Click here to switch to the map view.

The map label for this gene is dxs

Identifier: 103487835

GI number: 103487835

Start: 2477662

End: 2479590

Strand: Direct

Name: dxs

Synonym: Sala_2354

Alternate gene names: 103487835

Gene position: 2477662-2479590 (Clockwise)

Preceding gene: 103487834

Following gene: 103487844

Centisome position: 74.07

GC content: 66.2

Gene sequence:

>1929_bases
ATGACCGACCGCCCGCATACGCCGCTGCTCGACACGGTGGATGTCCCCGCCGACCTCCGCAAGCTGAAGCCCGAAGACCT
CCGCCAGTTCGCCGACGAGCTGCGCGCCGAGATGATTTCCGCCGTCGGGACCACGGGCGGGCACCTGGGTTCCGGGCTCG
GCGTCGTCGAGCTGACGACCGCGATCCATTATGTGTTCGACACCCCGCGCGACAAGCTGGTGTGGGACGTCGGCCACCAA
TGCTATCCGCACAAGATCATCACCGGGCGCCGCGACCGCATCCGTACGCTGCGCCAGGGCGGCGGCCTGTCGGGCTTCAC
CAAGCGCAGCGAGAGCGAATATGACCCGTTCGGCGCGGCGCACAGCTCAACCTCGATCAGCGCGGCGCTGGGTTTTGCCA
TCGCCAACAAGCTGAAGGACGAACCCGGCCGCGCGATCGCGGTGATCGGCGACGGGTCGATGTCGGCCGGCATGGCCTAT
GAGGCGATGAACAATGCGAAACAGGCGGGCAACCGGCTGATCGTCATTTTGAACGACAATGACATGTCGATCGCGCCGCC
CGTCGGCGGGCTGTCGGCCTATCTCGCCAAGCTCGTGTCGTCGCGGCCATTTCTCGAGCTGCGCGAGATTGCGCGGCGCT
TTGCGCGCAAGCTGCCCGAACCGCTGCACAAGGCGGCGAAAAAGACGGACGAATATGCCCGCGGCATGGCGATGGGCGGC
ACCTTGTTCGAGGAGCTGGGTTTTTATTATGTCGGGCCGATCGACGGGCATAATCTCGACCATCTGATCCCGATCCTGGA
AAATGTCCGCGACAGCGACCATGGCCCGGTGCTGATCCACGCAGTGACCAAGAAGGGCAAGGGGTACGCCCCTGCCGAGG
CCGCCGCCGACAAATATCACGGGGTGCAGAAGTTCGACGTCATCACCGGCGAACAGGCAAAGGCGCCACCGGGACCGCCC
GCCTATCAGAATGTGTTCGGCGAAACACTGGCGAAGCTGGCCGAAACGGACAAGCGCATCGTCGCGATCACCGCGGCGAT
GCCCTCGGGCACCGGCGTTGACAAGTTCGCGAAGGTGCATCCCGACCGCAGCTTCGACGTCGGCATCGCCGAACAACATG
CGGTGACCTTCGCCGCCGGATTGGCGGCGCAGGGGATGCGGCCGTTCGCGGCGATCTATTCGACCTTCCTCCAGCGCGCT
TATGACCAGGTCGTGCATGATGTGGCGATCCAGAACCTGCCGGTGCGCTTCGCGATCGACCGCGCGGGGCTGGTCGGCGC
CGACGGATCGACCCATGCGGGCTCGTTCGACATCACCTATCTGGCGACCTTGCCCAACATGGTGGTGATGGCGGCGGCCG
ACGAGGCCGAACTGGTCCACATGACCTATACCGCCGCCGAACATGACGCGGGGCCCATCGCCTTCCGCTATCCGCGCGGT
AACGGCACCGGCGTGGCACTGCCTGCGGTGCCGCAGAAGCTGGAAATCGGCAAGGGGCGCGTGGTGCGCGAGGGCAAGAC
CGTCGCGATCCTGTCGCTGGGCACCCGGCTTGCCGAGGCACTGAAGGCCGCCGACACGCTGGAGGCGCGCGGACTGTCGA
CAAGCGTCATCGACCTGCGATTCGCCAAGCCGCTCGACGAGGAGCTGATCCGCCGGACGCTCGCCGCCCATGAAGTGTGC
GTGACGGTCGAGGAAGGCAGCATCGGCGGGCTCGGCGCGCATGTGCTGACCCTGGCGAGCGACGAGGGACTGATCGACGC
GGGGCTGAAGCTGCGCACGCTGCGCCTGCCCGATATGTTCCAGGATCAGGATAAGCCCGAGCTGCAATATGACGCCGCGG
GGCTGAACGCGCCGCAGATCGTCGATACCGTGCTCAAGGCGCTGCGCCACAACAGCGCGGGGGTCGAGGAAGCGGGGGTT
CGGGCCTGA

Upstream 100 bases:

>100_bases
GTGGACGCGGCGAAGCGGCAAGGCGACGAGGAGCGCGACGGGCCGGGCGACTGAACCCTTTTCGTTCGACACCCCATGCG
CTTGGCGGTATGACGGCGCG

Downstream 100 bases:

>100_bases
GCCCTGCCGTCCCGTTCGCGTCGCGCCTCTGTCGGGCCATGATCCTGCCTTGCGCCCCGGCGCAAGCTTTGGAGAGGATC
ACTGCGCTTGGTTTCCTGCG

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 642; Mature: 641

Protein sequence:

>642_residues
MTDRPHTPLLDTVDVPADLRKLKPEDLRQFADELRAEMISAVGTTGGHLGSGLGVVELTTAIHYVFDTPRDKLVWDVGHQ
CYPHKIITGRRDRIRTLRQGGGLSGFTKRSESEYDPFGAAHSSTSISAALGFAIANKLKDEPGRAIAVIGDGSMSAGMAY
EAMNNAKQAGNRLIVILNDNDMSIAPPVGGLSAYLAKLVSSRPFLELREIARRFARKLPEPLHKAAKKTDEYARGMAMGG
TLFEELGFYYVGPIDGHNLDHLIPILENVRDSDHGPVLIHAVTKKGKGYAPAEAAADKYHGVQKFDVITGEQAKAPPGPP
AYQNVFGETLAKLAETDKRIVAITAAMPSGTGVDKFAKVHPDRSFDVGIAEQHAVTFAAGLAAQGMRPFAAIYSTFLQRA
YDQVVHDVAIQNLPVRFAIDRAGLVGADGSTHAGSFDITYLATLPNMVVMAAADEAELVHMTYTAAEHDAGPIAFRYPRG
NGTGVALPAVPQKLEIGKGRVVREGKTVAILSLGTRLAEALKAADTLEARGLSTSVIDLRFAKPLDEELIRRTLAAHEVC
VTVEEGSIGGLGAHVLTLASDEGLIDAGLKLRTLRLPDMFQDQDKPELQYDAAGLNAPQIVDTVLKALRHNSAGVEEAGV
RA

Sequences:

