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The map label for this gene is nat [H]

Identifier: 103487854

GI number: 103487854

Start: 2496139

End: 2497017

Strand: Reverse

Name: nat [H]

Synonym: Sala_2373

Alternate gene names: 103487854

Gene position: 2497017-2496139 (Counterclockwise)

Preceding gene: 103487855

Following gene: 103487853

Centisome position: 74.65

GC content: 70.31

Gene sequence:

>879_bases
ATGCTGCACCAACCCACCGCCGCGCCGCCCGATACCGATCAGGCCGGGGCCGAAACGGCCGCCGAAGCCTTCCTGCCGCG
CTATCTGGCGCGGATCGGCTATCGCGGCGCGCTTGTGCCGACGCTCGACGTGCTCGCGGCATTGCAGGCAGCGCATATCG
CCGCGATTCCGTTCGAGGCGATCGACGCGCTGACCGGCGCCGGGGTCGACATCGGCGCGGCGGCGGTCGAGGCCAAGTTG
ATCGGCCAGCGGCGCGGCGGTTATTGTTTCGAGCAGAATGGCCTTTTCCTGCGCGCCCTTCGCGTGATCGGCTTCGACGC
CGAAGGGCTGATCGGCCGGGTGCGCTGGATGCTGCCCGACGATGCGCCGCCGACGCCGCGCTCGCACATGGTGCTGCGCG
TGCGGATCGACGGTCGCGCCTGGCTGGCCGACGTCGGTTTTGGCGCCGCGGTGCCGCCGCAGCCGCTGGCGATGGACGAT
GAGACTCCGCAGCCGACGCGCCACGAAAGCTATCGCATCGTTCGCCAAGGCGCCGAATGGCAGGTCGCGGCGCTGGTCGA
GAGCGAGTGGCGGACGCTCTACCGGATCGAGGACGCGCCCCCGCCGACGATCGATTATGAGGTCGGCAACTGGTACACGT
CGGCGCATCCCGATTCGCATTTCCGCCACCAGCTGATCGCCGCGCGCACGACCGCCGAAGCGCGTTACGGGCTGCGCGAC
AACCGGCTGACGACGCGGCTTGCCGACGGGCGCATCGACCGCCGTTACCTGACCGCCGACGAGATCGAGCGCGTGCTGGC
GGAGATTTTCCTGCTGCCCGTCGCGCGCCACTGGCGCCCGGCGATCGAGCGTGCCGCGACCGCCGAAATCGCGGGATAG

Upstream 100 bases:

>100_bases
CTCCGGTCGGCGGTCGATTCGGCGTCGTTCAATTCGTTTGACCTCCACTGCACTTGAGCTTTCATAAGGCGCTCCATCGA
TTCGCAATGGAGACCCGATC

Downstream 100 bases:

>100_bases
CGGCGGCAAATTATGTTATTCCCTGTGCGGGAGGGGCTATCATGCAACAGATGAATCCGCCGCTTGTGCGGCCGGCAACG
CGCCCGGTGCGTTCATGGGT

Product: arylamine N-acetyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MLHQPTAAPPDTDQAGAETAAEAFLPRYLARIGYRGALVPTLDVLAALQAAHIAAIPFEAIDALTGAGVDIGAAAVEAKL
IGQRRGGYCFEQNGLFLRALRVIGFDAEGLIGRVRWMLPDDAPPTPRSHMVLRVRIDGRAWLADVGFGAAVPPQPLAMDD
ETPQPTRHESYRIVRQGAEWQVAALVESEWRTLYRIEDAPPPTIDYEVGNWYTSAHPDSHFRHQLIAARTTAEARYGLRD
NRLTTRLADGRIDRRYLTADEIERVLAEIFLLPVARHWRPAIERAATAEIAG

Sequences:

>Translated_292_residues
MLHQPTAAPPDTDQAGAETAAEAFLPRYLARIGYRGALVPTLDVLAALQAAHIAAIPFEAIDALTGAGVDIGAAAVEAKL
IGQRRGGYCFEQNGLFLRALRVIGFDAEGLIGRVRWMLPDDAPPTPRSHMVLRVRIDGRAWLADVGFGAAVPPQPLAMDD
ETPQPTRHESYRIVRQGAEWQVAALVESEWRTLYRIEDAPPPTIDYEVGNWYTSAHPDSHFRHQLIAARTTAEARYGLRD
NRLTTRLADGRIDRRYLTADEIERVLAEIFLLPVARHWRPAIERAATAEIAG
>Mature_292_residues
MLHQPTAAPPDTDQAGAETAAEAFLPRYLARIGYRGALVPTLDVLAALQAAHIAAIPFEAIDALTGAGVDIGAAAVEAKL
IGQRRGGYCFEQNGLFLRALRVIGFDAEGLIGRVRWMLPDDAPPTPRSHMVLRVRIDGRAWLADVGFGAAVPPQPLAMDD
ETPQPTRHESYRIVRQGAEWQVAALVESEWRTLYRIEDAPPPTIDYEVGNWYTSAHPDSHFRHQLIAARTTAEARYGLRD
NRLTTRLADGRIDRRYLTADEIERVLAEIFLLPVARHWRPAIERAATAEIAG

Specific function: Could have a role in acetylating, and hence inactivating, the antitubercular drug isoniazid [H]

COG id: COG2162

COG function: function code Q; Arylamine N-acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the arylamine N-acetyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI237649128, Length=278, Percent_Identity=28.4172661870504, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI237649126, Length=278, Percent_Identity=28.4172661870504, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI237649124, Length=278, Percent_Identity=28.4172661870504, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI237649122, Length=278, Percent_Identity=28.4172661870504, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI237649119, Length=278, Percent_Identity=28.4172661870504, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI42741671, Length=278, Percent_Identity=28.4172661870504, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI237649009, Length=278, Percent_Identity=28.4172661870504, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI237649132, Length=278, Percent_Identity=28.4172661870504, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI237649130, Length=278, Percent_Identity=28.4172661870504, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI116295260, Length=238, Percent_Identity=26.0504201680672, Blast_Score=86, Evalue=5e-17,
Organism=Escherichia coli, GI1787736, Length=205, Percent_Identity=38.5365853658537, Blast_Score=153, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001447 [H]

Pfam domain/function: PF00797 Acetyltransf_2 [H]

EC number: =2.3.1.5 [H]

Molecular weight: Translated: 32222; Mature: 32222

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHQPTAAPPDTDQAGAETAAEAFLPRYLARIGYRGALVPTLDVLAALQAAHIAAIPFEA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHH
IDALTGAGVDIGAAAVEAKLIGQRRGGYCFEQNGLFLRALRVIGFDAEGLIGRVRWMLPD
HHHHHCCCCCHHHHHHHHHHHHCCCCCEEEECCCHHEEHHHHHCCCCCHHHEEEEEECCC
DAPPTPRSHMVLRVRIDGRAWLADVGFGAAVPPQPLAMDDETPQPTRHESYRIVRQGAEW
CCCCCCCCCEEEEEEECCCEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCE
QVAALVESEWRTLYRIEDAPPPTIDYEVGNWYTSAHPDSHFRHQLIAARTTAEARYGLRD
EEEHHHHHHCCEEEEECCCCCCEEEEECCCEEECCCCCHHHHHHHHHHHHHHHHHCCCCC
NRLTTRLADGRIDRRYLTADEIERVLAEIFLLPVARHWRPAIERAATAEIAG
CCCEEEHHCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLHQPTAAPPDTDQAGAETAAEAFLPRYLARIGYRGALVPTLDVLAALQAAHIAAIPFEA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHH
IDALTGAGVDIGAAAVEAKLIGQRRGGYCFEQNGLFLRALRVIGFDAEGLIGRVRWMLPD
HHHHHCCCCCHHHHHHHHHHHHCCCCCEEEECCCHHEEHHHHHCCCCCHHHEEEEEECCC
DAPPTPRSHMVLRVRIDGRAWLADVGFGAAVPPQPLAMDDETPQPTRHESYRIVRQGAEW
CCCCCCCCCEEEEEEECCCEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCE
QVAALVESEWRTLYRIEDAPPPTIDYEVGNWYTSAHPDSHFRHQLIAARTTAEARYGLRD
EEEHHHHHHCCEEEEECCCCCCEEEEECCCEEECCCCCHHHHHHHHHHHHHHHHHCCCCC
NRLTTRLADGRIDRRYLTADEIERVLAEIFLLPVARHWRPAIERAATAEIAG
CCCEEEHHCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9973365; 12054803 [H]