Click here to switch to the map view.

The map label for this gene is uvrD [H]

Identifier: 103488489

GI number: 103488489

Start: 3152830

End: 3155142

Strand: Reverse

Name: uvrD [H]

Synonym: Sala_3012

Alternate gene names: 103488489

Gene position: 3155142-3152830 (Counterclockwise)

Preceding gene: 103488491

Following gene: 103488488

Centisome position: 94.32

GC content: 66.45

Gene sequence:

>2313_bases
GTGCCCCATCCCCCCGCCTCGACGCCTGACCTCCCCCGCCCCGACCCTTCGGACCCGCCCTATCTGCACGGCCTGAACGG
GCCGCAGCGGCAGGCGGTCCTCACTACCGAAGGGCCGGTGCTGATGCTTGCCGGCGCCGGTACGGGCAAGACCGCCGCGC
TCACCGCGCGCCTCGCGCACATCATCGCCACGCGGCGGGCATGGCCGTCCGAAATCCTCGCCGTCACCTTCACCAACAAG
GCGGCGCGCGAGATGCGCGAGCGGATCGGGCGAATGATCGGCGACGCGGTCGAGGGGATGCCCTGGCTCGGCACCTTTCA
CAGCATTTGCGCCAGGATGCTGCGCCGTCATGCCGAACTGGTGGGCCTGCAAAGCAATTTCACCATCCTCGATACCGACG
ACCAGCTTCGCGTCCTCAAACAGCTGATTCAGGCCGAGGGGCTCGACGAGAAGCGCTGGCCGGCGCGCCAGCTCGCCGGG
CTGATCGACAAATGGAAAAACCGCGGCCTCACCCCCGCCGACCTCGATGCCGCCGACAAGGAGGCCTATGCCGACGGCAA
GGGGCAGCATTTCTATGCGCTCTATCAGGCACGGCTGAAAACGCTGAATGCCTGCGATTTCGGCGACCTCCTGCTGCACA
TGCTGGTGATCCTGAAGACGCACCGCGACGTGCTCGAACAATATCAGGCGCGTTTCAAATATATCCTCGTCGACGAGTAT
CAGGACACCAATGCCAGCCAGTATCTCTGGCTCCGCCTGCTCGCGCAAAGCCGCAAAAACATCTGCTGTGTCGGCGACGA
CGACCAGTCGATCTATTCGTGGCGCGGCGCCGAGGTCGCGAACATCCTGCGCTTCGAAAAGGATTTTCCCGGCGCGACGG
TGATCCGCCTCGAACAGAATTACCGCTCGACGCCGCAGATCCTGGCGGCCGCGTCGGCGCTCATCGCGCAGAACTCGGAC
CGGCTCGGCAAGACGCTGTGGACCGAGCTCGACGCGGGCGACAAGCTGCGCGTCGTCGGCGTGTGGGACGGGCCGGAGGA
AGCACGCCGGATCGGCGAAGAACTGGAAACGCTCCAGCATCGGGGCGTGAACCTCGACCGCACCGCCATTCTTGTCCGCG
CGCAGTTCCAGACGCGCGAGTTCGAGGACCGCTTCATCGCGATCGGCTTGCCCTACCGCATCGTCGGGGGTTTCCGCTTC
TATGAACGCGCCGAAATCCGCGACGCCCTCGCCTACCTTCGCCTCGTCCAGTCGAGCGCCGACGACCTCGCCTTCGAGCG
CATCGTCAACGTCCCCAAACGCGGGCTGGGCGACAAGGCGCTGCAACGCATCCACCAGTTCGCGCGGGCCGAGCGCGCGC
CGCTGTTCCACGCCGCCTCGCGGATCACCGAAACCGACGAACTGACCCCGCAGGCCCGCCGTCAGCTCGCCAGTTTCATC
GCCCAGATGCGGAATTGGCAGGCGAAGGTCGGCGAACTCTCGCACCCCGAGCTGACGCAGCTCATCCTCGACGAATCGGG
CTACACCGCGATGCTGCAGGCCGACCGCAGCGCCGAAGCCGCGGGGCGCCTCGAAAACCTCTCCGAACTCGTCCGGGCGA
TGGAAGAGTATGACTCGCTCGAAGCCTTCCTCGAGCATGTCAGCCTCGTCATGGACCGCGACAATGACGAGTCGGCCGAA
ACCGTCACGATCATGACGATCCACGCCGCCAAGGGGCTCGAGTTCGACCATGTCTTCCTTGCGGGGTGGGAGGATGGCGT
TTTCCCGTCGCAGCGCGCGATGGACGAAGGCGGCACCGCCAGCCTCGAAGAAGAACGGCGCCTCGCCTATGTCGCGATCA
CCCGCGCGCGCCGGCGCGCGAGCATCTATCACGCCGCGAACCGCCGCATCTATGGCCAGTGGATGAGCAGCATCCCCAGC
CGCTTCATCGCCGAAATCCCGCCCGACCATATCGAGATGGAAAACAGCTTCGGCGGCGGGCAGAGCCTGTGGCGCGCCAA
TTGGTCGGCGCAGGGCGATCCCTTCGCGCATGTCGCTGAACGCCAGCCATCGCGAACGATGACGCGCGGCCCCGCGTGGC
AGCGCGCGGTAGCGGCATCGAACACCGTCACCCGCGCTCCGGCGCCCTCCGAACGCGGCCCCGCCGCGTCGGTCGGCGCC
AAGCCGCGCGCCGACCTCGCGATCGGGCAGCGCGTGTTCCACGAGAAGTTCGGCTACGGCGAAATCATCGACATCGACGG
CAACAAGCTGGAGGTCGAGTTCGACCAGGCGGGATCGAAACGCGTGCTCGACAGTTTCGTCCGCGCCGCCTGA

