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The map label for this gene is gcvPB [H]

Identifier: 103487351

GI number: 103487351

Start: 1962469

End: 1964022

Strand: Reverse

Name: gcvPB [H]

Synonym: Sala_1867

Alternate gene names: 103487351

Gene position: 1964022-1962469 (Counterclockwise)

Preceding gene: 103487352

Following gene: 103487350

Centisome position: 58.71

GC content: 66.02

Gene sequence:

>1554_bases
ATGACCGCGCTCAACCCTGCCGGCTGGCGCCCCGAAATGAATGCCGCGGGCGGTGCCGACGACAATGTGACCTTCACCGG
CAATCGCGCGCTGATGCTCGAAGAACCGCTGATTTTCGAGATCGGCTCGACCGAAACCACCGGCGTCGATTTCGACGAGG
AGCCGCACGCGCCCGACCTCGGTTCGCTGATGCGCAGCGGGCCAATCGGCCTGCCGGGACTCAGCGAATCCGAAACGGTG
CGCCACTATACGCGCCTCAGCCGCCAGAATTACGCGATCGACCTCGGCCTCTTCCCGCTCGGCAGCTGCACGATGAAGCA
CAACCCGCGCCTGAACGAAAAGGTCGCGCGGATGCCGGGCTTTGCCGACGTCCACCCGCTGCAACCGCAGGAAACGGTGC
AGGGCGCGCTCGCGGTGATCAACGAACTCGCGGTATGGCTGATCAAGCTCACCGGCATGTATGGTGTCGCCATGTCGCCC
AAGGCGGGCGCGCACGGCGAGCTGTGCGGCATATTGTGCATCAAGGCGGCATTGGAGGCGCGCGGCGAGGATCGCCGCGT
CATTCTCGTGCCGGAAAGCGCGCACGGCACCAACCCTGCGACCGCGGCCTTTGCGGGCTTCACCGTCGAGGATATTCCGG
CGACGAAGGAAGGTCGCGTCGATCTGGCGGCGCTGAAGGCACGGCTCGGCCCCGATGTCGCCGGGGTGATGATTACCAAC
CCCAACACCTGCGGCCTGTTCGAGCGCGACATGAAGGCGATTTCGGACGCGGTCCACGCCGCGGGCGGCTATGTCTATTG
CGATGGCGCCAATTTCAACGCGATCGTCGGGCGCGTGCGTCCGGGCGACCTTGGCATCGATGCGATGCACATCAACCTGC
ACAAGACTTTCTCGACCCCACACGGCGGCGGCGGGCCGGGGTCAGGGCCGGTCGTGCTGTCGGAGGCGCTGGCCCCCTAT
GGCCCGCTGCCCTTCGTCGCGCGCTATGCTGACGGCACGTTCAAGCTGATCGAGGAGGAAAATGCCGCCGACGAGCATCC
CGCGACCTTCGGCCGCATGACCGCCTTCCACGGTCAGATGGGCATGTTCACCCGCGCGCTCGCCTATATCCTCAGCCACG
GTGCCGACGGCCTCAAGCAGGTCGCCGAGGATGCGGTGCTCAACGCCAATTATGTGTTGCGCAGTCTGGAGGACGTGCTC
GACGCGCCCTTCGCGGCATCGGGGCCTTGTATGCACGAGGCGCTGTTCAGCGATAAGGGGCTGGCCGAGGGCTTTTCGAC
GCTCGACATCGCCAAGGGGCTGATCGACGAAGGTTATCATCCGATGACGGTCTATTTCCCGCTCGTCGTCCACGGCGCGA
TGCTGATCGAGCCGACCGAGACGGAGAGCAAGGCCGTGCTCGACCAGTTCATCGGCGCGCTGCGCAGCATCGCGATGCGC
GCGAAGAACGGCGACCCGGCGCTCAAATCGGCGCCGCATTTCGCCCCGCGCGCGCGGCTCGACGAGACGCTGGCGGCGCG
GAAGCCCGTGCTGGCGTGGGAAGGCGATCTATAA

Upstream 100 bases:

>100_bases
ACACGGCGGCCCTCGAAAACGGGCTCGTCGTCGCCGTGACCGAAACCGTGACCGAGGCGGATATTGCCGCCTTCGCCGCG
GCGCTGAAGGAGGTGCTGGC

Downstream 100 bases:

>100_bases
TCCATCGTCATCCCGGCGAAGGCCGGGATCTCGCCGGTGCGTCATGATTACAGGATGAGATCCCGGCCTTCGCCGGGATG
ACGGGTAACAGGGGAGGGTG

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2 [H]

Number of amino acids: Translated: 517; Mature: 516

Protein sequence:

>517_residues
MTALNPAGWRPEMNAAGGADDNVTFTGNRALMLEEPLIFEIGSTETTGVDFDEEPHAPDLGSLMRSGPIGLPGLSESETV
RHYTRLSRQNYAIDLGLFPLGSCTMKHNPRLNEKVARMPGFADVHPLQPQETVQGALAVINELAVWLIKLTGMYGVAMSP
KAGAHGELCGILCIKAALEARGEDRRVILVPESAHGTNPATAAFAGFTVEDIPATKEGRVDLAALKARLGPDVAGVMITN
PNTCGLFERDMKAISDAVHAAGGYVYCDGANFNAIVGRVRPGDLGIDAMHINLHKTFSTPHGGGGPGSGPVVLSEALAPY
GPLPFVARYADGTFKLIEEENAADEHPATFGRMTAFHGQMGMFTRALAYILSHGADGLKQVAEDAVLNANYVLRSLEDVL
DAPFAASGPCMHEALFSDKGLAEGFSTLDIAKGLIDEGYHPMTVYFPLVVHGAMLIEPTETESKAVLDQFIGALRSIAMR
AKNGDPALKSAPHFAPRARLDETLAARKPVLAWEGDL

Sequences:

>Translated_517_residues
MTALNPAGWRPEMNAAGGADDNVTFTGNRALMLEEPLIFEIGSTETTGVDFDEEPHAPDLGSLMRSGPIGLPGLSESETV
RHYTRLSRQNYAIDLGLFPLGSCTMKHNPRLNEKVARMPGFADVHPLQPQETVQGALAVINELAVWLIKLTGMYGVAMSP
KAGAHGELCGILCIKAALEARGEDRRVILVPESAHGTNPATAAFAGFTVEDIPATKEGRVDLAALKARLGPDVAGVMITN
PNTCGLFERDMKAISDAVHAAGGYVYCDGANFNAIVGRVRPGDLGIDAMHINLHKTFSTPHGGGGPGSGPVVLSEALAPY
GPLPFVARYADGTFKLIEEENAADEHPATFGRMTAFHGQMGMFTRALAYILSHGADGLKQVAEDAVLNANYVLRSLEDVL
DAPFAASGPCMHEALFSDKGLAEGFSTLDIAKGLIDEGYHPMTVYFPLVVHGAMLIEPTETESKAVLDQFIGALRSIAMR
AKNGDPALKSAPHFAPRARLDETLAARKPVLAWEGDL
>Mature_516_residues
TALNPAGWRPEMNAAGGADDNVTFTGNRALMLEEPLIFEIGSTETTGVDFDEEPHAPDLGSLMRSGPIGLPGLSESETVR
HYTRLSRQNYAIDLGLFPLGSCTMKHNPRLNEKVARMPGFADVHPLQPQETVQGALAVINELAVWLIKLTGMYGVAMSPK
AGAHGELCGILCIKAALEARGEDRRVILVPESAHGTNPATAAFAGFTVEDIPATKEGRVDLAALKARLGPDVAGVMITNP
NTCGLFERDMKAISDAVHAAGGYVYCDGANFNAIVGRVRPGDLGIDAMHINLHKTFSTPHGGGGPGSGPVVLSEALAPYG
PLPFVARYADGTFKLIEEENAADEHPATFGRMTAFHGQMGMFTRALAYILSHGADGLKQVAEDAVLNANYVLRSLEDVLD
APFAASGPCMHEALFSDKGLAEGFSTLDIAKGLIDEGYHPMTVYFPLVVHGAMLIEPTETESKAVLDQFIGALRSIAMRA
KNGDPALKSAPHFAPRARLDETLAARKPVLAWEGDL

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=411, Percent_Identity=39.4160583941606, Blast_Score=241, Evalue=2e-63,
Organism=Escherichia coli, GI1789269, Length=435, Percent_Identity=40, Blast_Score=264, Evalue=8e-72,
Organism=Caenorhabditis elegans, GI17535605, Length=465, Percent_Identity=35.6989247311828, Blast_Score=238, Evalue=5e-63,
Organism=Caenorhabditis elegans, GI32564013, Length=401, Percent_Identity=36.6583541147132, Blast_Score=214, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6323843, Length=436, Percent_Identity=38.7614678899083, Blast_Score=252, Evalue=8e-68,
Organism=Drosophila melanogaster, GI24645648, Length=448, Percent_Identity=38.3928571428571, Blast_Score=237, Evalue=2e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 54956; Mature: 54825

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALNPAGWRPEMNAAGGADDNVTFTGNRALMLEEPLIFEIGSTETTGVDFDEEPHAPDL
CCCCCCCCCCCCCCCCCCCCCCEEEECCEEEEECCCEEEEECCCCCCCCCCCCCCCCCCH
GSLMRSGPIGLPGLSESETVRHYTRLSRQNYAIDLGLFPLGSCTMKHNPRLNEKVARMPG
HHHHHCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHCCC
FADVHPLQPQETVQGALAVINELAVWLIKLTGMYGVAMSPKAGAHGELCGILCIKAALEA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCEEECCCCCCCCHHHHHHHHHHHHHC
RGEDRRVILVPESAHGTNPATAAFAGFTVEDIPATKEGRVDLAALKARLGPDVAGVMITN
CCCCCEEEEEECCCCCCCCCHHHCCCCEEECCCCCCCCCCHHHHHHHHCCCCEEEEEEEC
PNTCGLFERDMKAISDAVHAAGGYVYCDGANFNAIVGRVRPGDLGIDAMHINLHKTFSTP
CCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCEEEEEECCCCCCCEEEEEEEEEEEECCC
HGGGGPGSGPVVLSEALAPYGPLPFVARYADGTFKLIEEENAADEHPATFGRMTAFHGQM
CCCCCCCCCCEEHHHHHCCCCCCCHHEECCCCEEEEEECCCCCCCCCCHHHHHHHHHCHH
GMFTRALAYILSHGADGLKQVAEDAVLNANYVLRSLEDVLDAPFAASGPCMHEALFSDKG
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCC
LAEGFSTLDIAKGLIDEGYHPMTVYFPLVVHGAMLIEPTETESKAVLDQFIGALRSIAMR
HHHCCHHHHHHHHHHHCCCCCEEEEEHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHH
AKNGDPALKSAPHFAPRARLDETLAARKPVLAWEGDL
CCCCCCCHHCCCCCCCHHHHHHHHHHCCCCEEECCCC
>Mature Secondary Structure 
TALNPAGWRPEMNAAGGADDNVTFTGNRALMLEEPLIFEIGSTETTGVDFDEEPHAPDL
CCCCCCCCCCCCCCCCCCCCCEEEECCEEEEECCCEEEEECCCCCCCCCCCCCCCCCCH
GSLMRSGPIGLPGLSESETVRHYTRLSRQNYAIDLGLFPLGSCTMKHNPRLNEKVARMPG
HHHHHCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHCCC
FADVHPLQPQETVQGALAVINELAVWLIKLTGMYGVAMSPKAGAHGELCGILCIKAALEA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCEEECCCCCCCCHHHHHHHHHHHHHC
RGEDRRVILVPESAHGTNPATAAFAGFTVEDIPATKEGRVDLAALKARLGPDVAGVMITN
CCCCCEEEEEECCCCCCCCCHHHCCCCEEECCCCCCCCCCHHHHHHHHCCCCEEEEEEEC
PNTCGLFERDMKAISDAVHAAGGYVYCDGANFNAIVGRVRPGDLGIDAMHINLHKTFSTP
CCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCEEEEEECCCCCCCEEEEEEEEEEEECCC
HGGGGPGSGPVVLSEALAPYGPLPFVARYADGTFKLIEEENAADEHPATFGRMTAFHGQM
CCCCCCCCCCEEHHHHHCCCCCCCHHEECCCCEEEEEECCCCCCCCCCHHHHHHHHHCHH
GMFTRALAYILSHGADGLKQVAEDAVLNANYVLRSLEDVLDAPFAASGPCMHEALFSDKG
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCC
LAEGFSTLDIAKGLIDEGYHPMTVYFPLVVHGAMLIEPTETESKAVLDQFIGALRSIAMR
HHHCCHHHHHHHHHHHCCCCCEEEEEHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHH
AKNGDPALKSAPHFAPRARLDETLAARKPVLAWEGDL
CCCCCCCHHCCCCCCCHHHHHHHHHHCCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]