHHHHHHHHHCCCCEEEEECCCCCCCEEEEEECCCC
DRPGINCAEQGVMGALAGMVGTMAALETVRALSGWGTPLVGRLAIIDMLDRRWREVAVAK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCC
EPECPICRG
CCCCCCCCC
>Mature Secondary Structure
MLNDAELDRYARQIILPAFGGTGQAKLKGSHVAIIGAGGIGCPAITYLAAAGVGKLTIID
CCCHHHHHHHHHHEEEECCCCCCCEEECCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEE
DDHVELSNLQRQPLFTDADVGAPKAMVAADAAWRINPHVEAIAVAERLDEANAAALLAGA
CCCCCHHHCCCCCCCCCCCCCCCCCEEECCCEEEECCCHHHHHHHHHHCCCCHHHHHHHH
SLILDGCDNFATRLAVNRAAVTLQIPLLSAAIGAFEGQVALYEGWRGESPCYACLVGNDP
HHEEHHHHHHHHHHHHCCEEEEEEEHHHHHHHHHCCCCEEEEECCCCCCCEEEEEECCCC
DRPGINCAEQGVMGALAGMVGTMAALETVRALSGWGTPLVGRLAIIDMLDRRWREVAVAK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCC
EPECPICRG
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503 [H]