Upstream 100 bases:

>100_bases
TCGCCCTCGCCCCCATGCTGGATCGGTTCAGCCGCGCCCGCGGGTCAGGCTGCCCGTCCCACACTGGACAGTCCGCGCGC
CGTTCCCTAATCGTTCGCGC

Downstream 100 bases:

>100_bases
ACGCGCGGGCCCTCTGCTTGCAAAGGCCGGGTGCCGCGTTATGGCAAGGGCGATGACGACACCAACGACATGGCTGGAAC
AGGCGCGCGACGCGCACCGC

Product: UvrD/REP helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 770; Mature: 769

Protein sequence:

>770_residues
MPHPPASTPDLPRPDPSDPPYLHGLNGPQRQAVLTTEGPVLMLAGAGTGKTAALTARLAHIIATRRAWPSEILAVTFTNK
AAREMRERIGRMIGDAVEGMPWLGTFHSICARMLRRHAELVGLQSNFTILDTDDQLRVLKQLIQAEGLDEKRWPARQLAG
LIDKWKNRGLTPADLDAADKEAYADGKGQHFYALYQARLKTLNACDFGDLLLHMLVILKTHRDVLEQYQARFKYILVDEY
QDTNASQYLWLRLLAQSRKNICCVGDDDQSIYSWRGAEVANILRFEKDFPGATVIRLEQNYRSTPQILAAASALIAQNSD
RLGKTLWTELDAGDKLRVVGVWDGPEEARRIGEELETLQHRGVNLDRTAILVRAQFQTREFEDRFIAIGLPYRIVGGFRF
YERAEIRDALAYLRLVQSSADDLAFERIVNVPKRGLGDKALQRIHQFARAERAPLFHAASRITETDELTPQARRQLASFI
AQMRNWQAKVGELSHPELTQLILDESGYTAMLQADRSAEAAGRLENLSELVRAMEEYDSLEAFLEHVSLVMDRDNDESAE
TVTIMTIHAAKGLEFDHVFLAGWEDGVFPSQRAMDEGGTASLEEERRLAYVAITRARRRASIYHAANRRIYGQWMSSIPS
RFIAEIPPDHIEMENSFGGGQSLWRANWSAQGDPFAHVAERQPSRTMTRGPAWQRAVAASNTVTRAPAPSERGPAASVGA
KPRADLAIGQRVFHEKFGYGEIIDIDGNKLEVEFDQAGSKRVLDSFVRAA

Sequences:

