Click here to switch to the map view.

The map label for this gene is phbA [H]

Identifier: 103488373

GI number: 103488373

Start: 3047414

End: 3048628

Strand: Direct

Name: phbA [H]

Synonym: Sala_2896

Alternate gene names: 103488373

Gene position: 3047414-3048628 (Clockwise)

Preceding gene: 103488372

Following gene: 103488374

Centisome position: 91.1

GC content: 68.89

Gene sequence:

>1215_bases
ATGACCCTGCGCCGCGCCGCCATTGTCGCCCCGATCCGCACCGCCGTCGGCAAGTTCGGGGGCGCGCTGTCGTCGATGAG
TGCGGGCGCGCTCGGCGCGGTGATCCTGAAGGCGCTGATCGAGCGGACAAAGATCGACCCCGCGCGCGTCGACGACGTCG
TCTTTTCGCAGGGCTATGGCAATGGCGAGGCGCCGGCGATCGGCCACTGGTCGTGGCTCGCCGCGGGGCTGCCGCTCGAA
GTGCCGGGATATCAGCTCGACCGCCGTTGCGGGTCGGGGCTGCAGGCGGTCGTCAACGCCGCGATGATGGTCCAGACGGG
CATGGCCGATGTCGTCGTCGCGGGGGGCGTCGAATCGATGTCGAACGTCGAACATTACAGCATCGACATTCGCAAGGGCG
TGCGCGCGGGCAATCTGACGCTCCACGACCGGCTGACGCGCGGGCGGCTGATGTCGCAGCCCGTTGAGCGCTTCGGCGTG
ATCAGCGGCATGATCGAGACCGCCGAAAATCTGGCGAAGGATTATGGCATCAGCCGCGAGGCGGCCGACGCCTATGCGGT
GCGCAGCCACCAGCGCGCGGCGGCGGCGTGGGCGAAGGGGCTGTTCGACGACGAACTGGTACCGGTCGAAGTGCCGCAGA
AGAAGGGCGATCCGGTCATTTTCGCGCACGACGAGGGCTATCGCGCCGACGCGAGCCTGGAAACGCTCGGCAAGCTGCGC
GCGCTCGAGGGCGGCATCGTCACGGCGGGCAATGCCAGCCAGCAGAATGACGCCGCCGCGGCGTGCCTGGTGGTTGCCGA
GGACAAGCTCGATGAGCTCGGCCTGGAACCGATCGCCTGGTATCACAGCGCGGCGTCGGCGGGGTGCGATCCCAGCCGCA
TGGGCATCGGCCCGGTCCCCGCGGTCGAGCGGCTGTTCGCGCGCAGCGGGCTTGGCTGGGGCGACATCGACCTTGTCGAA
CTCAACGAGGCCTTTGCGCCGCAGGTGCTGGCGGTGCTCAAGGGCTGGGGTTGGGCGGACGACGACAGCCGCAACGAGAT
TCTCAATGTCAACGGATCGGGCATCTCGCTCGGCCATCCGATCGGCGCAACCGGCGGGCGCATCCTCGCCAATCTGACGC
GCGAGCTGGGACGTCGCAACGGGCGCTATGGGCTCGAGACGATGTGCATCGGCGGCGGGCAGGGAATCGCCGCGATCTTC
GAGCGCGCGGCCTGA

Upstream 100 bases:

>100_bases
GCGTCTCGACTTCGACCTTCGGTCGAAGTTTATCCTGAGCGCCTGCCAAGGCAGTCGAAGGGCTCGACGCGAACGGAAAA
GAAGAATTGGAGACTAAACC

Downstream 100 bases:

>100_bases
TGGGTTTGCGCTCCGCTCTCCAAGCGGCGCAGGCCTATCGCGACGCGGCGCAGGCGGCGCTTGCCGAACGGCTGGCGGCG
CGGCCGATCGACGAGGAACA

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MTLRRAAIVAPIRTAVGKFGGALSSMSAGALGAVILKALIERTKIDPARVDDVVFSQGYGNGEAPAIGHWSWLAAGLPLE
VPGYQLDRRCGSGLQAVVNAAMMVQTGMADVVVAGGVESMSNVEHYSIDIRKGVRAGNLTLHDRLTRGRLMSQPVERFGV
ISGMIETAENLAKDYGISREAADAYAVRSHQRAAAAWAKGLFDDELVPVEVPQKKGDPVIFAHDEGYRADASLETLGKLR
ALEGGIVTAGNASQQNDAAAACLVVAEDKLDELGLEPIAWYHSAASAGCDPSRMGIGPVPAVERLFARSGLGWGDIDLVE
LNEAFAPQVLAVLKGWGWADDDSRNEILNVNGSGISLGHPIGATGGRILANLTRELGRRNGRYGLETMCIGGGQGIAAIF
ERAA

Sequences:

>Translated_404_residues
MTLRRAAIVAPIRTAVGKFGGALSSMSAGALGAVILKALIERTKIDPARVDDVVFSQGYGNGEAPAIGHWSWLAAGLPLE
VPGYQLDRRCGSGLQAVVNAAMMVQTGMADVVVAGGVESMSNVEHYSIDIRKGVRAGNLTLHDRLTRGRLMSQPVERFGV
ISGMIETAENLAKDYGISREAADAYAVRSHQRAAAAWAKGLFDDELVPVEVPQKKGDPVIFAHDEGYRADASLETLGKLR
ALEGGIVTAGNASQQNDAAAACLVVAEDKLDELGLEPIAWYHSAASAGCDPSRMGIGPVPAVERLFARSGLGWGDIDLVE
LNEAFAPQVLAVLKGWGWADDDSRNEILNVNGSGISLGHPIGATGGRILANLTRELGRRNGRYGLETMCIGGGQGIAAIF
ERAA
>Mature_403_residues
TLRRAAIVAPIRTAVGKFGGALSSMSAGALGAVILKALIERTKIDPARVDDVVFSQGYGNGEAPAIGHWSWLAAGLPLEV
PGYQLDRRCGSGLQAVVNAAMMVQTGMADVVVAGGVESMSNVEHYSIDIRKGVRAGNLTLHDRLTRGRLMSQPVERFGVI
SGMIETAENLAKDYGISREAADAYAVRSHQRAAAAWAKGLFDDELVPVEVPQKKGDPVIFAHDEGYRADASLETLGKLRA
LEGGIVTAGNASQQNDAAAACLVVAEDKLDELGLEPIAWYHSAASAGCDPSRMGIGPVPAVERLFARSGLGWGDIDLVEL
NEAFAPQVLAVLKGWGWADDDSRNEILNVNGSGISLGHPIGATGGRILANLTRELGRRNGRYGLETMCIGGGQGIAAIFE
RAA

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=406, Percent_Identity=41.1330049261084, Blast_Score=266, Evalue=3e-71,
Organism=Homo sapiens, GI148539872, Length=402, Percent_Identity=37.0646766169154, Blast_Score=231, Evalue=9e-61,
Organism=Homo sapiens, GI4557237, Length=403, Percent_Identity=36.2282878411911, Blast_Score=219, Evalue=4e-57,
Organism=Homo sapiens, GI4501853, Length=397, Percent_Identity=35.5163727959698, Blast_Score=203, Evalue=3e-52,
Organism=Homo sapiens, GI4504327, Length=426, Percent_Identity=31.6901408450704, Blast_Score=172, Evalue=5e-43,
Organism=Homo sapiens, GI194353979, Length=391, Percent_Identity=24.2966751918159, Blast_Score=96, Evalue=8e-20,
Organism=Escherichia coli, GI87082165, Length=405, Percent_Identity=44.9382716049383, Blast_Score=285, Evalue=4e-78,
Organism=Escherichia coli, GI1788554, Length=406, Percent_Identity=45.0738916256158, Blast_Score=283, Evalue=9e-78,
Organism=Escherichia coli, GI1787663, Length=408, Percent_Identity=43.1372549019608, Blast_Score=277, Evalue=8e-76,
Organism=Escherichia coli, GI48994986, Length=413, Percent_Identity=38.2566585956416, Blast_Score=241, Evalue=6e-65,
Organism=Escherichia coli, GI1788683, Length=410, Percent_Identity=32.9268292682927, Blast_Score=187, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI133906874, Length=399, Percent_Identity=40.3508771929825, Blast_Score=260, Evalue=1e-69,
Organism=Caenorhabditis elegans, GI17535921, Length=405, Percent_Identity=32.8395061728395, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI25147385, Length=411, Percent_Identity=31.8734793187348, Blast_Score=196, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17551802, Length=421, Percent_Identity=29.2161520190024, Blast_Score=157, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI17535917, Length=396, Percent_Identity=26.2626262626263, Blast_Score=109, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6322031, Length=402, Percent_Identity=34.5771144278607, Blast_Score=197, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6325229, Length=407, Percent_Identity=33.9066339066339, Blast_Score=189, Evalue=6e-49,
Organism=Drosophila melanogaster, GI24655093, Length=397, Percent_Identity=42.8211586901763, Blast_Score=283, Evalue=1e-76,
Organism=Drosophila melanogaster, GI17648125, Length=399, Percent_Identity=38.0952380952381, Blast_Score=230, Evalue=1e-60,
Organism=Drosophila melanogaster, GI24640423, Length=401, Percent_Identity=34.9127182044888, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI17137578, Length=422, Percent_Identity=32.4644549763033, Blast_Score=174, Evalue=1e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 42491; Mature: 42360

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLRRAAIVAPIRTAVGKFGGALSSMSAGALGAVILKALIERTKIDPARVDDVVFSQGYG
CCCCHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCC
NGEAPAIGHWSWLAAGLPLEVPGYQLDRRCGSGLQAVVNAAMMVQTGMADVVVAGGVESM
CCCCCCCCCHHHHHCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHCCCHHEEEECCHHHH
SNVEHYSIDIRKGVRAGNLTLHDRLTRGRLMSQPVERFGVISGMIETAENLAKDYGISRE
HCCHHEEEEHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
AADAYAVRSHQRAAAAWAKGLFDDELVPVEVPQKKGDPVIFAHDEGYRADASLETLGKLR
HHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCEEEECCCCCCCCCHHHHHHHHH
ALEGGIVTAGNASQQNDAAAACLVVAEDKLDELGLEPIAWYHSAASAGCDPSRMGIGPVP
HHCCCEEECCCCCCCCCCCEEEEEEECCCHHHCCCCHHHHHHHHHHCCCCHHHCCCCCCH
AVERLFARSGLGWGDIDLVELNEAFAPQVLAVLKGWGWADDDSRNEILNVNGSGISLGHP
HHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCEECCCC
IGATGGRILANLTRELGRRNGRYGLETMCIGGGQGIAAIFERAA
CCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHCC
>Mature Secondary Structure 
TLRRAAIVAPIRTAVGKFGGALSSMSAGALGAVILKALIERTKIDPARVDDVVFSQGYG
CCCHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCC
NGEAPAIGHWSWLAAGLPLEVPGYQLDRRCGSGLQAVVNAAMMVQTGMADVVVAGGVESM
CCCCCCCCCHHHHHCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHCCCHHEEEECCHHHH
SNVEHYSIDIRKGVRAGNLTLHDRLTRGRLMSQPVERFGVISGMIETAENLAKDYGISRE
HCCHHEEEEHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
AADAYAVRSHQRAAAAWAKGLFDDELVPVEVPQKKGDPVIFAHDEGYRADASLETLGKLR
HHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCEEEECCCCCCCCCHHHHHHHHH
ALEGGIVTAGNASQQNDAAAACLVVAEDKLDELGLEPIAWYHSAASAGCDPSRMGIGPVP
HHCCCEEECCCCCCCCCCCEEEEEEECCCHHHCCCCHHHHHHHHHHCCCCHHHCCCCCCH
AVERLFARSGLGWGDIDLVELNEAFAPQVLAVLKGWGWADDDSRNEILNVNGSGISLGHP
HHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCEECCCC
IGATGGRILANLTRELGRRNGRYGLETMCIGGGQGIAAIFERAA
CCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7763384 [H]