Click here to switch to the map view.

The map label for this gene is purK [H]

Identifier: 103487842

GI number: 103487842

Start: 2486817

End: 2487902

Strand: Reverse

Name: purK [H]

Synonym: Sala_2361

Alternate gene names: 103487842

Gene position: 2487902-2486817 (Counterclockwise)

Preceding gene: 103487843

Following gene: 103487841

Centisome position: 74.37

GC content: 69.71

Gene sequence:

>1086_bases
TTGCTGTCTCCCGGTTCGACGATCGGCATCCTCGGCGGCGGCCAGCTCGGGCGGATGCTTGGCCAGGCGGCGGCGCAGCT
TGGTTACCGCGTCCACATCTATGCCCCCGACCGCGAAAGCGTCGCCGCCGATGTCGCCGCGCACCACACGCGGGCGGCCT
GGGACGACGACCCGCGCCTCGCGGCCTTTGCCGCGGCGTGCGACGTTGTCACCTTCGAGTTTGAAAATGTCCCCGTCGAC
ACGGTGCGCTTCCTGTCGGGGCATGTCGCGGTGCGCCCCGGCGCCGCGGCGCTGGAGATCGCGCAGGACCGGCTCGCCGA
AAAGCGATTTGTCGTGGGACTCGGCGGCCGTCCGGCGCCCTTTGCCGCGGTGCCCGACCGCCCGGCGCTCGACACGGCGC
TGGGCGAAGTCGGCGCGCCCGCGATCCTGAAAACGGTGCGTATGGGCTATGACGGCAAGGGGCAGGCGCGGCTTGCGACG
GCGGCCGACGCCGACGCGGCGTGGGACGCCATCGACCGCCACGCCGCGGTGCTCGAAGGTTTCGTGACCTTTACGCACGA
GTTTTCGGCGATTCTCGTGCGCGGGATCGACGGCGAGGTGCGCTTCTGGGACAGCCCGGTCAATGTCCATGCGAATGGCA
TCCTTGCCAGTTCCAGCCTGCCGCCGCCGCGCGAGGTGCTGGGTCAGCAGGAGGAGGCGCGCGGGCTGATGGCGCGGATC
GCTGCCGAACTCGACTATGTCGGGGTGCTCACCGGCGAGTTTTTCGCCACCGCCGACGGCCCGGTGTTCAACGAAATGGC
GCCGCGCGTCCACAACAGCGGCCACTGGACGATCGAGGGTGCCGTGACGAGCCAGTTCGAGAATCATATCCGCGCCGTCG
CCGGGCTGCCGCTCGGCAGCACGGCGACCACGGCGCTACCGGTCACGATGCGCAACCTGATCGGTGCAGAGATTGCCACC
GTCCCCGCGCTGCTCGCCGACGACGCCGCGCATGTGCATCATTATGGCAAGGCGGCGGTGCGCGACGGCCGCAAGCTGGG
CCATGTCACGTGGGTCGGCTTTGGGGTGGGAAACACACCGGCATGA

Upstream 100 bases:

>100_bases
CTCGCGAACGCAGACCCCGATCTGGCGCAAAAACTCGATGCGTGGCGGGCCAGACAGGCCGACAGCGTCGCACCTGCCCC
TGTTCGTGAGGGCTGAGCGC

Downstream 100 bases:

>100_bases
ACCACCCCGAAATCACGCTGATCCTGGCGCGCGCGGCCAATGGCGTGATCGGCGCGAAGGGCCGGATGCCGTGGCACCTG
CCCGCTGACCTCCGCCGGTT

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MLSPGSTIGILGGGQLGRMLGQAAAQLGYRVHIYAPDRESVAADVAAHHTRAAWDDDPRLAAFAAACDVVTFEFENVPVD
TVRFLSGHVAVRPGAAALEIAQDRLAEKRFVVGLGGRPAPFAAVPDRPALDTALGEVGAPAILKTVRMGYDGKGQARLAT
AADADAAWDAIDRHAAVLEGFVTFTHEFSAILVRGIDGEVRFWDSPVNVHANGILASSSLPPPREVLGQQEEARGLMARI
AAELDYVGVLTGEFFATADGPVFNEMAPRVHNSGHWTIEGAVTSQFENHIRAVAGLPLGSTATTALPVTMRNLIGAEIAT
VPALLADDAAHVHHYGKAAVRDGRKLGHVTWVGFGVGNTPA

Sequences:

>Translated_361_residues
MLSPGSTIGILGGGQLGRMLGQAAAQLGYRVHIYAPDRESVAADVAAHHTRAAWDDDPRLAAFAAACDVVTFEFENVPVD
TVRFLSGHVAVRPGAAALEIAQDRLAEKRFVVGLGGRPAPFAAVPDRPALDTALGEVGAPAILKTVRMGYDGKGQARLAT
AADADAAWDAIDRHAAVLEGFVTFTHEFSAILVRGIDGEVRFWDSPVNVHANGILASSSLPPPREVLGQQEEARGLMARI
AAELDYVGVLTGEFFATADGPVFNEMAPRVHNSGHWTIEGAVTSQFENHIRAVAGLPLGSTATTALPVTMRNLIGAEIAT
VPALLADDAAHVHHYGKAAVRDGRKLGHVTWVGFGVGNTPA
>Mature_361_residues
MLSPGSTIGILGGGQLGRMLGQAAAQLGYRVHIYAPDRESVAADVAAHHTRAAWDDDPRLAAFAAACDVVTFEFENVPVD
TVRFLSGHVAVRPGAAALEIAQDRLAEKRFVVGLGGRPAPFAAVPDRPALDTALGEVGAPAILKTVRMGYDGKGQARLAT
AADADAAWDAIDRHAAVLEGFVTFTHEFSAILVRGIDGEVRFWDSPVNVHANGILASSSLPPPREVLGQQEEARGLMARI
AAELDYVGVLTGEFFATADGPVFNEMAPRVHNSGHWTIEGAVTSQFENHIRAVAGLPLGSTATTALPVTMRNLIGAEIAT
VPALLADDAAHVHHYGKAAVRDGRKLGHVTWVGFGVGNTPA

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=346, Percent_Identity=35.5491329479769, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1788155, Length=367, Percent_Identity=26.4305177111717, Blast_Score=78, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6324702, Length=367, Percent_Identity=30.2452316076294, Blast_Score=154, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 37886; Mature: 37886

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSPGSTIGILGGGQLGRMLGQAAAQLGYRVHIYAPDRESVAADVAAHHTRAAWDDDPRL
CCCCCCEEEEECCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCH
AAFAAACDVVTFEFENVPVDTVRFLSGHVAVRPGAAALEIAQDRLAEKRFVVGLGGRPAP
HHHHHHHEEEEEEECCCCHHHHHHHCCCEEECCCHHHHHHHHHHHHCCEEEEECCCCCCC
FAAVPDRPALDTALGEVGAPAILKTVRMGYDGKGQARLATAADADAAWDAIDRHAAVLEG
CCCCCCCCCHHHHHHHCCCHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHH
FVTFTHEFSAILVRGIDGEVRFWDSPVNVHANGILASSSLPPPREVLGQQEEARGLMARI
HHHHHHHCEEEEEECCCCCEEEECCCCEEEECEEEECCCCCCCHHHHCCCHHHHHHHHHH
AAELDYVGVLTGEFFATADGPVFNEMAPRVHNSGHWTIEGAVTSQFENHIRAVAGLPLGS
HHHHCEEEEEECCEEECCCCCHHHHHCCCCCCCCCEEEECHHHHHHHHHHHHHHCCCCCC
TATTALPVTMRNLIGAEIATVPALLADDAAHVHHYGKAAVRDGRKLGHVTWVGFGVGNTP
CCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCHHHHHCCCCCCCEEEEEECCCCCC
A
C
>Mature Secondary Structure
MLSPGSTIGILGGGQLGRMLGQAAAQLGYRVHIYAPDRESVAADVAAHHTRAAWDDDPRL
CCCCCCEEEEECCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCH
AAFAAACDVVTFEFENVPVDTVRFLSGHVAVRPGAAALEIAQDRLAEKRFVVGLGGRPAP
HHHHHHHEEEEEEECCCCHHHHHHHCCCEEECCCHHHHHHHHHHHHCCEEEEECCCCCCC
FAAVPDRPALDTALGEVGAPAILKTVRMGYDGKGQARLATAADADAAWDAIDRHAAVLEG
CCCCCCCCCHHHHHHHCCCHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHH
FVTFTHEFSAILVRGIDGEVRFWDSPVNVHANGILASSSLPPPREVLGQQEEARGLMARI
HHHHHHHCEEEEEECCCCCEEEECCCCEEEECEEEECCCCCCCHHHHCCCHHHHHHHHHH
AAELDYVGVLTGEFFATADGPVFNEMAPRVHNSGHWTIEGAVTSQFENHIRAVAGLPLGS
HHHHCEEEEEECCEEECCCCCHHHHHCCCCCCCCCEEEECHHHHHHHHHHHHHHCCCCCC
TATTALPVTMRNLIGAEIATVPALLADDAAHVHHYGKAAVRDGRKLGHVTWVGFGVGNTP
CCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCHHHHHCCCCCCCEEEEEECCCCCC
A
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11756688 [H]