>Translated_770_residues
MPHPPASTPDLPRPDPSDPPYLHGLNGPQRQAVLTTEGPVLMLAGAGTGKTAALTARLAHIIATRRAWPSEILAVTFTNK
AAREMRERIGRMIGDAVEGMPWLGTFHSICARMLRRHAELVGLQSNFTILDTDDQLRVLKQLIQAEGLDEKRWPARQLAG
LIDKWKNRGLTPADLDAADKEAYADGKGQHFYALYQARLKTLNACDFGDLLLHMLVILKTHRDVLEQYQARFKYILVDEY
QDTNASQYLWLRLLAQSRKNICCVGDDDQSIYSWRGAEVANILRFEKDFPGATVIRLEQNYRSTPQILAAASALIAQNSD
RLGKTLWTELDAGDKLRVVGVWDGPEEARRIGEELETLQHRGVNLDRTAILVRAQFQTREFEDRFIAIGLPYRIVGGFRF
YERAEIRDALAYLRLVQSSADDLAFERIVNVPKRGLGDKALQRIHQFARAERAPLFHAASRITETDELTPQARRQLASFI
AQMRNWQAKVGELSHPELTQLILDESGYTAMLQADRSAEAAGRLENLSELVRAMEEYDSLEAFLEHVSLVMDRDNDESAE
TVTIMTIHAAKGLEFDHVFLAGWEDGVFPSQRAMDEGGTASLEEERRLAYVAITRARRRASIYHAANRRIYGQWMSSIPS
RFIAEIPPDHIEMENSFGGGQSLWRANWSAQGDPFAHVAERQPSRTMTRGPAWQRAVAASNTVTRAPAPSERGPAASVGA
KPRADLAIGQRVFHEKFGYGEIIDIDGNKLEVEFDQAGSKRVLDSFVRAA
>Mature_769_residues
PHPPASTPDLPRPDPSDPPYLHGLNGPQRQAVLTTEGPVLMLAGAGTGKTAALTARLAHIIATRRAWPSEILAVTFTNKA
AREMRERIGRMIGDAVEGMPWLGTFHSICARMLRRHAELVGLQSNFTILDTDDQLRVLKQLIQAEGLDEKRWPARQLAGL
IDKWKNRGLTPADLDAADKEAYADGKGQHFYALYQARLKTLNACDFGDLLLHMLVILKTHRDVLEQYQARFKYILVDEYQ
DTNASQYLWLRLLAQSRKNICCVGDDDQSIYSWRGAEVANILRFEKDFPGATVIRLEQNYRSTPQILAAASALIAQNSDR
LGKTLWTELDAGDKLRVVGVWDGPEEARRIGEELETLQHRGVNLDRTAILVRAQFQTREFEDRFIAIGLPYRIVGGFRFY
ERAEIRDALAYLRLVQSSADDLAFERIVNVPKRGLGDKALQRIHQFARAERAPLFHAASRITETDELTPQARRQLASFIA
QMRNWQAKVGELSHPELTQLILDESGYTAMLQADRSAEAAGRLENLSELVRAMEEYDSLEAFLEHVSLVMDRDNDESAET
VTIMTIHAAKGLEFDHVFLAGWEDGVFPSQRAMDEGGTASLEEERRLAYVAITRARRRASIYHAANRRIYGQWMSSIPSR
FIAEIPPDHIEMENSFGGGQSLWRANWSAQGDPFAHVAERQPSRTMTRGPAWQRAVAASNTVTRAPAPSERGPAASVGAK
PRADLAIGQRVFHEKFGYGEIIDIDGNKLEVEFDQAGSKRVLDSFVRAA

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=763, Percent_Identity=39.8427260812582, Blast_Score=513, Evalue=1e-146,
Organism=Escherichia coli, GI48994965, Length=648, Percent_Identity=38.7345679012346, Blast_Score=400, Evalue=1e-112,
Organism=Escherichia coli, GI1787196, Length=356, Percent_Identity=29.4943820224719, Blast_Score=109, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6322369, Length=727, Percent_Identity=28.8858321870702, Blast_Score=198, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6324477, Length=654, Percent_Identity=19.7247706422018, Blast_Score=91, Evalue=8e-19,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005751
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 86369; Mature: 86238

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHPPASTPDLPRPDPSDPPYLHGLNGPQRQAVLTTEGPVLMLAGAGTGKTAALTARLAH
CCCCCCCCCCCCCCCCCCCCEECCCCCCCCCEEEECCCCEEEEECCCCCCHHHHHHHHHH
IIATRRAWPSEILAVTFTNKAAREMRERIGRMIGDAVEGMPWLGTFHSICARMLRRHAEL
HHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
VGLQSNFTILDTDDQLRVLKQLIQAEGLDEKRWPARQLAGLIDKWKNRGLTPADLDAADK
EECCCCCEEECCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCH
EAYADGKGQHFYALYQARLKTLNACDFGDLLLHMLVILKTHRDVLEQYQARFKYILVDEY
HHCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECC
QDTNASQYLWLRLLAQSRKNICCVGDDDQSIYSWRGAEVANILRFEKDFPGATVIRLEQN
CCCCCHHHHHHHHHHHHCCCEEEECCCCCHHHHCCCHHHHHHHHHHCCCCCCEEEEEECC
YRSTPQILAAASALIAQNSDRLGKTLWTELDAGDKLRVVGVWDGPEEARRIGEELETLQH
CCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHH
RGVNLDRTAILVRAQFQTREFEDRFIAIGLPYRIVGGFRFYERAEIRDALAYLRLVQSSA
CCCCCCCEEEEEEEHHHCCCCCCCEEEEECCHHHHCCHHHHHHHHHHHHHHHHHHHHCCH
DDLAFERIVNVPKRGLGDKALQRIHQFARAERAPLFHAASRITETDELTPQARRQLASFI
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHH
AQMRNWQAKVGELSHPELTQLILDESGYTAMLQADRSAEAAGRLENLSELVRAMEEYDSL
HHHHHHHHHHCCCCCCHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
EAFLEHVSLVMDRDNDESAETVTIMTIHAAKGLEFDHVFLAGWEDGVFPSQRAMDEGGTA
HHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCEEEEECCCCCCCCCHHHHCCCCCC
SLEEERRLAYVAITRARRRASIYHAANRRIYGQWMSSIPSRFIAEIPPDHIEMENSFGGG
CCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCC
QSLWRANWSAQGDPFAHVAERQPSRTMTRGPAWQRAVAASNTVTRAPAPSERGPAASVGA
CHHHCCCCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHCCCEECCCCCCCCCCCCCCCC
KPRADLAIGQRVFHEKFGYGEIIDIDGNKLEVEFDQAGSKRVLDSFVRAA
CCCHHHHHHHHHHHHHCCCCCEEECCCCEEEEEECCCCCHHHHHHHHHCC
>Mature Secondary Structure 
PHPPASTPDLPRPDPSDPPYLHGLNGPQRQAVLTTEGPVLMLAGAGTGKTAALTARLAH
CCCCCCCCCCCCCCCCCCCEECCCCCCCCCEEEECCCCEEEEECCCCCCHHHHHHHHHH
IIATRRAWPSEILAVTFTNKAAREMRERIGRMIGDAVEGMPWLGTFHSICARMLRRHAEL
HHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
VGLQSNFTILDTDDQLRVLKQLIQAEGLDEKRWPARQLAGLIDKWKNRGLTPADLDAADK
EECCCCCEEECCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCH
EAYADGKGQHFYALYQARLKTLNACDFGDLLLHMLVILKTHRDVLEQYQARFKYILVDEY
HHCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECC
QDTNASQYLWLRLLAQSRKNICCVGDDDQSIYSWRGAEVANILRFEKDFPGATVIRLEQN
CCCCCHHHHHHHHHHHHCCCEEEECCCCCHHHHCCCHHHHHHHHHHCCCCCCEEEEEECC
YRSTPQILAAASALIAQNSDRLGKTLWTELDAGDKLRVVGVWDGPEEARRIGEELETLQH
CCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHH
RGVNLDRTAILVRAQFQTREFEDRFIAIGLPYRIVGGFRFYERAEIRDALAYLRLVQSSA
CCCCCCCEEEEEEEHHHCCCCCCCEEEEECCHHHHCCHHHHHHHHHHHHHHHHHHHHCCH
DDLAFERIVNVPKRGLGDKALQRIHQFARAERAPLFHAASRITETDELTPQARRQLASFI
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHH
AQMRNWQAKVGELSHPELTQLILDESGYTAMLQADRSAEAAGRLENLSELVRAMEEYDSL
HHHHHHHHHHCCCCCCHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
EAFLEHVSLVMDRDNDESAETVTIMTIHAAKGLEFDHVFLAGWEDGVFPSQRAMDEGGTA
HHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCEEEEECCCCCCCCCHHHHCCCCCC
SLEEERRLAYVAITRARRRASIYHAANRRIYGQWMSSIPSRFIAEIPPDHIEMENSFGGG
CCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCC
QSLWRANWSAQGDPFAHVAERQPSRTMTRGPAWQRAVAASNTVTRAPAPSERGPAASVGA
CHHHCCCCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHCCCEECCCCCCCCCCCCCCCC
KPRADLAIGQRVFHEKFGYGEIIDIDGNKLEVEFDQAGSKRVLDSFVRAA
CCCHHHHHHHHHHHHHCCCCCEEECCCCEEEEEECCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA