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The map label for this gene is uxaC

Identifier: 103488522

GI number: 103488522

Start: 3196593

End: 3198005

Strand: Direct

Name: uxaC

Synonym: Sala_3046

Alternate gene names: 103488522

Gene position: 3196593-3198005 (Clockwise)

Preceding gene: 103488521

Following gene: 103488523

Centisome position: 95.56

GC content: 65.46

Gene sequence:

>1413_bases
GTGCCGCGTCCGCTGTACCTGTCACCCGACCGCCTCTTCCCGTCCGACCCGGCGCAGCGCGACATCGCGCGCCGGCTGTA
TAAGGCGGTCGCAGGTCTGCCGATCGTCAGCCCGCACGGCCACACCGATCCGGCATGGTTCGCGGGCGATGCGCCGTTCG
GCAATGCTGCGGAGCTGCTGCTCCATCCCGATCATTATGTGTTCCGCATGCTCTATTCGCAGGGGGTGTCGCTCGACGCG
CTCGGGATCGGCAACGCCGACGCCGACCCGCGCGAGAGCTGGCGGCTGTTCGCTGAAAACTACCATCTCTTCCGCGCCAC
CCCGTCACGGATGTGGATGGACTGGGTGTTCGCCGAGGTGTTTGGCTTCGACGTGCAATTATCGGCAGAGACGTCGGACC
TTTATTACGACCGCATCACCGAAGCACTGGCGATCGACGCCTTTCGCCCGCGCGCGCTGTTTGACCGCTTCGGGATCGAG
GTGATCGCGACGACCGAAAGCCCGCTCGACAGCCTCGACCATCACGCCGTCATCCGCGCCGCCAACGCCAGCGGCGAGTG
GGGCGGGCGCGTTATTACGGCCTATCGCCCCGATCCCGTGGTCGATCCCGAATTTGAAGGATTCCGCGACAATCTTGCGC
GTTTCTCCAACCTGTCGGGCGAGGATGCATTCAGCTATTCGGGCTATCTCGCGGCACATCGCAAGCGCCGCGCCTTCTTC
GCCAGCATGGGTGCGACCTCGACCGATCACGGGCACCCGAGCGCGGCGACCGCCGATCTGTCGGAGACGCAAGCCGAGGC
GCTGTTCGCGCGCGTTACGGGCGAGGATATGAGCGCCGCCGACGCCGAGCTGTTCCGCGCGCATATGCTGACGGTGATGG
CGGGGATGAGCCTCGACGACGGCCTCGTCATGCAGATCCACCCCGGCGCCTTCCGCAACCACAACCCCTGGTTGTTCGCG
AATCATGGCCGCGACAAGGGCGCCGACATCCCGACCGCAACCGATTATGTCCACGCGCTGCGCCCGCTGCTTGGGCGTTA
TGGCAATGAGGCGGATCTGACGATCATCCTCTTCACGCTCGACGAGACGAGCTATGCGCGCGAACTCGCGCCGCTCGCCG
GCCATTATCCGGCGCTGAAGCTGGGTCCGGCGTGGTGGTTCCACGACAGTCCCGAAGGGATGCGGCGCTTCCGGTCGCAG
ATGACCGAGACCGCGGGCTTCTACAACACCGTCGGTTTCAACGACGACACGCGCGCCTTCCTGTCGATCCCCGCGCGGCA
CGATGTCGCGCGGCGCATCGACTGCGGCTTTTTGGCCCAACTCGTTTCCGAGCACCGGCTCGAGGAATGGGAGGCCGCCG
AACTCGCGGCCGATCTCAGCTACAATCTCGCCAAGGCGTCCTACAAACTGTGA

Upstream 100 bases:

>100_bases
TTCGCCGCCTGCACCACCGTCTATTTCCTCGCGGTGCTCGCGGTGCATATCCTCAGCCCGCGCCTCGCGCCGGTCAGCGT
CGAAGGCGCGAAATAGGCCC

Downstream 100 bases:

>100_bases
GGCTTGGTCCCGACACGCCGCTCCCGGCCTCGGTGCAGGCGCCGGGCTACGACCGCGCCGCGCAGGCCGCCGGTATCGTT
CATATCGGCATCGGCGCCTT

Product: glucuronate isomerase

Products: NA

Alternate protein names: Glucuronate isomerase; Uronic isomerase

Number of amino acids: Translated: 470; Mature: 469

Protein sequence:

>470_residues
MPRPLYLSPDRLFPSDPAQRDIARRLYKAVAGLPIVSPHGHTDPAWFAGDAPFGNAAELLLHPDHYVFRMLYSQGVSLDA
LGIGNADADPRESWRLFAENYHLFRATPSRMWMDWVFAEVFGFDVQLSAETSDLYYDRITEALAIDAFRPRALFDRFGIE
VIATTESPLDSLDHHAVIRAANASGEWGGRVITAYRPDPVVDPEFEGFRDNLARFSNLSGEDAFSYSGYLAAHRKRRAFF
ASMGATSTDHGHPSAATADLSETQAEALFARVTGEDMSAADAELFRAHMLTVMAGMSLDDGLVMQIHPGAFRNHNPWLFA
NHGRDKGADIPTATDYVHALRPLLGRYGNEADLTIILFTLDETSYARELAPLAGHYPALKLGPAWWFHDSPEGMRRFRSQ
MTETAGFYNTVGFNDDTRAFLSIPARHDVARRIDCGFLAQLVSEHRLEEWEAAELAADLSYNLAKASYKL

Sequences:

>Translated_470_residues
MPRPLYLSPDRLFPSDPAQRDIARRLYKAVAGLPIVSPHGHTDPAWFAGDAPFGNAAELLLHPDHYVFRMLYSQGVSLDA
LGIGNADADPRESWRLFAENYHLFRATPSRMWMDWVFAEVFGFDVQLSAETSDLYYDRITEALAIDAFRPRALFDRFGIE
VIATTESPLDSLDHHAVIRAANASGEWGGRVITAYRPDPVVDPEFEGFRDNLARFSNLSGEDAFSYSGYLAAHRKRRAFF
ASMGATSTDHGHPSAATADLSETQAEALFARVTGEDMSAADAELFRAHMLTVMAGMSLDDGLVMQIHPGAFRNHNPWLFA
NHGRDKGADIPTATDYVHALRPLLGRYGNEADLTIILFTLDETSYARELAPLAGHYPALKLGPAWWFHDSPEGMRRFRSQ
MTETAGFYNTVGFNDDTRAFLSIPARHDVARRIDCGFLAQLVSEHRLEEWEAAELAADLSYNLAKASYKL
>Mature_469_residues
PRPLYLSPDRLFPSDPAQRDIARRLYKAVAGLPIVSPHGHTDPAWFAGDAPFGNAAELLLHPDHYVFRMLYSQGVSLDAL
GIGNADADPRESWRLFAENYHLFRATPSRMWMDWVFAEVFGFDVQLSAETSDLYYDRITEALAIDAFRPRALFDRFGIEV
IATTESPLDSLDHHAVIRAANASGEWGGRVITAYRPDPVVDPEFEGFRDNLARFSNLSGEDAFSYSGYLAAHRKRRAFFA
SMGATSTDHGHPSAATADLSETQAEALFARVTGEDMSAADAELFRAHMLTVMAGMSLDDGLVMQIHPGAFRNHNPWLFAN
HGRDKGADIPTATDYVHALRPLLGRYGNEADLTIILFTLDETSYARELAPLAGHYPALKLGPAWWFHDSPEGMRRFRSQM
TETAGFYNTVGFNDDTRAFLSIPARHDVARRIDCGFLAQLVSEHRLEEWEAAELAADLSYNLAKASYKL

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG1904

COG function: function code G; Glucuronate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uronate isomerase family

Homologues:

Organism=Escherichia coli, GI2367192, Length=450, Percent_Identity=29.3333333333333, Blast_Score=171, Evalue=9e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UXAC_SPHAL (Q1GNM2)

Other databases:

- EMBL:   CP000356
- RefSeq:   YP_618083.1
- ProteinModelPortal:   Q1GNM2
- SMR:   Q1GNM2
- GeneID:   4083054
- GenomeReviews:   CP000356_GR
- KEGG:   sal:Sala_3046
- NMPDR:   fig|317655.9.peg.2900
- HOGENOM:   HBG293306
- OMA:   AWAKTVP
- ProtClustDB:   PRK02925
- BioCyc:   SALA317655:SALA_3046-MONOMER
- BRENDA:   5.3.1.12
- HAMAP:   MF_00675
- InterPro:   IPR003766
- InterPro:   IPR023177
- Gene3D:   G3DSA:1.10.2020.10

Pfam domain/function: PF02614 UxaC

EC number: =5.3.1.12

Molecular weight: Translated: 52409; Mature: 52278

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRPLYLSPDRLFPSDPAQRDIARRLYKAVAGLPIVSPHGHTDPAWFAGDAPFGNAAELL
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEECCCCCCCCCEECCCCCCCCCEEEE
LHPDHYVFRMLYSQGVSLDALGIGNADADPRESWRLFAENYHLFRATPSRMWMDWVFAEV
ECCHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHCCEEEEEECHHHHHHHHHHHHH
FGFDVQLSAETSDLYYDRITEALAIDAFRPRALFDRFGIEVIATTESPLDSLDHHAVIRA
HCCCEEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHCCEEEEEECCCCHHHCCCCEEEEE
ANASGEWGGRVITAYRPDPVVDPEFEGFRDNLARFSNLSGEDAFSYSGYLAAHRKRRAFF
CCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
ASMGATSTDHGHPSAATADLSETQAEALFARVTGEDMSAADAELFRAHMLTVMAGMSLDD
HHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCC
GLVMQIHPGAFRNHNPWLFANHGRDKGADIPTATDYVHALRPLLGRYGNEADLTIILFTL
CEEEEECCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEE
DETSYARELAPLAGHYPALKLGPAWWFHDSPEGMRRFRSQMTETAGFYNTVGFNDDTRAF
CCHHHHHHHHHHHCCCCCEEECCEEEECCCHHHHHHHHHHHHHHCCCCEECCCCCCCCEE
LSIPARHDVARRIDCGFLAQLVSEHRLEEWEAAELAADLSYNLAKASYKL
EECCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PRPLYLSPDRLFPSDPAQRDIARRLYKAVAGLPIVSPHGHTDPAWFAGDAPFGNAAELL
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEECCCCCCCCCEECCCCCCCCCEEEE
LHPDHYVFRMLYSQGVSLDALGIGNADADPRESWRLFAENYHLFRATPSRMWMDWVFAEV
ECCHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHCCEEEEEECHHHHHHHHHHHHH
FGFDVQLSAETSDLYYDRITEALAIDAFRPRALFDRFGIEVIATTESPLDSLDHHAVIRA
HCCCEEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHCCEEEEEECCCCHHHCCCCEEEEE
ANASGEWGGRVITAYRPDPVVDPEFEGFRDNLARFSNLSGEDAFSYSGYLAAHRKRRAFF
CCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
ASMGATSTDHGHPSAATADLSETQAEALFARVTGEDMSAADAELFRAHMLTVMAGMSLDD
HHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCC
GLVMQIHPGAFRNHNPWLFANHGRDKGADIPTATDYVHALRPLLGRYGNEADLTIILFTL
CEEEEECCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEE
DETSYARELAPLAGHYPALKLGPAWWFHDSPEGMRRFRSQMTETAGFYNTVGFNDDTRAF
CCHHHHHHHHHHHCCCCCEEECCEEEECCCHHHHHHHHHHHHHHCCCCEECCCCCCCCEE
LSIPARHDVARRIDCGFLAQLVSEHRLEEWEAAELAADLSYNLAKASYKL
EECCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA