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The map label for this gene is gcvT [H]

Identifier: 103487355

GI number: 103487355

Start: 1966618

End: 1967742

Strand: Reverse

Name: gcvT [H]

Synonym: Sala_1871

Alternate gene names: 103487355

Gene position: 1967742-1966618 (Counterclockwise)

Preceding gene: 103487356

Following gene: 103487354

Centisome position: 58.82

GC content: 65.96

Gene sequence:

>1125_bases
ATGCACGAAGACGATGAGATTCCGATCGAAACGGCGACGCTGCCGCTCGACGCCTGGCACCGCGCGAAGGGTGGCCGCAT
GGTCGCGTTCGCGGGTTACTGGATGCCGATCCAATATGACGGCATCATGGCCGAACATCTGTGGACGCGCGAGAATGCCG
GGCTGTTCGATGTCAGCCATATGGGCCAGCTGGCGCTGAGCGGCGAGGGCGTCGCCAAGGCGCTCGAAACGCTGGTCCCC
GGCGATATTTCGGCGCTGAAGCCCGGCCGGATGCGCTATTCGCTGCTGCTGAACGACGAAGGCGGTGTCCTCGATGACCT
GATGATCACCAACGAGGGCGACCAGTTCGGCATCGTCGTCAATGGCGCGGTCAAATGGGACGATATCGCCCATCTGCGCG
AGCATCTGCCCGATGATATCACGCTCAACCATAATGAGGATTACGGCCTGCTGGCGTTGCAGGGGCCAAAGGCGGTGACG
GCGCTCGCGCGCCTTGTGCCCGAAGCAGCGGACCTCGTCTTTATGCAGGCGATGCCGGCGACATGGAACGGCCATGCGAT
CGCGATCAGCCGCTCGGGCTATACCGGTGAGGACGGGTTCGAGATTTCGCTGCCGAACGACGCGCTGGAGAGTTTCGCCG
ACGCGCTTTGCGCGATGGAGGAGGTGAAGCCCATCGGCCTCGGCGCGCGCGACTCGCTCCGCCTCGAAGCGGGATTGCCG
CTCTATGGCCACGATCTCGACGAAAGCATCGACCCGGTCGAGGCCGACCTGGCCTTTGCGATCAGCAAGCGCCGCCGCGA
AGAGGGCGGCTTCCCCGGCGCGGCGCGCATCCTTGGGCATCTGGCCGACGGCTCTCCACGCAAGCGCGTCGGCCTTGTCA
TCGACGGCAAGCTGCCGGTGCGCGAGGGCGCCAAATTGTTCGACGGCAACACCGAGATCGGCGTCGTGACGTCGGGCGGC
TTTGCCCCCAGCGTCGGCGCGCCGATCGCCATGGGTTACGTCCCGACGGGGCTGTCCGAGCCGGGTACCGCGGTCGCCGC
CGAGGTGCGCGGCAAGCGCGTCGCCTGCACCGTCACCGCCATGCCATTCATTCCGCACCGCTATGTGCGCAAACAGGGAG
CCTGA

Upstream 100 bases:

>100_bases
CAACCGATGGAGGAAAACTCTCAGGTTCCCGTGACAGAGGGGGCATGGCGACCGCGCGGCACCGGGCCGCGCCGCGCCGT
GTCAACGACGGGAGTGCGAC

Downstream 100 bases:

>100_bases
CCGATGCCGCGTTATTATACCGAGGAACATGAGTGGATCGATGTCGATGGCGATGTCGCGACGGTCGGCATCACCGACTT
TGCGCAGGGCCAGCTTGGCG

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MHEDDEIPIETATLPLDAWHRAKGGRMVAFAGYWMPIQYDGIMAEHLWTRENAGLFDVSHMGQLALSGEGVAKALETLVP
GDISALKPGRMRYSLLLNDEGGVLDDLMITNEGDQFGIVVNGAVKWDDIAHLREHLPDDITLNHNEDYGLLALQGPKAVT
ALARLVPEAADLVFMQAMPATWNGHAIAISRSGYTGEDGFEISLPNDALESFADALCAMEEVKPIGLGARDSLRLEAGLP
LYGHDLDESIDPVEADLAFAISKRRREEGGFPGAARILGHLADGSPRKRVGLVIDGKLPVREGAKLFDGNTEIGVVTSGG
FAPSVGAPIAMGYVPTGLSEPGTAVAAEVRGKRVACTVTAMPFIPHRYVRKQGA

Sequences:

>Translated_374_residues
MHEDDEIPIETATLPLDAWHRAKGGRMVAFAGYWMPIQYDGIMAEHLWTRENAGLFDVSHMGQLALSGEGVAKALETLVP
GDISALKPGRMRYSLLLNDEGGVLDDLMITNEGDQFGIVVNGAVKWDDIAHLREHLPDDITLNHNEDYGLLALQGPKAVT
ALARLVPEAADLVFMQAMPATWNGHAIAISRSGYTGEDGFEISLPNDALESFADALCAMEEVKPIGLGARDSLRLEAGLP
LYGHDLDESIDPVEADLAFAISKRRREEGGFPGAARILGHLADGSPRKRVGLVIDGKLPVREGAKLFDGNTEIGVVTSGG
FAPSVGAPIAMGYVPTGLSEPGTAVAAEVRGKRVACTVTAMPFIPHRYVRKQGA
>Mature_374_residues
MHEDDEIPIETATLPLDAWHRAKGGRMVAFAGYWMPIQYDGIMAEHLWTRENAGLFDVSHMGQLALSGEGVAKALETLVP
GDISALKPGRMRYSLLLNDEGGVLDDLMITNEGDQFGIVVNGAVKWDDIAHLREHLPDDITLNHNEDYGLLALQGPKAVT
ALARLVPEAADLVFMQAMPATWNGHAIAISRSGYTGEDGFEISLPNDALESFADALCAMEEVKPIGLGARDSLRLEAGLP
LYGHDLDESIDPVEADLAFAISKRRREEGGFPGAARILGHLADGSPRKRVGLVIDGKLPVREGAKLFDGNTEIGVVTSGG
FAPSVGAPIAMGYVPTGLSEPGTAVAAEVRGKRVACTVTAMPFIPHRYVRKQGA

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=366, Percent_Identity=43.4426229508197, Blast_Score=260, Evalue=1e-69,
Organism=Homo sapiens, GI257796258, Length=347, Percent_Identity=43.2276657060519, Blast_Score=240, Evalue=1e-63,
Organism=Homo sapiens, GI257796254, Length=358, Percent_Identity=40.5027932960894, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI257796256, Length=317, Percent_Identity=41.6403785488959, Blast_Score=208, Evalue=6e-54,
Organism=Homo sapiens, GI197927446, Length=332, Percent_Identity=27.1084337349398, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI21361378, Length=332, Percent_Identity=27.1084337349398, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI24797151, Length=339, Percent_Identity=23.3038348082596, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1789272, Length=361, Percent_Identity=37.3961218836565, Blast_Score=193, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17560118, Length=370, Percent_Identity=37.8378378378378, Blast_Score=221, Evalue=6e-58,
Organism=Saccharomyces cerevisiae, GI6320222, Length=376, Percent_Identity=43.8829787234042, Blast_Score=257, Evalue=2e-69,
Organism=Drosophila melanogaster, GI20129441, Length=370, Percent_Identity=40, Blast_Score=251, Evalue=5e-67,
Organism=Drosophila melanogaster, GI20130091, Length=321, Percent_Identity=24.2990654205607, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 40007; Mature: 40007

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHEDDEIPIETATLPLDAWHRAKGGRMVAFAGYWMPIQYDGIMAEHLWTRENAGLFDVSH
CCCCCCCCEEEEECCHHHHHCCCCCEEEEEEEEEEEEEECCEEHHHHEECCCCCEEEHHH
MGQLALSGEGVAKALETLVPGDISALKPGRMRYSLLLNDEGGVLDDLMITNEGDQFGIVV
CCCEEECCCHHHHHHHHHCCCCHHHCCCCCEEEEEEECCCCCCEEEEEEECCCCEEEEEE
NGAVKWDDIAHLREHLPDDITLNHNEDYGLLALQGPKAVTALARLVPEAADLVFMQAMPA
ECCCCHHHHHHHHHHCCCCEEEECCCCEEEEEECCCHHHHHHHHHCCHHHHEEEEEECCC
TWNGHAIAISRSGYTGEDGFEISLPNDALESFADALCAMEEVKPIGLGARDSLRLEAGLP
CCCCEEEEEECCCCCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCC
LYGHDLDESIDPVEADLAFAISKRRREEGGFPGAARILGHLADGSPRKRVGLVIDGKLPV
EECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCEEEEEEECCCCH
REGAKLFDGNTEIGVVTSGGFAPSVGAPIAMGYVPTGLSEPGTAVAAEVRGKRVACTVTA
HCCCEEECCCCEEEEEECCCCCCCCCCCEEECEECCCCCCCCCEEEHHHCCCEEEEEEEE
MPFIPHRYVRKQGA
CCCCCHHHHHHCCC
>Mature Secondary Structure
MHEDDEIPIETATLPLDAWHRAKGGRMVAFAGYWMPIQYDGIMAEHLWTRENAGLFDVSH
CCCCCCCCEEEEECCHHHHHCCCCCEEEEEEEEEEEEEECCEEHHHHEECCCCCEEEHHH
MGQLALSGEGVAKALETLVPGDISALKPGRMRYSLLLNDEGGVLDDLMITNEGDQFGIVV
CCCEEECCCHHHHHHHHHCCCCHHHCCCCCEEEEEEECCCCCCEEEEEEECCCCEEEEEE
NGAVKWDDIAHLREHLPDDITLNHNEDYGLLALQGPKAVTALARLVPEAADLVFMQAMPA
ECCCCHHHHHHHHHHCCCCEEEECCCCEEEEEECCCHHHHHHHHHCCHHHHEEEEEECCC
TWNGHAIAISRSGYTGEDGFEISLPNDALESFADALCAMEEVKPIGLGARDSLRLEAGLP
CCCCEEEEEECCCCCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCC
LYGHDLDESIDPVEADLAFAISKRRREEGGFPGAARILGHLADGSPRKRVGLVIDGKLPV
EECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCEEEEEEECCCCH
REGAKLFDGNTEIGVVTSGGFAPSVGAPIAMGYVPTGLSEPGTAVAAEVRGKRVACTVTA
HCCCEEECCCCEEEEEECCCCCCCCCCCEEECEECCCCCCCCCEEEHHHCCCEEEEEEEE
MPFIPHRYVRKQGA
CCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA