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The map label for this gene is fadA [H]

Identifier: 103488633

GI number: 103488633

Start: 3305804

End: 3306973

Strand: Reverse

Name: fadA [H]

Synonym: Sala_3158

Alternate gene names: 103488633

Gene position: 3306973-3305804 (Counterclockwise)

Preceding gene: 103488634

Following gene: 103488632

Centisome position: 98.86

GC content: 65.9

Gene sequence:

>1170_bases
ATGGCCACAGCCTATATCGTAGACGCCGTCCGTACCGCCGGTGGCAAGCGCGGCGGCAAGCTTGCCGGCGTCCACCCCGT
CGACCTCGGCGCCGCGGTGTTCGATGCGATCGCCGCCCGCAATGATTTCGACACGTCGAAGATCGACGACGTCATCACCG
GCTGCGTGTCGCAGGGCGGGCAGCAGACGATGGATCTGGGCCGCAACGCCGTCCTCGCCTCGAACCTGCCCGACTCGATT
CCGGCGGTGACGATCGACCGCCAGTGCGGATCGTCGCAGCAGGCGATGATGTTCGCGGCGCAGGCGGTGATGTCGGGGAC
GCAGGACATCGTGCTGGCAAGCGGCATCGAGAGCATGACGCGCGTGCCGATGGGCAGCGTCGCTACCTTGTTCATCAAGG
AAGGGCTCGGCCACTACAAGTCCGAGCGGCTGGAGGAAAAATATCCCGGTATCATGTTCAGCCAGTTCATGGGCGCCGAA
ATGATCGTCCAGAAGCATGGCTTCACCAAGGACGACCTCGACGCCTTTGCGCTCGAAAGCCACCGCCGCGCGAAGGCGGC
AACCGAAGCGGGCAAGTTCGAGCGCGAGATCGTGCCGATCGAAATCGAAACCCCCGAAGGCCGCGAGCTGCACAAGGTCG
ACGAGGGCATCCGCTTCGACGCGACGCTGGAGGGGATCGCCGGGGTGAAACTGCTCCAGGAAGGCGGCGCGATCACCGCC
GCGACGTCGAGCCAGATCTGCGACGGCGCATCGGCGGTGCTGATCGTCTCCGAACAGGCGTTGAAGGATCACGGCCTGAC
CCCCCGCGCGCGCATCCACCATGTCTCGGTAACGGCGGGCGACCCGGTGATCATGCTGGAAGAACCTTTGTTCGCGACCG
AAAAGGCGCTGAAGCGCGCGGGCATGACGATCGCGGACATCGACGCCTATGAGGTCAACGAGGCCTTTGCCCCGGTGCCG
CTCGCCTGGATGAAATATCTCGGCGCCGATCATGCGCGGCTCAACCAGCACGGCGGCGCGATCGCGCTCGGCCACCCGCT
CGGCGCCAGCGGCACCAAGCTGATGGCGACCCTGCTCGGCGTGCTCGACGCCACGGGGGGCAGATACGGCCTCCAGACGA
TGTGCGAAGGCGGCGGCCAGGCCAATGTCACGATCGTCGAGCGGCTTTGA

Upstream 100 bases:

>100_bases
GCCGTCGCCCCAGCGAAAGCTGGGGCCGCCATCGTCCGAAAACCATCGAGCGATCCCAGCTTTCGCTGGGATGACGAACA
GGAAACGAAAGGACTCCCAA

Downstream 100 bases:

>100_bases
TATCTTCATGTGCTCCTGCGAACGCAGGAGCCCAGGGTGGGATGGCGCCGACGCTGCGTTCTGACGCCCCGGGTTCCGGC
TTTCGCCGGAACGCGCAGCT

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta [H]

