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The map label for this gene is deoA [C]

Identifier: 103487952

GI number: 103487952

Start: 2612223

End: 2613767

Strand: Reverse

Name: deoA [C]

Synonym: Sala_2473

Alternate gene names: 103487952

Gene position: 2613767-2612223 (Counterclockwise)

Preceding gene: 103487953

Following gene: 103487951

Centisome position: 78.14

GC content: 66.99

Gene sequence:

>1545_bases
ATGACCCACCCCGTCCCGGATACCGGACCCGCGTCGGAGAATATGGCACCCCATCGCCTCCGGGCTCGGCCCCTCGGCCT
GTTCCTGCCGCAGCAACAACCGGCCGTCGTCATGCGAACCGATTGCTACATATGCCGCTCGGAAGGTCTTGCGGCGCGCA
GTCAGGTGCTGATCCAGGCAGGGGGGCGGGAGATATTGGCCTCGCTCCTGCATTCGTCCGGCGAAATGATCGCGCCGGGG
GAGATCGGCCTTTCGGAATCGGCCGCCGCGGCGCTCGGGGTCGCGCCCGGCGATGCGGTCAGCGTGCGTCACGCACCGCC
GATCGATTCCTTCGGAGCATTACGCGGTCGCGTGTATGGAAATCGTCTCGATGGCGCGGCCTTTCGGTCGATCGTCGACG
ATATCGTTGCTGGCCGGTATAGCGACGTCCATCTGTCCGCCTTCGTAACGGCCTGCTCCGCCTTCCCTCTGGATCATGCG
GAAACGGTGGCGCTGACCGGTGCCATGGTCGCGTCCGGCGAGCGGCTGGCCTGGGGTTCGGACGTCGTCGTCGACAAGCA
CAGCGTGGGAGGCCTGCCCGGAAACCGGACCACCCCGATCGTGGTCGCGATTGTCGCCGCGCTGGGCCTCATCATGCCAA
AGACATCGTCCCGAGCGATCACCTCTCCGGCAGGCACGGCCGACACCATGGAAACGCTCGCGCCCGTGAATCTCGACGTC
GGCGCGATCCGACGTGTCGTCGACCACGAAGGCGGGTGCATCGTGTGGGGCGGCGCCGTCTCGCTCAGTCCGGCTGATGA
CATCATCATCGGTGTTGAGCGGGTGCTCGATCTCGATGCGGCGGGCCAACTGGTCGCCTCGGTCCTGTCCAAGAAGCTCG
CGGCGGGCGCAACGCACCTCGTCGTCGACATGCCGATCGGACCGACGGCAAAGGTACGCTCGCCCGCCGATGCTGCCGCA
CTTTCGGGGGCGCTTCAGAAGGTTGCAGCGGAGTTCGGCCTGATCCTCAAGGTGATGCAAGGCGATGGTCGCGAACCTAT
CGGTCGGGGAATCGGCCCTGCCCTCGAGGCGCGCGACATCCTGGCTGTGCTCGAGGGACGCGATCCGCCCCCTGATCTCG
CCCGCCGCGCCTGCGAATTGGCAGGCGCGCTCATCGAACTCGCGGGCCGCGCCAGCCCCGGCACCGGTGCGGCCCTGGCC
GCTCAAGTGCTGGCCGACGGGTCGGCTTGGAGCAAGTTCCAGCGAATCTGCGAGGCGCAGGGCGGCATGCGGACACCGCC
CCTGTCGAATCATCGTCATGTGATGACTGCGCAGAGGCCGGGACGCGTTTCGGCGATCGACAATCGCAGGCTCGCCAAAC
TCGCCAAACTTGCAGGCGCGCCAGCCGCGAAAAGTGCCGGCCTCGAAATGCACGTCCGGCTCGGCTCCGCGGTCGAAACA
GGAACGCCCCTCCTCACAGTGCACGCCGAAAGCCAGGGCGAACTGGCCTATGCGCTGGCCTATGCCGAGGCCGTTGGCCC
CATTCTCGAGCTATCCGACCGATGA

Upstream 100 bases:

>100_bases
ATGGTGAGCCCGATGCCGCGGCCGCTCTTGCGCGGCGCATCGGCGACGAGCTCGGCTGGCCGTGCCAGATACCCGGCCTT
GGTGATCGAGTGGTGCTCGA

Downstream 100 bases:

>100_bases
CCCCGCCGATGTTCCTGCCGCTGCCCGGTAACGGCAAGTTCGCGGTTGGACTCGCGGGCCTGCTCGGGGGCGAGGTCGGA
CGGATCGAAACCCGCAGATT

Product: thymidine phosphorylase

Products: NA

Alternate protein names: TdRPase

Number of amino acids: Translated: 514; Mature: 513

Protein sequence:

>514_residues
MTHPVPDTGPASENMAPHRLRARPLGLFLPQQQPAVVMRTDCYICRSEGLAARSQVLIQAGGREILASLLHSSGEMIAPG
EIGLSESAAAALGVAPGDAVSVRHAPPIDSFGALRGRVYGNRLDGAAFRSIVDDIVAGRYSDVHLSAFVTACSAFPLDHA
ETVALTGAMVASGERLAWGSDVVVDKHSVGGLPGNRTTPIVVAIVAALGLIMPKTSSRAITSPAGTADTMETLAPVNLDV
GAIRRVVDHEGGCIVWGGAVSLSPADDIIIGVERVLDLDAAGQLVASVLSKKLAAGATHLVVDMPIGPTAKVRSPADAAA
LSGALQKVAAEFGLILKVMQGDGREPIGRGIGPALEARDILAVLEGRDPPPDLARRACELAGALIELAGRASPGTGAALA
AQVLADGSAWSKFQRICEAQGGMRTPPLSNHRHVMTAQRPGRVSAIDNRRLAKLAKLAGAPAAKSAGLEMHVRLGSAVET
GTPLLTVHAESQGELAYALAYAEAVGPILELSDR

Sequences:

>Translated_514_residues
MTHPVPDTGPASENMAPHRLRARPLGLFLPQQQPAVVMRTDCYICRSEGLAARSQVLIQAGGREILASLLHSSGEMIAPG
EIGLSESAAAALGVAPGDAVSVRHAPPIDSFGALRGRVYGNRLDGAAFRSIVDDIVAGRYSDVHLSAFVTACSAFPLDHA
ETVALTGAMVASGERLAWGSDVVVDKHSVGGLPGNRTTPIVVAIVAALGLIMPKTSSRAITSPAGTADTMETLAPVNLDV
GAIRRVVDHEGGCIVWGGAVSLSPADDIIIGVERVLDLDAAGQLVASVLSKKLAAGATHLVVDMPIGPTAKVRSPADAAA
LSGALQKVAAEFGLILKVMQGDGREPIGRGIGPALEARDILAVLEGRDPPPDLARRACELAGALIELAGRASPGTGAALA
AQVLADGSAWSKFQRICEAQGGMRTPPLSNHRHVMTAQRPGRVSAIDNRRLAKLAKLAGAPAAKSAGLEMHVRLGSAVET
GTPLLTVHAESQGELAYALAYAEAVGPILELSDR
>Mature_513_residues
THPVPDTGPASENMAPHRLRARPLGLFLPQQQPAVVMRTDCYICRSEGLAARSQVLIQAGGREILASLLHSSGEMIAPGE
IGLSESAAAALGVAPGDAVSVRHAPPIDSFGALRGRVYGNRLDGAAFRSIVDDIVAGRYSDVHLSAFVTACSAFPLDHAE
TVALTGAMVASGERLAWGSDVVVDKHSVGGLPGNRTTPIVVAIVAALGLIMPKTSSRAITSPAGTADTMETLAPVNLDVG
AIRRVVDHEGGCIVWGGAVSLSPADDIIIGVERVLDLDAAGQLVASVLSKKLAAGATHLVVDMPIGPTAKVRSPADAAAL
SGALQKVAAEFGLILKVMQGDGREPIGRGIGPALEARDILAVLEGRDPPPDLARRACELAGALIELAGRASPGTGAALAA
QVLADGSAWSKFQRICEAQGGMRTPPLSNHRHVMTAQRPGRVSAIDNRRLAKLAKLAGAPAAKSAGLEMHVRLGSAVETG
TPLLTVHAESQGELAYALAYAEAVGPILELSDR

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI166158925, Length=431, Percent_Identity=31.7865429234339, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI4503445, Length=431, Percent_Identity=31.7865429234339, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI166158922, Length=431, Percent_Identity=31.7865429234339, Blast_Score=131, Evalue=1e-30,
Organism=Escherichia coli, GI1790842, Length=405, Percent_Identity=26.9135802469136, Blast_Score=97, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TYPH_SPHAL (Q1GQ92)

Other databases:

- EMBL:   CP000356
- RefSeq:   YP_617513.1
- GeneID:   4081311
- GenomeReviews:   CP000356_GR
- KEGG:   sal:Sala_2473
- NMPDR:   fig|317655.9.peg.2384
- HOGENOM:   HBG460532
- OMA:   ACADGRM
- ProtClustDB:   PRK04350
- BioCyc:   SALA317655:SALA_2473-MONOMER
- BRENDA:   2.4.2.4
- HAMAP:   MF_00703
- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR000053
- InterPro:   IPR017872
- InterPro:   IPR013466
- Gene3D:   G3DSA:1.20.970.10
- Gene3D:   G3DSA:3.40.1030.10
- PANTHER:   PTHR10515
- PIRSF:   PIRSF000478
- SMART:   SM00941
- TIGRFAMs:   TIGR02645

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C; SSF47648 Glyco_trans_3; SSF52418 Glyco_trans_3; SSF54680 PYNP_C

EC number: =2.4.2.4

Molecular weight: Translated: 52830; Mature: 52699

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHPVPDTGPASENMAPHRLRARPLGLFLPQQQPAVVMRTDCYICRSEGLAARSQVLIQA
CCCCCCCCCCCCCCCCCHHHHCCCCEEECCCCCCCEEEECCEEEECCCCCHHHHHHHHHC
GGREILASLLHSSGEMIAPGEIGLSESAAAALGVAPGDAVSVRHAPPIDSFGALRGRVYG
CCHHHHHHHHHCCCCEECCCCCCCCCHHHHHEECCCCCCEEECCCCCCCHHHHHHHHCCC
NRLDGAAFRSIVDDIVAGRYSDVHLSAFVTACSAFPLDHAETVALTGAMVASGERLAWGS
CCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEECCC
DVVVDKHSVGGLPGNRTTPIVVAIVAALGLIMPKTSSRAITSPAGTADTMETLAPVNLDV
CEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCCCCCH
GAIRRVVDHEGGCIVWGGAVSLSPADDIIIGVERVLDLDAAGQLVASVLSKKLAAGATHL
HHHHHHHHCCCCEEEECCEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEE
VVDMPIGPTAKVRSPADAAALSGALQKVAAEFGLILKVMQGDGREPIGRGIGPALEARDI
EEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCHHHHHHH
LAVLEGRDPPPDLARRACELAGALIELAGRASPGTGAALAAQVLADGSAWSKFQRICEAQ
HHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHC
GGMRTPPLSNHRHVMTAQRPGRVSAIDNRRLAKLAKLAGAPAAKSAGLEMHVRLGSAVET
CCCCCCCCCCCCEEEEECCCCCEECCCHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCC
GTPLLTVHAESQGELAYALAYAEAVGPILELSDR
CCCEEEEEECCCCCCHHHHHHHHHHCCHHHCCCC
>Mature Secondary Structure 
THPVPDTGPASENMAPHRLRARPLGLFLPQQQPAVVMRTDCYICRSEGLAARSQVLIQA
CCCCCCCCCCCCCCCCHHHHCCCCEEECCCCCCCEEEECCEEEECCCCCHHHHHHHHHC
GGREILASLLHSSGEMIAPGEIGLSESAAAALGVAPGDAVSVRHAPPIDSFGALRGRVYG
CCHHHHHHHHHCCCCEECCCCCCCCCHHHHHEECCCCCCEEECCCCCCCHHHHHHHHCCC
NRLDGAAFRSIVDDIVAGRYSDVHLSAFVTACSAFPLDHAETVALTGAMVASGERLAWGS
CCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEECCC
DVVVDKHSVGGLPGNRTTPIVVAIVAALGLIMPKTSSRAITSPAGTADTMETLAPVNLDV
CEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCCCCCH
GAIRRVVDHEGGCIVWGGAVSLSPADDIIIGVERVLDLDAAGQLVASVLSKKLAAGATHL
HHHHHHHHCCCCEEEECCEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEE
VVDMPIGPTAKVRSPADAAALSGALQKVAAEFGLILKVMQGDGREPIGRGIGPALEARDI
EEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCHHHHHHH
LAVLEGRDPPPDLARRACELAGALIELAGRASPGTGAALAAQVLADGSAWSKFQRICEAQ
HHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHC
GGMRTPPLSNHRHVMTAQRPGRVSAIDNRRLAKLAKLAGAPAAKSAGLEMHVRLGSAVET
CCCCCCCCCCCCEEEEECCCCCEECCCHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCC
GTPLLTVHAESQGELAYALAYAEAVGPILELSDR
CCCEEEEEECCCCCCHHHHHHHHHHCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA