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The map label for this gene is hutC [H]

Identifier: 103487888

GI number: 103487888

Start: 2542523

End: 2543323

Strand: Direct

Name: hutC [H]

Synonym: Sala_2408

Alternate gene names: 103487888

Gene position: 2542523-2543323 (Clockwise)

Preceding gene: 103487887

Following gene: 103487896

Centisome position: 76.01

GC content: 62.42

Gene sequence:

>801_bases
ATGGATGTTACCACTCGCACCCCCGGACGCGGATCAAAACTCTCGAATGGATCTGCGGCCGCCCGGCCCGGCAACTCCGA
TGACGAAAATGACAAGTCTCCGCCTCGCTATGCCGCCATCAAGCAGAGCATTTGCGATGCCGTTCGCGACGGACTTCTTA
AGCCGGGCGACCGGGTTCCATCGGAAGCAGAGCTAGTCCAACAATTCGACGTGTCACGGATGACCGCCAATCGGGCGCTT
CGCGAACTACAGGCGGCAGGCGTTCTTGTACGCCGCGCGGGTAGCGGATCGTTCATCGCCGAGCCCAAGCCGATCGGCCA
GATGATCGAAATTCGCAATATCGCCGAAGAGATCCGCGAGCGCGGTCACATCTATCGGGCCCGCGTCGTGCAGAATGACG
AGATACGCGCCAATGCGGACCTTGCGGCGCTACTGGAGGTTCCGGTCGGCACGAGGCTTTTCCACTCGATCATCGTTCAT
CACGAAGCCGAGTTCCCGATCCAGCTCGAGGAGCGTTTCGTGCTCGCGTCGGCGGCTCCCGATTATGGGAAGATCGACTT
CACCCAGATGACGCCGAACGAATATCTGACGCGGACGGCGCCGCTCGAGCGCGTCGAACATCGGGTTCGCGCCGAGATGC
CCGACGCGCACACCCACAGCATGCTGGGGCTCTCGGACGGCGAACCCGTGTTGCGGATGACGCGGCGGACGTGGAGCCAT
TCGCGCCTCGTCAGCCATGCCTGGCTGACGCATCCCGGATCGCGATTCGAGCTGTCGGCGGCCTTCTCGATCGACGATTG
A

Upstream 100 bases:

>100_bases
GCTGTATAATTCCTTCAATGCCACCATCAGCTTCTGAAACCGGCGCAGGTCGCAAACAGCATGCTTGGCTTCTGCGAGCA
GCAACCTGTATAGACGGGTT

Downstream 100 bases:

>100_bases
CGCCGCTCAGCTGGTGCGCGTGACGACCACCGGTTTGCGGCGCCGGCGCAGCCAGCGGAAATCGGCGCGGCTGAAGCTCT
TGAACAGCAGATAGAAGCCG

Product: histidine utilization repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 266; Mature: 266

Protein sequence:

>266_residues
MDVTTRTPGRGSKLSNGSAAARPGNSDDENDKSPPRYAAIKQSICDAVRDGLLKPGDRVPSEAELVQQFDVSRMTANRAL
RELQAAGVLVRRAGSGSFIAEPKPIGQMIEIRNIAEEIRERGHIYRARVVQNDEIRANADLAALLEVPVGTRLFHSIIVH
HEAEFPIQLEERFVLASAAPDYGKIDFTQMTPNEYLTRTAPLERVEHRVRAEMPDAHTHSMLGLSDGEPVLRMTRRTWSH
SRLVSHAWLTHPGSRFELSAAFSIDD

Sequences:

>Translated_266_residues
MDVTTRTPGRGSKLSNGSAAARPGNSDDENDKSPPRYAAIKQSICDAVRDGLLKPGDRVPSEAELVQQFDVSRMTANRAL
RELQAAGVLVRRAGSGSFIAEPKPIGQMIEIRNIAEEIRERGHIYRARVVQNDEIRANADLAALLEVPVGTRLFHSIIVH
HEAEFPIQLEERFVLASAAPDYGKIDFTQMTPNEYLTRTAPLERVEHRVRAEMPDAHTHSMLGLSDGEPVLRMTRRTWSH
SRLVSHAWLTHPGSRFELSAAFSIDD
>Mature_266_residues
MDVTTRTPGRGSKLSNGSAAARPGNSDDENDKSPPRYAAIKQSICDAVRDGLLKPGDRVPSEAELVQQFDVSRMTANRAL
RELQAAGVLVRRAGSGSFIAEPKPIGQMIEIRNIAEEIRERGHIYRARVVQNDEIRANADLAALLEVPVGTRLFHSIIVH
HEAEFPIQLEERFVLASAAPDYGKIDFTQMTPNEYLTRTAPLERVEHRVRAEMPDAHTHSMLGLSDGEPVLRMTRRTWSH
SRLVSHAWLTHPGSRFELSAAFSIDD

Specific function: Repressor which binds to the hutP region in the histidine utilization (hut) operon. It blocks the expression of all the hut genes in the absence of inducer [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082252, Length=204, Percent_Identity=25, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI1786950, Length=237, Percent_Identity=27.0042194092827, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788418, Length=198, Percent_Identity=27.7777777777778, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010248
- InterPro:   IPR000524
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 29590; Mature: 29590

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVTTRTPGRGSKLSNGSAAARPGNSDDENDKSPPRYAAIKQSICDAVRDGLLKPGDRVP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
SEAELVQQFDVSRMTANRALRELQAAGVLVRRAGSGSFIAEPKPIGQMIEIRNIAEEIRE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCHHHHHHHHHHHHHHHH
RGHIYRARVVQNDEIRANADLAALLEVPVGTRLFHSIIVHHEAEFPIQLEERFVLASAAP
CCCEEEEEEECCCCCCCCCCHHHHHHCCCCHHHHHHHHHHCCCCCCEEECCEEEEEECCC
DYGKIDFTQMTPNEYLTRTAPLERVEHRVRAEMPDAHTHSMLGLSDGEPVLRMTRRTWSH
CCCCEEEEEECCHHHHHHCCHHHHHHHHHHHCCCCCHHHHEECCCCCCHHHHHHHHHHHH
SRLVSHAWLTHPGSRFELSAAFSIDD
HHHHHHHHHCCCCCCEEEEEEEECCC
>Mature Secondary Structure
MDVTTRTPGRGSKLSNGSAAARPGNSDDENDKSPPRYAAIKQSICDAVRDGLLKPGDRVP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
SEAELVQQFDVSRMTANRALRELQAAGVLVRRAGSGSFIAEPKPIGQMIEIRNIAEEIRE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCHHHHHHHHHHHHHHHH
RGHIYRARVVQNDEIRANADLAALLEVPVGTRLFHSIIVHHEAEFPIQLEERFVLASAAP
CCCEEEEEEECCCCCCCCCCHHHHHHCCCCHHHHHHHHHHCCCCCCEEECCEEEEEECCC
DYGKIDFTQMTPNEYLTRTAPLERVEHRVRAEMPDAHTHSMLGLSDGEPVLRMTRRTWSH
CCCCEEEEEECCHHHHHHCCHHHHHHHHHHHCCCCCHHHHEECCCCCCHHHHHHHHHHHH
SRLVSHAWLTHPGSRFELSAAFSIDD
HHHHHHHHHCCCCCCEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2203754; 2834335 [H]