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MATAYIVDAVRTAGGKRGGKLAGVHPVDLGAAVFDAIAARNDFDTSKIDDVITGCVSQGGQQTMDLGRNAVLASNLPDSI
PAVTIDRQCGSSQQAMMFAAQAVMSGTQDIVLASGIESMTRVPMGSVATLFIKEGLGHYKSERLEEKYPGIMFSQFMGAE
MIVQKHGFTKDDLDAFALESHRRAKAATEAGKFEREIVPIEIETPEGRELHKVDEGIRFDATLEGIAGVKLLQEGGAITA
ATSSQICDGASAVLIVSEQALKDHGLTPRARIHHVSVTAGDPVIMLEEPLFATEKALKRAGMTIADIDAYEVNEAFAPVP
LAWMKYLGADHARLNQHGGAIALGHPLGASGTKLMATLLGVLDATGGRYGLQTMCEGGGQANVTIVERL

Sequences:

>Translated_389_residues
MATAYIVDAVRTAGGKRGGKLAGVHPVDLGAAVFDAIAARNDFDTSKIDDVITGCVSQGGQQTMDLGRNAVLASNLPDSI
PAVTIDRQCGSSQQAMMFAAQAVMSGTQDIVLASGIESMTRVPMGSVATLFIKEGLGHYKSERLEEKYPGIMFSQFMGAE
MIVQKHGFTKDDLDAFALESHRRAKAATEAGKFEREIVPIEIETPEGRELHKVDEGIRFDATLEGIAGVKLLQEGGAITA
ATSSQICDGASAVLIVSEQALKDHGLTPRARIHHVSVTAGDPVIMLEEPLFATEKALKRAGMTIADIDAYEVNEAFAPVP
LAWMKYLGADHARLNQHGGAIALGHPLGASGTKLMATLLGVLDATGGRYGLQTMCEGGGQANVTIVERL
>Mature_388_residues
ATAYIVDAVRTAGGKRGGKLAGVHPVDLGAAVFDAIAARNDFDTSKIDDVITGCVSQGGQQTMDLGRNAVLASNLPDSIP
AVTIDRQCGSSQQAMMFAAQAVMSGTQDIVLASGIESMTRVPMGSVATLFIKEGLGHYKSERLEEKYPGIMFSQFMGAEM
IVQKHGFTKDDLDAFALESHRRAKAATEAGKFEREIVPIEIETPEGRELHKVDEGIRFDATLEGIAGVKLLQEGGAITAA
TSSQICDGASAVLIVSEQALKDHGLTPRARIHHVSVTAGDPVIMLEEPLFATEKALKRAGMTIADIDAYEVNEAFAPVPL
AWMKYLGADHARLNQHGGAIALGHPLGASGTKLMATLLGVLDATGGRYGLQTMCEGGGQANVTIVERL

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=390, Percent_Identity=37.1794871794872, Blast_Score=232, Evalue=4e-61,
Organism=Homo sapiens, GI148539872, Length=388, Percent_Identity=35.3092783505155, Blast_Score=205, Evalue=7e-53,
Organism=Homo sapiens, GI4557237, Length=394, Percent_Identity=33.502538071066, Blast_Score=198, Evalue=6e-51,
Organism=Homo sapiens, GI4501853, Length=395, Percent_Identity=32.1518987341772, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI4504327, Length=426, Percent_Identity=30.9859154929577, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI194353979, Length=388, Percent_Identity=25.2577319587629, Blast_Score=108, Evalue=7e-24,
Organism=Escherichia coli, GI48994986, Length=397, Percent_Identity=39.2947103274559, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI1787663, Length=404, Percent_Identity=38.3663366336634, Blast_Score=246, Evalue=2e-66,
Organism=Escherichia coli, GI1788554, Length=394, Percent_Identity=38.0710659898477, Blast_Score=221, Evalue=6e-59,
Organism=Escherichia coli, GI87082165, Length=395, Percent_Identity=35.4430379746835, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI1788683, Length=413, Percent_Identity=28.8135593220339, Blast_Score=147, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI133906874, Length=392, Percent_Identity=37.7551020408163, Blast_Score=224, Evalue=8e-59,
Organism=Caenorhabditis elegans, GI25147385, Length=402, Percent_Identity=31.3432835820896, Blast_Score=194, Evalue=7e-50,
Organism=Caenorhabditis elegans, GI17535921, Length=395, Percent_Identity=31.6455696202532, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17551802, Length=427, Percent_Identity=28.1030444964871, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17535917, Length=391, Percent_Identity=28.6445012787724, Blast_Score=144, Evalue=8e-35,
Organism=Saccharomyces cerevisiae, GI6325229, Length=403, Percent_Identity=34.7394540942928, Blast_Score=208, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6322031, Length=340, Percent_Identity=33.8235294117647, Blast_Score=157, Evalue=3e-39,
Organism=Drosophila melanogaster, GI24655093, Length=392, Percent_Identity=36.2244897959184, Blast_Score=226, Evalue=2e-59,
Organism=Drosophila melanogaster, GI17648125, Length=391, Percent_Identity=34.5268542199489, Blast_Score=202, Evalue=4e-52,
Organism=Drosophila melanogaster, GI24640423, Length=401, Percent_Identity=33.4164588528678, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI17137578, Length=422, Percent_Identity=29.3838862559242, Blast_Score=165, Evalue=5e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012805
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 41058; Mature: 40927

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATAYIVDAVRTAGGKRGGKLAGVHPVDLGAAVFDAIAARNDFDTSKIDDVITGCVSQGG
CCHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCC
QQTMDLGRNAVLASNLPDSIPAVTIDRQCGSSQQAMMFAAQAVMSGTQDIVLASGIESMT
HHHHHHCCCEEEECCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEHHCHHHHH
RVPMGSVATLFIKEGLGHYKSERLEEKYPGIMFSQFMGAEMIVQKHGFTKDDLDAFALES
HCCCCHHHHHHHHHHHCHHHHHHHHHHCCCHHHHHHCCHHHHHHHCCCCHHHHHHHHHHH
HRRAKAATEAGKFEREIVPIEIETPEGRELHKVDEGIRFDATLEGIAGVKLLQEGGAITA
HHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHCCCEECCCHHHHHHHHHHHCCCCEEE
ATSSQICDGASAVLIVSEQALKDHGLTPRARIHHVSVTAGDPVIMLEEPLFATEKALKRA
ECCHHHCCCCCEEEEEEHHHHHHCCCCCCCEEEEEEEECCCCEEEECCCHHHHHHHHHHC
GMTIADIDAYEVNEAFAPVPLAWMKYLGADHARLNQHGGAIALGHPLGASGTKLMATLLG
CCEEEECCCHHCCCCCCCCHHHHHHHHCCCHHHHHCCCCEEEECCCCCCCHHHHHHHHHH
VLDATGGRYGLQTMCEGGGQANVTIVERL
HHHCCCCCCCHHHHHCCCCCCCEEEEECC
>Mature Secondary Structure 
ATAYIVDAVRTAGGKRGGKLAGVHPVDLGAAVFDAIAARNDFDTSKIDDVITGCVSQGG
CHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCC
QQTMDLGRNAVLASNLPDSIPAVTIDRQCGSSQQAMMFAAQAVMSGTQDIVLASGIESMT
HHHHHHCCCEEEECCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEHHCHHHHH
RVPMGSVATLFIKEGLGHYKSERLEEKYPGIMFSQFMGAEMIVQKHGFTKDDLDAFALES
HCCCCHHHHHHHHHHHCHHHHHHHHHHCCCHHHHHHCCHHHHHHHCCCCHHHHHHHHHHH
HRRAKAATEAGKFEREIVPIEIETPEGRELHKVDEGIRFDATLEGIAGVKLLQEGGAITA
HHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHCCCEECCCHHHHHHHHHHHCCCCEEE
ATSSQICDGASAVLIVSEQALKDHGLTPRARIHHVSVTAGDPVIMLEEPLFATEKALKRA
ECCHHHCCCCCEEEEEEHHHHHHCCCCCCCEEEEEEEECCCCEEEECCCHHHHHHHHHHC
GMTIADIDAYEVNEAFAPVPLAWMKYLGADHARLNQHGGAIALGHPLGASGTKLMATLLG
CCEEEECCCHHCCCCCCCCHHHHHHHHCCCHHHHHCCCCEEEECCCCCCCHHHHHHHHHH
VLDATGGRYGLQTMCEGGGQANVTIVERL
HHHCCCCCCCHHHHHCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA