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The map label for this gene is pyrH

Identifier: 103487442

GI number: 103487442

Start: 2064568

End: 2065293

Strand: Reverse

Name: pyrH

Synonym: Sala_1958

Alternate gene names: 103487442

Gene position: 2065293-2064568 (Counterclockwise)

Preceding gene: 103487443

Following gene: 103487441

Centisome position: 61.74

GC content: 65.01

Gene sequence:

>726_bases
ATGGCATTGCCCGGCCTGAAACGCATATTGCTGAAATTGTCGGGCGAGGCGCTGATGGGCCCCAGCCCCTTCGGTATCGA
CCCCGAAACGGTCGCGAGCATGGCGGCCGAGGTCAAGGAAGCCAAGGATCGCGGGCTCGAAATCTGCCTCGTCATCGGCG
GGGGCAACATCTTTCGCGGCATGGCGGGTGCGGCCAAGGGCATGGACCGCGCGCAGGCCGACTATATGGGCATGCTCGCG
ACGGTGATGAACGCATTGGCGATGCAGAATGCGCTCGAACAGCTGGGGGTCCAGACGCGCGTTCAGTCGGCGATCGAGAT
GGACAAGGTGTGCGAACCGGTGATCCGTCGCCGCGCCGAACGCCATATGGAAAAGGGCCGCGTGGTGATCTTTGCCGCGG
GCGTGGGTGCGCCTTACTTCACCACCGACAGCGGCGCGGCGCTGCGCGCGGCCGAGATGAAGTGCGACGCGCTGCTGAAA
GGCACCAGCGTCGACGGCGTCTATAACGCCGATCCCAAGCAGGACGCCAATGCGGTGCGCTATGATCGGCTGAGCTATGA
CCGCGTGCTCGCGGACAATCTGAAGGTGATGGACGCGAGCGCGGTGGCGCTGTGCCGCGACAACCATATCCCGATCGTGG
TGTTCAACATTCGCGAACCCGGAAATCTGGCGCGCGTGCTGGCGGGCGAGGGCGTCTCGACCGTCGTCGGCGACGGCGCA
GTCTGA

Upstream 100 bases:

>100_bases
TTGCCGCGTCGGTCGCGGCAGTCCGCTTGGCAATGGCGCGCACCCGCTCTAGGGTGCGCGCCATTCGCTTATATCGAGTT
TGCAAGAGGTTCTCCCGATC

Downstream 100 bases:

>100_bases
TGGATTATATAATGCAGGCTTTGGTTTTCCATTTTCCGTTCGCGTCGAGCGAAGTCGAGACGCCCATAAGGCGCGTGCTA
CCGATGGGCATCTCGACTTC

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 241; Mature: 240

Protein sequence:

>241_residues
MALPGLKRILLKLSGEALMGPSPFGIDPETVASMAAEVKEAKDRGLEICLVIGGGNIFRGMAGAAKGMDRAQADYMGMLA
TVMNALAMQNALEQLGVQTRVQSAIEMDKVCEPVIRRRAERHMEKGRVVIFAAGVGAPYFTTDSGAALRAAEMKCDALLK
GTSVDGVYNADPKQDANAVRYDRLSYDRVLADNLKVMDASAVALCRDNHIPIVVFNIREPGNLARVLAGEGVSTVVGDGA
V

Sequences:

>Translated_241_residues
MALPGLKRILLKLSGEALMGPSPFGIDPETVASMAAEVKEAKDRGLEICLVIGGGNIFRGMAGAAKGMDRAQADYMGMLA
TVMNALAMQNALEQLGVQTRVQSAIEMDKVCEPVIRRRAERHMEKGRVVIFAAGVGAPYFTTDSGAALRAAEMKCDALLK
GTSVDGVYNADPKQDANAVRYDRLSYDRVLADNLKVMDASAVALCRDNHIPIVVFNIREPGNLARVLAGEGVSTVVGDGA
V
>Mature_240_residues
ALPGLKRILLKLSGEALMGPSPFGIDPETVASMAAEVKEAKDRGLEICLVIGGGNIFRGMAGAAKGMDRAQADYMGMLAT
VMNALAMQNALEQLGVQTRVQSAIEMDKVCEPVIRRRAERHMEKGRVVIFAAGVGAPYFTTDSGAALRAAEMKCDALLKG
TSVDGVYNADPKQDANAVRYDRLSYDRVLADNLKVMDASAVALCRDNHIPIVVFNIREPGNLARVLAGEGVSTVVGDGAV

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=237, Percent_Identity=49.789029535865, Blast_Score=228, Evalue=2e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_SPHAL (Q1GRQ2)

Other databases:

- EMBL:   CP000356
- RefSeq:   YP_617003.1
- ProteinModelPortal:   Q1GRQ2
- SMR:   Q1GRQ2
- GeneID:   4080507
- GenomeReviews:   CP000356_GR
- KEGG:   sal:Sala_1958
- NMPDR:   fig|317655.9.peg.1889
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- ProtClustDB:   PRK00358
- BioCyc:   SALA317655:SALA_1958-MONOMER
- BRENDA:   2.7.4.22
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 25566; Mature: 25435

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: BINDING 54-54 BINDING 55-55 BINDING 59-59 BINDING 74-74 BINDING 162-162 BINDING 168-168 BINDING 171-171

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALPGLKRILLKLSGEALMGPSPFGIDPETVASMAAEVKEAKDRGLEICLVIGGGNIFRG
CCCCHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHH
MAGAAKGMDRAQADYMGMLATVMNALAMQNALEQLGVQTRVQSAIEMDKVCEPVIRRRAE
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RHMEKGRVVIFAAGVGAPYFTTDSGAALRAAEMKCDALLKGTSVDGVYNADPKQDANAVR
HHHHCCCEEEEEECCCCCEEECCCCCEEHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHH
YDRLSYDRVLADNLKVMDASAVALCRDNHIPIVVFNIREPGNLARVLAGEGVSTVVGDGA
HHHHHHHHHHHCCCEEECHHHHEEECCCCCCEEEEEECCCCCHHHHHHCCCCCCCCCCCC
V
C
>Mature Secondary Structure 
ALPGLKRILLKLSGEALMGPSPFGIDPETVASMAAEVKEAKDRGLEICLVIGGGNIFRG
CCCHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHH
MAGAAKGMDRAQADYMGMLATVMNALAMQNALEQLGVQTRVQSAIEMDKVCEPVIRRRAE
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RHMEKGRVVIFAAGVGAPYFTTDSGAALRAAEMKCDALLKGTSVDGVYNADPKQDANAVR
HHHHCCCEEEEEECCCCCEEECCCCCEEHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHH
YDRLSYDRVLADNLKVMDASAVALCRDNHIPIVVFNIREPGNLARVLAGEGVSTVVGDGA
HHHHHHHHHHHCCCEEECHHHHEEECCCCCCEEEEEECCCCCHHHHHHCCCCCCCCCCCC
V
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA