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The map label for this gene is uxuB [H]

Identifier: 103488523

GI number: 103488523

Start: 3198038

End: 3199330

Strand: Direct

Name: uxuB [H]

Synonym: Sala_3047

Alternate gene names: 103488523

Gene position: 3198038-3199330 (Clockwise)

Preceding gene: 103488522

Following gene: 103488525

Centisome position: 95.6

GC content: 69.61

Gene sequence:

>1293_bases
GTGCAGGCGCCGGGCTACGACCGCGCCGCGCAGGCCGCCGGTATCGTTCATATCGGCATCGGCGCCTTTCACCGCGCGCA
TCAGGCGGTTTACACCGACGACGCGATGGGCGCGGGCGACCGCGATTGGGGCATCATCGGTGTGTCGCTGCGCTCGGGCG
TTGTCGCGGCGCAGCTGGGTCCGCAGGACGGGCTCTATACCGTCAGCACGCGCAGCGCAGCGGGGAGCGCGCTGCGCCTG
ATCGGCTCGGTGCAGCGGGTGCTCGTCGCGGCAGACGTGCCGCAGGGGGTGGTCGATGCCATCGCGGCATCCACGACGCA
TATTGTCAGCTTCACAGTGACCGAAAAGGGCTATCTGCGCGCCGCCGACGGCACGCTCGACCTTGCGGCGGCCAACGGCA
CGTCGAGCCTCTATCGCTTCGTCGGCGCCGCGCTCGCCGCGCGCCAAGCGGCAGGACTGTCGGGGCTGACGCTGCTGAGC
TGCGACAATCTGGCGAATAACGGCGCCGTTCTGGGACGGCTGATGCGGCAGTATCTCGCCGCCGAGTATCCGGGTCTTGT
CGATTGGTTCGATGCGAATTGCACCTGTCCCGCGACGATGATCGACCGCATCGTCCCCGCCACCACCGACGCCGACCGCG
CGGCGGTCGAAGCCGCGCTCGGCGCGCGCGACGAGGGCGCCGTCGTCACCGAAGGCTTCAGCCAGTGGGTGATAGAGGAT
GATTTCGCGGGCCCGCGCCCGCGTTGGGAGGCGGCCGGGGTCGAACTCGTCGCCGATGTCGCGCCCTATGAGACCGCGAA
GCTCCGGATGCTCAACGGCGCGCATTCGGCGCTCGCCTATATCGGGCTGGGGCGCGGCCATGATTTTGTCCATCAGGCGA
TCGCCGATCCCGACATCTGCCCGGTGATCGAGCGGTTGATGCGCGCCGAGGCCGCGCCGACGATCGACGCGGCGCCGGGG
CAGGATCTCGCCGCCTACGCCAGTGCGCTGCTCGATCGCTTCGCCAATCCGGCGCTCCATCACCGGCTGACCCAGATCGC
GATGGACGGCAGCCAGAAGATCCCGCAGCGCTGGCTGGAGACGCTGGCGTGGCATCAGGCACGCGGTGCGCGGTGCCCGT
CGCTCGAAGCGGCCGTTGCGGCGTGGATCGCCTTTTTGCGGAGCGGTCAGCCGGTCGACGATCCGCTGGCGGACAGGTTG
CGCGAGGCGGCGGCGGGGCCCGATGCGATGGACCGACTCTTCGGCGAAGGCGGCCTGATCGCGTCGCAGTGGCAGCCCCG
CAATCGAGAATAA

Upstream 100 bases:

>100_bases
AATGGGAGGCCGCCGAACTCGCGGCCGATCTCAGCTACAATCTCGCCAAGGCGTCCTACAAACTGTGAGGCTTGGTCCCG
ACACGCCGCTCCCGGCCTCG

Downstream 100 bases:

>100_bases
TCCCGTCATTGCGAGCGAAGCGAAGCAATCTCCAGCTATCGGTCCGCGATGTCGATGGCTGGGGATTGCTTCGTCGCTAC
GCTCCTCGCAATGACGAAGG

Product: mannitol dehydrogenase-like protein

Products: NA

Alternate protein names: Fructuronate reductase [H]

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MQAPGYDRAAQAAGIVHIGIGAFHRAHQAVYTDDAMGAGDRDWGIIGVSLRSGVVAAQLGPQDGLYTVSTRSAAGSALRL
IGSVQRVLVAADVPQGVVDAIAASTTHIVSFTVTEKGYLRAADGTLDLAAANGTSSLYRFVGAALAARQAAGLSGLTLLS
CDNLANNGAVLGRLMRQYLAAEYPGLVDWFDANCTCPATMIDRIVPATTDADRAAVEAALGARDEGAVVTEGFSQWVIED
DFAGPRPRWEAAGVELVADVAPYETAKLRMLNGAHSALAYIGLGRGHDFVHQAIADPDICPVIERLMRAEAAPTIDAAPG
QDLAAYASALLDRFANPALHHRLTQIAMDGSQKIPQRWLETLAWHQARGARCPSLEAAVAAWIAFLRSGQPVDDPLADRL
REAAAGPDAMDRLFGEGGLIASQWQPRNRE

Sequences:

>Translated_430_residues
MQAPGYDRAAQAAGIVHIGIGAFHRAHQAVYTDDAMGAGDRDWGIIGVSLRSGVVAAQLGPQDGLYTVSTRSAAGSALRL
IGSVQRVLVAADVPQGVVDAIAASTTHIVSFTVTEKGYLRAADGTLDLAAANGTSSLYRFVGAALAARQAAGLSGLTLLS
CDNLANNGAVLGRLMRQYLAAEYPGLVDWFDANCTCPATMIDRIVPATTDADRAAVEAALGARDEGAVVTEGFSQWVIED
DFAGPRPRWEAAGVELVADVAPYETAKLRMLNGAHSALAYIGLGRGHDFVHQAIADPDICPVIERLMRAEAAPTIDAAPG
QDLAAYASALLDRFANPALHHRLTQIAMDGSQKIPQRWLETLAWHQARGARCPSLEAAVAAWIAFLRSGQPVDDPLADRL
REAAAGPDAMDRLFGEGGLIASQWQPRNRE
>Mature_430_residues
MQAPGYDRAAQAAGIVHIGIGAFHRAHQAVYTDDAMGAGDRDWGIIGVSLRSGVVAAQLGPQDGLYTVSTRSAAGSALRL
IGSVQRVLVAADVPQGVVDAIAASTTHIVSFTVTEKGYLRAADGTLDLAAANGTSSLYRFVGAALAARQAAGLSGLTLLS
CDNLANNGAVLGRLMRQYLAAEYPGLVDWFDANCTCPATMIDRIVPATTDADRAAVEAALGARDEGAVVTEGFSQWVIED
DFAGPRPRWEAAGVELVADVAPYETAKLRMLNGAHSALAYIGLGRGHDFVHQAIADPDICPVIERLMRAEAAPTIDAAPG
QDLAAYASALLDRFANPALHHRLTQIAMDGSQKIPQRWLETLAWHQARGARCPSLEAAVAAWIAFLRSGQPVDDPLADRL
REAAAGPDAMDRLFGEGGLIASQWQPRNRE

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family. UxuB subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790779, Length=448, Percent_Identity=39.9553571428571, Blast_Score=300, Evalue=1e-82,
Organism=Escherichia coli, GI1787823, Length=418, Percent_Identity=42.3444976076555, Blast_Score=296, Evalue=2e-81,
Organism=Escherichia coli, GI1788497, Length=431, Percent_Identity=40.3712296983759, Blast_Score=293, Evalue=2e-80,
Organism=Escherichia coli, GI48994885, Length=430, Percent_Identity=30.2325581395349, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1790028, Length=258, Percent_Identity=25.968992248062, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324401, Length=424, Percent_Identity=35.8490566037736, Blast_Score=278, Evalue=1e-75,
Organism=Saccharomyces cerevisiae, GI6320765, Length=424, Percent_Identity=35.8490566037736, Blast_Score=278, Evalue=1e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR023027
- InterPro:   IPR013131
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C [H]

EC number: =1.1.1.57 [H]

Molecular weight: Translated: 45320; Mature: 45320

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAPGYDRAAQAAGIVHIGIGAFHRAHQAVYTDDAMGAGDRDWGIIGVSLRSGVVAAQLG
CCCCCCCHHHHHCCEEEECHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEHHCCEEEEECC
PQDGLYTVSTRSAAGSALRLIGSVQRVLVAADVPQGVVDAIAASTTHIVSFTVTEKGYLR
CCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEEEEEEEECCCEEE
AADGTLDLAAANGTSSLYRFVGAALAARQAAGLSGLTLLSCDNLANNGAVLGRLMRQYLA
ECCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHH
AEYPGLVDWFDANCTCPATMIDRIVPATTDADRAAVEAALGARDEGAVVTEGFSQWVIED
HCCCCCEEECCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCEEECCCHHHEEEC
DFAGPRPRWEAAGVELVADVAPYETAKLRMLNGAHSALAYIGLGRGHDFVHQAIADPDIC
CCCCCCCCCHHCCHHHEECCCCCCHHHEEECCCHHHHHHHHCCCCCHHHHHHHHCCCCHH
PVIERLMRAEAAPTIDAAPGQDLAAYASALLDRFANPALHHRLTQIAMDGSQKIPQRWLE
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHH
TLAWHQARGARCPSLEAAVAAWIAFLRSGQPVDDPLADRLREAAAGPDAMDRLFGEGGLI
HHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCEE
ASQWQPRNRE
ECCCCCCCCC
>Mature Secondary Structure
MQAPGYDRAAQAAGIVHIGIGAFHRAHQAVYTDDAMGAGDRDWGIIGVSLRSGVVAAQLG
CCCCCCCHHHHHCCEEEECHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEHHCCEEEEECC
PQDGLYTVSTRSAAGSALRLIGSVQRVLVAADVPQGVVDAIAASTTHIVSFTVTEKGYLR
CCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEEEEEEEECCCEEE
AADGTLDLAAANGTSSLYRFVGAALAARQAAGLSGLTLLSCDNLANNGAVLGRLMRQYLA
ECCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHH
AEYPGLVDWFDANCTCPATMIDRIVPATTDADRAAVEAALGARDEGAVVTEGFSQWVIED
HCCCCCEEECCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCEEECCCHHHEEEC
DFAGPRPRWEAAGVELVADVAPYETAKLRMLNGAHSALAYIGLGRGHDFVHQAIADPDIC
CCCCCCCCCHHCCHHHEECCCCCCHHHEEECCCHHHHHHHHCCCCCHHHHHHHHCCCCHH
PVIERLMRAEAAPTIDAAPGQDLAAYASALLDRFANPALHHRLTQIAMDGSQKIPQRWLE
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHH
TLAWHQARGARCPSLEAAVAAWIAFLRSGQPVDDPLADRLREAAAGPDAMDRLFGEGGLI
HHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCEE
ASQWQPRNRE
ECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503 [H]