>Translated_642_residues
MTDRPHTPLLDTVDVPADLRKLKPEDLRQFADELRAEMISAVGTTGGHLGSGLGVVELTTAIHYVFDTPRDKLVWDVGHQ
CYPHKIITGRRDRIRTLRQGGGLSGFTKRSESEYDPFGAAHSSTSISAALGFAIANKLKDEPGRAIAVIGDGSMSAGMAY
EAMNNAKQAGNRLIVILNDNDMSIAPPVGGLSAYLAKLVSSRPFLELREIARRFARKLPEPLHKAAKKTDEYARGMAMGG
TLFEELGFYYVGPIDGHNLDHLIPILENVRDSDHGPVLIHAVTKKGKGYAPAEAAADKYHGVQKFDVITGEQAKAPPGPP
AYQNVFGETLAKLAETDKRIVAITAAMPSGTGVDKFAKVHPDRSFDVGIAEQHAVTFAAGLAAQGMRPFAAIYSTFLQRA
YDQVVHDVAIQNLPVRFAIDRAGLVGADGSTHAGSFDITYLATLPNMVVMAAADEAELVHMTYTAAEHDAGPIAFRYPRG
NGTGVALPAVPQKLEIGKGRVVREGKTVAILSLGTRLAEALKAADTLEARGLSTSVIDLRFAKPLDEELIRRTLAAHEVC
VTVEEGSIGGLGAHVLTLASDEGLIDAGLKLRTLRLPDMFQDQDKPELQYDAAGLNAPQIVDTVLKALRHNSAGVEEAGV
RA
>Mature_641_residues
TDRPHTPLLDTVDVPADLRKLKPEDLRQFADELRAEMISAVGTTGGHLGSGLGVVELTTAIHYVFDTPRDKLVWDVGHQC
YPHKIITGRRDRIRTLRQGGGLSGFTKRSESEYDPFGAAHSSTSISAALGFAIANKLKDEPGRAIAVIGDGSMSAGMAYE
AMNNAKQAGNRLIVILNDNDMSIAPPVGGLSAYLAKLVSSRPFLELREIARRFARKLPEPLHKAAKKTDEYARGMAMGGT
LFEELGFYYVGPIDGHNLDHLIPILENVRDSDHGPVLIHAVTKKGKGYAPAEAAADKYHGVQKFDVITGEQAKAPPGPPA
YQNVFGETLAKLAETDKRIVAITAAMPSGTGVDKFAKVHPDRSFDVGIAEQHAVTFAAGLAAQGMRPFAAIYSTFLQRAY
DQVVHDVAIQNLPVRFAIDRAGLVGADGSTHAGSFDITYLATLPNMVVMAAADEAELVHMTYTAAEHDAGPIAFRYPRGN
GTGVALPAVPQKLEIGKGRVVREGKTVAILSLGTRLAEALKAADTLEARGLSTSVIDLRFAKPLDEELIRRTLAAHEVCV
TVEEGSIGGLGAHVLTLASDEGLIDAGLKLRTLRLPDMFQDQDKPELQYDAAGLNAPQIVDTVLKALRHNSAGVEEAGVR
A

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=492, Percent_Identity=25.4065040650407, Blast_Score=103, Evalue=7e-22,
Organism=Homo sapiens, GI4507521, Length=492, Percent_Identity=25.4065040650407, Blast_Score=103, Evalue=7e-22,
Organism=Homo sapiens, GI133778974, Length=528, Percent_Identity=25.3787878787879, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI225637459, Length=415, Percent_Identity=26.5060240963855, Blast_Score=97, Evalue=5e-20,
Organism=Homo sapiens, GI225637461, Length=415, Percent_Identity=26.5060240963855, Blast_Score=97, Evalue=7e-20,
Organism=Homo sapiens, GI225637463, Length=415, Percent_Identity=26.5060240963855, Blast_Score=97, Evalue=7e-20,
Organism=Escherichia coli, GI1786622, Length=613, Percent_Identity=50.5709624796085, Blast_Score=592, Evalue=1e-170,
Organism=Caenorhabditis elegans, GI17539652, Length=434, Percent_Identity=26.7281105990783, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI45551847, Length=433, Percent_Identity=27.4826789838337, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI45550715, Length=433, Percent_Identity=27.4826789838337, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24645119, Length=433, Percent_Identity=27.4826789838337, Blast_Score=112, Evalue=7e-25,
Organism=Drosophila melanogaster, GI24666278, Length=373, Percent_Identity=25.7372654155496, Blast_Score=87, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_SPHAL (Q1GQK9)

Other databases:

- EMBL:   CP000356
- RefSeq:   YP_617396.1
- ProteinModelPortal:   Q1GQK9
- SMR:   Q1GQK9
- GeneID:   4080755
- GenomeReviews:   CP000356_GR
- KEGG:   sal:Sala_2354
- NMPDR:   fig|317655.9.peg.2277
- HOGENOM:   HBG571647
- OMA:   ILITIEE
- ProtClustDB:   PRK05444
- BioCyc:   SALA317655:SALA_2354-MONOMER
- BRENDA:   2.2.1.7
- HAMAP:   MF_00315
- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 68727; Mature: 68596

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDRPHTPLLDTVDVPADLRKLKPEDLRQFADELRAEMISAVGTTGGHLGSGLGVVELTT
CCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
AIHYVFDTPRDKLVWDVGHQCYPHKIITGRRDRIRTLRQGGGLSGFTKRSESEYDPFGAA
HHHHHHCCCCHHEEECCCCCCCCCHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
HSSTSISAALGFAIANKLKDEPGRAIAVIGDGSMSAGMAYEAMNNAKQAGNRLIVILNDN
CCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCEEEEEECCC
DMSIAPPVGGLSAYLAKLVSSRPFLELREIARRFARKLPEPLHKAAKKTDEYARGMAMGG
CCEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCC
TLFEELGFYYVGPIDGHNLDHLIPILENVRDSDHGPVLIHAVTKKGKGYAPAEAAADKYH
HHHHHCCCEEECCCCCCCHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHC
GVQKFDVITGEQAKAPPGPPAYQNVFGETLAKLAETDKRIVAITAAMPSGTGVDKFAKVH
CCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHC
PDRSFDVGIAEQHAVTFAAGLAAQGMRPFAAIYSTFLQRAYDQVVHDVAIQNLPVRFAID
CCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEC
RAGLVGADGSTHAGSFDITYLATLPNMVVMAAADEAELVHMTYTAAEHDAGPIAFRYPRG
CCCEECCCCCCCCCCEEEEEHHHCCCEEEEEECCCCEEEEEEEECCCCCCCCEEEEECCC
NGTGVALPAVPQKLEIGKGRVVREGKTVAILSLGTRLAEALKAADTLEARGLSTSVIDLR
CCCEEECCCCCCHHCCCCCEEEECCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
FAKPLDEELIRRTLAAHEVCVTVEEGSIGGLGAHVLTLASDEGLIDAGLKLRTLRLPDMF
ECCCHHHHHHHHHHHHHHEEEEEECCCCCCCCCEEEEEECCCCCCCCCCEEEEEECCHHH
QDQDKPELQYDAAGLNAPQIVDTVLKALRHNSAGVEEAGVRA
CCCCCCCCEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TDRPHTPLLDTVDVPADLRKLKPEDLRQFADELRAEMISAVGTTGGHLGSGLGVVELTT
CCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
AIHYVFDTPRDKLVWDVGHQCYPHKIITGRRDRIRTLRQGGGLSGFTKRSESEYDPFGAA
HHHHHHCCCCHHEEECCCCCCCCCHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
HSSTSISAALGFAIANKLKDEPGRAIAVIGDGSMSAGMAYEAMNNAKQAGNRLIVILNDN
CCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCEEEEEECCC
DMSIAPPVGGLSAYLAKLVSSRPFLELREIARRFARKLPEPLHKAAKKTDEYARGMAMGG
CCEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCC
TLFEELGFYYVGPIDGHNLDHLIPILENVRDSDHGPVLIHAVTKKGKGYAPAEAAADKYH
HHHHHCCCEEECCCCCCCHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHC
GVQKFDVITGEQAKAPPGPPAYQNVFGETLAKLAETDKRIVAITAAMPSGTGVDKFAKVH
CCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHC
PDRSFDVGIAEQHAVTFAAGLAAQGMRPFAAIYSTFLQRAYDQVVHDVAIQNLPVRFAID
CCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEC
RAGLVGADGSTHAGSFDITYLATLPNMVVMAAADEAELVHMTYTAAEHDAGPIAFRYPRG
CCCEECCCCCCCCCCEEEEEHHHCCCEEEEEECCCCEEEEEEEECCCCCCCCEEEEECCC
NGTGVALPAVPQKLEIGKGRVVREGKTVAILSLGTRLAEALKAADTLEARGLSTSVIDLR
CCCEEECCCCCCHHCCCCCEEEECCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
FAKPLDEELIRRTLAAHEVCVTVEEGSIGGLGAHVLTLASDEGLIDAGLKLRTLRLPDMF
ECCCHHHHHHHHHHHHHHEEEEEECCCCCCCCCEEEEEECCCCCCCCCCEEEEEECCHHH
QDQDKPELQYDAAGLNAPQIVDTVLKALRHNSAGVEEAGVRA
CCCCCCCCEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA