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The map label for this gene is yxbG [H]

Identifier: 103488632

GI number: 103488632

Start: 3304899

End: 3305762

Strand: Reverse

Name: yxbG [H]

Synonym: Sala_3157

Alternate gene names: 103488632

Gene position: 3305762-3304899 (Counterclockwise)

Preceding gene: 103488633

Following gene: 103488631

Centisome position: 98.82

GC content: 65.05

Gene sequence:

>864_bases
ATGGCGCCGACGCTGCGTTCTGACGCCCCGGGTTCCGGCTTTCGCCGGAACGCGCAGCTATTTTATGGAAAGGATGTCCG
CATGAAACTTGATTCCACCGTATCCGCCGTCGTCACCGGCGGCGCCTCGGGCCTTGGCGCCGCGACCGCGCGCGCGCTCG
CGGCGAAGGGCGTGAAAGTCGCGATCTTCGACCTGCAGGAAGAAAAGGGCAAAGCCATCGCCGAAGAACTCGGCGGCATA
TTCTGCGAATGCAACGTCACCGATGACGCCAGCGTCGACGCCGCCTTTGAAAAGGCGCGCGCGGCGATCGGGCAGGAACG
CATCCTCGTCAATTGCGCGGGCACCGGCAATGCGATCAAGACCGCGAGCCGCAGCAAGGAAGACGGCAGCATCAAGCATT
TCCCGCTCGATGCCTTCAACTGGATCATCCAGATCAACCTCGTCGGCACCTTCCGCTGCATCGCCAAGTCGGCGGCGGGA
ATGCTGACGCTCGATCCGATGGCGGACGGCGAGCGCGGCGCGATCGTCAACACCGCATCGGTCGCGGCCGAGGACGGCCA
GATCGGTCAGGCGGCTTACTCCGCGTCGAAGGGCGGCGTTGTCGGCATGACGCTCCCCATCGCGCGCGACCTCGCGTCGG
AGAATATCCGCGTCAACACCATCCTTCCGGGCATCTTCGACACCCCGCTCCTCGCGGGCGCGCCGCAGAATGTCCGCGAT
GCGCTCGGCGCCTCGGTGCTCAATCCGAAGCGGCTGGGCGTGCCCGATGAATATGCCCATCTTGCGCTGTGCATGATCGA
AAATGGCTATTTCAACGGCGAGGACGTCCGCCTCGACGGCGGCATCCGCATGGGTCCGCGCTGA

Upstream 100 bases:

>100_bases
TCCAGACGATGTGCGAAGGCGGCGGCCAGGCCAATGTCACGATCGTCGAGCGGCTTTGATATCTTCATGTGCTCCTGCGA
ACGCAGGAGCCCAGGGTGGG

Downstream 100 bases:

>100_bases
CATGCCCAAACCGGAAAGCTGGCGGCTGAACCCCGCCAGCTACCCCGTCTGCGCCGAGTTCCAGACGCGCTTTCAGGACA
TGGACATCAACGGCCATCTC

Product: short-chain dehydrogenase/reductase SDR

Products: 3-oxoacyl-CoA; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MAPTLRSDAPGSGFRRNAQLFYGKDVRMKLDSTVSAVVTGGASGLGAATARALAAKGVKVAIFDLQEEKGKAIAEELGGI
FCECNVTDDASVDAAFEKARAAIGQERILVNCAGTGNAIKTASRSKEDGSIKHFPLDAFNWIIQINLVGTFRCIAKSAAG
MLTLDPMADGERGAIVNTASVAAEDGQIGQAAYSASKGGVVGMTLPIARDLASENIRVNTILPGIFDTPLLAGAPQNVRD
ALGASVLNPKRLGVPDEYAHLALCMIENGYFNGEDVRLDGGIRMGPR

Sequences:

>Translated_287_residues
MAPTLRSDAPGSGFRRNAQLFYGKDVRMKLDSTVSAVVTGGASGLGAATARALAAKGVKVAIFDLQEEKGKAIAEELGGI
FCECNVTDDASVDAAFEKARAAIGQERILVNCAGTGNAIKTASRSKEDGSIKHFPLDAFNWIIQINLVGTFRCIAKSAAG
MLTLDPMADGERGAIVNTASVAAEDGQIGQAAYSASKGGVVGMTLPIARDLASENIRVNTILPGIFDTPLLAGAPQNVRD
ALGASVLNPKRLGVPDEYAHLALCMIENGYFNGEDVRLDGGIRMGPR
>Mature_286_residues
APTLRSDAPGSGFRRNAQLFYGKDVRMKLDSTVSAVVTGGASGLGAATARALAAKGVKVAIFDLQEEKGKAIAEELGGIF
CECNVTDDASVDAAFEKARAAIGQERILVNCAGTGNAIKTASRSKEDGSIKHFPLDAFNWIIQINLVGTFRCIAKSAAGM
LTLDPMADGERGAIVNTASVAAEDGQIGQAAYSASKGGVVGMTLPIARDLASENIRVNTILPGIFDTPLLAGAPQNVRDA
LGASVLNPKRLGVPDEYAHLALCMIENGYFNGEDVRLDGGIRMGPR

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4758504, Length=253, Percent_Identity=49.4071146245059, Blast_Score=220, Evalue=1e-57,
Organism=Homo sapiens, GI83715985, Length=253, Percent_Identity=47.0355731225296, Blast_Score=202, Evalue=4e-52,
Organism=Homo sapiens, GI15277342, Length=264, Percent_Identity=30.6818181818182, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI40254992, Length=249, Percent_Identity=29.718875502008, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI31542939, Length=207, Percent_Identity=33.3333333333333, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI59889578, Length=244, Percent_Identity=28.2786885245902, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI5031737, Length=258, Percent_Identity=27.906976744186, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI33667109, Length=201, Percent_Identity=29.8507462686567, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI224922801, Length=178, Percent_Identity=33.7078651685393, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI19923817, Length=267, Percent_Identity=26.2172284644195, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787335, Length=254, Percent_Identity=34.251968503937, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1789057, Length=204, Percent_Identity=31.3725490196078, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI87082100, Length=262, Percent_Identity=30.9160305343511, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI1790717, Length=256, Percent_Identity=27.34375, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI2367175, Length=259, Percent_Identity=28.957528957529, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787905, Length=266, Percent_Identity=27.4436090225564, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1789208, Length=261, Percent_Identity=27.9693486590038, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1788459, Length=257, Percent_Identity=26.4591439688716, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1786812, Length=194, Percent_Identity=30.9278350515464, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI87082160, Length=259, Percent_Identity=27.7992277992278, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17538182, Length=249, Percent_Identity=50.2008032128514, Blast_Score=238, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI17555706, Length=269, Percent_Identity=31.2267657992565, Blast_Score=119, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI25147288, Length=258, Percent_Identity=29.8449612403101, Blast_Score=104, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17561272, Length=258, Percent_Identity=31.0077519379845, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17538480, Length=202, Percent_Identity=30.1980198019802, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17561402, Length=265, Percent_Identity=28.3018867924528, Blast_Score=64, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17563726, Length=271, Percent_Identity=25.4612546125461, Blast_Score=64, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17536025, Length=270, Percent_Identity=30.7407407407407, Blast_Score=64, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6320089, Length=238, Percent_Identity=27.3109243697479, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322861, Length=249, Percent_Identity=26.5060240963855, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17737361, Length=253, Percent_Identity=52.1739130434783, Blast_Score=241, Evalue=3e-64,
Organism=Drosophila melanogaster, GI24639444, Length=254, Percent_Identity=32.2834645669291, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI21355319, Length=255, Percent_Identity=27.4509803921569, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.35

Molecular weight: Translated: 29882; Mature: 29751

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPTLRSDAPGSGFRRNAQLFYGKDVRMKLDSTVSAVVTGGASGLGAATARALAAKGVKV
CCCCCCCCCCCCCCCCCCEEEECCCEEEEECCCEEEEEECCCCCCCHHHHHHHHHCCCEE
AIFDLQEEKGKAIAEELGGIFCECNVTDDASVDAAFEKARAAIGQERILVNCAGTGNAIK
EEEECCCHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCHHH
TASRSKEDGSIKHFPLDAFNWIIQINLVGTFRCIAKSAAGMLTLDPMADGERGAIVNTAS
HCCCCCCCCCEEECCCHHEEEEEEEEEEHHHHHHHHHCCCEEEECCCCCCCCCCEEEEHH
VAAEDGQIGQAAYSASKGGVVGMTLPIARDLASENIRVNTILPGIFDTPLLAGAPQNVRD
EECCCCCCCHHHHCCCCCCEEEEEHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCHHHH
ALGASVLNPKRLGVPDEYAHLALCMIENGYFNGEDVRLDGGIRMGPR
HHCHHHCCCCCCCCCCHHHEEEEEEEECCCCCCCEEEECCCEECCCC
>Mature Secondary Structure 
APTLRSDAPGSGFRRNAQLFYGKDVRMKLDSTVSAVVTGGASGLGAATARALAAKGVKV
CCCCCCCCCCCCCCCCCEEEECCCEEEEECCCEEEEEECCCCCCCHHHHHHHHHCCCEE
AIFDLQEEKGKAIAEELGGIFCECNVTDDASVDAAFEKARAAIGQERILVNCAGTGNAIK
EEEECCCHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCHHH
TASRSKEDGSIKHFPLDAFNWIIQINLVGTFRCIAKSAAGMLTLDPMADGERGAIVNTAS
HCCCCCCCCCEEECCCHHEEEEEEEEEEHHHHHHHHHCCCEEEECCCCCCCCCCEEEEHH
VAAEDGQIGQAAYSASKGGVVGMTLPIARDLASENIRVNTILPGIFDTPLLAGAPQNVRD
EECCCCCCCHHHHCCCCCCEEEEEHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCHHHH
ALGASVLNPKRLGVPDEYAHLALCMIENGYFNGEDVRLDGGIRMGPR
HHCHHHCCCCCCCCCCHHHEEEEEEEECCCCCCCEEEECCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-3-hydroxyacyl-CoA; NAD+

Specific reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584049; 9384377 [H]