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The map label for this gene is frmA [H]

Identifier: 103488549

GI number: 103488549

Start: 3223188

End: 3224279

Strand: Reverse

Name: frmA [H]

Synonym: Sala_3073

Alternate gene names: 103488549

Gene position: 3224279-3223188 (Counterclockwise)

Preceding gene: 103488550

Following gene: 103488548

Centisome position: 96.39

GC content: 66.58

Gene sequence:

>1092_bases
ATGACCAAAGCCGCGATCCTGATCGAACCGGGCAAGCCGCTCGTCATCGAGGATATCGTCGTCGACAAGCCCGGCCCGCA
TGAGGTGCGCATCCGCACCGCGGCGTGCGGCCTGTGCCATTCGGACCTGCATTTCATCGACGGCGCCTATCCGCATCCGC
TGCCCGCGATCCCCGGCCACGAAGCCGCGGGGATCGTCGAGGCGGTCGGCAGCGAGGTGCGCACGGTGAAGGTCGGCGAT
GCGGTCGTCACCTGCCTCAGCGCCTTTTGCGGCCACTGCGAGTTCTGCGTCACCGGGCGTATGTCGCTGTGCATGGGCGG
CGACACGCGGCGCCCCGCCGGATCGGCATCGCGGATCACGCGCCCCGACGGGTCGCCGGTGAACCAGATGCTCAATCTCA
GTGCCTTTTCGGAGGTGATGCTGGTCCACGAACATGCCTGCGTCGCGATCGATCCCGAAATGCCGCTCGATCGCGCGGCG
GTGATCGGCTGCGCGGTGACGACGGGTGCCGGGACAATCTTCAACGCATGCAAGGTCACGCCGGGCGAAACGGTCGCGGT
CGTCGGTTGCGGCGGCGTCGGTCTCGCCACCATCAACGCGGCGAAGATAGCGGGCGCCGGACGCATCATCGCCGCCGATC
CGATTCCCGAGAAGCGCGAACTCGCGAAGAAGCTGGGCGCCACCGACGTCGTCGATGCGCTGTCGGACGATGCCGCGAAG
CAGATCGTCGAAATCTCCAAAGGCGGCGTCGATCATGCGATCGAGGCGGTCGGGCGCCCCGCCTCGGCGAGCCTCGCGGT
CGCGTCGCTGCGGCGCGGCGGCACCGCGACGATCCTGGGCATGATGCCGCTCAACGAAAAGGTCGGGCTCGGCGCGATGG
ACCTGCTTTCGGGCAAGAAACTGCAGGGCGCGATCATGGGCGGCAACCGCTTCCCGGTCGACATCCCGCGACTCGTCGAT
TTCTACCTCCGCGGGCTGCTCGACCTCGATTCGATCATTGCCGAGACGATCCCGCTTGACCGCATCAACGAGGGATTCGA
CAAGATGAAGAAGGGCGACGCCGCACGATCGGTGATCGTATTCGACCAATGA

Upstream 100 bases:

>100_bases
CGCGGCCGACCCCGGTTTTTCGTCGGGCGACATCGGGGTTTCGCGGTAAACACGCCCCCCCCTTCCCGCTTGCGGGAGGG
GGAATGATACGGAGCTATAA

Downstream 100 bases:

>100_bases
TGGCGGGGCGCATCTCTTCGCCCTCCCCTTCAGGGGAGGGCAGCGAGACTTGCCAGCTTGCTGGCTTAGTCGCAGCGGGT
GGGGGCCATCGGCCTTGCGC

Product: zinc-binding alcohol dehydrogenase

Products: NA

Alternate protein names: Alcohol dehydrogenase class-3; Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH [H]

Number of amino acids: Translated: 363; Mature: 362

Protein sequence:

>363_residues
MTKAAILIEPGKPLVIEDIVVDKPGPHEVRIRTAACGLCHSDLHFIDGAYPHPLPAIPGHEAAGIVEAVGSEVRTVKVGD
AVVTCLSAFCGHCEFCVTGRMSLCMGGDTRRPAGSASRITRPDGSPVNQMLNLSAFSEVMLVHEHACVAIDPEMPLDRAA
VIGCAVTTGAGTIFNACKVTPGETVAVVGCGGVGLATINAAKIAGAGRIIAADPIPEKRELAKKLGATDVVDALSDDAAK
QIVEISKGGVDHAIEAVGRPASASLAVASLRRGGTATILGMMPLNEKVGLGAMDLLSGKKLQGAIMGGNRFPVDIPRLVD
FYLRGLLDLDSIIAETIPLDRINEGFDKMKKGDAARSVIVFDQ

Sequences:

>Translated_363_residues
MTKAAILIEPGKPLVIEDIVVDKPGPHEVRIRTAACGLCHSDLHFIDGAYPHPLPAIPGHEAAGIVEAVGSEVRTVKVGD
AVVTCLSAFCGHCEFCVTGRMSLCMGGDTRRPAGSASRITRPDGSPVNQMLNLSAFSEVMLVHEHACVAIDPEMPLDRAA
VIGCAVTTGAGTIFNACKVTPGETVAVVGCGGVGLATINAAKIAGAGRIIAADPIPEKRELAKKLGATDVVDALSDDAAK
QIVEISKGGVDHAIEAVGRPASASLAVASLRRGGTATILGMMPLNEKVGLGAMDLLSGKKLQGAIMGGNRFPVDIPRLVD
FYLRGLLDLDSIIAETIPLDRINEGFDKMKKGDAARSVIVFDQ
>Mature_362_residues
TKAAILIEPGKPLVIEDIVVDKPGPHEVRIRTAACGLCHSDLHFIDGAYPHPLPAIPGHEAAGIVEAVGSEVRTVKVGDA
VVTCLSAFCGHCEFCVTGRMSLCMGGDTRRPAGSASRITRPDGSPVNQMLNLSAFSEVMLVHEHACVAIDPEMPLDRAAV
IGCAVTTGAGTIFNACKVTPGETVAVVGCGGVGLATINAAKIAGAGRIIAADPIPEKRELAKKLGATDVVDALSDDAAKQ
IVEISKGGVDHAIEAVGRPASASLAVASLRRGGTATILGMMPLNEKVGLGAMDLLSGKKLQGAIMGGNRFPVDIPRLVDF
YLRGLLDLDSIIAETIPLDRINEGFDKMKKGDAARSVIVFDQ

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI34577061, Length=367, Percent_Identity=40.3269754768392, Blast_Score=261, Evalue=5e-70,
Organism=Homo sapiens, GI4501933, Length=367, Percent_Identity=39.7820163487738, Blast_Score=259, Evalue=3e-69,
Organism=Homo sapiens, GI4501929, Length=368, Percent_Identity=39.945652173913, Blast_Score=254, Evalue=6e-68,
Organism=Homo sapiens, GI71565152, Length=371, Percent_Identity=37.7358490566038, Blast_Score=231, Evalue=6e-61,
Organism=Homo sapiens, GI156523966, Length=368, Percent_Identity=36.4130434782609, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI71565154, Length=366, Percent_Identity=35.5191256830601, Blast_Score=219, Evalue=2e-57,
Organism=Homo sapiens, GI4501939, Length=359, Percent_Identity=37.0473537604457, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI71743840, Length=366, Percent_Identity=36.0655737704918, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI262073058, Length=366, Percent_Identity=36.0655737704918, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI156627571, Length=351, Percent_Identity=27.3504273504274, Blast_Score=101, Evalue=1e-21,
Organism=Escherichia coli, GI1786552, Length=369, Percent_Identity=36.3143631436314, Blast_Score=218, Evalue=6e-58,
Organism=Escherichia coli, GI1786518, Length=354, Percent_Identity=30.5084745762712, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1788073, Length=370, Percent_Identity=27.8378378378378, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1790045, Length=368, Percent_Identity=25.5434782608696, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI87082125, Length=282, Percent_Identity=29.7872340425532, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI1788075, Length=352, Percent_Identity=26.9886363636364, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI87081918, Length=339, Percent_Identity=29.2035398230088, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1787863, Length=354, Percent_Identity=26.271186440678, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1788407, Length=260, Percent_Identity=29.6153846153846, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1790718, Length=335, Percent_Identity=25.3731343283582, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI226510992, Length=366, Percent_Identity=23.4972677595628, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87082401, Length=369, Percent_Identity=23.5772357723577, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI25146526, Length=374, Percent_Identity=35.5614973262032, Blast_Score=222, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI71997431, Length=376, Percent_Identity=35.3723404255319, Blast_Score=218, Evalue=6e-57,
Organism=Caenorhabditis elegans, GI17565904, Length=337, Percent_Identity=34.4213649851632, Blast_Score=194, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI17562584, Length=366, Percent_Identity=27.5956284153005, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17562876, Length=366, Percent_Identity=28.4153005464481, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71988145, Length=365, Percent_Identity=25.7534246575342, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17562878, Length=358, Percent_Identity=25.1396648044693, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17562582, Length=375, Percent_Identity=26.1333333333333, Blast_Score=81, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6320033, Length=373, Percent_Identity=35.9249329758713, Blast_Score=238, Evalue=1e-63,
Organism=Saccharomyces cerevisiae, GI6319621, Length=369, Percent_Identity=30.6233062330623, Blast_Score=116, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6323729, Length=359, Percent_Identity=31.1977715877437, Blast_Score=116, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6323961, Length=369, Percent_Identity=30.6233062330623, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6324486, Length=369, Percent_Identity=29.2682926829268, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6319257, Length=346, Percent_Identity=27.7456647398844, Blast_Score=93, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6319258, Length=306, Percent_Identity=30.3921568627451, Blast_Score=84, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6322619, Length=359, Percent_Identity=27.2980501392758, Blast_Score=76, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6319955, Length=359, Percent_Identity=27.0194986072423, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6319949, Length=349, Percent_Identity=27.5071633237822, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17737895, Length=369, Percent_Identity=37.6693766937669, Blast_Score=239, Evalue=2e-63,
Organism=Drosophila melanogaster, GI17737897, Length=357, Percent_Identity=26.890756302521, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17137530, Length=276, Percent_Identity=30.4347826086957, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014183
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284; =1.1.1.1 [H]

Molecular weight: Translated: 37636; Mature: 37505

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKAAILIEPGKPLVIEDIVVDKPGPHEVRIRTAACGLCHSDLHFIDGAYPHPLPAIPGH
CCCEEEEECCCCCEEEEEEEECCCCCCEEEEEEHHHCCHHCCHHHHCCCCCCCCCCCCCC
EAAGIVEAVGSEVRTVKVGDAVVTCLSAFCGHCEFCVTGRMSLCMGGDTRRPAGSASRIT
CHHHHHHHCCCCEEEEEEHHHHHHHHHHHHCCCEEEECCCEEEEECCCCCCCCCCCCCCC
RPDGSPVNQMLNLSAFSEVMLVHEHACVAIDPEMPLDRAAVIGCAVTTGAGTIFNACKVT
CCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHEEEEEEECCCCHHHHHEECC
PGETVAVVGCGGVGLATINAAKIAGAGRIIAADPIPEKRELAKKLGATDVVDALSDDAAK
CCCEEEEEECCCCCEEEEEHHHCCCCCEEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHH
QIVEISKGGVDHAIEAVGRPASASLAVASLRRGGTATILGMMPLNEKVGLGAMDLLSGKK
HHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHCCCC
LQGAIMGGNRFPVDIPRLVDFYLRGLLDLDSIIAETIPLDRINEGFDKMKKGDAARSVIV
EEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEE
FDQ
ECC
>Mature Secondary Structure 
TKAAILIEPGKPLVIEDIVVDKPGPHEVRIRTAACGLCHSDLHFIDGAYPHPLPAIPGH
CCEEEEECCCCCEEEEEEEECCCCCCEEEEEEHHHCCHHCCHHHHCCCCCCCCCCCCCC
EAAGIVEAVGSEVRTVKVGDAVVTCLSAFCGHCEFCVTGRMSLCMGGDTRRPAGSASRIT
CHHHHHHHCCCCEEEEEEHHHHHHHHHHHHCCCEEEECCCEEEEECCCCCCCCCCCCCCC
RPDGSPVNQMLNLSAFSEVMLVHEHACVAIDPEMPLDRAAVIGCAVTTGAGTIFNACKVT
CCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHEEEEEEECCCCHHHHHEECC
PGETVAVVGCGGVGLATINAAKIAGAGRIIAADPIPEKRELAKKLGATDVVDALSDDAAK
CCCEEEEEECCCCCEEEEEHHHCCCCCEEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHH
QIVEISKGGVDHAIEAVGRPASASLAVASLRRGGTATILGMMPLNEKVGLGAMDLLSGKK
HHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHCCCC
LQGAIMGGNRFPVDIPRLVDFYLRGLLDLDSIIAETIPLDRINEGFDKMKKGDAARSVIV
EEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEE
FDQ
ECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]