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The map label for this gene is purE [H]

Identifier: 103487843

GI number: 103487843

Start: 2487907

End: 2488416

Strand: Reverse

Name: purE [H]

Synonym: Sala_2362

Alternate gene names: 103487843

Gene position: 2488416-2487907 (Counterclockwise)

Preceding gene: 103487848

Following gene: 103487842

Centisome position: 74.39

GC content: 70.39

Gene sequence:

>510_bases
ATGGGCGACAGCGCGCCGCAGGCCGAGGTGAGCGTGGGCGTCATCATGGGCAGCCAGTCGGACTGGCCGACGATGGCGCA
TTCGGTTCAGATCCTTGAAGAATTCGGCATCGCGTGCGAGGTCCGGATCGTGTCCGCGCACCGCACCCCCGACCGCCTCG
TCGCCTATGCCAAGGGCGCGGCGGACCGCGGGCTGAAGGCGATCATCGCGGGCGCGGGCGGCGCCGCGCACCTGCCGGGC
ATGGTCGCAGCGATGACGCGCGTACCCGTGCTGGGGGTGCCCGTGCAGTCGGCGGCGCTGTCGGGCGTCGACAGCCTCTA
TTCGATCGTCCAGATGCCCGGCGGCGTTCCCGTCGCCACCTTTGCGATCGGCAAGGCGGGGGCGACCAACGCGGGCCTTT
TCGCTGTGGCGCTGCTCGCGAACGCAGACCCCGATCTGGCGCAAAAACTCGATGCGTGGCGGGCCAGACAGGCCGACAGC
GTCGCACCTGCCCCTGTTCGTGAGGGCTGA

Upstream 100 bases:

>100_bases
TTGCGAAACCGGCGGCGTTGCCCGCGCGCAACCTTGCCGCTAGGGGGAGGGCGGCGGCGATTCATCGACGGACCGGCCGC
CCGCACAAGGAGGGATCGGG

Downstream 100 bases:

>100_bases
GCGCTTGCTGTCTCCCGGTTCGACGATCGGCATCCTCGGCGGCGGCCAGCTCGGGCGGATGCTTGGCCAGGCGGCGGCGC
AGCTTGGTTACCGCGTCCAC

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 169; Mature: 168

Protein sequence:

>169_residues
MGDSAPQAEVSVGVIMGSQSDWPTMAHSVQILEEFGIACEVRIVSAHRTPDRLVAYAKGAADRGLKAIIAGAGGAAHLPG
MVAAMTRVPVLGVPVQSAALSGVDSLYSIVQMPGGVPVATFAIGKAGATNAGLFAVALLANADPDLAQKLDAWRARQADS
VAPAPVREG

Sequences:

>Translated_169_residues
MGDSAPQAEVSVGVIMGSQSDWPTMAHSVQILEEFGIACEVRIVSAHRTPDRLVAYAKGAADRGLKAIIAGAGGAAHLPG
MVAAMTRVPVLGVPVQSAALSGVDSLYSIVQMPGGVPVATFAIGKAGATNAGLFAVALLANADPDLAQKLDAWRARQADS
VAPAPVREG
>Mature_168_residues
GDSAPQAEVSVGVIMGSQSDWPTMAHSVQILEEFGIACEVRIVSAHRTPDRLVAYAKGAADRGLKAIIAGAGGAAHLPGM
VAAMTRVPVLGVPVQSAALSGVDSLYSIVQMPGGVPVATFAIGKAGATNAGLFAVALLANADPDLAQKLDAWRARQADSV
APAPVREG

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=154, Percent_Identity=61.038961038961, Blast_Score=164, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6324702, Length=150, Percent_Identity=58.6666666666667, Blast_Score=168, Evalue=3e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17080; Mature: 16949

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGDSAPQAEVSVGVIMGSQSDWPTMAHSVQILEEFGIACEVRIVSAHRTPDRLVAYAKGA
CCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHCCEEEEEEEECCCCHHHHHHHHCCC
ADRGLKAIIAGAGGAAHLPGMVAAMTRVPVLGVPVQSAALSGVDSLYSIVQMPGGVPVAT
CCCCCEEEEECCCCCHHHHHHHHHHHHCCEECCCHHHHHHHHHHHHHHHHHCCCCCCEEE
FAIGKAGATNAGLFAVALLANADPDLAQKLDAWRARQADSVAPAPVREG
EEECCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
GDSAPQAEVSVGVIMGSQSDWPTMAHSVQILEEFGIACEVRIVSAHRTPDRLVAYAKGA
CCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHCCEEEEEEEECCCCHHHHHHHHCCC
ADRGLKAIIAGAGGAAHLPGMVAAMTRVPVLGVPVQSAALSGVDSLYSIVQMPGGVPVAT
CCCCCEEEEECCCCCHHHHHHHHHHHHCCEECCCHHHHHHHHHHHHHHHHHCCCCCCEEE
FAIGKAGATNAGLFAVALLANADPDLAQKLDAWRARQADSVAPAPVREG
EEECCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3036807; 9384377 [H]