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The map label for this gene is uppS [H]

Identifier: 103487440

GI number: 103487440

Start: 2063061

End: 2063747

Strand: Reverse

Name: uppS [H]

Synonym: Sala_1956

Alternate gene names: 103487440

Gene position: 2063747-2063061 (Counterclockwise)

Preceding gene: 103487441

Following gene: 103487439

Centisome position: 61.69

GC content: 64.34

Gene sequence:

>687_bases
GTGACGGTTTCAGACCACGCCGCGCGCCATGTCGCCATCATCATGGACGGCAACGGCCGCTGGGCCAAAAAACGCATGTT
GCCGCGCGTCGCGGGACACAGGGCGGGGGTCGAGACGGTGCGCACGATCGTGCGCGCGGCGGGCGATCTGGGGCTGGAGG
CGATGACGCTCTATGCCTTCAGTTCGGAAAACTGGAAACGGCCCGAGGAAGAGGTCAACGACCTGATGGGGCTGATGAAG
CGCTTCATCCTCTCCGACCTCGATGAATTTGCCGCCAATGACGTGAAGCTGAAGGTCATCGGCAACTGGCGCGCGCTGGC
GCCCGATGTCGTCGCGCTGATCGACAATGCGCTCGACCGGACATCGGGCAACAAGCGCACGACGCTGGCGGTCGCGCTCA
ACTATGGCGCGCAGGACGAGCTGGTGCGCGCGGCGAATGCCGCCGCAGCGATCGGCGAAATCACCGCCGAGGCGATCGAG
GCCCATCTCGATACCGCCGACATGCCGCCGCTCGACCTGCTGATCCGAACCTCGGGCGAACTGCGGCTGTCCAATTTCCT
GCTCTGGCAGTCGGCTTATGCCGAGCTGTATTTCACCGAAAAGCTGTGGCCGGATTTTACCCCGGCGGACCTGAAAGCGG
CGCTGGATCAATTTGCACGGCGCGATCGCCGGTACGGGGGGCTTTGA

Upstream 100 bases:

>100_bases
TCCGCTCGTGTCGAGCGAAGTCGAGACACCCATCGGACTGGAACACGGCCGAGGGGCATCTCGACTTCGCTCGATGCGAA
CGGATTTTGAGGTTTTTCCG

Downstream 100 bases:

>100_bases
CGATGGCGGCAAAATCGGACCTTTGGGTGCGGGTGGGATCGGCGATCATATTGTTTGCGATTGCGGGGACCGCGCTGTGG
TTCGGCGGCATCGCGTTCGG

Product: undecaprenyl diphosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 228; Mature: 227

Protein sequence:

>228_residues
MTVSDHAARHVAIIMDGNGRWAKKRMLPRVAGHRAGVETVRTIVRAAGDLGLEAMTLYAFSSENWKRPEEEVNDLMGLMK
RFILSDLDEFAANDVKLKVIGNWRALAPDVVALIDNALDRTSGNKRTTLAVALNYGAQDELVRAANAAAAIGEITAEAIE
AHLDTADMPPLDLLIRTSGELRLSNFLLWQSAYAELYFTEKLWPDFTPADLKAALDQFARRDRRYGGL

Sequences:

>Translated_228_residues
MTVSDHAARHVAIIMDGNGRWAKKRMLPRVAGHRAGVETVRTIVRAAGDLGLEAMTLYAFSSENWKRPEEEVNDLMGLMK
RFILSDLDEFAANDVKLKVIGNWRALAPDVVALIDNALDRTSGNKRTTLAVALNYGAQDELVRAANAAAAIGEITAEAIE
AHLDTADMPPLDLLIRTSGELRLSNFLLWQSAYAELYFTEKLWPDFTPADLKAALDQFARRDRRYGGL
>Mature_227_residues
TVSDHAARHVAIIMDGNGRWAKKRMLPRVAGHRAGVETVRTIVRAAGDLGLEAMTLYAFSSENWKRPEEEVNDLMGLMKR
FILSDLDEFAANDVKLKVIGNWRALAPDVVALIDNALDRTSGNKRTTLAVALNYGAQDELVRAANAAAAIGEITAEAIEA
HLDTADMPPLDLLIRTSGELRLSNFLLWQSAYAELYFTEKLWPDFTPADLKAALDQFARRDRRYGGL

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=221, Percent_Identity=35.2941176470588, Blast_Score=132, Evalue=2e-31,
Organism=Homo sapiens, GI45580742, Length=221, Percent_Identity=35.2941176470588, Blast_Score=132, Evalue=2e-31,
Organism=Escherichia coli, GI1786371, Length=230, Percent_Identity=45.6521739130435, Blast_Score=202, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI71993029, Length=221, Percent_Identity=35.7466063348416, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6319474, Length=228, Percent_Identity=37.280701754386, Blast_Score=135, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6323748, Length=225, Percent_Identity=33.3333333333333, Blast_Score=106, Evalue=3e-24,
Organism=Drosophila melanogaster, GI18857969, Length=221, Percent_Identity=35.7466063348416, Blast_Score=138, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 25253; Mature: 25122

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS01066 UPP_SYNTHETASE ; PS00213 LIPOCALIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVSDHAARHVAIIMDGNGRWAKKRMLPRVAGHRAGVETVRTIVRAAGDLGLEAMTLYAF
CCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHEEEEEE
SSENWKRPEEEVNDLMGLMKRFILSDLDEFAANDVKLKVIGNWRALAPDVVALIDNALDR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHHH
TSGNKRTTLAVALNYGAQDELVRAANAAAAIGEITAEAIEAHLDTADMPPLDLLIRTSGE
CCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHEEEECCCC
LRLSNFLLWQSAYAELYFTEKLWPDFTPADLKAALDQFARRDRRYGGL
EEHHHHHHHHHHHHHHEEHHHHCCCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TVSDHAARHVAIIMDGNGRWAKKRMLPRVAGHRAGVETVRTIVRAAGDLGLEAMTLYAF
CCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHEEEEEE
SSENWKRPEEEVNDLMGLMKRFILSDLDEFAANDVKLKVIGNWRALAPDVVALIDNALDR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHHH
TSGNKRTTLAVALNYGAQDELVRAANAAAAIGEITAEAIEAHLDTADMPPLDLLIRTSGE
CCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHEEEECCCC
LRLSNFLLWQSAYAELYFTEKLWPDFTPADLKAALDQFARRDRRYGGL
EEHHHHHHHHHHHHHHEEHHHHCCCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA