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The map label for this gene is lysR [H]

Identifier: 103487896

GI number: 103487896

Start: 2553069

End: 2553974

Strand: Direct

Name: lysR [H]

Synonym: Sala_2416

Alternate gene names: 103487896

Gene position: 2553069-2553974 (Clockwise)

Preceding gene: 103487888

Following gene: 103487898

Centisome position: 76.32

GC content: 65.12

Gene sequence:

>906_bases
ATGAACCTGCGTCACCTCGAAGCCTTCAGGGCCGTGATGCTCTCGGGATCGGTCACCCAGGCCGCGCAGTCGCTCAACCT
GTCGCAACCCGCGGTGAGCAAGATGCTTGCCGAGCTCGAGCATCAGCTGGGCTTTCAGCTCTTCCTGCGTTCGCGCGGCA
GCGCGCTCACCGTGACGCCCGAAGCCGACGCCTTTTTCTACGAAGTCGAGCGGAGCTTCTCCGGTATTGCGGCCCTGAAG
CGGGTAGCGGAAGACATCCGCAACATGGCGACCGGCACGCTCCGGATCGCCGCCCTCCCGGCGCTCGCGGTCAGTTTCCT
GCCGCGCGTGATCGCGGCCTTTCGCGAGACGCATCCCGGCGTCACCGTTCAGCTCCAGACCCGCAGTTCCTCGACGGTGC
GGCAATGGATGGCGAACCAGCAGTTCGACATCGGGCTCGCGACGCCGGCGCGCGAATTGCCCGGCATAAGGATGGAGCGC
TTCCTGCGCTGCCCCGGCGCCTGCGTTCTCCCTGCCGGCCACCGCTTGGCCGTCAAGGACGTCATCCGGCCGGCCGATCT
CGAGGGCGAGCCCTTCATTTCGCTCGCGCTCGAGGACGGCGTGCGTCACCGCATCGACCGCATTTTCGAGGACGCGGGCG
TCCACCGCGAGATGGTCATCGAAACCCAATATGCGATGACCATCTGCGCGCTTGTCATGCAGGGGGTCGGATGTTCGATT
CTCAACCCCGTGACCGCAGCGGATTATGCCGAGCGGGGCCTTACGGTCCGTGATTTCGCGCCGGAGGTCCATTTCGAATA
TATGCTCTTCACGCCGAAGTTGAGGCCGATGTCCCAAGTCGCTGCGGCCTTTATCGCGGTGCTCGAATCCCACCGCGACG
CGATGTTCGGCTCCGACGCCAGCTGA

Upstream 100 bases:

>100_bases
GAGCAGCGCCGGTAACCAGCGGCGCGATGCGTGCGACCTATTCATAAACGAGGCTTTCAATGCTAGCGCCATAAGAAATA
GCTATAGGGAGCGATGTCCG

Downstream 100 bases:

>100_bases
AGACACAAGACGCCGCACGGCCCTCACGGCCACCGATCAGAAGGAGGCGGTCGCGCGGACGTACCAGAAGCCCCCGTTGA
ACCCCGTCGGCGCGAAGCGG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MNLRHLEAFRAVMLSGSVTQAAQSLNLSQPAVSKMLAELEHQLGFQLFLRSRGSALTVTPEADAFFYEVERSFSGIAALK
RVAEDIRNMATGTLRIAALPALAVSFLPRVIAAFRETHPGVTVQLQTRSSSTVRQWMANQQFDIGLATPARELPGIRMER
FLRCPGACVLPAGHRLAVKDVIRPADLEGEPFISLALEDGVRHRIDRIFEDAGVHREMVIETQYAMTICALVMQGVGCSI
LNPVTAADYAERGLTVRDFAPEVHFEYMLFTPKLRPMSQVAAAFIAVLESHRDAMFGSDAS

Sequences:

>Translated_301_residues
MNLRHLEAFRAVMLSGSVTQAAQSLNLSQPAVSKMLAELEHQLGFQLFLRSRGSALTVTPEADAFFYEVERSFSGIAALK
RVAEDIRNMATGTLRIAALPALAVSFLPRVIAAFRETHPGVTVQLQTRSSSTVRQWMANQQFDIGLATPARELPGIRMER
FLRCPGACVLPAGHRLAVKDVIRPADLEGEPFISLALEDGVRHRIDRIFEDAGVHREMVIETQYAMTICALVMQGVGCSI
LNPVTAADYAERGLTVRDFAPEVHFEYMLFTPKLRPMSQVAAAFIAVLESHRDAMFGSDAS
>Mature_301_residues
MNLRHLEAFRAVMLSGSVTQAAQSLNLSQPAVSKMLAELEHQLGFQLFLRSRGSALTVTPEADAFFYEVERSFSGIAALK
RVAEDIRNMATGTLRIAALPALAVSFLPRVIAAFRETHPGVTVQLQTRSSSTVRQWMANQQFDIGLATPARELPGIRMER
FLRCPGACVLPAGHRLAVKDVIRPADLEGEPFISLALEDGVRHRIDRIFEDAGVHREMVIETQYAMTICALVMQGVGCSI
LNPVTAADYAERGLTVRDFAPEVHFEYMLFTPKLRPMSQVAAAFIAVLESHRDAMFGSDAS

Specific function: This protein activates the transcription of the lysA gene encoding diaminopimelate decarboxylase. LysR is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789204, Length=290, Percent_Identity=40.6896551724138, Blast_Score=217, Evalue=8e-58,
Organism=Escherichia coli, GI157672245, Length=258, Percent_Identity=30.2325581395349, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI87081904, Length=147, Percent_Identity=34.6938775510204, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1788296, Length=246, Percent_Identity=28.8617886178862, Blast_Score=81, Evalue=9e-17,
Organism=Escherichia coli, GI1787530, Length=242, Percent_Identity=28.099173553719, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788887, Length=198, Percent_Identity=31.3131313131313, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1788748, Length=296, Percent_Identity=25, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI1788481, Length=253, Percent_Identity=29.2490118577075, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI145693105, Length=245, Percent_Identity=24.4897959183673, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1788297, Length=260, Percent_Identity=25, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1789173, Length=264, Percent_Identity=26.8939393939394, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787879, Length=246, Percent_Identity=29.6747967479675, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787601, Length=128, Percent_Identity=32.8125, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1789506, Length=271, Percent_Identity=23.2472324723247, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1786401, Length=121, Percent_Identity=34.7107438016529, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33129; Mature: 33129

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLRHLEAFRAVMLSGSVTQAAQSLNLSQPAVSKMLAELEHQLGFQLFLRSRGSALTVTP
CCCHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECC
EADAFFYEVERSFSGIAALKRVAEDIRNMATGTLRIAALPALAVSFLPRVIAAFRETHPG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VTVQLQTRSSSTVRQWMANQQFDIGLATPARELPGIRMERFLRCPGACVLPAGHRLAVKD
EEEEEECCCHHHHHHHHCCCCCCEEECCCHHHCCCHHHHHHHCCCCCEECCCCCEEEHHH
VIRPADLEGEPFISLALEDGVRHRIDRIFEDAGVHREMVIETQYAMTICALVMQGVGCSI
HCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHH
LNPVTAADYAERGLTVRDFAPEVHFEYMLFTPKLRPMSQVAAAFIAVLESHRDAMFGSDA
HCCHHHHHHHHHCCCHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
S
C
>Mature Secondary Structure
MNLRHLEAFRAVMLSGSVTQAAQSLNLSQPAVSKMLAELEHQLGFQLFLRSRGSALTVTP
CCCHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECC
EADAFFYEVERSFSGIAALKRVAEDIRNMATGTLRIAALPALAVSFLPRVIAAFRETHPG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VTVQLQTRSSSTVRQWMANQQFDIGLATPARELPGIRMERFLRCPGACVLPAGHRLAVKD
EEEEEECCCHHHHHHHHCCCCCCEEECCCHHHCCCHHHHHHHCCCCCEECCCCCEEEHHH
VIRPADLEGEPFISLALEDGVRHRIDRIFEDAGVHREMVIETQYAMTICALVMQGVGCSI
HCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHH
LNPVTAADYAERGLTVRDFAPEVHFEYMLFTPKLRPMSQVAAAFIAVLESHRDAMFGSDA
HCCHHHHHHHHHCCCHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
S
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6350602; 9278503; 2836407 [H]