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The map label for this gene is prs [H]

Identifier: 103487951

GI number: 103487951

Start: 2611327

End: 2612226

Strand: Reverse

Name: prs [H]

Synonym: Sala_2472

Alternate gene names: 103487951

Gene position: 2612226-2611327 (Counterclockwise)

Preceding gene: 103487952

Following gene: 103487950

Centisome position: 78.09

GC content: 64.89

Gene sequence:

>900_bases
ATGACCCCGCCGATGTTCCTGCCGCTGCCCGGTAACGGCAAGTTCGCGGTTGGACTCGCGGGCCTGCTCGGGGGCGAGGT
CGGACGGATCGAAACCCGCAGATTTCCGGACGGTGAGACCTATCTGCGGCTCCTTTCCGAGGTTGCCGGCCGCGACATCG
TGCTCGTCTGCACGCTGGATCGCCCCGATACCAAGCTGGTTTCGCTTCTTATCGCAGCCGACGCGGCCCGCGAGCTCGGC
GCCTTCAGCGTAGGGCTCGTAGCCCCATATCTTGCCTATATGCGCCAGGACCGGCGCTTTCAGAATGGCGAGGCAATCAG
CTCGCGCAGTTTCGCGCGCCGCATTTCGGGCGCCGTCGACTGGCTGGTCACGGCGGATCCCCATCTTCATCGATATGCCT
CGCTCGGCGACATCTATGATATTCGGGCCGAGGCCGTGCATGCCGCAGCGCCGATTTCCGACTGGATCAGAACCCATGTC
GAGCGGCCGCTCATCATCGGTCCCGACAGCGAAAGCGAACAATGGGCGAGCGCGATCGCACGCCGCGCCGGTGCCCCTCA
CGCCGTTTGCAGCAAGCTGAGATTGGGCGATCGCGACGTCAGGATCGCGCTACCCGATCTCTCGGCGCATACAGGGCGCA
CCCCGGTTCTGGTCGACGATATCGCGTCATCGGCCCGCACGCTGATCGAAGCGGCGCGGGGAATAGGAGAGGCTGGTTTT
CCGCCGCCCGAATGCGTCATCGTGCATCCGTTATTCGCTCGCGGCGCCTTCGCGGCACTGTCCGCCGAGGCGGGGCGTAT
CGTCAGTACCGATGCTGTCGCTCATTCCAGCAACGCCATCAGCCTGCAGCCGGTCGTCGCGGAAGGCGTGCAGCGCCTCC
TCGCTAAACCCGATCGATAA

Upstream 100 bases:

>100_bases
GAACGCCCCTCCTCACAGTGCACGCCGAAAGCCAGGGCGAACTGGCCTATGCGCTGGCCTATGCCGAGGCCGTTGGCCCC
ATTCTCGAGCTATCCGACCG

Downstream 100 bases:

>100_bases
AGCGGCCGATATCTAGGTATTTTCCGAAGTTGCGAACACTACGTATGTCGAGCTTGGACTCTGGACCCTAGTCCTGTTGC
CGAAGAACAGGATTCTTCGA

Product: phosphoribosylpyrophosphate synthetase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 299; Mature: 298

Protein sequence:

>299_residues
MTPPMFLPLPGNGKFAVGLAGLLGGEVGRIETRRFPDGETYLRLLSEVAGRDIVLVCTLDRPDTKLVSLLIAADAARELG
AFSVGLVAPYLAYMRQDRRFQNGEAISSRSFARRISGAVDWLVTADPHLHRYASLGDIYDIRAEAVHAAAPISDWIRTHV
ERPLIIGPDSESEQWASAIARRAGAPHAVCSKLRLGDRDVRIALPDLSAHTGRTPVLVDDIASSARTLIEAARGIGEAGF
PPPECVIVHPLFARGAFAALSAEAGRIVSTDAVAHSSNAISLQPVVAEGVQRLLAKPDR

Sequences:

>Translated_299_residues
MTPPMFLPLPGNGKFAVGLAGLLGGEVGRIETRRFPDGETYLRLLSEVAGRDIVLVCTLDRPDTKLVSLLIAADAARELG
AFSVGLVAPYLAYMRQDRRFQNGEAISSRSFARRISGAVDWLVTADPHLHRYASLGDIYDIRAEAVHAAAPISDWIRTHV
ERPLIIGPDSESEQWASAIARRAGAPHAVCSKLRLGDRDVRIALPDLSAHTGRTPVLVDDIASSARTLIEAARGIGEAGF
PPPECVIVHPLFARGAFAALSAEAGRIVSTDAVAHSSNAISLQPVVAEGVQRLLAKPDR
>Mature_298_residues
TPPMFLPLPGNGKFAVGLAGLLGGEVGRIETRRFPDGETYLRLLSEVAGRDIVLVCTLDRPDTKLVSLLIAADAARELGA
FSVGLVAPYLAYMRQDRRFQNGEAISSRSFARRISGAVDWLVTADPHLHRYASLGDIYDIRAEAVHAAAPISDWIRTHVE
RPLIIGPDSESEQWASAIARRAGAPHAVCSKLRLGDRDVRIALPDLSAHTGRTPVLVDDIASSARTLIEAARGIGEAGFP
PPECVIVHPLFARGAFAALSAEAGRIVSTDAVAHSSNAISLQPVVAEGVQRLLAKPDR

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI84875539, Length=292, Percent_Identity=26.027397260274, Blast_Score=88, Evalue=9e-18,
Organism=Homo sapiens, GI4506127, Length=289, Percent_Identity=26.643598615917, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI4506129, Length=289, Percent_Identity=25.6055363321799, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI28557709, Length=290, Percent_Identity=25.5172413793103, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI1787458, Length=307, Percent_Identity=26.3843648208469, Blast_Score=81, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI25149168, Length=281, Percent_Identity=24.1992882562278, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17554702, Length=284, Percent_Identity=24.2957746478873, Blast_Score=78, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17554704, Length=281, Percent_Identity=24.1992882562278, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI71989924, Length=284, Percent_Identity=24.2957746478873, Blast_Score=77, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6319403, Length=302, Percent_Identity=22.8476821192053, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6321776, Length=295, Percent_Identity=23.728813559322, Blast_Score=69, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6320946, Length=293, Percent_Identity=21.8430034129693, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21355239, Length=246, Percent_Identity=25.609756097561, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI45551540, Length=269, Percent_Identity=23.7918215613383, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 31984; Mature: 31853

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPPMFLPLPGNGKFAVGLAGLLGGEVGRIETRRFPDGETYLRLLSEVAGRDIVLVCTLD
CCCCCEEECCCCCCEEEEHHHHHCCCCCCEECCCCCCHHHHHHHHHHHCCCCEEEEEECC
RPDTKLVSLLIAADAARELGAFSVGLVAPYLAYMRQDRRFQNGEAISSRSFARRISGAVD
CCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHE
WLVTADPHLHRYASLGDIYDIRAEAVHAAAPISDWIRTHVERPLIIGPDSESEQWASAIA
EEEECCCHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHCCCCEEECCCCCHHHHHHHHH
RRAGAPHAVCSKLRLGDRDVRIALPDLSAHTGRTPVLVDDIASSARTLIEAARGIGEAGF
HHCCCCHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCC
PPPECVIVHPLFARGAFAALSAEAGRIVSTDAVAHSSNAISLQPVVAEGVQRLLAKPDR
CCCCEEEECCHHHCCHHHHHHCCCCCEEECHHHHCCCCCEEECHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TPPMFLPLPGNGKFAVGLAGLLGGEVGRIETRRFPDGETYLRLLSEVAGRDIVLVCTLD
CCCCEEECCCCCCEEEEHHHHHCCCCCCEECCCCCCHHHHHHHHHHHCCCCEEEEEECC
RPDTKLVSLLIAADAARELGAFSVGLVAPYLAYMRQDRRFQNGEAISSRSFARRISGAVD
CCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHE
WLVTADPHLHRYASLGDIYDIRAEAVHAAAPISDWIRTHVERPLIIGPDSESEQWASAIA
EEEECCCHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHCCCCEEECCCCCHHHHHHHHH
RRAGAPHAVCSKLRLGDRDVRIALPDLSAHTGRTPVLVDDIASSARTLIEAARGIGEAGF
HHCCCCHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCC
PPPECVIVHPLFARGAFAALSAEAGRIVSTDAVAHSSNAISLQPVVAEGVQRLLAKPDR
CCCCEEEECCHHHCCHHHHHHCCCCCEEECHHHHCCCCCEEECHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014 [H]