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The map label for this gene is bioA [H]

Identifier: 103486960

GI number: 103486960

Start: 1534336

End: 1535592

Strand: Direct

Name: bioA [H]

Synonym: Sala_1475

Alternate gene names: 103486960

Gene position: 1534336-1535592 (Clockwise)

Preceding gene: 103486959

Following gene: 103486961

Centisome position: 45.87

GC content: 66.43

Gene sequence:

>1257_bases
ATGGCCAAAAACCCTTCCCCCGTCTGGCACCCCTTTACCCAGCACGGTCTCGGCGAACCGATCCCGCTGATCAGCCACGC
GAGCGGCGCCAGGCTCCACGATGCCGCGGGCAACAGCTGGATCGACGCCATCTCGAGCTGGTGGATCACCACCCACGGCC
ACGCGCACCCGCGCATCATGGCTGCGATCCGCGCCCAGACCGAAAAGCTTGACCAGATCATCTTCGCCGGCTGGACGCAC
GAACCCGCCGAAACGCTCGCCGCCGCGCTGGTGCGCATCACCCCCGATCCGCTCACCCGCGTCTTCTTCTCGGACTCGGG
CTCGACCAGCGTGGAGGTCGCGCTGAAGATGGCGCTCGGATACTGGTTCAACATCGGCGAGGCGCGCAGCCGCATCCTTG
TCCTCGAACACAGCTATCACGGCGACACGATCGGCACGATGTCGGTCGGCGAGCGCGGCGTCTATAACCGCGCCTGGCAG
CCTTTGCTCTTCGATGTCGACACCATCCCCTTCCCGCACGAAGGGGGGGAGCAGGCGACGCTCGACGCGCTCGATGCCGC
GTGCACGGAAAAACCCGCCGCTTTCATCGTCGAACCGCTCATCCTCGGCGCCGGCGGGATGCTCGTCTATCCCGCGTGGG
TACTCGCCGAGATGCGAAGCATCTGCGCGCGCCACGGCGTCCTCTTTATCGCCGACGAGGTGATGACCGGGTGGGGCCGC
ACGGGCACACGCTTCGCTTGCGACCAGGCGGGAATCATCCCCGACATCATGTGCCTTTCGAAAGGGCTGACGGGCGGCGC
GATCCCGCTTGCGGTGACGCTGTGTATCGAGCCGGTCTTCGACGCGCATTATTCGCACGACCGCAGCAAGACCTTTTATC
ATTCATCGAGCTACACGGCGAACCCGATCGCGTGCGCCGCGGCGAATGCGAACCTGGAAATCTGGCGCGACGAGCCGGTA
CAGCAGCGGATCGACGCGCTCGCAGGGGCACAGGCCGCGCATCTGGCGCTCCTCTCGCGCCATCCGCGCGTCGCCAATCC
TCGCCGGATCGGCACGATCGCCGCGCTCGACGTGACCACCCCCGATTCGGGCTATCTGTCGAACCTCGCGCCCCGGCTCG
CCGCCTTCTACCGCGAGCGCGGCGTCCTTCTCCGCCCGCTCGGCAACAGTGTCTATGTGATGCCGCCCTATTGCACCGAT
GCCACCGAACTGGCCCAGGTGTGGGAGGCGATTGCGGACTCGCTCGACACGATCTGA

Upstream 100 bases:

>100_bases
CGCCGCGGCGTTCGGCGCCAACTTCGACATCGCCGATTTCCGCTGAATTGGCCATTTCCGCTTTCGCTGGAATGACGAAG
GGATGTAAGGCGCGCCCGAC

Downstream 100 bases:

>100_bases
CATTCTGGCTCGCTCAGCCTGCGTTCAGCGTCGCGGCGCTATTGGCGGGCAACAAATGGCTCCAACGGCGGATTGCGCTG
GACCATCGGGCGTGTCCGCT

Product: adenosylmethionine--8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MAKNPSPVWHPFTQHGLGEPIPLISHASGARLHDAAGNSWIDAISSWWITTHGHAHPRIMAAIRAQTEKLDQIIFAGWTH
EPAETLAAALVRITPDPLTRVFFSDSGSTSVEVALKMALGYWFNIGEARSRILVLEHSYHGDTIGTMSVGERGVYNRAWQ
PLLFDVDTIPFPHEGGEQATLDALDAACTEKPAAFIVEPLILGAGGMLVYPAWVLAEMRSICARHGVLFIADEVMTGWGR
TGTRFACDQAGIIPDIMCLSKGLTGGAIPLAVTLCIEPVFDAHYSHDRSKTFYHSSSYTANPIACAAANANLEIWRDEPV
QQRIDALAGAQAAHLALLSRHPRVANPRRIGTIAALDVTTPDSGYLSNLAPRLAAFYRERGVLLRPLGNSVYVMPPYCTD
ATELAQVWEAIADSLDTI

Sequences:

>Translated_418_residues
MAKNPSPVWHPFTQHGLGEPIPLISHASGARLHDAAGNSWIDAISSWWITTHGHAHPRIMAAIRAQTEKLDQIIFAGWTH
EPAETLAAALVRITPDPLTRVFFSDSGSTSVEVALKMALGYWFNIGEARSRILVLEHSYHGDTIGTMSVGERGVYNRAWQ
PLLFDVDTIPFPHEGGEQATLDALDAACTEKPAAFIVEPLILGAGGMLVYPAWVLAEMRSICARHGVLFIADEVMTGWGR
TGTRFACDQAGIIPDIMCLSKGLTGGAIPLAVTLCIEPVFDAHYSHDRSKTFYHSSSYTANPIACAAANANLEIWRDEPV
QQRIDALAGAQAAHLALLSRHPRVANPRRIGTIAALDVTTPDSGYLSNLAPRLAAFYRERGVLLRPLGNSVYVMPPYCTD
ATELAQVWEAIADSLDTI
>Mature_417_residues
AKNPSPVWHPFTQHGLGEPIPLISHASGARLHDAAGNSWIDAISSWWITTHGHAHPRIMAAIRAQTEKLDQIIFAGWTHE
PAETLAAALVRITPDPLTRVFFSDSGSTSVEVALKMALGYWFNIGEARSRILVLEHSYHGDTIGTMSVGERGVYNRAWQP
LLFDVDTIPFPHEGGEQATLDALDAACTEKPAAFIVEPLILGAGGMLVYPAWVLAEMRSICARHGVLFIADEVMTGWGRT
GTRFACDQAGIIPDIMCLSKGLTGGAIPLAVTLCIEPVFDAHYSHDRSKTFYHSSSYTANPIACAAANANLEIWRDEPVQ
QRIDALAGAQAAHLALLSRHPRVANPRRIGTIAALDVTTPDSGYLSNLAPRLAAFYRERGVLLRPLGNSVYVMPPYCTDA
TELAQVWEAIADSLDTI

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=408, Percent_Identity=27.6960784313726, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI13994255, Length=337, Percent_Identity=29.080118694362, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI284507298, Length=316, Percent_Identity=28.7974683544304, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI24119277, Length=416, Percent_Identity=24.5192307692308, Blast_Score=105, Evalue=1e-22,
Organism=Escherichia coli, GI1786991, Length=420, Percent_Identity=39.7619047619048, Blast_Score=265, Evalue=5e-72,
Organism=Escherichia coli, GI145693181, Length=394, Percent_Identity=30.4568527918782, Blast_Score=171, Evalue=8e-44,
Organism=Escherichia coli, GI1789016, Length=422, Percent_Identity=27.7251184834123, Blast_Score=149, Evalue=4e-37,
Organism=Escherichia coli, GI1788044, Length=313, Percent_Identity=33.5463258785943, Blast_Score=137, Evalue=9e-34,
Organism=Escherichia coli, GI1789759, Length=344, Percent_Identity=30.2325581395349, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1787560, Length=405, Percent_Identity=28.1481481481481, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1786349, Length=332, Percent_Identity=29.8192771084337, Blast_Score=99, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI25144271, Length=403, Percent_Identity=24.317617866005, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI32564660, Length=434, Percent_Identity=25.1152073732719, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71992977, Length=432, Percent_Identity=24.3055555555556, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI25144274, Length=286, Percent_Identity=26.5734265734266, Blast_Score=97, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6324386, Length=457, Percent_Identity=29.7592997811816, Blast_Score=194, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6323470, Length=417, Percent_Identity=28.537170263789, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6324432, Length=393, Percent_Identity=26.4631043256997, Blast_Score=115, Evalue=9e-27,
Organism=Drosophila melanogaster, GI21357415, Length=405, Percent_Identity=25.1851851851852, Blast_Score=125, Evalue=7e-29,
Organism=Drosophila melanogaster, GI161085790, Length=443, Percent_Identity=27.0880361173815, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI28574759, Length=425, Percent_Identity=27.7647058823529, Blast_Score=102, Evalue=7e-22,
Organism=Drosophila melanogaster, GI21356575, Length=402, Percent_Identity=24.6268656716418, Blast_Score=100, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 45387; Mature: 45256

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKNPSPVWHPFTQHGLGEPIPLISHASGARLHDAAGNSWIDAISSWWITTHGHAHPRIM
CCCCCCCCCCCHHHHCCCCCCCCEECCCCCEEECCCCCHHHHHHHHCEEEECCCCCHHHH
AAIRAQTEKLDQIIFAGWTHEPAETLAAALVRITPDPLTRVFFSDSGSTSVEVALKMALG
HHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHCCCCHHEEEEECCCCCCHHHHHHHHHHH
YWFNIGEARSRILVLEHSYHGDTIGTMSVGERGVYNRAWQPLLFDVDTIPFPHEGGEQAT
HHCCCCCCCCEEEEEEECCCCCCEEECCCCCCCCHHHCCCCEEEECCCCCCCCCCCCCHH
LDALDAACTEKPAAFIVEPLILGAGGMLVYPAWVLAEMRSICARHGVLFIADEVMTGWGR
HHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHCCCC
TGTRFACDQAGIIPDIMCLSKGLTGGAIPLAVTLCIEPVFDAHYSHDRSKTFYHSSSYTA
CCCEEECCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCC
NPIACAAANANLEIWRDEPVQQRIDALAGAQAAHLALLSRHPRVANPRRIGTIAALDVTT
CCEEEEECCCCEEEECCCHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCEEEEEEEECC
PDSGYLSNLAPRLAAFYRERGVLLRPLGNSVYVMPPYCTDATELAQVWEAIADSLDTI
CCCCHHHHHHHHHHHHHHHCCEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AKNPSPVWHPFTQHGLGEPIPLISHASGARLHDAAGNSWIDAISSWWITTHGHAHPRIM
CCCCCCCCCCHHHHCCCCCCCCEECCCCCEEECCCCCHHHHHHHHCEEEECCCCCHHHH
AAIRAQTEKLDQIIFAGWTHEPAETLAAALVRITPDPLTRVFFSDSGSTSVEVALKMALG
HHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHCCCCHHEEEEECCCCCCHHHHHHHHHHH
YWFNIGEARSRILVLEHSYHGDTIGTMSVGERGVYNRAWQPLLFDVDTIPFPHEGGEQAT
HHCCCCCCCCEEEEEEECCCCCCEEECCCCCCCCHHHCCCCEEEECCCCCCCCCCCCCHH
LDALDAACTEKPAAFIVEPLILGAGGMLVYPAWVLAEMRSICARHGVLFIADEVMTGWGR
HHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHCCCC
TGTRFACDQAGIIPDIMCLSKGLTGGAIPLAVTLCIEPVFDAHYSHDRSKTFYHSSSYTA
CCCEEECCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCC
NPIACAAANANLEIWRDEPVQQRIDALAGAQAAHLALLSRHPRVANPRRIGTIAALDVTT
CCEEEEECCCCEEEECCCHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCEEEEEEEECC
PDSGYLSNLAPRLAAFYRERGVLLRPLGNSVYVMPPYCTDATELAQVWEAIADSLDTI
CCCCHHHHHHHHHHHHHHHCCEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]