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The map label for this gene is gcvPA

Identifier: 103487352

GI number: 103487352

Start: 1964019

End: 1965377

Strand: Reverse

Name: gcvPA

Synonym: Sala_1868

Alternate gene names: 103487352

Gene position: 1965377-1964019 (Counterclockwise)

Preceding gene: 103487353

Following gene: 103487351

Centisome position: 58.75

GC content: 65.93

Gene sequence:

>1359_bases
ATGCGTTATCTCCCGCTCACTCCCGATGACCGCGCAGCGATGCTGGGGGCCATCGGTGCGTCGTCGATCGACGAACTGTT
CGCCGATGTCCCCGCCGGGGCGCGGCTCGACGGTCCGATTGCCGGATTGCCGATGCACGCGAGCGAGCTTGCGGTCGAAC
GCCATATGGGCGCGCTTGCGCGCCGCAATCGCGCCGCGGGCGACGGGCCTTTCTTCCTCGGCGCGGGCGCCTATCGTCAC
CATGTGCCCGCCAGCGTCGATCATCTGATCCAGCGCGGCGAGTTTCTGACCGCCTATACCCCCTATCAGCCCGAAATCGC
GCAGGGCACGTTGCAGATGCTCTTCGAGTTCCAGAGCCAGGTCGCGCGGCTGTTCGGCACCGACGTCGCCAATGCGTCGA
TGTACGATGGCTCGACCGCCTGCTGGGAAGCGATCGTCATGGCGCGGCGCATTACCAGGCGCAGCAAGGCCTTGCTGTCG
ACCGGCCTGCACCCGCATTATCGCAGCGTCGCGCGGACGATGGCCAAATATACCCGCGATGTGCTCGTCGACGGCGATCC
TCGCCTTGAACCCGGCACCGACTGGGCGGCGCTCGCGGGCCGCATCGACACGGAGACGAGCTGCGTCGTCGTCCAATATC
CCGACATCCTCGGCCGCATCGACGATATGACGACGCTTGCCGAGGCCTGTCAGACTGCGGGCGCGCTGCTGATCGCGGTC
GTCACCGAACCCGTCGCGCTGGGCCTCATCAAGTCGCCGGGCGAAATGGGCGCCGACATTGTGGTTGGCGAGGGCCAGTC
GCTCGGCGTCGGCCTGCAATTCGGCGGCCCCTATGTCGGCCTTTTTGCGTGCAAGAGTAAATATGTCCGCCAGATGCCGG
GGCGGCTGTGCGGCGAGACGGTCGACGCCAATGGCAAGCGCGGTTTCGTGCTGACGCTCTCGACGCGCGAACAGCATATT
CGCCGCGAGAAGGCGACGAGTAATATCTGCACCAATTCAGGACTTTGTGCGCTGGCATTCAGCATCCACATGACGTTGCT
GGGCGAGGCCGGGCTGCGCCAGCTCGCCACGATCAACCATGGCCGGGCCAAGGCAGCGGCGACGGAACTTGCGAAGGTGC
CTGCCGTGTCGGTGATGAACGACAGCTTCTTCAACGAGTTCACGCTGCTGCTGCCCACCGCCGCCCGGCCGGTGGTCCAC
AGGCTCGCGGAGCAGGACATATTGGGCGGCGTTTCGCTCGGCCGTCTCTATCCCGACACGGCGGCCCTCGAAAACGGGCT
CGTCGTCGCCGTGACCGAAACCGTGACCGAGGCGGATATTGCCGCCTTCGCCGCGGCGCTGAAGGAGGTGCTGGCATGA

Upstream 100 bases:

>100_bases
GGTCCGCACCACCCATGCGGGGCCGATGGTCTTCGCCGGTGCGCTTGCCGACACGGCGCAGCTTTATTCTGTCAATCCAG
ACTCTTCTGTGGAGTAGTTC

Downstream 100 bases:

>100_bases
CCGCGCTCAACCCTGCCGGCTGGCGCCCCGAAATGAATGCCGCGGGCGGTGCCGACGACAATGTGACCTTCACCGGCAAT
CGCGCGCTGATGCTCGAAGA

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MRYLPLTPDDRAAMLGAIGASSIDELFADVPAGARLDGPIAGLPMHASELAVERHMGALARRNRAAGDGPFFLGAGAYRH
HVPASVDHLIQRGEFLTAYTPYQPEIAQGTLQMLFEFQSQVARLFGTDVANASMYDGSTACWEAIVMARRITRRSKALLS
TGLHPHYRSVARTMAKYTRDVLVDGDPRLEPGTDWAALAGRIDTETSCVVVQYPDILGRIDDMTTLAEACQTAGALLIAV
VTEPVALGLIKSPGEMGADIVVGEGQSLGVGLQFGGPYVGLFACKSKYVRQMPGRLCGETVDANGKRGFVLTLSTREQHI
RREKATSNICTNSGLCALAFSIHMTLLGEAGLRQLATINHGRAKAAATELAKVPAVSVMNDSFFNEFTLLLPTAARPVVH
RLAEQDILGGVSLGRLYPDTAALENGLVVAVTETVTEADIAAFAAALKEVLA

Sequences:

>Translated_452_residues
MRYLPLTPDDRAAMLGAIGASSIDELFADVPAGARLDGPIAGLPMHASELAVERHMGALARRNRAAGDGPFFLGAGAYRH
HVPASVDHLIQRGEFLTAYTPYQPEIAQGTLQMLFEFQSQVARLFGTDVANASMYDGSTACWEAIVMARRITRRSKALLS
TGLHPHYRSVARTMAKYTRDVLVDGDPRLEPGTDWAALAGRIDTETSCVVVQYPDILGRIDDMTTLAEACQTAGALLIAV
VTEPVALGLIKSPGEMGADIVVGEGQSLGVGLQFGGPYVGLFACKSKYVRQMPGRLCGETVDANGKRGFVLTLSTREQHI
RREKATSNICTNSGLCALAFSIHMTLLGEAGLRQLATINHGRAKAAATELAKVPAVSVMNDSFFNEFTLLLPTAARPVVH
RLAEQDILGGVSLGRLYPDTAALENGLVVAVTETVTEADIAAFAAALKEVLA
>Mature_452_residues
MRYLPLTPDDRAAMLGAIGASSIDELFADVPAGARLDGPIAGLPMHASELAVERHMGALARRNRAAGDGPFFLGAGAYRH
HVPASVDHLIQRGEFLTAYTPYQPEIAQGTLQMLFEFQSQVARLFGTDVANASMYDGSTACWEAIVMARRITRRSKALLS
TGLHPHYRSVARTMAKYTRDVLVDGDPRLEPGTDWAALAGRIDTETSCVVVQYPDILGRIDDMTTLAEACQTAGALLIAV
VTEPVALGLIKSPGEMGADIVVGEGQSLGVGLQFGGPYVGLFACKSKYVRQMPGRLCGETVDANGKRGFVLTLSTREQHI
RREKATSNICTNSGLCALAFSIHMTLLGEAGLRQLATINHGRAKAAATELAKVPAVSVMNDSFFNEFTLLLPTAARPVVH
RLAEQDILGGVSLGRLYPDTAALENGLVVAVTETVTEADIAAFAAALKEVLA

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily

Homologues:

Organism=Homo sapiens, GI108773801, Length=434, Percent_Identity=35.4838709677419, Blast_Score=230, Evalue=2e-60,
Organism=Escherichia coli, GI1789269, Length=362, Percent_Identity=35.0828729281768, Blast_Score=177, Evalue=9e-46,
Organism=Caenorhabditis elegans, GI17535605, Length=438, Percent_Identity=33.1050228310502, Blast_Score=188, Evalue=5e-48,
Organism=Saccharomyces cerevisiae, GI6323843, Length=461, Percent_Identity=32.1041214750542, Blast_Score=197, Evalue=4e-51,
Organism=Drosophila melanogaster, GI24645648, Length=442, Percent_Identity=35.5203619909502, Blast_Score=221, Evalue=9e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCSPA_SPHAL (Q1GRZ2)

Other databases:

- EMBL:   CP000356
- RefSeq:   YP_616913.1
- ProteinModelPortal:   Q1GRZ2
- SMR:   Q1GRZ2
- GeneID:   4080183
- GenomeReviews:   CP000356_GR
- KEGG:   sal:Sala_1868
- NMPDR:   fig|317655.9.peg.1796
- HOGENOM:   HBG288345
- OMA:   VTEKRTK
- ProtClustDB:   PRK00451
- BioCyc:   SALA317655:SALA_1868-MONOMER
- BRENDA:   1.4.4.2
- HAMAP:   MF_00712
- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421
- Gene3D:   G3DSA:3.40.640.10
- PANTHER:   PTHR11773

Pfam domain/function: PF02347 GDC-P; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =1.4.4.2

Molecular weight: Translated: 48146; Mature: 48146

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYLPLTPDDRAAMLGAIGASSIDELFADVPAGARLDGPIAGLPMHASELAVERHMGALA
CCCCCCCCCCHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
RRNRAAGDGPFFLGAGAYRHHVPASVDHLIQRGEFLTAYTPYQPEIAQGTLQMLFEFQSQ
HCCCCCCCCCEEECCCCHHHCCCHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHH
VARLFGTDVANASMYDGSTACWEAIVMARRITRRSKALLSTGLHPHYRSVARTMAKYTRD
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
VLVDGDPRLEPGTDWAALAGRIDTETSCVVVQYPDILGRIDDMTTLAEACQTAGALLIAV
EEECCCCCCCCCCCHHHHHCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHEEEEE
VTEPVALGLIKSPGEMGADIVVGEGQSLGVGLQFGGPYVGLFACKSKYVRQMPGRLCGET
HHCHHHHHEECCCCCCCCCEEEECCCCCEEEEECCCCEEHHHHHHHHHHHHCCHHHCCCC
VDANGKRGFVLTLSTREQHIRREKATSNICTNSGLCALAFSIHMTLLGEAGLRQLATINH
CCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
GRAKAAATELAKVPAVSVMNDSFFNEFTLLLPTAARPVVHRLAEQDILGGVSLGRLYPDT
CHHHHHHHHHHHCCCHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHCCCHHCCCCCCH
AALENGLVVAVTETVTEADIAAFAAALKEVLA
HHHCCCEEEEEECHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MRYLPLTPDDRAAMLGAIGASSIDELFADVPAGARLDGPIAGLPMHASELAVERHMGALA
CCCCCCCCCCHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
RRNRAAGDGPFFLGAGAYRHHVPASVDHLIQRGEFLTAYTPYQPEIAQGTLQMLFEFQSQ
HCCCCCCCCCEEECCCCHHHCCCHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHH
VARLFGTDVANASMYDGSTACWEAIVMARRITRRSKALLSTGLHPHYRSVARTMAKYTRD
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
VLVDGDPRLEPGTDWAALAGRIDTETSCVVVQYPDILGRIDDMTTLAEACQTAGALLIAV
EEECCCCCCCCCCCHHHHHCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHEEEEE
VTEPVALGLIKSPGEMGADIVVGEGQSLGVGLQFGGPYVGLFACKSKYVRQMPGRLCGET
HHCHHHHHEECCCCCCCCCEEEECCCCCEEEEECCCCEEHHHHHHHHHHHHCCHHHCCCC
VDANGKRGFVLTLSTREQHIRREKATSNICTNSGLCALAFSIHMTLLGEAGLRQLATINH
CCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
GRAKAAATELAKVPAVSVMNDSFFNEFTLLLPTAARPVVHRLAEQDILGGVSLGRLYPDT
CHHHHHHHHHHHCCCHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHCCCHHCCCCCCH
AALENGLVVAVTETVTEADIAAFAAALKEVLA
HHHCCCEEEEEECHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA